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Efficacy of cineole in patients suffering from acute bronchitis: a placebo-controlled double-blind trial

Identifieur interne : 000399 ( Pmc/Curation ); précédent : 000398; suivant : 000400

Efficacy of cineole in patients suffering from acute bronchitis: a placebo-controlled double-blind trial

Auteurs : Juergen Fischer [Allemagne] ; Uwe Dethlefsen [Allemagne]

Source :

Cough (London, England) [ 1745-9974 ] ; 2013.

RBID : PMC:3842692

Abstract

Objective

Cineole has mucolytic, bronchodilating and anti-inflammatory properties and reduces the exacerbation rate in patients suffering from COPD, as well as ameliorates symptoms in patients suffering from asthma and rhinosinusitis. Based on these effects, we therefore postulated the hypothesis that patients with acute bronchitis would also benefit from therapy with Cineole.

Methods

As part of a double-blind, placebo-controlled, multi-center-study, a total of 242 patients with confirmed acute bronchitis was randomly selected to participate. Over a period of 10 days, all patients were administered 3 x 200 mg of Cineole, or a respective placebo, per day. The primary outcome measure was a Bronchitis Sum Score, which summarises the relevant symptoms of acute bronchitis.

Results

After 4 days of treatment it was notable, that the patient group treated with Cineole, showed significantly more improvements of the bronchitis-sum-score than those of the placebo group (p = 0.0383). The statistical significant difference of the individual outcome measures was especially underlined by the frequency of cough fits by p = 0.0001 after 4 days.

Conclusions

The effects of Cineole in the treatment of acute bronchitis were clearly measurable and could be proven after a treatment period of merely 4 days. This study corroborates the fact that Cineole actively and significantly reduces cough frequency after four days. Therefore it has been shown to have a great socioeconomic impact.

Trial registration

ISRCTN: ISRCTN37784439

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842692

DOI: 10.1186/1745-9974-9-25
PubMed: 24261680
PubMed Central: 3842692

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<author><name sortKey="Fischer, Juergen" sort="Fischer, Juergen" uniqKey="Fischer J" first="Juergen" last="Fischer">Juergen Fischer</name>
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<author><name sortKey="Dethlefsen, Uwe" sort="Dethlefsen, Uwe" uniqKey="Dethlefsen U" first="Uwe" last="Dethlefsen">Uwe Dethlefsen</name>
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<front><div type="abstract" xml:lang="en"><sec><title>Objective</title>
<p>Cineole has mucolytic, bronchodilating and anti-inflammatory properties and reduces the exacerbation rate in patients suffering from COPD, as well as ameliorates symptoms in patients suffering from asthma and rhinosinusitis. Based on these effects, we therefore postulated the hypothesis that patients with acute bronchitis would also benefit from therapy with Cineole.</p>
</sec>
<sec><title>Methods</title>
<p>As part of a double-blind, placebo-controlled, multi-center-study, a total of 242 patients with confirmed acute bronchitis was randomly selected to participate. Over a period of 10 days, all patients were administered 3 x 200 mg of Cineole, or a respective placebo, per day. The primary outcome measure was a Bronchitis Sum Score, which summarises the relevant symptoms of acute bronchitis.</p>
</sec>
<sec><title>Results</title>
<p>After 4 days of treatment it was notable, that the patient group treated with Cineole, showed significantly more improvements of the bronchitis-sum-score than those of the placebo group (p = 0.0383). The statistical significant difference of the individual outcome measures was especially underlined by the frequency of cough fits by p = 0.0001 after 4 days.</p>
</sec>
<sec><title>Conclusions</title>
<p>The effects of Cineole in the treatment of acute bronchitis were clearly measurable and could be proven after a treatment period of merely 4 days. This study corroborates the fact that Cineole actively and significantly reduces cough frequency after four days. Therefore it has been shown to have a great socioeconomic impact.</p>
</sec>
<sec><title>Trial registration</title>
<p>ISRCTN: <ext-link ext-link-type="uri" xlink:href="http://www.copntrolled-trials.com.com/ISRCTN37784439">ISRCTN37784439</ext-link>
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  <front><journal-meta><journal-id journal-id-type="nlm-ta">Cough</journal-id>
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<email>jfischerp@aol.de</email>
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<contrib contrib-type="author" id="A2"><name><surname>Dethlefsen</surname>
<given-names>Uwe</given-names>
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<email>mklklifo@t-online.de</email>
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<aff id="I1"><label>1</label>
Norderney Hospital, Kaiserstr. 26, Norderney D-26548, Germany</aff>
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MKL Institute of Clinical Research, Pauwelsstr. 17, Aachen D-52074, Germany</aff>
<pub-date pub-type="collection"><year>2013</year>
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<pub-date pub-type="epub"><day>21</day>
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<volume>9</volume>
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<lpage>25</lpage>
<history><date date-type="received"><day>19</day>
<month>3</month>
<year>2013</year>
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<date date-type="accepted"><day>19</day>
<month>11</month>
<year>2013</year>
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<permissions><copyright-statement>Copyright © 2013 Fischer and Dethlefsen; licensee BioMed Central Ltd.</copyright-statement>
<copyright-year>2013</copyright-year>
<copyright-holder>Fischer and Dethlefsen; licensee BioMed Central Ltd.</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<self-uri xlink:href="http://www.coughjournal.com/content/9/1/25"></self-uri>
<abstract><sec><title>Objective</title>
<p>Cineole has mucolytic, bronchodilating and anti-inflammatory properties and reduces the exacerbation rate in patients suffering from COPD, as well as ameliorates symptoms in patients suffering from asthma and rhinosinusitis. Based on these effects, we therefore postulated the hypothesis that patients with acute bronchitis would also benefit from therapy with Cineole.</p>
</sec>
<sec><title>Methods</title>
<p>As part of a double-blind, placebo-controlled, multi-center-study, a total of 242 patients with confirmed acute bronchitis was randomly selected to participate. Over a period of 10 days, all patients were administered 3 x 200 mg of Cineole, or a respective placebo, per day. The primary outcome measure was a Bronchitis Sum Score, which summarises the relevant symptoms of acute bronchitis.</p>
</sec>
<sec><title>Results</title>
<p>After 4 days of treatment it was notable, that the patient group treated with Cineole, showed significantly more improvements of the bronchitis-sum-score than those of the placebo group (p = 0.0383). The statistical significant difference of the individual outcome measures was especially underlined by the frequency of cough fits by p = 0.0001 after 4 days.</p>
</sec>
<sec><title>Conclusions</title>
<p>The effects of Cineole in the treatment of acute bronchitis were clearly measurable and could be proven after a treatment period of merely 4 days. This study corroborates the fact that Cineole actively and significantly reduces cough frequency after four days. Therefore it has been shown to have a great socioeconomic impact.</p>
</sec>
<sec><title>Trial registration</title>
<p>ISRCTN: <ext-link ext-link-type="uri" xlink:href="http://www.copntrolled-trials.com.com/ISRCTN37784439">ISRCTN37784439</ext-link>
</p>
</sec>
</abstract>
<kwd-group><kwd>Acute bronchitis</kwd>
<kwd>Cough</kwd>
<kwd>Anti-inflammatory effects</kwd>
<kwd>Monoterpene Cineole</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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Efficacy of cineole in patients suffering from acute bronchitis: a placebo-controlled double-blind trial

Efficacy of cineole in patients suffering from acute bronchitis: a placebo-controlled double-blind trial

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