Human rhinovirus and coronavirus detection among allogeneic hematopoietic stem cell transplantation recipients
Identifieur interne : 000420 ( Pmc/Curation ); précédent : 000419; suivant : 000421Human rhinovirus and coronavirus detection among allogeneic hematopoietic stem cell transplantation recipients
Auteurs : Filippo Milano [États-Unis, Italie] ; Angela P. Campbell [États-Unis] ; Katherine A. Guthrie [États-Unis] ; Jane Kuypers [États-Unis] ; Janet A. Englund [États-Unis] ; Lawrence Corey [États-Unis] ; Michael Boeckh [Italie, États-Unis]Source :
- Blood [ 0006-4971 ] ; 2010.
Abstract
Little is known about clinical and virologic manifestations of rhinovirus (HRV) and coronavirus (HCoV) infections after hematopoietic cell transplantation (HCT). We performed surveillance for 1 year and describe the natural history of these infections during the first 100 days after allogeneic HCT, when symptom surveys and upper respiratory samples were collected weekly. Samples were tested using RT-PCR for HRVs and HCoVs (OC43, 229E, HKU1, and NL63). Among 215 patients, 64 (30%) patients had 67 infections. Day 100 cumulative incidence estimate was 22.3% for HRV and 11.1% for HCoV. Median duration of viral shedding was 3 weeks; prolonged shedding of at least 3 months occurred in 6 of 45 patients with HRV and 3 of 22 with HCoV. Six patients with HRV and 9 with HCoV were asymptomatic. HRV infection was associated with rhinorrhea, congestion, postnasal drip, sputum, and cough; HCoV infection was not associated with respiratory symptoms or hepatic dysfunction. Lower respiratory infection developed in 2 patients with HRV before day 100, and 1 each with HRV and HCoV after day 100. HRV and HCoV infections are common in the first 100 days after HCT, viral shedding lasts more than 3 weeks in half, and lower respiratory infection is rare.
Url:
DOI: 10.1182/blood-2009-09-244152
PubMed: 20042728
PubMed Central: 2837322
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000420
Links to Exploration step
PMC:2837322Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Human rhinovirus and coronavirus detection among allogeneic hematopoietic stem cell transplantation recipients</title><author><name sortKey="Milano, Filippo" sort="Milano, Filippo" uniqKey="Milano F" first="Filippo" last="Milano">Filippo Milano</name><affiliation wicri:level="2"><nlm:aff id="aff1">Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">University La Sapienza, Rome, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University La Sapienza, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Campbell, Angela P" sort="Campbell, Angela P" uniqKey="Campbell A" first="Angela P." last="Campbell">Angela P. Campbell</name><affiliation wicri:level="2"><nlm:aff id="aff1">Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="4"><nlm:aff wicri:cut="; and" id="aff3">University of Washington, Seattle</nlm:aff><orgName type="university">Université de Washington</orgName><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff4">Seattle Children's Hospital, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Seattle Children's Hospital</wicri:cityArea></affiliation></author><author><name sortKey="Guthrie, Katherine A" sort="Guthrie, Katherine A" uniqKey="Guthrie K" first="Katherine A." last="Guthrie">Katherine A. Guthrie</name><affiliation wicri:level="2"><nlm:aff id="aff1">Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Kuypers, Jane" sort="Kuypers, Jane" uniqKey="Kuypers J" first="Jane" last="Kuypers">Jane Kuypers</name><affiliation wicri:level="2"><nlm:aff id="aff1">Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="4"><nlm:aff wicri:cut="; and" id="aff3">University of Washington, Seattle</nlm:aff><orgName type="university">Université de Washington</orgName><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Englund, Janet A" sort="Englund, Janet A" uniqKey="Englund J" first="Janet A." last="Englund">Janet A. Englund</name><affiliation wicri:level="2"><nlm:aff id="aff1">Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="4"><nlm:aff wicri:cut="; and" id="aff3">University of Washington, Seattle</nlm:aff><orgName type="university">Université de Washington</orgName><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff4">Seattle Children's Hospital, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Seattle Children's Hospital</wicri:cityArea></affiliation></author><author><name sortKey="Corey, Lawrence" sort="Corey, Lawrence" uniqKey="Corey L" first="Lawrence" last="Corey">Lawrence Corey</name><affiliation wicri:level="2"><nlm:aff id="aff1">Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="4"><nlm:aff wicri:cut="; and" id="aff3">University of Washington, Seattle</nlm:aff><orgName type="university">Université de Washington</orgName><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Boeckh, Michael" sort="Boeckh, Michael" uniqKey="Boeckh M" first="Michael" last="Boeckh">Michael Boeckh</name><affiliation wicri:level="1"><nlm:aff id="aff2">University La Sapienza, Rome, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University La Sapienza, Rome</wicri:regionArea></affiliation><affiliation wicri:level="4"><nlm:aff wicri:cut="; and" id="aff3">University of Washington, Seattle</nlm:aff><orgName type="university">Université de Washington</orgName><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20042728</idno><idno type="pmc">2837322</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837322</idno><idno type="RBID">PMC:2837322</idno><idno type="doi">10.1182/blood-2009-09-244152</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000420</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000420</idno><idno type="wicri:Area/Pmc/Curation">000420</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000420</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Human rhinovirus and coronavirus detection among allogeneic hematopoietic stem cell transplantation recipients</title><author><name sortKey="Milano, Filippo" sort="Milano, Filippo" uniqKey="Milano F" first="Filippo" last="Milano">Filippo Milano</name><affiliation wicri:level="2"><nlm:aff id="aff1">Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">University La Sapienza, Rome, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University La Sapienza, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Campbell, Angela P" sort="Campbell, Angela P" uniqKey="Campbell A" first="Angela P." last="Campbell">Angela P. Campbell</name><affiliation wicri:level="2"><nlm:aff id="aff1">Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="4"><nlm:aff wicri:cut="; and" id="aff3">University of Washington, Seattle</nlm:aff><orgName type="university">Université de Washington</orgName><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff4">Seattle Children's Hospital, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Seattle Children's Hospital</wicri:cityArea></affiliation></author><author><name sortKey="Guthrie, Katherine A" sort="Guthrie, Katherine A" uniqKey="Guthrie K" first="Katherine A." last="Guthrie">Katherine A. Guthrie</name><affiliation wicri:level="2"><nlm:aff id="aff1">Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Kuypers, Jane" sort="Kuypers, Jane" uniqKey="Kuypers J" first="Jane" last="Kuypers">Jane Kuypers</name><affiliation wicri:level="2"><nlm:aff id="aff1">Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="4"><nlm:aff wicri:cut="; and" id="aff3">University of Washington, Seattle</nlm:aff><orgName type="university">Université de Washington</orgName><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Englund, Janet A" sort="Englund, Janet A" uniqKey="Englund J" first="Janet A." last="Englund">Janet A. Englund</name><affiliation wicri:level="2"><nlm:aff id="aff1">Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="4"><nlm:aff wicri:cut="; and" id="aff3">University of Washington, Seattle</nlm:aff><orgName type="university">Université de Washington</orgName><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff4">Seattle Children's Hospital, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Seattle Children's Hospital</wicri:cityArea></affiliation></author><author><name sortKey="Corey, Lawrence" sort="Corey, Lawrence" uniqKey="Corey L" first="Lawrence" last="Corey">Lawrence Corey</name><affiliation wicri:level="2"><nlm:aff id="aff1">Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="4"><nlm:aff wicri:cut="; and" id="aff3">University of Washington, Seattle</nlm:aff><orgName type="university">Université de Washington</orgName><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Boeckh, Michael" sort="Boeckh, Michael" uniqKey="Boeckh M" first="Michael" last="Boeckh">Michael Boeckh</name><affiliation wicri:level="1"><nlm:aff id="aff2">University La Sapienza, Rome, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University La Sapienza, Rome</wicri:regionArea></affiliation><affiliation wicri:level="4"><nlm:aff wicri:cut="; and" id="aff3">University of Washington, Seattle</nlm:aff><orgName type="university">Université de Washington</orgName><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author></analytic><series><title level="j">Blood</title><idno type="ISSN">0006-4971</idno><idno type="eISSN">1528-0020</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Little is known about clinical and virologic manifestations of rhinovirus (HRV) and coronavirus (HCoV) infections after hematopoietic cell transplantation (HCT). We performed surveillance for 1 year and describe the natural history of these infections during the first 100 days after allogeneic HCT, when symptom surveys and upper respiratory samples were collected weekly. Samples were tested using RT-PCR for HRVs and HCoVs (OC43, 229E, HKU1, and NL63). Among 215 patients, 64 (30%) patients had 67 infections. Day 100 cumulative incidence estimate was 22.3% for HRV and 11.1% for HCoV. Median duration of viral shedding was 3 weeks; prolonged shedding of at least 3 months occurred in 6 of 45 patients with HRV and 3 of 22 with HCoV. Six patients with HRV and 9 with HCoV were asymptomatic. HRV infection was associated with rhinorrhea, congestion, postnasal drip, sputum, and cough; HCoV infection was not associated with respiratory symptoms or hepatic dysfunction. Lower respiratory infection developed in 2 patients with HRV before day 100, and 1 each with HRV and HCoV after day 100. HRV and HCoV infections are common in the first 100 days after HCT, viral shedding lasts more than 3 weeks in half, and lower respiratory infection is rare.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Blood</journal-id><journal-id journal-id-type="hwp">bloodjournal</journal-id><journal-id journal-id-type="pmc">blood</journal-id><journal-id journal-id-type="publisher-id">Blood</journal-id><journal-title-group><journal-title>Blood</journal-title></journal-title-group><issn pub-type="ppub">0006-4971</issn><issn pub-type="epub">1528-0020</issn><publisher><publisher-name>American Society of Hematology</publisher-name><publisher-loc>Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20042728</article-id><article-id pub-id-type="pmc">2837322</article-id><article-id pub-id-type="publisher-id">2009/244152</article-id><article-id pub-id-type="doi">10.1182/blood-2009-09-244152</article-id><article-categories><subj-group subj-group-type="heading"><subject>Transplantation</subject></subj-group><series-title>Transplantation</series-title></article-categories><title-group><article-title>Human rhinovirus and coronavirus detection among allogeneic hematopoietic stem cell transplantation recipients</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Milano</surname><given-names>Filippo</given-names></name><xref ref-type="author-notes" rid="FN1">*</xref><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Campbell</surname><given-names>Angela P.</given-names></name><xref ref-type="author-notes" rid="FN1">*</xref><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Guthrie</surname><given-names>Katherine A.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kuypers</surname><given-names>Jane</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Englund</surname><given-names>Janet A.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Corey</surname><given-names>Lawrence</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Boeckh</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><aff id="aff1"><label>1</label>Fred Hutchinson Cancer Research Center, Seattle, WA;</aff><aff id="aff2"><label>2</label>University La Sapienza, Rome, Italy;</aff><aff id="aff3"><label>3</label>University of Washington, Seattle; and</aff><aff id="aff4"><label>4</label>Seattle Children's Hospital, WA</aff></contrib-group><author-notes><fn id="FN1" fn-type="equal"><label>*</label><p>F.M. and A.P.C. contributed equally to this study.</p></fn></author-notes><pub-date pub-type="ppub"><day>11</day><month>3</month><year>2010</year></pub-date><pub-date pub-type="epreprint"><day>30</day><month>12</month><year>2009</year></pub-date><pub-date pub-type="pmc-release"><day>11</day><month>3</month><year>2011</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>115</volume><issue>10</issue><fpage>2088</fpage><lpage>2094</lpage><history><date date-type="received"><day>20</day><month>9</month><year>2009</year></date><date date-type="accepted"><day>2</day><month>12</month><year>2009</year></date></history><permissions><copyright-statement>© 2010 by The American Society of Hematology</copyright-statement></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zh801010002088.pdf"></self-uri><abstract><p>Little is known about clinical and virologic manifestations of rhinovirus (HRV) and coronavirus (HCoV) infections after hematopoietic cell transplantation (HCT). We performed surveillance for 1 year and describe the natural history of these infections during the first 100 days after allogeneic HCT, when symptom surveys and upper respiratory samples were collected weekly. Samples were tested using RT-PCR for HRVs and HCoVs (OC43, 229E, HKU1, and NL63). Among 215 patients, 64 (30%) patients had 67 infections. Day 100 cumulative incidence estimate was 22.3% for HRV and 11.1% for HCoV. Median duration of viral shedding was 3 weeks; prolonged shedding of at least 3 months occurred in 6 of 45 patients with HRV and 3 of 22 with HCoV. Six patients with HRV and 9 with HCoV were asymptomatic. HRV infection was associated with rhinorrhea, congestion, postnasal drip, sputum, and cough; HCoV infection was not associated with respiratory symptoms or hepatic dysfunction. Lower respiratory infection developed in 2 patients with HRV before day 100, and 1 each with HRV and HCoV after day 100. HRV and HCoV infections are common in the first 100 days after HCT, viral shedding lasts more than 3 weeks in half, and lower respiratory infection is rare.</p></abstract><funding-group><award-group><funding-source id="CS100">National Institutes of Health</funding-source><award-id rid="CS100">CA 18029</award-id><award-id rid="CS100">HL081595</award-id><award-id rid="CS100">K23HL091059</award-id><award-id rid="CS100">L40 AI071572</award-id><award-id rid="CS100">K24HL093294</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000420 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000420 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV1
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:2837322
|texte= Human rhinovirus and coronavirus detection among allogeneic hematopoietic stem cell transplantation recipients
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:20042728" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a CovidV1
| This area was generated with Dilib version V0.6.33. |  |