Cardiac Function in Kawasaki Disease Patients with Respiratory Symptoms
Identifieur interne : 000024 ( Pmc/Curation ); précédent : 000023; suivant : 000025Cardiac Function in Kawasaki Disease Patients with Respiratory Symptoms
Auteurs : Seul Bee Lee [Corée du Sud] ; Han Seul Choi [Corée du Sud] ; Sejung Son [Corée du Sud] ; Young Mi Hong [Corée du Sud]Source :
- Korean Circulation Journal [ 1738-5520 ] ; 2015.
Abstract
Respiratory symptoms are often observed in children with Kawasaki disease (KD) during the acute phase. The association of respiratory viruses in children with KD was investigated using multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) and tissue Doppler echocardiography.
138 KD patients were included from January 2010 to June 2013. We compared 3 groups (group 1: n=94, KD without respiratory symptoms; group 2: n=44, KD with respiratory symptoms; and group 3: n=50, febrile patients with respiratory symptoms). Laboratory data were obtained from each patient including N-terminal pro-brain natriuretic peptide (NT-proBNP). Echocardiographic measurements were compared between group 1 and group 2. RT-PCR was performed using nasopharyngeal secretion to screen for the presence of 14 viruses in groups 2 and 3.
The incidence of KD with respiratory symptoms was 31.8%. The duration of fever was significantly longer, and coronary artery diameter was larger in group 2 than in group 1. Tei index was significantly higher and coronary artery diameter larger in group 2 than group 1. Coronary artery diameter, C-reactive protein levels, platelet count, alanine aminotransferase levels, and NT-pro BNP levels were significantly higher and albumin levels lower in group 2 compared with group 3.
NT-pro BNP was a valuable diagnostic tool in differentiating KD from other febrile viral respiratory infections. Some viruses were more frequently observed in KD patients than in febrile controls. Tei index using tissue Doppler imaging was increased in KD patients with respiratory symptoms.
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DOI: 10.4070/kcj.2015.45.4.317
PubMed: 26240586
PubMed Central: 4521110
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cardiac Function in Kawasaki Disease Patients with Respiratory Symptoms</title><author><name sortKey="Lee, Seul Bee" sort="Lee, Seul Bee" uniqKey="Lee S" first="Seul Bee" last="Lee">Seul Bee Lee</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Ewha Womans University School of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Choi, Han Seul" sort="Choi, Han Seul" uniqKey="Choi H" first="Han Seul" last="Choi">Han Seul Choi</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Ewha Womans University School of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Son, Sejung" sort="Son, Sejung" uniqKey="Son S" first="Sejung" last="Son">Sejung Son</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Ewha Womans University School of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Hong, Young Mi" sort="Hong, Young Mi" uniqKey="Hong Y" first="Young Mi" last="Hong">Young Mi Hong</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Ewha Womans University School of Medicine, Seoul</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26240586</idno><idno type="pmc">4521110</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521110</idno><idno type="RBID">PMC:4521110</idno><idno type="doi">10.4070/kcj.2015.45.4.317</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000024</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000024</idno><idno type="wicri:Area/Pmc/Curation">000024</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000024</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cardiac Function in Kawasaki Disease Patients with Respiratory Symptoms</title><author><name sortKey="Lee, Seul Bee" sort="Lee, Seul Bee" uniqKey="Lee S" first="Seul Bee" last="Lee">Seul Bee Lee</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Ewha Womans University School of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Choi, Han Seul" sort="Choi, Han Seul" uniqKey="Choi H" first="Han Seul" last="Choi">Han Seul Choi</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Ewha Womans University School of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Son, Sejung" sort="Son, Sejung" uniqKey="Son S" first="Sejung" last="Son">Sejung Son</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Ewha Womans University School of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Hong, Young Mi" sort="Hong, Young Mi" uniqKey="Hong Y" first="Young Mi" last="Hong">Young Mi Hong</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Ewha Womans University School of Medicine, Seoul</wicri:regionArea></affiliation></author></analytic><series><title level="j">Korean Circulation Journal</title><idno type="ISSN">1738-5520</idno><idno type="eISSN">1738-5555</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background and Objectives</title><p>Respiratory symptoms are often observed in children with Kawasaki disease (KD) during the acute phase. The association of respiratory viruses in children with KD was investigated using multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) and tissue Doppler echocardiography.</p></sec><sec><title>Subjects and Methods</title><p>138 KD patients were included from January 2010 to June 2013. We compared 3 groups (group 1: n=94, KD without respiratory symptoms; group 2: n=44, KD with respiratory symptoms; and group 3: n=50, febrile patients with respiratory symptoms). Laboratory data were obtained from each patient including N-terminal pro-brain natriuretic peptide (NT-proBNP). Echocardiographic measurements were compared between group 1 and group 2. RT-PCR was performed using nasopharyngeal secretion to screen for the presence of 14 viruses in groups 2 and 3.</p></sec><sec><title>Results</title><p>The incidence of KD with respiratory symptoms was 31.8%. The duration of fever was significantly longer, and coronary artery diameter was larger in group 2 than in group 1. Tei index was significantly higher and coronary artery diameter larger in group 2 than group 1. Coronary artery diameter, C-reactive protein levels, platelet count, alanine aminotransferase levels, and NT-pro BNP levels were significantly higher and albumin levels lower in group 2 compared with group 3.</p></sec><sec><title>Conclusion</title><p>NT-pro BNP was a valuable diagnostic tool in differentiating KD from other febrile viral respiratory infections. Some viruses were more frequently observed in KD patients than in febrile controls. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Korean Circ J</journal-id><journal-id journal-id-type="iso-abbrev">Korean Circ J</journal-id><journal-id journal-id-type="publisher-id">KCJ</journal-id><journal-title-group><journal-title>Korean Circulation Journal</journal-title></journal-title-group><issn pub-type="ppub">1738-5520</issn><issn pub-type="epub">1738-5555</issn><publisher><publisher-name>The Korean Society of Cardiology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26240586</article-id><article-id pub-id-type="pmc">4521110</article-id><article-id pub-id-type="doi">10.4070/kcj.2015.45.4.317</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Cardiac Function in Kawasaki Disease Patients with Respiratory Symptoms</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Seul Bee</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1"></xref></contrib><contrib contrib-type="author"><name><surname>Choi</surname><given-names>Han Seul</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1"></xref></contrib><contrib contrib-type="author"><name><surname>Son</surname><given-names>Sejung</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1"></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Hong</surname><given-names>Young Mi</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1"></xref></contrib></contrib-group><aff id="A1">Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea.</aff><author-notes><corresp>Correspondence: Young Mi Hong, MD, Department of Pediatrics, Ewha Womans University School of Medicine, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 158-710, Korea. Tel: 82-2-2650-2841, Fax: 82-2-2653-3718, <email>ymhong@ewha.ac.kr</email></corresp></author-notes><pub-date pub-type="ppub"><month>7</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>16</day><month>7</month><year>2015</year></pub-date><volume>45</volume><issue>4</issue><fpage>317</fpage><lpage>324</lpage><history><date date-type="received"><day>13</day><month>1</month><year>2015</year></date><date date-type="rev-recd"><day>03</day><month>3</month><year>2015</year></date><date date-type="accepted"><day>14</day><month>4</month><year>2015</year></date></history><permissions><copyright-statement>Copyright © 2015 The Korean Society of Cardiology</copyright-statement><copyright-year>2015</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec><title>Background and Objectives</title><p>Respiratory symptoms are often observed in children with Kawasaki disease (KD) during the acute phase. The association of respiratory viruses in children with KD was investigated using multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) and tissue Doppler echocardiography.</p></sec><sec><title>Subjects and Methods</title><p>138 KD patients were included from January 2010 to June 2013. We compared 3 groups (group 1: n=94, KD without respiratory symptoms; group 2: n=44, KD with respiratory symptoms; and group 3: n=50, febrile patients with respiratory symptoms). Laboratory data were obtained from each patient including N-terminal pro-brain natriuretic peptide (NT-proBNP). Echocardiographic measurements were compared between group 1 and group 2. RT-PCR was performed using nasopharyngeal secretion to screen for the presence of 14 viruses in groups 2 and 3.</p></sec><sec><title>Results</title><p>The incidence of KD with respiratory symptoms was 31.8%. The duration of fever was significantly longer, and coronary artery diameter was larger in group 2 than in group 1. Tei index was significantly higher and coronary artery diameter larger in group 2 than group 1. Coronary artery diameter, C-reactive protein levels, platelet count, alanine aminotransferase levels, and NT-pro BNP levels were significantly higher and albumin levels lower in group 2 compared with group 3.</p></sec><sec><title>Conclusion</title><p>NT-pro BNP was a valuable diagnostic tool in differentiating KD from other febrile viral respiratory infections. Some viruses were more frequently observed in KD patients than in febrile controls. Tei index using tissue Doppler imaging was increased in KD patients with respiratory symptoms.</p></sec></abstract><kwd-group><kwd>Mucocutaneous lymph node syndrome</kwd><kwd>Reverse transcriptase polymerase chain reaction</kwd><kwd>Respiratory virus</kwd><kwd>Natriuretic peptide, brain</kwd><kwd>Echocardiography, Doppler</kwd></kwd-group></article-meta></front><floats-group><fig id="F1" orientation="portrait" position="float"><label>Fig. 1</label><caption><title>Tei index using tissue Doppler imaging in Kawasaki disease patients. Tei index= (a-b)/b=(IVCT+IVRT)/ET. IVCT: isovolumetric contraction time, IVRT: isovolumetric relaxation time, ET: ejection time, LV Eject T: left ventricular ejection time, S': systolic myocardial velocity, A': late diastolic myocardial velocity, E': early diastolic myocardial velocity.</title></caption><graphic xlink:href="kcj-45-317-g001"></graphic></fig><fig id="F2" orientation="portrait" position="float"><label>Fig. 2</label><caption><title>Parasternal short axis echocardiographic imaging showing a dilated right coronary artery. RCA: right coronary artery.</title></caption><graphic xlink:href="kcj-45-317-g002"></graphic></fig><table-wrap id="T1" orientation="portrait" position="float"><label>Table 1</label><caption><title>Comparison of clinical characteristics between KD patients without respiratory symptoms and KD patients with respiratory symptoms</title></caption><alternatives><graphic xlink:href="kcj-45-317-i001"></graphic><table frame="hsides" rules="rows"><thead><tr><th valign="top" align="left" rowspan="1" colspan="1"></th><th valign="top" align="center" rowspan="1" colspan="1">Group 1 (n=94)</th><th valign="top" align="center" rowspan="1" colspan="1">Group 2 (n=44)</th><th valign="top" align="center" rowspan="1" colspan="1">p</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">Male, n (%)</td><td valign="top" align="center" rowspan="1" colspan="1">52 (55.3)</td><td valign="top" align="center" rowspan="1" colspan="1">28 (63.6)</td><td valign="top" align="center" rowspan="1" colspan="1">0.459</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Age (months)</td><td valign="top" align="center" rowspan="1" colspan="1">36.2±27.9</td><td valign="top" align="center" rowspan="1" colspan="1">31.9±25.0</td><td valign="top" align="center" rowspan="1" colspan="1">0.754</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Duration of fever (days)</td><td valign="top" align="center" rowspan="1" colspan="1">5.3±1.6</td><td valign="top" align="center" rowspan="1" colspan="1">6.2±2.1<sup>*</sup></td><td valign="top" align="center" rowspan="1" colspan="1">0.001</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Conjunctival injection, n (%)</td><td valign="top" align="center" rowspan="1" colspan="1">76 (80.9)</td><td valign="top" align="center" rowspan="1" colspan="1">32 (72.7)</td><td valign="top" align="center" rowspan="1" colspan="1">0.376</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Cervical lymphadenopathy, n (%)</td><td valign="top" align="center" rowspan="1" colspan="1">31 (33.0)</td><td valign="top" align="center" rowspan="1" colspan="1">8 (18.2)</td><td valign="top" align="center" rowspan="1" colspan="1">0.104</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Polymorphous skin rash, n (%)</td><td valign="top" align="center" rowspan="1" colspan="1">67 (71.3)</td><td valign="top" align="center" rowspan="1" colspan="1">23 (52.3)</td><td valign="top" align="center" rowspan="1" colspan="1">0.036</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Abnormalities of lip or oral mucosa, n (%)</td><td valign="top" align="center" rowspan="1" colspan="1">71 (75.5)</td><td valign="top" align="center" rowspan="1" colspan="1">14 (31.8)<sup>*</sup></td><td valign="top" align="center" rowspan="1" colspan="1">0.001</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Abnormalities of extremities, n (%)</td><td valign="top" align="center" rowspan="1" colspan="1">59 (62.8)</td><td valign="top" align="center" rowspan="1" colspan="1">10 (22.7)<sup>*</sup></td><td valign="top" align="center" rowspan="1" colspan="1">0.001</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">BCGitis, n (%)</td><td valign="top" align="center" rowspan="1" colspan="1">28 (29.8)</td><td valign="top" align="center" rowspan="1" colspan="1">10 (22.7)</td><td valign="top" align="center" rowspan="1" colspan="1">0.421</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Incomplete type, n (%)</td><td valign="top" align="center" rowspan="1" colspan="1">58 (61.6)</td><td valign="top" align="center" rowspan="1" colspan="1">36 (81.8)<sup>*</sup></td><td valign="top" align="center" rowspan="1" colspan="1">0.019</td></tr></tbody></table></alternatives><table-wrap-foot><fn><p>Data are n (%) or mean±SD. Group 1: KD patients without respiratory symptoms, Group 2: KD patients with respiratory symptoms. <sup>*</sup>p<0.05 significantly different from group 1. KD: Kawasaki disease, BCG: Bacillus Calmette-Guérin</p></fn></table-wrap-foot></table-wrap><table-wrap id="T2" orientation="portrait" position="float"><label>Table 2</label><caption><title>Comparison of laboratory data between KD groups and the control group</title></caption><alternatives><graphic xlink:href="kcj-45-317-i002"></graphic><table frame="hsides" rules="rows"><thead><tr><th valign="top" align="left" rowspan="1" colspan="1"></th><th valign="top" align="center" rowspan="1" colspan="1">Group 1 (n=94)</th><th valign="top" align="center" rowspan="1" colspan="1">Group 2 (n=44)</th><th valign="top" align="center" rowspan="1" colspan="1">Group 3 (n=50)</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">Hb (g/dL)</td><td valign="top" align="center" rowspan="1" colspan="1">11.5±0.9</td><td valign="top" align="center" rowspan="1" colspan="1">11.2±0.6</td><td valign="top" align="center" rowspan="1" colspan="1">11.7±0.9</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">WBC (×10<sup>9</sup>/L)</td><td valign="top" align="center" rowspan="1" colspan="1">11.8±5.4</td><td valign="top" align="center" rowspan="1" colspan="1">9.5±5.1</td><td valign="top" align="center" rowspan="1" colspan="1">9.6±5.3</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">SEG %</td><td valign="top" align="center" rowspan="1" colspan="1">58.2±18.1</td><td valign="top" align="center" rowspan="1" colspan="1">52.0±22.5</td><td valign="top" align="center" rowspan="1" colspan="1">46.7±18.1</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Platelet count (×10<sup>9</sup>/L)</td><td valign="top" align="center" rowspan="1" colspan="1">305.8±82.7</td><td valign="top" align="center" rowspan="1" colspan="1">301.3±53.4<sup>†</sup></td><td valign="top" align="center" rowspan="1" colspan="1">239.4±74.9</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">ESR (mm/hr)</td><td valign="top" align="center" rowspan="1" colspan="1">36.6±24.5</td><td valign="top" align="center" rowspan="1" colspan="1">35.6±24.2</td><td valign="top" align="center" rowspan="1" colspan="1">22.8±16.3</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">CRP (mg/dL)</td><td valign="top" align="center" rowspan="1" colspan="1">7.2±8.7</td><td valign="top" align="center" rowspan="1" colspan="1">5.9±4.4<sup>†</sup></td><td valign="top" align="center" rowspan="1" colspan="1">3.0±2.8</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">AST (IU/L)</td><td valign="top" align="center" rowspan="1" colspan="1">56.6±85.6</td><td valign="top" align="center" rowspan="1" colspan="1">114.9±264.5</td><td valign="top" align="center" rowspan="1" colspan="1">37.8±15.8</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">ALT (IU/L)</td><td valign="top" align="center" rowspan="1" colspan="1">56.7±84.2</td><td valign="top" align="center" rowspan="1" colspan="1">93.2±133.7<sup>*†</sup></td><td valign="top" align="center" rowspan="1" colspan="1">25.7±43.8</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Total protein (g/dL)</td><td valign="top" align="center" rowspan="1" colspan="1">6.5±0.6</td><td valign="top" align="center" rowspan="1" colspan="1">6.4±0.5</td><td valign="top" align="center" rowspan="1" colspan="1">6.6±0.4</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Albumin (g/dL)</td><td valign="top" align="center" rowspan="1" colspan="1">4.1±3.4</td><td valign="top" align="center" rowspan="1" colspan="1">3.6±0.3<sup>†</sup></td><td valign="top" align="center" rowspan="1" colspan="1">4.0±0.3</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">NT-pro BNP (pg/mL)</td><td valign="top" align="center" rowspan="1" colspan="1">714.3±1342.8</td><td valign="top" align="center" rowspan="1" colspan="1">698.9±907.7<sup>†</sup></td><td valign="top" align="center" rowspan="1" colspan="1">156.5±112.0</td></tr></tbody></table></alternatives><table-wrap-foot><fn><p>Data are mean±SD. Group 1: KD patients without respiratory symptoms, Group 2: KD patients with respiratory symptoms, Group 3: control patients with respiratory symptoms. <sup>*</sup>p<0.05, significantly different from group1 (group 1 vs. group 2). <sup>†</sup>p<0.05, significantly different from group 3 (group 2 vs. group 3). KD: Kawasaki disease, Hb: hemoglobin, WBC: white blood cell, SEG %: percentage of segmented neutrophils, ESR: erythrocyte sedimentation rate, CRP: Creactive protein, AST: aspartate aminotransferase, ALT: alanine aminotransferase, NT-pro BNP: N-terminal pro-brain type natriuretic peptide</p></fn></table-wrap-foot></table-wrap><table-wrap id="T3" orientation="portrait" position="float"><label>Table 3</label><caption><title>Comparison of respiratory virus between KD patients and the control group</title></caption><alternatives><graphic xlink:href="kcj-45-317-i003"></graphic><table frame="hsides" rules="rows"><thead><tr><th valign="top" align="left" rowspan="1" colspan="1"></th><th valign="top" align="center" rowspan="1" colspan="1">Group 2 (n=44) (%)</th><th valign="top" align="center" rowspan="1" colspan="1">Group 3 (n=50) (%)</th><th valign="top" align="center" rowspan="1" colspan="1">p</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">Coronavirus</td><td valign="top" align="center" rowspan="1" colspan="1">0</td><td valign="top" align="center" rowspan="1" colspan="1">1 (2.0)</td><td valign="top" align="center" rowspan="1" colspan="1">1.000</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Parainfluenza virus 1 and 2</td><td valign="top" align="center" rowspan="1" colspan="1">0</td><td valign="top" align="center" rowspan="1" colspan="1">0</td><td valign="top" align="center" rowspan="1" colspan="1">1.000</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Parainfluenza virus 3</td><td valign="top" align="center" rowspan="1" colspan="1">0<sup>*</sup></td><td valign="top" align="center" rowspan="1" colspan="1">12 (24.0)</td><td valign="top" align="center" rowspan="1" colspan="1">0.001</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Influenza A and B</td><td valign="top" align="center" rowspan="1" colspan="1">0</td><td valign="top" align="center" rowspan="1" colspan="1">2 (4.0)</td><td valign="top" align="center" rowspan="1" colspan="1">1.000</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Respiratory syncytial virus A</td><td valign="top" align="center" rowspan="1" colspan="1">2 (4.5)</td><td valign="top" align="center" rowspan="1" colspan="1">5 (10.0)</td><td valign="top" align="center" rowspan="1" colspan="1">1.000</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Respiratory syncytial virus B</td><td valign="top" align="center" rowspan="1" colspan="1">3 (6.8)</td><td valign="top" align="center" rowspan="1" colspan="1">1 (2.0)</td><td valign="top" align="center" rowspan="1" colspan="1">0.182</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Rhinovirus A, B and C</td><td valign="top" align="center" rowspan="1" colspan="1">1 (2.2)</td><td valign="top" align="center" rowspan="1" colspan="1">10 (20.0)</td><td valign="top" align="center" rowspan="1" colspan="1">0.159</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Metapneumo virus</td><td valign="top" align="center" rowspan="1" colspan="1">0</td><td valign="top" align="center" rowspan="1" colspan="1">5 (10.0)</td><td valign="top" align="center" rowspan="1" colspan="1">0.058</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Adenovirus</td><td valign="top" align="center" rowspan="1" colspan="1">22 (54.5)<sup>*</sup></td><td valign="top" align="center" rowspan="1" colspan="1">15 (30.0)</td><td valign="top" align="center" rowspan="1" colspan="1">0.027</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Bocavirus</td><td valign="top" align="center" rowspan="1" colspan="1">1 (2.2)</td><td valign="top" align="center" rowspan="1" colspan="1">3 (6.0)</td><td valign="top" align="center" rowspan="1" colspan="1">1.000</td></tr></tbody></table></alternatives><table-wrap-foot><fn><p>Data are n (%). Group 2: KD patients with respiratory symptoms, Group 3: control patients with respiratory symptoms. <sup>*</sup>p<0.05, significantly different from Group 3. KD: Kawasaki disease</p></fn></table-wrap-foot></table-wrap><table-wrap id="T4" orientation="portrait" position="float"><label>Table 4</label><caption><title>Comparison of echocardiographic findings between KD patients without respiratory symptoms and KD patients with respiratory symptoms</title></caption><alternatives><graphic xlink:href="kcj-45-317-i004"></graphic><table frame="hsides" rules="rows"><thead><tr><th valign="top" align="left" rowspan="1" colspan="1"></th><th valign="top" align="center" rowspan="1" colspan="1">Group 1 (n=94)</th><th valign="top" align="center" rowspan="1" colspan="1">Group 2 (n=44)</th><th valign="top" align="center" rowspan="1" colspan="1">p</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">EF (%)</td><td valign="top" align="center" rowspan="1" colspan="1">72.0±7.3</td><td valign="top" align="center" rowspan="1" colspan="1">67.2±18.0</td><td valign="top" align="center" rowspan="1" colspan="1">0.078</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">FS (%)</td><td valign="top" align="center" rowspan="1" colspan="1">39.9±6.0</td><td valign="top" align="center" rowspan="1" colspan="1">42.9±9.4</td><td valign="top" align="center" rowspan="1" colspan="1">0.073</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Tissue Doppler imaging (cm/s)</td><td valign="top" align="center" rowspan="1" colspan="1"></td><td valign="top" align="center" rowspan="1" colspan="1"></td><td valign="top" align="center" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> E'</td><td valign="top" align="center" rowspan="1" colspan="1">9.9±2.2</td><td valign="top" align="center" rowspan="1" colspan="1">11.6±6.1</td><td valign="top" align="center" rowspan="1" colspan="1">0.052</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> A'</td><td valign="top" align="center" rowspan="1" colspan="1">5.6±2.7</td><td valign="top" align="center" rowspan="1" colspan="1">6.2±2.6</td><td valign="top" align="center" rowspan="1" colspan="1">0.320</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> S'</td><td valign="top" align="center" rowspan="1" colspan="1">5.6±1.2</td><td valign="top" align="center" rowspan="1" colspan="1">6.2±1.4</td><td valign="top" align="center" rowspan="1" colspan="1">0.320</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Tei index (ms)</td><td valign="top" align="center" rowspan="1" colspan="1">0.34±0.07</td><td valign="top" align="center" rowspan="1" colspan="1">0.44±0.06<sup>*</sup></td><td valign="top" align="center" rowspan="1" colspan="1">0.048</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> IVCT</td><td valign="top" align="center" rowspan="1" colspan="1">49.5±15.9</td><td valign="top" align="center" rowspan="1" colspan="1">61.4±8.9<sup>*</sup></td><td valign="top" align="center" rowspan="1" colspan="1">0.010</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> IVRT</td><td valign="top" align="center" rowspan="1" colspan="1">41.0±11.7</td><td valign="top" align="center" rowspan="1" colspan="1">46.0±12.6</td><td valign="top" align="center" rowspan="1" colspan="1">0.114</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> LVET</td><td valign="top" align="center" rowspan="1" colspan="1">236.4±78.9</td><td valign="top" align="center" rowspan="1" colspan="1">210.4±80.2</td><td valign="top" align="center" rowspan="1" colspan="1">0.183</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Coronary artery diameter (mm)</td><td valign="top" align="center" rowspan="1" colspan="1">2.7±0.9</td><td valign="top" align="center" rowspan="1" colspan="1">3.3±1.1<sup>*</sup></td><td valign="top" align="center" rowspan="1" colspan="1">0.005</td></tr></tbody></table></alternatives><table-wrap-foot><fn><p>Data are mean±SD. Group 1: KD patients without respiratory symptoms, Group 2: KD patients with respiratory symptoms. <sup>*</sup>p<0.05, significantly different from Group 1. KD: Kawasaki disease, EF: ejection fraction, FS: fractional shortening, E': early diastolic myocardial velocity, A': late diastolic myocardial velocity, S': systolic myocardial velocity, IVCT: isovolumetric contraction time, IVRT: isovolumetric relaxation time, LVET: left ventricle ejection time</p></fn></table-wrap-foot></table-wrap><table-wrap id="T5" orientation="portrait" position="float"><label>Table 5</label><caption><title>Response to intravenous immunoglobulin between KD patients without respiratory symptoms and those with respiratory symptoms</title></caption><alternatives><graphic xlink:href="kcj-45-317-i005"></graphic><table frame="hsides" rules="rows"><thead><tr><th valign="top" align="left" rowspan="1" colspan="1"></th><th valign="top" align="center" rowspan="1" colspan="1">Group 1 (n=94)</th><th valign="top" align="center" rowspan="1" colspan="1">Group 2 (n=44)</th><th valign="top" align="center" rowspan="1" colspan="1">p</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">Responder</td><td valign="top" align="center" rowspan="1" colspan="1">88 (93.6)</td><td valign="top" align="center" rowspan="1" colspan="1">39 (88.6)</td><td valign="top" align="center" rowspan="1" colspan="1">0.327</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Family history</td><td valign="top" align="center" rowspan="1" colspan="1">2 (2.1)</td><td valign="top" align="center" rowspan="1" colspan="1">0 (0)</td><td valign="top" align="center" rowspan="1" colspan="1">1.000</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Recurrence</td><td valign="top" align="center" rowspan="1" colspan="1">4 (4.3)</td><td valign="top" align="center" rowspan="1" colspan="1">1 (2.4)</td><td valign="top" align="center" rowspan="1" colspan="1">1.000</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Retreated</td><td valign="top" align="center" rowspan="1" colspan="1">6 (6.4)</td><td valign="top" align="center" rowspan="1" colspan="1">4 (9.1)</td><td valign="top" align="center" rowspan="1" colspan="1">0.726</td></tr></tbody></table></alternatives><table-wrap-foot><fn><p>Data are n (%). KD: Kawasaki disease</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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