Nasopharyngeal microbiota composition of children is related to the frequency of upper respiratory infection and acute sinusitis
Identifieur interne : 000146 ( Pmc/Curation ); précédent : 000145; suivant : 000147Nasopharyngeal microbiota composition of children is related to the frequency of upper respiratory infection and acute sinusitis
Auteurs : Clark A. Santee [États-Unis] ; Nabeetha A. Nagalingam [États-Unis] ; Ali A. Faruqi [États-Unis] ; Gregory P. Demuri [États-Unis] ; James E. Gern [États-Unis] ; Ellen R. Wald [États-Unis] ; Susan V. Lynch [États-Unis]Source :
- Microbiome [ 2049-2618 ] ; 2016.
Abstract
Upper respiratory infections (URI) and their complications are a major healthcare burden for pediatric populations. Although the microbiology of the nasopharynx is an important determinant of the complications of URI, little is known of the nasopharyngeal (NP) microbiota of children, the factors that affect its composition, and its precise relationship with URI.
Healthy children (
These preliminary data suggest that previous history of acute sinusitis influences the composition of the NP microbiota, characterized by a depletion in relative abundance of specific taxa. Diminished diversity was associated with more frequent URIs.
The online version of this article (doi:10.1186/s40168-016-0179-9) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s40168-016-0179-9
PubMed: 27364497
PubMed Central: 4929776
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Nabeetha A. Nagalingam<affiliation><nlm:aff id="Aff3">Present address: Janssen Prevention Center, 2 Royal College Street, London, NW1 0TU UK</nlm:aff>
<wicri:noCountry code="subfield">NW1 0TU UK</wicri:noCountry>
</affiliation>
Le document en format XML
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Upper respiratory infections (URI) and their complications are a major healthcare burden for pediatric populations. Although the microbiology of the nasopharynx is an important determinant of the complications of URI, little is known of the nasopharyngeal (NP) microbiota of children, the factors that affect its composition, and its precise relationship with URI.</p>
</sec>
<sec><title>Results</title>
<p>Healthy children (<italic>n</italic>
= 47) aged 49–84 months from a prospective cohort study based in Wisconsin, USA, were examined. Demographic and clinical data and NP swab samples were obtained from participants upon entry to the study. All NP samples were profiled for bacterial microbiota using a phylogenetic microarray, and these data were related to demographic characteristics and upper respiratory health outcomes. The composition of the NP bacterial community of children was significantly related prior to the history of acute sinusitis (<italic>R</italic>
<sup>2</sup>
= 0.070, <italic>P</italic>
< 0.009). History of acute sinusitis was associated with significant depletion in relative abundance of taxa including <italic>Faecalibacterium prausnitzii</italic>
and <italic>Akkermansia</italic>
spp. and enrichment of <italic>Moraxella nonliquefaciens</italic>
. Enrichment of <italic>M. nonliquefaciens</italic>
was also a characteristic of baseline NP samples of children who subsequently developed acute sinusitis over the 1-year study period. Time to develop URI was significantly positively correlated with NP diversity, and children who experienced more frequent URIs exhibited significantly diminished NP microbiota diversity (<italic>P</italic>
≤ 0.05).</p>
</sec>
<sec><title>Conclusions</title>
<p>These preliminary data suggest that previous history of acute sinusitis influences the composition of the NP microbiota, characterized by a depletion in relative abundance of specific taxa. Diminished diversity was associated with more frequent URIs.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/s40168-016-0179-9) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Microbiome</journal-id>
<journal-id journal-id-type="iso-abbrev">Microbiome</journal-id>
<journal-title-group><journal-title>Microbiome</journal-title>
</journal-title-group>
<issn pub-type="epub">2049-2618</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">27364497</article-id>
<article-id pub-id-type="pmc">4929776</article-id>
<article-id pub-id-type="publisher-id">179</article-id>
<article-id pub-id-type="doi">10.1186/s40168-016-0179-9</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research</subject>
</subj-group>
</article-categories>
<title-group><article-title>Nasopharyngeal microbiota composition of children is related to the frequency of upper respiratory infection and acute sinusitis</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Santee</surname>
<given-names>Clark A.</given-names>
</name>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author" equal-contrib="yes"><name><surname>Nagalingam</surname>
<given-names>Nabeetha A.</given-names>
</name>
<xref ref-type="aff" rid="Aff1"></xref>
<xref ref-type="aff" rid="Aff3"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Faruqi</surname>
<given-names>Ali A.</given-names>
</name>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>DeMuri</surname>
<given-names>Gregory P.</given-names>
</name>
<xref ref-type="aff" rid="Aff2"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gern</surname>
<given-names>James E.</given-names>
</name>
<xref ref-type="aff" rid="Aff2"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wald</surname>
<given-names>Ellen R.</given-names>
</name>
<xref ref-type="aff" rid="Aff2"></xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Lynch</surname>
<given-names>Susan V.</given-names>
</name>
<address><phone>415-476-6784</phone>
<email>susan.lynch@ucsf.edu</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<aff id="Aff1"><label></label>
Division of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco, CA 94143 USA</aff>
<aff id="Aff2"><label></label>
Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792 USA</aff>
<aff id="Aff3"><label></label>
Present address: Janssen Prevention Center, 2 Royal College Street, London, NW1 0TU UK</aff>
</contrib-group>
<pub-date pub-type="epub"><day>1</day>
<month>7</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>1</day>
<month>7</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="collection"><year>2016</year>
</pub-date>
<volume>4</volume>
<elocation-id>34</elocation-id>
<history><date date-type="received"><day>23</day>
<month>10</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>13</day>
<month>6</month>
<year>2016</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s). 2016</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<abstract id="Abs1"><sec><title>Background</title>
<p>Upper respiratory infections (URI) and their complications are a major healthcare burden for pediatric populations. Although the microbiology of the nasopharynx is an important determinant of the complications of URI, little is known of the nasopharyngeal (NP) microbiota of children, the factors that affect its composition, and its precise relationship with URI.</p>
</sec>
<sec><title>Results</title>
<p>Healthy children (<italic>n</italic>
= 47) aged 49–84 months from a prospective cohort study based in Wisconsin, USA, were examined. Demographic and clinical data and NP swab samples were obtained from participants upon entry to the study. All NP samples were profiled for bacterial microbiota using a phylogenetic microarray, and these data were related to demographic characteristics and upper respiratory health outcomes. The composition of the NP bacterial community of children was significantly related prior to the history of acute sinusitis (<italic>R</italic>
<sup>2</sup>
= 0.070, <italic>P</italic>
< 0.009). History of acute sinusitis was associated with significant depletion in relative abundance of taxa including <italic>Faecalibacterium prausnitzii</italic>
and <italic>Akkermansia</italic>
spp. and enrichment of <italic>Moraxella nonliquefaciens</italic>
. Enrichment of <italic>M. nonliquefaciens</italic>
was also a characteristic of baseline NP samples of children who subsequently developed acute sinusitis over the 1-year study period. Time to develop URI was significantly positively correlated with NP diversity, and children who experienced more frequent URIs exhibited significantly diminished NP microbiota diversity (<italic>P</italic>
≤ 0.05).</p>
</sec>
<sec><title>Conclusions</title>
<p>These preliminary data suggest that previous history of acute sinusitis influences the composition of the NP microbiota, characterized by a depletion in relative abundance of specific taxa. Diminished diversity was associated with more frequent URIs.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/s40168-016-0179-9) contains supplementary material, which is available to authorized users.</p>
</sec>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Microbiota</kwd>
<kwd>Upper respiratory infection</kwd>
<kwd>URI</kwd>
<kwd>Acute sinusitis</kwd>
<kwd>Pediatrics</kwd>
<kwd>Children</kwd>
</kwd-group>
<funding-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/100000002</institution-id>
<institution>National Institutes of Health</institution>
</institution-wrap>
</funding-source>
<award-id>5RO1AI097172-03</award-id>
<principal-award-recipient><name><surname>Wald</surname>
<given-names>Ellen R.</given-names>
</name>
</principal-award-recipient>
</award-group>
</funding-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2016</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
</record>
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