First identification of a single amino acid change in the spike protein region of feline coronavirus detected from a coronavirus-associated cutaneous nodule in a cat
Identifieur interne : 000317 ( Pmc/Curation ); précédent : 000316; suivant : 000318First identification of a single amino acid change in the spike protein region of feline coronavirus detected from a coronavirus-associated cutaneous nodule in a cat
Auteurs : Takafumi Osumi [Japon] ; Ikki Mitsui [Japon] ; Christian M. Leutenegger [États-Unis] ; Ryo Okabe [Japon] ; Kaori Ide [Japon] ; Koji Nishifuji [Japon]Source :
- JFMS Open Reports [ 2055-1169 ] ; 2018.
Abstract
A 32-month-old spayed female Singapura cat presented with a non-pruritic erythematous nodule on the upper lip. The cat also had multiple nodules in the liver but exhibited no other clinical signs consistent with classical feline infectious peritonitis (FIP), such as pleural effusion or ascites, uveitis or neurological symptoms. Histopathological and immunohistochemical analyses of the cutaneous nodule revealed pyogranulomatous dermatitis with intralesional macrophages laden with feline coronavirus (FCoV) antigen. Real-time reverse transcription (RT)-PCR of a cutaneous sample revealed a single nucleotide substitution in the spike protein gene of FCoV (mutation M1058L), which is consistent with an FCoV genotype commonly associated with FIP. The cat received a blood transfusion and supportive therapy, but the owner declined to continue the treatments owing to poor response. The cat was lost to follow-up 5 months after discharge.
This report describes a case of a coronavirus-associated cutaneous nodule in which the evidence of amino acid changes in the spike protein gene identified by RT-PCR were consistent with an FCoV genotype commonly seen in cases of FIP. To the best of our knowledge, this is the first report of a case of cutaneous disease associated with the mutated FCoV that was confirmed by molecular diagnostic testing.
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DOI: 10.1177/2055116918801385
PubMed: 30263143
PubMed Central: 6149024
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Leutenegger</name><affiliation wicri:level="1"><nlm:aff id="aff3-2055116918801385">IDEXX Laboratories, West Sacramento, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>IDEXX Laboratories, West Sacramento, CA</wicri:regionArea></affiliation></author><author><name sortKey="Okabe, Ryo" sort="Okabe, Ryo" uniqKey="Okabe R" first="Ryo" last="Okabe">Ryo Okabe</name><affiliation wicri:level="1"><nlm:aff id="aff1-2055116918801385">Animal Medical Center, Tokyo University of Agriculture and Technology, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Animal Medical Center, Tokyo University of Agriculture and Technology, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Ide, Kaori" sort="Ide, Kaori" uniqKey="Ide K" first="Kaori" last="Ide">Kaori Ide</name><affiliation wicri:level="1"><nlm:aff id="aff1-2055116918801385">Animal Medical Center, Tokyo University of Agriculture and Technology, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Animal Medical Center, Tokyo University of Agriculture and Technology, Tokyo</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4-2055116918801385">Division of Animal Life Science, Graduate School, Tokyo University of Agriculture and Technology, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Animal Life Science, Graduate School, Tokyo University of Agriculture and Technology, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Nishifuji, Koji" sort="Nishifuji, Koji" uniqKey="Nishifuji K" first="Koji" last="Nishifuji">Koji Nishifuji</name><affiliation wicri:level="1"><nlm:aff id="aff1-2055116918801385">Animal Medical Center, Tokyo University of Agriculture and Technology, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Animal Medical Center, Tokyo University of Agriculture and Technology, Tokyo</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4-2055116918801385">Division of Animal Life Science, Graduate School, Tokyo University of Agriculture and Technology, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Animal Life Science, Graduate School, Tokyo University of Agriculture and Technology, Tokyo</wicri:regionArea></affiliation></author></analytic><series><title level="j">JFMS Open Reports</title><idno type="eISSN">2055-1169</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="section1-2055116918801385"><title>Case summary</title><p>A 32-month-old spayed female Singapura cat presented with a non-pruritic erythematous nodule on the upper lip. The cat also had multiple nodules in the liver but exhibited no other clinical signs consistent with classical feline infectious peritonitis (FIP), such as pleural effusion or ascites, uveitis or neurological symptoms. Histopathological and immunohistochemical analyses of the cutaneous nodule revealed pyogranulomatous dermatitis with intralesional macrophages laden with feline coronavirus (FCoV) antigen. Real-time reverse transcription (RT)-PCR of a cutaneous sample revealed a single nucleotide substitution in the spike protein gene of FCoV (mutation M1058L), which is consistent with an FCoV genotype commonly associated with FIP. The cat received a blood transfusion and supportive therapy, but the owner declined to continue the treatments owing to poor response. The cat was lost to follow-up 5 months after discharge.</p></sec><sec id="section2-2055116918801385"><title>Relevance and novel information</title><p>This report describes a case of a coronavirus-associated cutaneous nodule in which the evidence of amino acid changes in the spike protein gene identified by RT-PCR were consistent with an FCoV genotype commonly seen in cases of FIP. To the best of our knowledge, this is the first report of a case of cutaneous disease associated with the mutated FCoV that was confirmed by molecular diagnostic testing.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Vennema, H" uniqKey="Vennema H">H Vennema</name></author><author><name sortKey="Poland, A" uniqKey="Poland A">A Poland</name></author><author><name sortKey="Foley, J" uniqKey="Foley J">J Foley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Licitra, Bn" uniqKey="Licitra B">BN Licitra</name></author><author><name sortKey="Millet, Jk" uniqKey="Millet J">JK Millet</name></author><author><name sortKey="Regan, Ad" uniqKey="Regan A">AD Regan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pedersen, Nc" uniqKey="Pedersen N">NC. Pedersen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bauer, Bs" uniqKey="Bauer B">BS Bauer</name></author><author><name sortKey="Kerr, Me" uniqKey="Kerr M">ME Kerr</name></author><author><name sortKey="Sandmeyer, Ls" uniqKey="Sandmeyer L">LS Sandmeyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Declercq, J" uniqKey="Declercq J">J Declercq</name></author><author><name sortKey="De Bosschere, H" uniqKey="De Bosschere H">H De Bosschere</name></author><author><name sortKey="Schwarzkopf, I" uniqKey="Schwarzkopf I">I Schwarzkopf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cannon, Mj" uniqKey="Cannon M">MJ Cannon</name></author><author><name sortKey="Silkstone, Ma" uniqKey="Silkstone M">MA Silkstone</name></author><author><name sortKey="Kipar, Am" uniqKey="Kipar A">AM. Kipar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chang, Hw" uniqKey="Chang H">HW Chang</name></author><author><name sortKey="Egberink, Hf" uniqKey="Egberink H">HF Egberink</name></author><author><name sortKey="Halpin, R" uniqKey="Halpin R">R Halpin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kipar, A" uniqKey="Kipar A">A Kipar</name></author><author><name sortKey="May, H" uniqKey="May H">H May</name></author><author><name sortKey="Menger, S" uniqKey="Menger S">S Menger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sangl, L" uniqKey="Sangl L">L Sangl</name></author><author><name sortKey="Matiasek, K" uniqKey="Matiasek K">K Matiasek</name></author><author><name sortKey="Felten, S" uniqKey="Felten S">S Felten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pederson, Nc" uniqKey="Pederson N">NC Pederson</name></author><author><name sortKey="Eckstrand, C" uniqKey="Eckstrand C">C Eckstrand</name></author><author><name sortKey="Liu, H" uniqKey="Liu H">H Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pedersen, Nc" uniqKey="Pedersen N">NC Pedersen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hartmann, K" uniqKey="Hartmann K">K Hartmann</name></author><author><name sortKey="Binder, C" uniqKey="Binder C">C Binder</name></author><author><name sortKey="Hirschberger, J" uniqKey="Hirschberger J">J Hirschberger</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="case-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">JFMS Open Rep</journal-id><journal-id journal-id-type="iso-abbrev">JFMS Open Rep</journal-id><journal-id journal-id-type="publisher-id">JOR</journal-id><journal-id journal-id-type="hwp">spjor</journal-id><journal-title-group><journal-title>JFMS Open Reports</journal-title></journal-title-group><issn pub-type="epub">2055-1169</issn><publisher><publisher-name>SAGE Publications</publisher-name><publisher-loc>Sage UK: London, England</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">30263143</article-id><article-id pub-id-type="pmc">6149024</article-id><article-id pub-id-type="doi">10.1177/2055116918801385</article-id><article-id pub-id-type="publisher-id">10.1177_2055116918801385</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>First identification of a single amino acid change in the spike protein region of feline coronavirus detected from a coronavirus-associated cutaneous nodule in a cat</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Osumi</surname><given-names>Takafumi</given-names></name><xref ref-type="aff" rid="aff1-2055116918801385">1</xref></contrib><contrib contrib-type="author"><name><surname>Mitsui</surname><given-names>Ikki</given-names></name><xref ref-type="aff" rid="aff2-2055116918801385">2</xref></contrib><contrib contrib-type="author"><name><surname>Leutenegger</surname><given-names>Christian M</given-names></name><xref ref-type="aff" rid="aff3-2055116918801385">3</xref></contrib><contrib contrib-type="author"><name><surname>Okabe</surname><given-names>Ryo</given-names></name><xref ref-type="aff" rid="aff1-2055116918801385">1</xref></contrib><contrib contrib-type="author"><name><surname>Ide</surname><given-names>Kaori</given-names></name><xref ref-type="aff" rid="aff1-2055116918801385">1</xref><xref ref-type="aff" rid="aff4-2055116918801385">4</xref></contrib><contrib contrib-type="author"><name><surname>Nishifuji</surname><given-names>Koji</given-names></name><xref ref-type="aff" rid="aff1-2055116918801385">1</xref><xref ref-type="aff" rid="aff4-2055116918801385">4</xref><xref ref-type="corresp" rid="corresp1-2055116918801385"></xref></contrib></contrib-group><aff id="aff1-2055116918801385"><label>1</label>Animal Medical Center, Tokyo University of Agriculture and Technology, Tokyo, Japan</aff><aff id="aff2-2055116918801385"><label>2</label>No Boundaries Animal Pathology, Tokyo, Japan</aff><aff id="aff3-2055116918801385"><label>3</label>IDEXX Laboratories, West Sacramento, CA, USA</aff><aff id="aff4-2055116918801385"><label>4</label>Division of Animal Life Science, Graduate School, Tokyo University of Agriculture and Technology, Tokyo, Japan</aff><author-notes><corresp id="corresp1-2055116918801385">Koji Nishifuji DVM, PhD, DAiCVD, Laboratory of Veterinary Internal Medicine, Division of Animal Life Science, Graduate School, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan Email: <email>kojimail@cc.tuat.ac.jp</email></corresp></author-notes><pub-date pub-type="epub"><day>20</day><month>9</month><year>2018</year></pub-date><pub-date pub-type="collection"><season>Jul-Dec</season><year>2018</year></pub-date><volume>4</volume><issue>2</issue><elocation-id>2055116918801385</elocation-id><permissions><copyright-statement>© The Author(s) 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder content-type="sage">SAGE Publications Ltd, International Society of Feline Medicine and American Association of Feline Practitioners, unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses.</copyright-holder><license license-type="creative-commons" xlink:href="http://www.creativecommons.org/licenses/by-nc/4.0/"><license-p>This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (<ext-link ext-link-type="uri" xlink:href="http://www.creativecommons.org/licenses/by-nc/4.0/">http://www.creativecommons.org/licenses/by-nc/4.0/</ext-link>) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (<ext-link ext-link-type="uri" xlink:href="https://us.sagepub.com/en-us/nam/open-access-at-sage">https://us.sagepub.com/en-us/nam/open-access-at-sage</ext-link>).</license-p></license></permissions><abstract><sec id="section1-2055116918801385"><title>Case summary</title><p>A 32-month-old spayed female Singapura cat presented with a non-pruritic erythematous nodule on the upper lip. The cat also had multiple nodules in the liver but exhibited no other clinical signs consistent with classical feline infectious peritonitis (FIP), such as pleural effusion or ascites, uveitis or neurological symptoms. Histopathological and immunohistochemical analyses of the cutaneous nodule revealed pyogranulomatous dermatitis with intralesional macrophages laden with feline coronavirus (FCoV) antigen. Real-time reverse transcription (RT)-PCR of a cutaneous sample revealed a single nucleotide substitution in the spike protein gene of FCoV (mutation M1058L), which is consistent with an FCoV genotype commonly associated with FIP. The cat received a blood transfusion and supportive therapy, but the owner declined to continue the treatments owing to poor response. The cat was lost to follow-up 5 months after discharge.</p></sec><sec id="section2-2055116918801385"><title>Relevance and novel information</title><p>This report describes a case of a coronavirus-associated cutaneous nodule in which the evidence of amino acid changes in the spike protein gene identified by RT-PCR were consistent with an FCoV genotype commonly seen in cases of FIP. To the best of our knowledge, this is the first report of a case of cutaneous disease associated with the mutated FCoV that was confirmed by molecular diagnostic testing.</p></sec></abstract><kwd-group><kwd>Skin</kwd><kwd>coronavirus</kwd><kwd>feline infectious peritonitis</kwd><kwd>immunohistochemistry</kwd><kwd>spike protein</kwd><kwd>single nucleotide substitution</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>cover-date</meta-name><meta-value>July-December 2018</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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