Epidemiology, Molecular Epidemiology and Evolution of Bovine Respiratory Syncytial Virus
Identifieur interne : 000801 ( Pmc/Corpus ); précédent : 000800; suivant : 000802Epidemiology, Molecular Epidemiology and Evolution of Bovine Respiratory Syncytial Virus
Auteurs : Rosa Elena Sarmiento-Silva ; Yuko Nakamura-Lopez ; Gilberto VaughanSource :
- Viruses [ 1999-4915 ] ; 2012.
Abstract
The bovine respiratory syncytial virus (BRSV) is an enveloped, negative sense, single-stranded RNA virus belonging to the pneumovirus genus within the family Paramyxoviridae. BRSV has been recognized as a major cause of respiratory disease in young calves since the early 1970s. The analysis of BRSV infection was originally hampered by its characteristic lability and poor growth
Url:
DOI: 10.3390/v4123452
PubMed: 23202546
PubMed Central: 3528274
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PMC:3528274Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Epidemiology, Molecular Epidemiology and Evolution of Bovine Respiratory Syncytial Virus</title><author><name sortKey="Sarmiento Silva, Rosa Elena" sort="Sarmiento Silva, Rosa Elena" uniqKey="Sarmiento Silva R" first="Rosa Elena" last="Sarmiento-Silva">Rosa Elena Sarmiento-Silva</name><affiliation><nlm:aff id="af1-viruses-04-03452">Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Delegación Coyoacán, México, D.F. 04510, Mexico; Email:<email>rosass@unam.mx</email> (R.E.S-S.)</nlm:aff></affiliation></author><author><name sortKey="Nakamura Lopez, Yuko" sort="Nakamura Lopez, Yuko" uniqKey="Nakamura Lopez Y" first="Yuko" last="Nakamura-Lopez">Yuko Nakamura-Lopez</name><affiliation><nlm:aff id="af2-viruses-04-03452">Consejo Estatal para la Prevencion y Control del Sida-Centro Ambulatorio para la Prevencion y Atencion del Sida e ITS (COESIDA-CAPASITS) Oaxaca, Mexico; Email:<email>yuko@unam.mx</email> (Y. N.)</nlm:aff></affiliation></author><author><name sortKey="Vaughan, Gilberto" sort="Vaughan, Gilberto" uniqKey="Vaughan G" first="Gilberto" last="Vaughan">Gilberto Vaughan</name><affiliation><nlm:aff id="af3-viruses-04-03452">Instituto de Diagnóstico y Referencia Epidemiológicos, Carpio 470, Col. Santo Tomas, Mexico D.F. 11340, Mexico; Email:<email>gilvaughan@yahoo.com</email> (G.V.)</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23202546</idno><idno type="pmc">3528274</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528274</idno><idno type="RBID">PMC:3528274</idno><idno type="doi">10.3390/v4123452</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000801</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000801</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Epidemiology, Molecular Epidemiology and Evolution of Bovine Respiratory Syncytial Virus</title><author><name sortKey="Sarmiento Silva, Rosa Elena" sort="Sarmiento Silva, Rosa Elena" uniqKey="Sarmiento Silva R" first="Rosa Elena" last="Sarmiento-Silva">Rosa Elena Sarmiento-Silva</name><affiliation><nlm:aff id="af1-viruses-04-03452">Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Delegación Coyoacán, México, D.F. 04510, Mexico; Email:<email>rosass@unam.mx</email> (R.E.S-S.)</nlm:aff></affiliation></author><author><name sortKey="Nakamura Lopez, Yuko" sort="Nakamura Lopez, Yuko" uniqKey="Nakamura Lopez Y" first="Yuko" last="Nakamura-Lopez">Yuko Nakamura-Lopez</name><affiliation><nlm:aff id="af2-viruses-04-03452">Consejo Estatal para la Prevencion y Control del Sida-Centro Ambulatorio para la Prevencion y Atencion del Sida e ITS (COESIDA-CAPASITS) Oaxaca, Mexico; Email:<email>yuko@unam.mx</email> (Y. N.)</nlm:aff></affiliation></author><author><name sortKey="Vaughan, Gilberto" sort="Vaughan, Gilberto" uniqKey="Vaughan G" first="Gilberto" last="Vaughan">Gilberto Vaughan</name><affiliation><nlm:aff id="af3-viruses-04-03452">Instituto de Diagnóstico y Referencia Epidemiológicos, Carpio 470, Col. Santo Tomas, Mexico D.F. 11340, Mexico; Email:<email>gilvaughan@yahoo.com</email> (G.V.)</nlm:aff></affiliation></author></analytic><series><title level="j">Viruses</title><idno type="eISSN">1999-4915</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The bovine respiratory syncytial virus (BRSV) is an enveloped, negative sense, single-stranded RNA virus belonging to the pneumovirus genus within the family Paramyxoviridae. BRSV has been recognized as a major cause of respiratory disease in young calves since the early 1970s. The analysis of BRSV infection was originally hampered by its characteristic lability and poor growth <italic>in vitro</italic>. However, the advent of numerous immunological and molecular methods has facilitated the study of BRSV enormously. The knowledge gained from these studies has also provided the opportunity to develop safe, stable, attenuated virus vaccine candidates. Nonetheless, many aspects of the epidemiology, molecular epidemiology and evolution of the virus are still not fully understood. The natural course of infection is rather complex and further complicates diagnosis, treatment and the implementation of preventive measures aimed to control the disease. Therefore, understanding the mechanisms by which BRSV is able to establish infection is needed to prevent viral and disease spread. This review discusses important information regarding the epidemiology and molecular epidemiology of BRSV worldwide, and it highlights the importance of viral evolution in virus transmission.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Paccaud, M F" uniqKey="Paccaud M">M.F. Paccaud</name></author><author><name sortKey="Jacquier, C" uniqKey="Jacquier C">C. Jacquier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wellemans, G" uniqKey="Wellemans G">G. Wellemans</name></author><author><name sortKey="Leunen, J" uniqKey="Leunen J">J. Leunen</name></author><author><name sortKey="Luchsinger, E" uniqKey="Luchsinger E">E. Luchsinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, R A" uniqKey="Smith R">R.A. Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lamb, R A" uniqKey="Lamb R">R.A. Lamb</name></author><author><name sortKey="Parks, G D" uniqKey="Parks G">G.D. Parks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Poel, W H" uniqKey="Van Der Poel W">W.H. Van der Poel</name></author><author><name sortKey="Brand, A" uniqKey="Brand A">A. Brand</name></author><author><name sortKey="Kramps, J A" uniqKey="Kramps J">J.A. Kramps</name></author><author><name sortKey="Van Oirschot, J T" uniqKey="Van Oirschot J">J.T. Van Oirschot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ames, T R" uniqKey="Ames T">T.R. Ames</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Masot, A J" uniqKey="Masot A">A.J. Masot</name></author><author><name sortKey="Kelling, C L" uniqKey="Kelling C">C.L. Kelling</name></author><author><name sortKey="Lopez, O" uniqKey="Lopez O">O. Lopez</name></author><author><name sortKey="Sur, J H" uniqKey="Sur J">J.H. Sur</name></author><author><name sortKey="Redondo, E" uniqKey="Redondo E">E. Redondo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ohlson, A" uniqKey="Ohlson A">A. Ohlson</name></author><author><name sortKey="Emanuelson, U" uniqKey="Emanuelson U">U. Emanuelson</name></author><author><name sortKey="Traven, M" uniqKey="Traven M">M. Traven</name></author><author><name sortKey="Alenius, S" uniqKey="Alenius S">S. Alenius</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ohlson, A" uniqKey="Ohlson A">A. Ohlson</name></author><author><name sortKey="Heuer, C" uniqKey="Heuer C">C. Heuer</name></author><author><name sortKey="Lockhart, C" uniqKey="Lockhart C">C. Lockhart</name></author><author><name sortKey="Traven, M" uniqKey="Traven M">M. Traven</name></author><author><name sortKey="Emanuelson, U" uniqKey="Emanuelson U">U. Emanuelson</name></author><author><name sortKey="Alenius, S" uniqKey="Alenius S">S. Alenius</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saa, L R" uniqKey="Saa L">L.R. Saa</name></author><author><name sortKey="Perea, A" uniqKey="Perea A">A. Perea</name></author><author><name sortKey="Jara, D V" uniqKey="Jara D">D.V. Jara</name></author><author><name sortKey="Arenas, A J" uniqKey="Arenas A">A.J. Arenas</name></author><author><name sortKey="Garcia Bocanegra, I" uniqKey="Garcia Bocanegra I">I. Garcia-Bocanegra</name></author><author><name sortKey="Borge, C" uniqKey="Borge C">C. Borge</name></author><author><name sortKey="Carbonero, A" uniqKey="Carbonero A">A. Carbonero</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valarcher, J F" uniqKey="Valarcher J">J.F. Valarcher</name></author><author><name sortKey="Taylor, G" uniqKey="Taylor G">G. Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bidokhti, M R" uniqKey="Bidokhti M">M.R. Bidokhti</name></author><author><name sortKey="Traven, M" uniqKey="Traven M">M. Traven</name></author><author><name sortKey="Ohlson, A" uniqKey="Ohlson A">A. Ohlson</name></author><author><name sortKey="Zarnegar, B" uniqKey="Zarnegar B">B. Zarnegar</name></author><author><name sortKey="Baule, C" uniqKey="Baule C">C. Baule</name></author><author><name sortKey="Belak, S" uniqKey="Belak S">S. Belak</name></author><author><name sortKey="Alenius, S" uniqKey="Alenius S">S. Alenius</name></author><author><name sortKey="Liu, L" uniqKey="Liu L">L. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elvander, M" uniqKey="Elvander M">M. Elvander</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woldemeskel, M" uniqKey="Woldemeskel M">M. Woldemeskel</name></author><author><name sortKey="Kebede, E" uniqKey="Kebede E">E. Kebede</name></author><author><name sortKey="Yigezu, L" uniqKey="Yigezu L">L. Yigezu</name></author><author><name sortKey="Potgieter, L N" uniqKey="Potgieter L">L.N. Potgieter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Collins, J K" uniqKey="Collins J">J.K. Collins</name></author><author><name sortKey="Teegarden, R M" uniqKey="Teegarden R">R.M. Teegarden</name></author><author><name sortKey="Macvean, D W" uniqKey="Macvean D">D.W. MacVean</name></author><author><name sortKey="Salman" uniqKey="Salman">Salman</name></author><author><name sortKey="Smith, G H" uniqKey="Smith G">G.H. Smith</name></author><author><name sortKey="Frank, G R" uniqKey="Frank G">G.R. Frank</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elazhary, M A" uniqKey="Elazhary M">M.A. Elazhary</name></author><author><name sortKey="Silim, A" uniqKey="Silim A">A. Silim</name></author><author><name sortKey="Dea, S" uniqKey="Dea S">S. Dea</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elazhary, M A" uniqKey="Elazhary M">M.A. Elazhary</name></author><author><name sortKey="Roy, R S" uniqKey="Roy R">R.S. Roy</name></author><author><name sortKey="Champlin, R" uniqKey="Champlin R">R. Champlin</name></author><author><name sortKey="Higgins, R" uniqKey="Higgins R">R. Higgins</name></author><author><name sortKey="Marsolais, G" uniqKey="Marsolais G">G. Marsolais</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baker, J C" uniqKey="Baker J">J.C. Baker</name></author><author><name sortKey="Ames, T R" uniqKey="Ames T">T.R. Ames</name></author><author><name sortKey="Markham, R J" uniqKey="Markham R">R.J. Markham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kimman, T G" uniqKey="Kimman T">T.G. Kimman</name></author><author><name sortKey="Zimmer, G M" uniqKey="Zimmer G">G.M. Zimmer</name></author><author><name sortKey="Westenbrink, F" uniqKey="Westenbrink F">F. Westenbrink</name></author><author><name sortKey="Mars, J" uniqKey="Mars J">J. Mars</name></author><author><name sortKey="Van Leeuwen, E" uniqKey="Van Leeuwen E">E. van Leeuwen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hagglund, S" uniqKey="Hagglund S">S. Hagglund</name></author><author><name sortKey="Svensson, C" uniqKey="Svensson C">C. Svensson</name></author><author><name sortKey="Emanuelson, U" uniqKey="Emanuelson U">U. Emanuelson</name></author><author><name sortKey="Valarcher, J F" uniqKey="Valarcher J">J.F. Valarcher</name></author><author><name sortKey="Alenius, S" uniqKey="Alenius S">S. Alenius</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raaperi, K" uniqKey="Raaperi K">K. Raaperi</name></author><author><name sortKey="Bougeard, S" uniqKey="Bougeard S">S. Bougeard</name></author><author><name sortKey="Aleksejev, A" uniqKey="Aleksejev A">A. Aleksejev</name></author><author><name sortKey="Orro, T" uniqKey="Orro T">T. Orro</name></author><author><name sortKey="Viltrop, A" uniqKey="Viltrop A">A. Viltrop</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bidokhti, M R" uniqKey="Bidokhti M">M.R. Bidokhti</name></author><author><name sortKey="Traven, M" uniqKey="Traven M">M. Traven</name></author><author><name sortKey="Fall, N" uniqKey="Fall N">N. Fall</name></author><author><name sortKey="Emanuelson, U" uniqKey="Emanuelson U">U. Emanuelson</name></author><author><name sortKey="Alenius, S" uniqKey="Alenius S">S. Alenius</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stott, E J" uniqKey="Stott E">E.J. Stott</name></author><author><name sortKey="Thomas, L H" uniqKey="Thomas L">L.H. Thomas</name></author><author><name sortKey="Collins, A P" uniqKey="Collins A">A.P. Collins</name></author><author><name sortKey="Crouch, S" uniqKey="Crouch S">S. Crouch</name></author><author><name sortKey="Jebbett, J" uniqKey="Jebbett J">J. Jebbett</name></author><author><name sortKey="Smith, G S" uniqKey="Smith G">G.S. Smith</name></author><author><name sortKey="Luther, P D" uniqKey="Luther P">P.D. Luther</name></author><author><name sortKey="Caswell, R" uniqKey="Caswell R">R. Caswell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brodersen, B W" uniqKey="Brodersen B">B.W. Brodersen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baker, J C" uniqKey="Baker J">J.C. Baker</name></author><author><name sortKey="Werdin, R E" uniqKey="Werdin R">R.E. Werdin</name></author><author><name sortKey="Ames, T R" uniqKey="Ames T">T.R. Ames</name></author><author><name sortKey="Markham, R J" uniqKey="Markham R">R.J. Markham</name></author><author><name sortKey="Larson, V L" uniqKey="Larson V">V.L. Larson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Jong, M C" uniqKey="De Jong M">M.C. De Jong</name></author><author><name sortKey="Van Der Poel, W H" uniqKey="Van Der Poel W">W.H. van der Poel</name></author><author><name sortKey="Kramps, J A" uniqKey="Kramps J">J.A. Kramps</name></author><author><name sortKey="Brand, A" uniqKey="Brand A">A. Brand</name></author><author><name sortKey="Van Oirschot, J T" uniqKey="Van Oirschot J">J.T. van Oirschot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rossi, C R" uniqKey="Rossi C">C.R. Rossi</name></author><author><name sortKey="Kiesel, G K" uniqKey="Kiesel G">G.K. Kiesel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, M H" uniqKey="Smith M">M.H. Smith</name></author><author><name sortKey="Frey, M L" uniqKey="Frey M">M.L. Frey</name></author><author><name sortKey="Dierks, R E" uniqKey="Dierks R">R.E. Dierks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baker, J C" uniqKey="Baker J">J.C. Baker</name></author><author><name sortKey="Ames, T R" uniqKey="Ames T">T.R. Ames</name></author><author><name sortKey="Markham, R J" uniqKey="Markham R">R.J. Markham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lehmkuhl, H D" uniqKey="Lehmkuhl H">H.D. Lehmkuhl</name></author><author><name sortKey="Gough, P M" uniqKey="Gough P">P.M. Gough</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grubbs, S T" uniqKey="Grubbs S">S.T. Grubbs</name></author><author><name sortKey="Kania, S A" uniqKey="Kania S">S.A. Kania</name></author><author><name sortKey="Potgieter, L N" uniqKey="Potgieter L">L.N. Potgieter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fulton, R W" uniqKey="Fulton R">R.W. Fulton</name></author><author><name sortKey="Purdy, C W" uniqKey="Purdy C">C.W. Purdy</name></author><author><name sortKey="Confer, A W" uniqKey="Confer A">A.W. Confer</name></author><author><name sortKey="Saliki, J T" uniqKey="Saliki J">J.T. Saliki</name></author><author><name sortKey="Loan, R W" uniqKey="Loan R">R.W. Loan</name></author><author><name sortKey="Briggs, R E" uniqKey="Briggs R">R.E. Briggs</name></author><author><name sortKey="Burge, L J" uniqKey="Burge L">L.J. Burge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin, S W" uniqKey="Martin S">S.W. Martin</name></author><author><name sortKey="Bateman, K G" uniqKey="Bateman K">K.G. Bateman</name></author><author><name sortKey="Shewen, P E" uniqKey="Shewen P">P.E. Shewen</name></author><author><name sortKey="Rosendal, S" uniqKey="Rosendal S">S. Rosendal</name></author><author><name sortKey="Bohac, J E" uniqKey="Bohac J">J.E. Bohac</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gagea, M I" uniqKey="Gagea M">M.I. Gagea</name></author><author><name sortKey="Bateman, K G" uniqKey="Bateman K">K.G. Bateman</name></author><author><name sortKey="Van Dreumel, T" uniqKey="Van Dreumel T">T. van Dreumel</name></author><author><name sortKey="Mcewen, B J" uniqKey="Mcewen B">B.J. McEwen</name></author><author><name sortKey="Carman, S" uniqKey="Carman S">S. Carman</name></author><author><name sortKey="Archambault, M" uniqKey="Archambault M">M. Archambault</name></author><author><name sortKey="Shanahan, R A" uniqKey="Shanahan R">R.A. Shanahan</name></author><author><name sortKey="Caswell, J L" uniqKey="Caswell J">J.L. Caswell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Figueroa Chavez, D" uniqKey="Figueroa Chavez D">D. Figueroa-Chavez</name></author><author><name sortKey="Segura Correa, J C" uniqKey="Segura Correa J">J.C. Segura-Correa</name></author><author><name sortKey="Garcia Marquez, L J" uniqKey="Garcia Marquez L">L.J. Garcia-Marquez</name></author><author><name sortKey="Pescador Rubio, A" uniqKey="Pescador Rubio A">A. Pescador-Rubio</name></author><author><name sortKey="Valdivia Flores, A G" uniqKey="Valdivia Flores A">A.G. Valdivia-Flores</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Solis Calderon, J J" uniqKey="Solis Calderon J">J.J. Solis-Calderon</name></author><author><name sortKey="Segura Correa, J C" uniqKey="Segura Correa J">J.C. Segura-Correa</name></author><author><name sortKey="Aguilar Romero, F" uniqKey="Aguilar Romero F">F. Aguilar-Romero</name></author><author><name sortKey="Segura Correa, V M" uniqKey="Segura Correa V">V.M. Segura-Correa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Almeida, R S" uniqKey="Almeida R">R.S. Almeida</name></author><author><name sortKey="Domingues, H G" uniqKey="Domingues H">H.G. Domingues</name></author><author><name sortKey="Spilki, F R" uniqKey="Spilki F">F.R. Spilki</name></author><author><name sortKey="Larsen, L E" uniqKey="Larsen L">L.E. Larsen</name></author><author><name sortKey="Hagglund, S" uniqKey="Hagglund S">S. Hagglund</name></author><author><name sortKey="Belak, S" uniqKey="Belak S">S. Belak</name></author><author><name sortKey="Arns, C W" uniqKey="Arns C">C.W. Arns</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arns, C W" uniqKey="Arns C">C.W. Arns</name></author><author><name sortKey="Campalans, J" uniqKey="Campalans J">J. Campalans</name></author><author><name sortKey="Costa, S C" uniqKey="Costa S">S.C. Costa</name></author><author><name sortKey="Domingues, H G" uniqKey="Domingues H">H.G. Domingues</name></author><author><name sortKey="D Arce, R C" uniqKey="D Arce R">R.C. D'Arce</name></author><author><name sortKey="Almeida, R S" uniqKey="Almeida R">R.S. Almeida</name></author><author><name sortKey="Coswig, L T" uniqKey="Coswig L">L.T. Coswig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jacobs, J W" uniqKey="Jacobs J">J.W. Jacobs</name></author><author><name sortKey="Edington, N" uniqKey="Edington N">N. Edington</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beaudeau, F" uniqKey="Beaudeau F">F. Beaudeau</name></author><author><name sortKey="Bjorkman, C" uniqKey="Bjorkman C">C. Bjorkman</name></author><author><name sortKey="Alenius, S" uniqKey="Alenius S">S. Alenius</name></author><author><name sortKey="Frossling, J" uniqKey="Frossling J">J. Frossling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uttenthal, A" uniqKey="Uttenthal A">A. Uttenthal</name></author><author><name sortKey="Larsen, L E" uniqKey="Larsen L">L.E. Larsen</name></author><author><name sortKey="Philipsen, J S" uniqKey="Philipsen J">J.S. Philipsen</name></author><author><name sortKey="Tjornehoj, K" uniqKey="Tjornehoj K">K. Tjornehoj</name></author><author><name sortKey="Viuff, B" uniqKey="Viuff B">B. Viuff</name></author><author><name sortKey="Nielsen, K H" uniqKey="Nielsen K">K.H. Nielsen</name></author><author><name sortKey="Nielsen, T K" uniqKey="Nielsen T">T.K. Nielsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pardon, B" uniqKey="Pardon B">B. Pardon</name></author><author><name sortKey="De Bleecker, K" uniqKey="De Bleecker K">K. De Bleecker</name></author><author><name sortKey="Dewulf, J" uniqKey="Dewulf J">J. Dewulf</name></author><author><name sortKey="Callens, J" uniqKey="Callens J">J. Callens</name></author><author><name sortKey="Boyen, F" uniqKey="Boyen F">F. Boyen</name></author><author><name sortKey="Catry, B" uniqKey="Catry B">B. Catry</name></author><author><name sortKey="Deprez, P" uniqKey="Deprez P">P. Deprez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hotchkiss, E J" uniqKey="Hotchkiss E">E.J. Hotchkiss</name></author><author><name sortKey="Dagleish, M P" uniqKey="Dagleish M">M.P. Dagleish</name></author><author><name sortKey="Willoughby, K" uniqKey="Willoughby K">K. Willoughby</name></author><author><name sortKey="Mckendrick, I J" uniqKey="Mckendrick I">I.J. McKendrick</name></author><author><name sortKey="Finlayson, J" uniqKey="Finlayson J">J. Finlayson</name></author><author><name sortKey="Zadoks, R N" uniqKey="Zadoks R">R.N. Zadoks</name></author><author><name sortKey="Newsome, E" uniqKey="Newsome E">E. Newsome</name></author><author><name sortKey="Brulisauer, F" uniqKey="Brulisauer F">F. Brulisauer</name></author><author><name sortKey="Gunn, G J" uniqKey="Gunn G">G.J. Gunn</name></author><author><name sortKey="Hodgson, J C" uniqKey="Hodgson J">J.C. Hodgson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paton, D J" uniqKey="Paton D">D.J. Paton</name></author><author><name sortKey="Christiansen, K H" uniqKey="Christiansen K">K.H. Christiansen</name></author><author><name sortKey="Alenius, S" uniqKey="Alenius S">S. Alenius</name></author><author><name sortKey="Cranwell, M P" uniqKey="Cranwell M">M.P. Cranwell</name></author><author><name sortKey="Pritchard, G C" uniqKey="Pritchard G">G.C. Pritchard</name></author><author><name sortKey="Drew, T W" uniqKey="Drew T">T.W. Drew</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raaperi, K" uniqKey="Raaperi K">K. Raaperi</name></author><author><name sortKey="Bougeard, S" uniqKey="Bougeard S">S. Bougeard</name></author><author><name sortKey="Aleksejev, A" uniqKey="Aleksejev A">A. Aleksejev</name></author><author><name sortKey="Orro, T" uniqKey="Orro T">T. Orro</name></author><author><name sortKey="Viltrop, A" uniqKey="Viltrop A">A. Viltrop</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Vuuren, M" uniqKey="Van Vuuren M">M. Van Vuuren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mahin, L" uniqKey="Mahin L">L. Mahin</name></author><author><name sortKey="Wellemans, G" uniqKey="Wellemans G">G. Wellemans</name></author><author><name sortKey="Shimi, A" uniqKey="Shimi A">A. Shimi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mahin, L" uniqKey="Mahin L">L. Mahin</name></author><author><name sortKey="Wellemans, G" uniqKey="Wellemans G">G. Wellemans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yesilbag, K" uniqKey="Yesilbag K">K. Yesilbag</name></author><author><name sortKey="Gungor, B" uniqKey="Gungor B">B. Gungor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valarcher, J F" uniqKey="Valarcher J">J.F. Valarcher</name></author><author><name sortKey="Schelcher, F" uniqKey="Schelcher F">F. Schelcher</name></author><author><name sortKey="Bourhy, H" uniqKey="Bourhy H">H. Bourhy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deplanche, M" uniqKey="Deplanche M">M. Deplanche</name></author><author><name sortKey="Lemaire, M" uniqKey="Lemaire M">M. Lemaire</name></author><author><name sortKey="Mirandette, C" uniqKey="Mirandette C">C. Mirandette</name></author><author><name sortKey="Bonnet, M" uniqKey="Bonnet M">M. Bonnet</name></author><author><name sortKey="Schelcher, F" uniqKey="Schelcher F">F. Schelcher</name></author><author><name sortKey="Meyer, G" uniqKey="Meyer G">G. Meyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lam, T T" uniqKey="Lam T">T.T. Lam</name></author><author><name sortKey="Hon, C C" uniqKey="Hon C">C.C. Hon</name></author><author><name sortKey="Tang, J W" uniqKey="Tang J">J.W. Tang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khudyakov, Y" uniqKey="Khudyakov Y">Y. Khudyakov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spilki, F R" uniqKey="Spilki F">F.R. Spilki</name></author><author><name sortKey="Almeida, R S" uniqKey="Almeida R">R.S. Almeida</name></author><author><name sortKey="Domingues, H G" uniqKey="Domingues H">H.G. Domingues</name></author><author><name sortKey="D Arce, R C F" uniqKey="D Arce R">R.C.F. D'Arce</name></author><author><name sortKey="Ferreira, H L" uniqKey="Ferreira H">H.L. Ferreira</name></author><author><name sortKey="Campalans, J" uniqKey="Campalans J">J. Campalans</name></author><author><name sortKey="Costa, S C B" uniqKey="Costa S">S.C.B. Costa</name></author><author><name sortKey="Arns, C W" uniqKey="Arns C">C.W. Arns</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Samal, S K" uniqKey="Samal S">S.K. Samal</name></author><author><name sortKey="Zamora, M" uniqKey="Zamora M">M. Zamora</name></author><author><name sortKey="Mcphillips, T H" uniqKey="Mcphillips T">T.H. McPhillips</name></author><author><name sortKey="Mohanty, S B" uniqKey="Mohanty S">S.B. Mohanty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kovarcik, K" uniqKey="Kovarcik K">K. Kovarcik</name></author><author><name sortKey="Valentova, V" uniqKey="Valentova V">V. Valentova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lerch, R A" uniqKey="Lerch R">R.A. Lerch</name></author><author><name sortKey="Stott, E J" uniqKey="Stott E">E.J. Stott</name></author><author><name sortKey="Wertz, G W" uniqKey="Wertz G">G.W. Wertz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baker, J C" uniqKey="Baker J">J.C. Baker</name></author><author><name sortKey="Wilson, E G" uniqKey="Wilson E">E.G. Wilson</name></author><author><name sortKey="Mckay, G L" uniqKey="Mckay G">G.L. McKay</name></author><author><name sortKey="Stanek, R J" uniqKey="Stanek R">R.J. Stanek</name></author><author><name sortKey="Underwood, W J" uniqKey="Underwood W">W.J. Underwood</name></author><author><name sortKey="Velicer, L F" uniqKey="Velicer L">L.F. Velicer</name></author><author><name sortKey="Mufson, M A" uniqKey="Mufson M">M.A. Mufson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mallipeddi, S K" uniqKey="Mallipeddi S">S.K. Mallipeddi</name></author><author><name sortKey="Samal, S K" uniqKey="Samal S">S.K. Samal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prozzi, D" uniqKey="Prozzi D">D. Prozzi</name></author><author><name sortKey="Walravens, K" uniqKey="Walravens K">K. Walravens</name></author><author><name sortKey="Langedijk, J P" uniqKey="Langedijk J">J.P. Langedijk</name></author><author><name sortKey="Daus, F" uniqKey="Daus F">F. Daus</name></author><author><name sortKey="Kramps, J A" uniqKey="Kramps J">J.A. Kramps</name></author><author><name sortKey="Letesson, J J" uniqKey="Letesson J">J.J. Letesson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Furze, J" uniqKey="Furze J">J. Furze</name></author><author><name sortKey="Wertz, G" uniqKey="Wertz G">G. Wertz</name></author><author><name sortKey="Lerch, R" uniqKey="Lerch R">R. Lerch</name></author><author><name sortKey="Taylor, G" uniqKey="Taylor G">G. Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meyer, G" uniqKey="Meyer G">G. Meyer</name></author><author><name sortKey="Deplanche, M" uniqKey="Deplanche M">M. Deplanche</name></author><author><name sortKey="Schelcher, F" uniqKey="Schelcher F">F. Schelcher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lerch, R A" uniqKey="Lerch R">R.A. Lerch</name></author><author><name sortKey="Anderson, K" uniqKey="Anderson K">K. Anderson</name></author><author><name sortKey="Wertz, G W" uniqKey="Wertz G">G.W. Wertz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walravens, K" uniqKey="Walravens K">K. Walravens</name></author><author><name sortKey="Kettmann, R" uniqKey="Kettmann R">R. Kettmann</name></author><author><name sortKey="Collard, A" uniqKey="Collard A">A. Collard</name></author><author><name sortKey="Coppe, P" uniqKey="Coppe P">P. Coppe</name></author><author><name sortKey="Burny, A" uniqKey="Burny A">A. Burny</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Samal, S K" uniqKey="Samal S">S.K. Samal</name></author><author><name sortKey="Zamora, M" uniqKey="Zamora M">M. Zamora</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zamora, M" uniqKey="Zamora M">M. Zamora</name></author><author><name sortKey="Samal, S K" uniqKey="Samal S">S.K. Samal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mallipeddi, S K" uniqKey="Mallipeddi S">S.K. Mallipeddi</name></author><author><name sortKey="Samal, S K" uniqKey="Samal S">S.K. Samal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mallipeddi, S K" uniqKey="Mallipeddi S">S.K. Mallipeddi</name></author><author><name sortKey="Samal, S K" uniqKey="Samal S">S.K. Samal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Langedijk, J P" uniqKey="Langedijk J">J.P. Langedijk</name></author><author><name sortKey="Meloen, R H" uniqKey="Meloen R">R.H. Meloen</name></author><author><name sortKey="Taylor, G" uniqKey="Taylor G">G. Taylor</name></author><author><name sortKey="Furze, J M" uniqKey="Furze J">J.M. Furze</name></author><author><name sortKey="Van Oirschot, J T" uniqKey="Van Oirschot J">J.T. van Oirschot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stine, L C" uniqKey="Stine L">L.C. Stine</name></author><author><name sortKey="Hoppe, D K" uniqKey="Hoppe D">D.K. Hoppe</name></author><author><name sortKey="Kelling, C L" uniqKey="Kelling C">C.L. Kelling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elvander, M" uniqKey="Elvander M">M. Elvander</name></author><author><name sortKey="Vilcek, S" uniqKey="Vilcek S">S. Vilcek</name></author><author><name sortKey="Baule, C" uniqKey="Baule C">C. Baule</name></author><author><name sortKey="Uttenthal, A" uniqKey="Uttenthal A">A. Uttenthal</name></author><author><name sortKey="Ballagi Pordany, A" uniqKey="Ballagi Pordany A">A. Ballagi-Pordany</name></author><author><name sortKey="Belak, S" uniqKey="Belak S">S. Belak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Larsen, L E" uniqKey="Larsen L">L.E. Larsen</name></author><author><name sortKey="Uttenthal, A" uniqKey="Uttenthal A">A. Uttenthal</name></author><author><name sortKey="Arctander, P" uniqKey="Arctander P">P. Arctander</name></author><author><name sortKey="Tjornehoj, K" uniqKey="Tjornehoj K">K. Tjornehoj</name></author><author><name sortKey="Viuff, B" uniqKey="Viuff B">B. Viuff</name></author><author><name sortKey="Rontved, C" uniqKey="Rontved C">C. Rontved</name></author><author><name sortKey="Ronsholt, L" uniqKey="Ronsholt L">L. Ronsholt</name></author><author><name sortKey="Alexandersen, S" uniqKey="Alexandersen S">S. Alexandersen</name></author><author><name sortKey="Blixenkrone Moller, M" uniqKey="Blixenkrone Moller M">M. Blixenkrone-Moller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kovarcik, K" uniqKey="Kovarcik K">K. Kovarcik</name></author><author><name sortKey="Valentova, V" uniqKey="Valentova V">V. Valentova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Larsen, L E" uniqKey="Larsen L">L.E. Larsen</name></author><author><name sortKey="Tjornehoj, K" uniqKey="Tjornehoj K">K. Tjornehoj</name></author><author><name sortKey="Viuff, B" uniqKey="Viuff B">B. Viuff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valentova, V" uniqKey="Valentova V">V. Valentova</name></author><author><name sortKey="Antonis, A F" uniqKey="Antonis A">A.F. Antonis</name></author><author><name sortKey="Kovarcik, K" uniqKey="Kovarcik K">K. Kovarcik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yaegashi, G" uniqKey="Yaegashi G">G. Yaegashi</name></author><author><name sortKey="Seimiya, Y M" uniqKey="Seimiya Y">Y.M. Seimiya</name></author><author><name sortKey="Seki, Y" uniqKey="Seki Y">Y. Seki</name></author><author><name sortKey="Tsunemitsu, H" uniqKey="Tsunemitsu H">H. Tsunemitsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spilki, F R" uniqKey="Spilki F">F.R. Spilki</name></author><author><name sortKey="Almeida, R S" uniqKey="Almeida R">R.S. Almeida</name></author><author><name sortKey="Domingues, H G" uniqKey="Domingues H">H.G. Domingues</name></author><author><name sortKey="D Arce, R C" uniqKey="D Arce R">R.C. D'Arce</name></author><author><name sortKey="Ferreira, H L" uniqKey="Ferreira H">H.L. Ferreira</name></author><author><name sortKey="Campalans, J" uniqKey="Campalans J">J. Campalans</name></author><author><name sortKey="Costa, S C" uniqKey="Costa S">S.C. Costa</name></author><author><name sortKey="Arns, C W" uniqKey="Arns C">C.W. Arns</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nettleton, P F" uniqKey="Nettleton P">P.F. Nettleton</name></author><author><name sortKey="Gilray, J A" uniqKey="Gilray J">J.A. Gilray</name></author><author><name sortKey="Caldow, G" uniqKey="Caldow G">G. Caldow</name></author><author><name sortKey="Gidlow, J R" uniqKey="Gidlow J">J.R. Gidlow</name></author><author><name sortKey="Durkovic, B" uniqKey="Durkovic B">B. Durkovic</name></author><author><name sortKey="Vilcek, S" uniqKey="Vilcek S">S. Vilcek</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Viruses</journal-id><journal-id journal-id-type="iso-abbrev">Viruses</journal-id><journal-id journal-id-type="publisher-id">viruses</journal-id><journal-title-group><journal-title>Viruses</journal-title></journal-title-group><issn pub-type="epub">1999-4915</issn><publisher><publisher-name>MDPI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23202546</article-id><article-id pub-id-type="pmc">3528274</article-id><article-id pub-id-type="doi">10.3390/v4123452</article-id><article-id pub-id-type="publisher-id">viruses-04-03452</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Epidemiology, Molecular Epidemiology and Evolution of Bovine Respiratory Syncytial Virus</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Sarmiento-Silva</surname><given-names>Rosa Elena</given-names></name><xref ref-type="aff" rid="af1-viruses-04-03452">1</xref></contrib><contrib contrib-type="author"><name><surname>Nakamura-Lopez</surname><given-names>Yuko</given-names></name><xref ref-type="aff" rid="af2-viruses-04-03452">2</xref></contrib><contrib contrib-type="author"><name><surname>Vaughan</surname><given-names>Gilberto</given-names></name><xref ref-type="aff" rid="af3-viruses-04-03452">3</xref><xref rid="c1-viruses-04-03452" ref-type="corresp">*</xref></contrib></contrib-group><aff id="af1-viruses-04-03452"><label>1</label>Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Delegación Coyoacán, México, D.F. 04510, Mexico; Email:<email>rosass@unam.mx</email> (R.E.S-S.)</aff><aff id="af2-viruses-04-03452"><label>2</label>Consejo Estatal para la Prevencion y Control del Sida-Centro Ambulatorio para la Prevencion y Atencion del Sida e ITS (COESIDA-CAPASITS) Oaxaca, Mexico; Email:<email>yuko@unam.mx</email> (Y. N.)</aff><aff id="af3-viruses-04-03452"><label>3</label>Instituto de Diagnóstico y Referencia Epidemiológicos, Carpio 470, Col. Santo Tomas, Mexico D.F. 11340, Mexico; Email:<email>gilvaughan@yahoo.com</email> (G.V.)</aff><author-notes><corresp id="c1-viruses-04-03452"><label>*</label> Author to whom correspondence should be addressed; Email: <email>gilvaughan@yahoo.com</email>; Tel.: +52-55-5342-7563; Fax: +52-55-5342-1230.</corresp></author-notes><pub-date pub-type="epub"><day>30</day><month>11</month><year>2012</year></pub-date><pub-date pub-type="collection"><month>12</month><year>2012</year></pub-date><volume>4</volume><issue>12</issue><fpage>3452</fpage><lpage>3467</lpage><history><date date-type="received"><day>29</day><month>10</month><year>2012</year></date><date date-type="rev-recd"><day>22</day><month>11</month><year>2012</year></date><date date-type="accepted"><day>23</day><month>11</month><year>2012</year></date></history><permissions><copyright-statement>© 2012 by the authors; licensee MDPI, Basel, Switzerland.</copyright-statement><copyright-year>2012</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/3.0/"><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/3.0/">http://creativecommons.org/licenses/by/3.0/</ext-link>).</license-p></license></permissions><abstract><p>The bovine respiratory syncytial virus (BRSV) is an enveloped, negative sense, single-stranded RNA virus belonging to the pneumovirus genus within the family Paramyxoviridae. BRSV has been recognized as a major cause of respiratory disease in young calves since the early 1970s. The analysis of BRSV infection was originally hampered by its characteristic lability and poor growth <italic>in vitro</italic>. However, the advent of numerous immunological and molecular methods has facilitated the study of BRSV enormously. The knowledge gained from these studies has also provided the opportunity to develop safe, stable, attenuated virus vaccine candidates. Nonetheless, many aspects of the epidemiology, molecular epidemiology and evolution of the virus are still not fully understood. The natural course of infection is rather complex and further complicates diagnosis, treatment and the implementation of preventive measures aimed to control the disease. Therefore, understanding the mechanisms by which BRSV is able to establish infection is needed to prevent viral and disease spread. This review discusses important information regarding the epidemiology and molecular epidemiology of BRSV worldwide, and it highlights the importance of viral evolution in virus transmission.</p></abstract><kwd-group><kwd>BRSV</kwd><kwd>global distribution</kwd><kwd>genotypes</kwd><kwd>evolution.</kwd></kwd-group></article-meta></front><body><sec><title>1. Introduction</title><p>The bovine respiratory syncytial virus (BRSV) has been recognized as a pathogen in cattle responsible of an acute respiratory disease syndrome in beef and dairy calves since the early 1970s [<xref ref-type="bibr" rid="B1-viruses-04-03452">1</xref>,<xref ref-type="bibr" rid="B2-viruses-04-03452">2</xref>]. The impact of BRSV infection on the cattle industry results in economic losses due to the morbidity, mortality, treatment and prevention costs that eventually lead to loss of production and reduced carcass value [<xref ref-type="bibr" rid="B3-viruses-04-03452">3</xref>]. </p><p>BRSV is an enveloped, non-segmented, negative-stranded RNA virus belonging to the <italic>Pneumovirus</italic> genus within the subfamily <italic>Pneumovirinae</italic>, family <italic>Paramyxoviridae</italic> [<xref ref-type="bibr" rid="B4-viruses-04-03452">4</xref>]. The BRSV virion consists of a lipid envelope containing three surface glycoproteins (glycoprotein [G], the fusion protein [F] and the small hydrophobic protein [SH]) (<xref ref-type="fig" rid="viruses-04-03452-f001">Figure 1</xref>). The envelope encloses a helical nucleocapsid composed by the nucleoprotein (N), the phosphoprotein (P), the viral RNA-dependent polymerase protein (L) the M protein and a transcriptional anti-termination factor known as M2-1. The genomic RNA (~15,000 nucleotides in length) also encodes an RNA regulatory protein M2-2 and two non-structural proteins, NS1 and NS2 [<xref ref-type="bibr" rid="B4-viruses-04-03452">4</xref>].</p><fig id="viruses-04-03452-f001" position="float"><label>Figure 1</label><caption><p>Bovine respiratory syncytial virus (BRSV) genome scheme and commonly used region for molecular epidemiology studies. The areas encoding the BRSV proteins are represented in boxes. Targeting regions are following: region (1), N region (nt 1294 to nt 1984); region (2), SH complete genome (nt 4268 to 4513); region (3), G region (nt 4864 to 5353); region (3), F region (nt 6071 to nt 6812). Nucleotide positions were given in reference to strain NC_001989.</p></caption><graphic xlink:href="viruses-04-03452-g001"></graphic></fig><p>BRSV is closely related to human RSV (HRSV), and the epidemiology and pathogenesis of infection between these two viruses share some similarities and also many differences [<xref ref-type="bibr" rid="B5-viruses-04-03452">5</xref>]. The similarities between the two viruses have facilitated the unveiling of some of the mechanisms by which BSRV can cause disease. However, the means used by the virus to warrant transmission among individuals within and between herds have remained elusive.</p><p>Understanding of the global epidemiology and molecular epidemiology of BRSV has significantly improved over recent years. In this review, we discuss various aspects of the epidemiology and molecular epidemiology of BRSV as well as their relationship with viral evolution.</p></sec><sec><title>2. Epidemiology of BRSV</title><p>BRSV infection is widely spread around the world, most likely as a direct result of the movement of cattle [<xref ref-type="bibr" rid="B6-viruses-04-03452">6</xref>]. Regardless of the geographical location, infectivity rates are usually rather high, suggesting that viral transmission is a common event among herds. Cattle are the principal reservoir of infection; however, sheep can also become infected [<xref ref-type="bibr" rid="B7-viruses-04-03452">7</xref>]. Intra-herd transmission usually occurs by aerosols, allowing the virus to enter susceptible cattle via the respiratory tract. However, local spread and airborne transmission between herds are not of great importance for inter-herd transmission despite the circulation of BRSV in a given geographical region [<xref ref-type="bibr" rid="B8-viruses-04-03452">8</xref>]. On the other hand, direct transmission between herds is frequently a consequence of the introduction of new infected animals, while indirect transmission occurs by individuals visiting farms. Some of the main risk factors for BRSV transmission include large herd size and common farm practices such as not providing boots to visitors and dual-purpose farms [<xref ref-type="bibr" rid="B9-viruses-04-03452">9</xref>,<xref ref-type="bibr" rid="B10-viruses-04-03452">10</xref>]. Additionally, it has also been proposed that good management and better hygienic routines have a direct impact on overall health status [<xref ref-type="bibr" rid="B8-viruses-04-03452">8</xref>].</p><p>BRSV outbreaks commonly occur during winter [<xref ref-type="bibr" rid="B11-viruses-04-03452">11</xref>]. Thus, clinical disease is commonly diagnosed during autumn and winter in temperate regions [<xref ref-type="bibr" rid="B12-viruses-04-03452">12</xref>]. Nevertheless, infection can also be observed during summer [<xref ref-type="bibr" rid="B12-viruses-04-03452">12</xref>,<xref ref-type="bibr" rid="B13-viruses-04-03452">13</xref>]. The sero-prevalence of BRSV infection varies greatly across different geographical regions [<xref ref-type="bibr" rid="B10-viruses-04-03452">10</xref>,<xref ref-type="bibr" rid="B14-viruses-04-03452">14</xref>,<xref ref-type="bibr" rid="B15-viruses-04-03452">15</xref>,<xref ref-type="bibr" rid="B16-viruses-04-03452">16</xref>,<xref ref-type="bibr" rid="B17-viruses-04-03452">17</xref>]. The distribution of BRSV is most likely affected by the movement of cattle, as insect vectors are not believed to play a role in viral transmission [<xref ref-type="bibr" rid="B6-viruses-04-03452">6</xref>]. The morbidity of the disease is quite high, and in some instances, it has been responsible for up to 60% of the clinical respiratory diseases among dairy herds [<xref ref-type="bibr" rid="B13-viruses-04-03452">13</xref>,<xref ref-type="bibr" rid="B18-viruses-04-03452">18</xref>]. In general, the frequency of BRSV is strongly associated with cattle population density in the region and with the age of the host [<xref ref-type="bibr" rid="B13-viruses-04-03452">13</xref>,<xref ref-type="bibr" rid="B19-viruses-04-03452">19</xref>,<xref ref-type="bibr" rid="B20-viruses-04-03452">20</xref>]. Interestingly, BRSV infection is also associated with a high morbidity of up to 80% and with mortality that can reach up to 20% in some outbreaks.</p><p>BRSV outbreaks can become epidemics affecting animals in all age groups. However, the age distribution of BRSV infection seems to be a function of exposure. In other words, herds that have been previously exposed to the virus tend to experience infections that are limited to younger, more susceptible animals. In consequence, morbidity is commonly high during the occurrence of outbreaks [<xref ref-type="bibr" rid="B21-viruses-04-03452">21</xref>]. Importantly, natural infection affects both beef and dairy cattle, although management practices can significantly impact the infectivity rates [<xref ref-type="bibr" rid="B22-viruses-04-03452">22</xref>]. Climate also favors the dissemination of the virus during winter, after the sudden drop in temperature [<xref ref-type="bibr" rid="B11-viruses-04-03452">11</xref>], although infection can occur throughout the year.</p><p>The mechanisms that are responsible for the survival of the virus within a given population are not fully understood. Controversial information has been reported about viral persistence. Nonetheless, chronicity has been proposed as a mechanism that might play role in disease spread [<xref ref-type="bibr" rid="B23-viruses-04-03452">23</xref>]. BRSV can be isolated from asymptomatic animals and can persist for several months [<xref ref-type="bibr" rid="B6-viruses-04-03452">6</xref>]. Thus, one possibility is the existence of persistently infected calves, which might start shedding the virus under specific conditions [<xref ref-type="bibr" rid="B24-viruses-04-03452">24</xref>,<xref ref-type="bibr" rid="B25-viruses-04-03452">25</xref>]. Therefore, latent infection among herds might occur, providing a possible explanation for the occurrence of outbreaks among relatively isolated calves. However, some reports have suggested that subclinical infection in cattle is not a plausible mechanism for the persistence of BRSV in dairy herds [<xref ref-type="bibr" rid="B26-viruses-04-03452">26</xref>].On the other hand, clinically ill animals are believed to be the most likely sources of infection, and therefore, the most likely explanation for recurrent infections is the reintroduction of the virus into the herd before the occurrence of a new outbreak. This controversial issue requires more detailed studies aiming to assess the role of persistence in virus spread to fully understand the mechanism exploited by the BRSV to warrant transmission.</p><p>The prevalence of the disease varies greatly in North America. For instance, in the United States, original studies conducted during the early 1970s showed a frequency of infection of 67% among adult cattle [<xref ref-type="bibr" rid="B27-viruses-04-03452">27</xref>]. However, in a few instances, 100% of the animals within herds showed the presence of specific antibodies. Subsequently published reports showed that up to 81% of herds had specific antibodies against BRSV [<xref ref-type="bibr" rid="B28-viruses-04-03452">28</xref>,<xref ref-type="bibr" rid="B29-viruses-04-03452">29</xref>]. Additionally, the incidence of sero-conversion soon after the occurrence of an outbreak has been reported to be as high as 45% [<xref ref-type="bibr" rid="B30-viruses-04-03452">30</xref>]. Furthermore, the sero-positivity rate among asymptomatic cattle has been shown to reach up to 95% [<xref ref-type="bibr" rid="B15-viruses-04-03452">15</xref>]. Importantly, the sero-positivity rate seems to be closely associated with the age of the host, showing a higher prevalence among older animals. Moreover, southern regions of the U.S. commonly exhibit a higher sero-prevalence than the northern parts of the country [<xref ref-type="bibr" rid="B31-viruses-04-03452">31</xref>]. These discrepancies could be explained by differences in the vaccination practices in those regions, as well as by management practices or by sampling errors. Thus, the frequency of BRSV infection in a particular region is subject to a number of factors that can drastically change the prevalence of the disease. Interestingly, the mortality among herds experiencing respiratory disease in the U.S. can reach up to 13% [<xref ref-type="bibr" rid="B32-viruses-04-03452">32</xref>]. While other viruses, such as the bovine viral diarrhea and parainfluenza viruses, could also account for the elevated mortality rates seen in the U.S., BRSV remains as a very important ethological agent and a probable cause of death due to respiratory disease in cattle.</p><p>In Canada, initial reports have shown that the overall frequency of BRSV infection might be nearly 36% [<xref ref-type="bibr" rid="B16-viruses-04-03452">16</xref>,<xref ref-type="bibr" rid="B17-viruses-04-03452">17</xref>]. However, during outbreaks, the percentage of sero-positive individuals within a herd can range between 22% and 53%. Subsequent studies confirmed the high frequency of the disease (40%) among feedlot calves [<xref ref-type="bibr" rid="B33-viruses-04-03452">33</xref>]. Similar to what has been observed in the U.S., BRSV is still an important cause of mortality among cattle in Canada [<xref ref-type="bibr" rid="B34-viruses-04-03452">34</xref>]. In Mexico, the circulation of BRSV was recently reported in two different regions of the country [<xref ref-type="bibr" rid="B35-viruses-04-03452">35</xref>,<xref ref-type="bibr" rid="B36-viruses-04-03452">36</xref>]. Both studies reported rather high overall frequencies of BRSV infection (52% and 90.8%). The reasons for the significant differences in the distribution of BRSV infection between the two regions are not known; however, age played a major role in the distribution of infection. Additionally, BRSV has also been shown to circulate in other regions of the Americas [<xref ref-type="bibr" rid="B10-viruses-04-03452">10</xref>,<xref ref-type="bibr" rid="B37-viruses-04-03452">37</xref>,<xref ref-type="bibr" rid="B38-viruses-04-03452">38</xref>].</p><p>In Europe, shortly after the virus’s discovery, it was reported to have widely circulated in different parts of the continent [<xref ref-type="bibr" rid="B39-viruses-04-03452">39</xref>]. In Sweden, different studies have shown high frequencies of antibodies in milk, ranging between 41% and 89% depending on the geographical region of the country [<xref ref-type="bibr" rid="B13-viruses-04-03452">13</xref>]. In general, higher antibody frequencies in milk samples were observed in samples from the southern regions of Sweden, while lower frequencies were detected in samples from the northern part of the country. The authors attributed the discrepancies observed among differences herds to cattle population density, as highly populated regions were more common in the southern part of Sweden. More recently, the geographical distribution of BRSV in the country has been studied [<xref ref-type="bibr" rid="B40-viruses-04-03452">40</xref>]. The aforementioned study showed that infection with BRSV occurs predominantly in the central-western and southern parts of Sweden. In particular, two regions of the country, Skaraborg and Skåne, displayed a high prevalence of BRSV infection. Similarly, Danish reports have also shown rather high frequencies of BRSV infection (54%) [<xref ref-type="bibr" rid="B41-viruses-04-03452">41</xref>]. Likewise, a high prevalence of BRSV infection has been observed in Belgium [<xref ref-type="bibr" rid="B42-viruses-04-03452">42</xref>]. Circulation of the virus in Scotland has also been reported, although conclusive figures regarding BRSV prevalence are not available [<xref ref-type="bibr" rid="B43-viruses-04-03452">43</xref>]. Furthermore, the presence of antibodies in bulk tank milk samples has been reported in herds from England [<xref ref-type="bibr" rid="B44-viruses-04-03452">44</xref>]. Additionally, a high sero-prevalence of BRSV has also been reported in Northern Europe [<xref ref-type="bibr" rid="B21-viruses-04-03452">21</xref>,<xref ref-type="bibr" rid="B45-viruses-04-03452">45</xref>].</p><p>In Africa, Ethiopia and South Africa have also been shown to have high incidences of BRSV infection [<xref ref-type="bibr" rid="B14-viruses-04-03452">14</xref>,<xref ref-type="bibr" rid="B46-viruses-04-03452">46</xref>,<xref ref-type="bibr" rid="B47-viruses-04-03452">47</xref>,<xref ref-type="bibr" rid="B48-viruses-04-03452">48</xref>]. Other countries, in different regions, such as Turkey, have also been shown to a have high sero-prevalence, which can reach up to 43% [<xref ref-type="bibr" rid="B49-viruses-04-03452">49</xref>]. Unsurprisingly, high sero-prevalence has also been associated with large-capacity facilities, rather than with small farms. Interestingly, organic farms have been shown to exhibit lower antibody prevalence when compared to conventional farms [<xref ref-type="bibr" rid="B22-viruses-04-03452">22</xref>]. These findings highlight the importance of management for the effective control of viral transmission and disease spread, which are closely associated with different farming methods</p><p>Thus, more information is required to understand the mechanisms that allow for viral survival in a given geographical region. Monitoring of outbreaks among herds is likely to provide valuable information that might help us to understand in greater detail the epidemiology of BRSV infection.</p></sec><sec><title>3. Molecular Epidemiology and Evolution of BRSV</title><p>Limited information is available regarding the molecular epidemiology of BRSV infection. However, the rapidly changing field of DNA sequencing might help to unveil the molecular mechanisms exploited by BRSV to assure transmission. Additionally, the field of phylogenetics has contributed to identify the existence of diverse BRSV genotypes and their genetic relationship while helping understand the molecular basis of BRSV genetic history [<xref ref-type="bibr" rid="B50-viruses-04-03452">50</xref>,<xref ref-type="bibr" rid="B51-viruses-04-03452">51</xref>]. Phylogeny approaches have also been particularly useful for studying the origins and subsequent evolution of BRSV [<xref ref-type="bibr" rid="B51-viruses-04-03452">51</xref>]. Recent advances in phylogenetics have allowed for the analysis in greater detail of sequence information, which could also help to understand the patterns of BRSV infection [<xref ref-type="bibr" rid="B52-viruses-04-03452">52</xref>]. Additionally, current phylogenetic methods facilitate the estimation of the time to the origin of a new viral strain, of the emergence of new species, identification of viral recombination, of population size, and of how the virus spread and evolve in particular settings [<xref ref-type="bibr" rid="B53-viruses-04-03452">53</xref>]. Thus, the information obtained from phylogenetic studies could assist in the design and implementation of measures aimed to prevent BRSV transmission. Molecular epidemiological approaches have provided important insights into BRSV evolution, spread and transmission [<xref ref-type="bibr" rid="B50-viruses-04-03452">50</xref>,<xref ref-type="bibr" rid="B54-viruses-04-03452">54</xref>]. Phylogentic analysis have also helped to identify the presence of mutations mapping along the immunodominat region located on the G protein [<xref ref-type="bibr" rid="B55-viruses-04-03452">55</xref>] and to elucidate the origin circulating strains in certain geographical regions [<xref ref-type="bibr" rid="B56-viruses-04-03452">56</xref>]. Thus, the study of the molecular epidemiology of the virus will most likely improve our understanding of the dynamics of virus transmission and help us to implement informed public health policies.</p><p>The occurrence of antigenic variation among BRSV isolates was first suggested by the lack of reaction between a polyclonal serum made against one particular viral strain, which failed to recognize a different isolate [<xref ref-type="bibr" rid="B57-viruses-04-03452">57</xref>]. Furthermore, viral heterogeneity was also inferred from the differences observed among the molecular sizes of some of the structural proteins, which implied that BRSV was composed of distinct subgroups [<xref ref-type="bibr" rid="B58-viruses-04-03452">58</xref>,<xref ref-type="bibr" rid="B59-viruses-04-03452">59</xref>]. The existence of diversity among BRSV isolates was further assessed by the reactivity of a set of strains against anti-HRSV monoclonal antibodies [<xref ref-type="bibr" rid="B58-viruses-04-03452">58</xref>]. In that pioneering study, the authors showed the existence of different recognition patterns among different BRSV isolates, thus implying antigenic diversity. The aforementioned findings highlighted the limitations and efficacy of the BRSV vaccine, suggesting that vaccine failure could be at least partially attributed to a possible broader antigenic spectrum of the BRSV population [<xref ref-type="bibr" rid="B58-viruses-04-03452">58</xref>]. Thus, these initial reports suggested the presence of two distinct BRSV subgroups. These observations were later confirmed by another study [<xref ref-type="bibr" rid="B60-viruses-04-03452">60</xref>]. Estimation of BRSV antigenic variation further confirmed the presence of two major and one intermediate subgroups [<xref ref-type="bibr" rid="B61-viruses-04-03452">61</xref>]. Currently, four antigenic subgroups (A, B, AB, untyped) have been identified in BRSV; however, they might only represent variants of a single major antigenic group [<xref ref-type="bibr" rid="B62-viruses-04-03452">62</xref>].</p><p>The study of the molecular epidemiology of BRSV began with the identification of the nucleotide sequences of the glycoprotein (G), fusion (F), nucleocapsid (N), matrix (M), phosphoprotein (P), small hydrophobic (SH) and M2 proteins during the early 1990s [<xref ref-type="bibr" rid="B55-viruses-04-03452">55</xref>,<xref ref-type="bibr" rid="B63-viruses-04-03452">63</xref>,<xref ref-type="bibr" rid="B64-viruses-04-03452">64</xref>,<xref ref-type="bibr" rid="B65-viruses-04-03452">65</xref>,<xref ref-type="bibr" rid="B66-viruses-04-03452">66</xref>,<xref ref-type="bibr" rid="B67-viruses-04-03452">67</xref>]. The initial assessment of the homology along the P protein between two isolates showed an identity of 97% at the nucleotide level [<xref ref-type="bibr" rid="B67-viruses-04-03452">67</xref>]. Subsequent studies, which analyzed the nucleotide variation of a limited number of isolates at the G protein level, showed that the levels of identity between BRSV strains ranged between 84% and 95% [<xref ref-type="bibr" rid="B60-viruses-04-03452">60</xref>,<xref ref-type="bibr" rid="B68-viruses-04-03452">68</xref>]. This degree of heterogeneity was suggestive of only one single genetic group. The first direct comparison between the antigenic heterogeneity and molecular diversity among BRSV isolates showed that the antigenic divergence observed among BRSV strains was the result of inter-subgroup variation [<xref ref-type="bibr" rid="B60-viruses-04-03452">60</xref>]. The characterization of the antigenic structure of the BRSV G protein provided further information about the mutations responsible for the distinctive BRSV groups reported at that time [<xref ref-type="bibr" rid="B69-viruses-04-03452">69</xref>]. Subsequent studies further confirmed the existence of antigenic divergence and antigenic variability among wild BRSV isolates [<xref ref-type="bibr" rid="B70-viruses-04-03452">70</xref>]. The partial nucleotide sequences of the G protein from a set of isolates, along with the recognition pattern by monoclonal antibodies against the BRSV G, F, N, and P proteins, showed random antigenic differences among the isolates, although cross-reactivity to the viral protein epitopes was observed, particularly with the F protein. Moreover, structural differences between the F and P proteins were also observed. The P protein exhibited diverse patterns, due to differences in molecular size, when subjected to polyacrylamide gel electrophoresis analysis. However, the structural differences along the P protein were not correlated with the antigenic differences observed in the F and N proteins. Overall, the nucleotide sequence identity in the G protein ranged from 94.1% to 99.9%. In comparison, the predicted amino acid sequence homology ranged from 89.9% to 99.6%, supporting the theory that BRSV belonged to a monophyletic group [<xref ref-type="bibr" rid="B70-viruses-04-03452">70</xref>].</p><p>More comprehensive studies, which analyzed the reaction patterns against anti-BRSV G protein and the genetic diversity occurring in a larger segment of the G protein gene from several isolates obtained from different geographical regions, showed that the intragroup genetic variation among BRSV strains ranged between 88% and 100% [<xref ref-type="bibr" rid="B71-viruses-04-03452">71</xref>]. The corresponding phylogenetic analysis revealed the presence of two main branches. Branch I was further subdivided into two groups, Ia and Ib, and then into five different lineages, each representing a geographic cluster. Thus, group Ia contained strains belonging to the antigenic subgroup A, whereas branch Ib consisted of strains of European origin belonging to the subgroup AB. Branch II, in contrast, grouped all viral strains classified as antigenic subgroup B. A third independent cluster included a set of Scandinavian strains that were not grouped with any of the aforementioned branches. A direct correlation was also observed between the positions along the phylogenetic tree and some of the strains and their antigenic patterns. Thus, this study can be considered to be the first research demonstrating that BRSV belongs to a single antigenic group with different genetic variants [<xref ref-type="bibr" rid="B71-viruses-04-03452">71</xref>]. A subsequent study demonstrated that isolates of Danish origin formed three distinctive lineages within a separate cluster. These isolates were also closely related to the 220-69Bel strain, the prototype strain of the intermediate antigenic group [<xref ref-type="bibr" rid="B72-viruses-04-03452">72</xref>]. Interestingly, viral isolates from the Czech Republic were closely related to the Danish strains isolated during the mid-1990s, a finding that was most likely due to animals being imported into the country, rather than due to virus evolution [<xref ref-type="bibr" rid="B73-viruses-04-03452">73</xref>]. Moreover, a recently comparative analysis between Swedish and Danish isolates showed that the reduced sequence diversity among Swedish strains might be due to the relatively closed cattle population in Sweden as a consequence of the limited import of cows into the country [<xref ref-type="bibr" rid="B12-viruses-04-03452">12</xref>]. In conjunction, these findings support the participation of import of cows in the increase of nucleotide sequence diversity of BRSV lineages in given regions.</p><p>A large-scale study addressing the global molecular epidemiology and evolution of BRSV included 54 European and North American isolates, in addition to previously reported sequences [<xref ref-type="bibr" rid="B50-viruses-04-03452">50</xref>]. The study assessed the diversity of the N, F and G protein nucleotides and analyzed amino acid sequences, as well as their phylogenetic relationships. The average percentage of pairwise divergences was lowest for the N and F protein genes (2%), in comparison to the G protein gene (8%). In general, complete homology was observed among all of the BRSV proteins among animals within the same herd. A limited number of differences were detected within the N and G protein gene sequences among a few herds. This finding suggests that a single virus or a group of very closely related viruses would seem to infect predominantly a given herd at a given time [<xref ref-type="bibr" rid="B74-viruses-04-03452">74</xref>]. Phylogenetic analysis, based on the G protein sequence, classified the isolates into six different groups (<xref ref-type="fig" rid="viruses-04-03452-f002">Figure 2</xref>A) [<xref ref-type="bibr" rid="B50-viruses-04-03452">50</xref>]. The topology of the phylogeny was retained when the analysis of the N and F protein gene sequences was conducted; however, only five phylogenetic groups were observed for either protein (<xref ref-type="fig" rid="viruses-04-03452-f002">Figure 2</xref>B and 2C) [<xref ref-type="bibr" rid="B50-viruses-04-03452">50</xref>]. As expected, the characteristic clustering of BRSV sequences, according to geographical origin and date of isolation, was observed, further supporting the theory of geographical and temporal clustering. Subgroup I consisted of old European strains isolated before 1976. Subgroup III included viruses exclusively from the United States. Subgroups II, IV, V, and VI were composed entirely of “younger” European isolates. Strains from northern Europe, Denmark, and Sweden were clustered in subgroup II, while those from the Netherlands, Belgium, and France were found in subgroups II, IV, V, and VI [<xref ref-type="bibr" rid="B75-viruses-04-03452">75</xref>]. Interestingly, the study identified vaccine failure among animals harboring infections with BRSV groups V and VI, indicating that commercial vaccines performed poorly against infections by such viral groups. Moreover, continuous evolution of the BRSV N, G, and F proteins was also observed, which seemed to be correlated with the implementation of vaccination in different countries. Moreover, strong, positive selection was shown on the mucin-like region of the G protein and on particular sites of the N and F proteins. The analysis of French BRSV isolates included in this study also showed the presence of mutations located along the conserved central hydrophobic part of the ectodomain of the G protein, resulting in the loss of four Cys residues, two disulfide bridges and, consequently, a helix, which is critical for the three-dimensional structure of the G protein. These observations suggested the continuous modification of the highly conserved central region of the immunodominant G protein, thus highlighting the importance of considering BRSV evolution in the rational development of vaccines [<xref ref-type="bibr" rid="B50-viruses-04-03452">50</xref>]. Overall, this work could be considered as the foundation of modern BRSV molecular epidemiology, it has also established the basis for subsequent studies looking at the molecular epidemiological patterns of BRSV infection in different geographical regions [<xref ref-type="bibr" rid="B37-viruses-04-03452">37</xref>,<xref ref-type="bibr" rid="B56-viruses-04-03452">56</xref>,<xref ref-type="bibr" rid="B76-viruses-04-03452">76</xref>,<xref ref-type="bibr" rid="B77-viruses-04-03452">77</xref>].</p><fig id="viruses-04-03452-f002" position="float"><label>Figure 2</label><caption><p>Phylogenetic analysis of BRSV genomic regions. Maximum likelihood phylogenetic trees from the G (A), F (B) and N (C) proteins were generated using representative strains from each BRSV genotype [<xref ref-type="bibr" rid="B50-viruses-04-03452">50</xref>].</p></caption><graphic xlink:href="viruses-04-03452-g002"></graphic></fig><p>Importantly, BRSV intrahost population has been shown to exist as a complex mixture of viral variants, ambiguously referred as “quasispecies” [<xref ref-type="bibr" rid="B51-viruses-04-03452">51</xref>]. Analyses of the BRSV G protein gene have demonstrated the spectrum of subpopulations co-existing in clinical isolates. Clonal analysis revealed the nucleotide heterogeneity along the G-coding region, exhibiting mutation frequencies ranging from 6.8x10<sup>4</sup> to 10.1x10<sup>4</sup> substitutions per nucleotide. These findings suggest that BRSV populations evolve as complex and dynamic mutant swarms, despite the virus’s apparent genetic stability.</p><p>Molecular epidemiology approaches have shown the circulation of identical viruses among animals within the same herds, especially during the occurrence of outbreaks [<xref ref-type="bibr" rid="B74-viruses-04-03452">74</xref>]. However, viral strains from recurrent outbreaks have varied significantly (up to 11%), suggesting the circulation of different BRSV viral variants that can persistently infect calves within a herd. In consequence, and because of intrahost viral evolution, new, highly fit viruses became dominant and spread from a single, or a few, animals associated with each new outbreak. Alternatively, and based on the high level of diversity observed between outbreaks, this finding might suggest that BRSV outbreaks are the result of the introduction of new viral strains into the population [<xref ref-type="bibr" rid="B74-viruses-04-03452">74</xref>]. Interestingly, the reduced exposure to new BRSV strains has been shown to limit the diversity of the circulating BRSV population [<xref ref-type="bibr" rid="B12-viruses-04-03452">12</xref>]. Importantly, all aforesaid studies have focus on the nucleotide sequence of the gene coding for the G protein. While the information obtained from the G protein has been extremely valuable to understand the landscape and sequence space available to BRSV, the somehow limited sequence information provided by this region significantly handicaps our capacity to fully characterize viral strains. Future studies analyzing longer sections of the BRSV, and possibly the full-length of the viral genome, will likely provide a more accurate picture of the viral strains circulating worldwide.</p><p>The global molecular epidemiology of BRSV has remained elusive. Only sparse reports addressing the distribution of BRSV groups are available in the literature. Consequently, the molecular characterization of BRSV isolates from representative regions of the world is still rather incomplete. A study conducted in Japan in the early 2000s reported the circulation of strains belonging to subgroup III. The isolates were further subdivided into two distinctive lineages [<xref ref-type="bibr" rid="B76-viruses-04-03452">76</xref>]. Unfortunately, this study only accounted for a very limited number of isolates, which notably precluded us from fully understanding the molecular epidemiology of BRSV in the region. More recently, two Brazilian studies identified a handful of isolates belonging to BRSV group B [<xref ref-type="bibr" rid="B37-viruses-04-03452">37</xref>,<xref ref-type="bibr" rid="B77-viruses-04-03452">77</xref>]. Likewise, this information was limited, and the inference of the molecular epidemiology of BRSV in the country was not possible. Recently, a Swedish report was published describing the molecular epidemiology of BRSV from recent outbreaks (2007<bold>–</bold>2011) occurring among 30 different herds [<xref ref-type="bibr" rid="B12-viruses-04-03452">12</xref>]. The report highlighted the circulation of BRSV strains belonging to subgroup II, for the most part, in the southern region of Sweden. A second study showed that isolates from England are related genetically to U.S. strains. [<xref ref-type="bibr" rid="B78-viruses-04-03452">78</xref>]. Thus, both reports suggest that live cattle importation plays an important role in the global molecular epidemiology of BRSV.</p><p>In summary, the study of the molecular epidemiology of BRSV has evolved considerably over the past two decades. The information generated by the study of the molecular characterization, phylogenetics and evolution of BRSV strains have broadly advanced our understanding of the molecular mechanisms controlling virus transmission and disease spread. However, this field requires extensive research to unveil the means exploited by the virus to attain persistence in a given population. The establishment of molecular surveillance of BRSV in different geographical regions will likely improve the identification of outbreaks, resulting in the implementation of preventive measures aimed to control the disease. The advent of next-generation sequencing platforms on the eve of the “DNA-sequencing era” could also provide a unique opportunity for the discovery of the underlying processes responsible for viral replication and survival in the host.</p></sec><sec><title>4. Concluding Remarks</title><p>BRSV has been recognized as an important cause of respiratory disease in cattle for nearly four decades. The characteristic heterogeneity of the viral genome and its low fidelity in replication are some of the most important features that the virus exploits to assure its survival and persistence within the host. The instability of the viral particle usually leads to unsuccessful attempts to isolate viral strains in the laboratory from clinical specimens. Consequently, molecular approaches are rapidly becoming the gold standard for the correct identification and characterization of BRSV in clinical cases. As result, the field of the molecular epidemiology of BRSV has gained significant strength and has further enhanced our knowledge about BRSV distribution and transmission patterns worldwide. The arrival of new and more sophisticated molecular methods, including next-generation sequencing, will most likely help to unveil the genetic makeup of the circulating viral population in different geographical regions, as well as the mechanisms on which the virus relies for survival, persistence and transmission.</p></sec></body><back><ack><title>Acknowledgments</title><p>This work was supported by the “Instituto de Ciencias y Tecnologías del Distrito Federal” (grant Icyt/248/2010).</p></ack><ref-list><title>References and Notes</title><ref id="B1-viruses-04-03452"><label>1.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Paccaud</surname><given-names>M.F.</given-names></name><name><surname>Jacquier</surname><given-names>C.</given-names></name></person-group><article-title>A respiratory syncytial virus of bovine origin</article-title><source>Arch. Gesamte Virusforsch.</source><year>1970</year><volume>30</volume><fpage>327</fpage><lpage>342</lpage><pub-id pub-id-type="doi">10.1007/BF01258363</pub-id><pub-id pub-id-type="pmid">4195627</pub-id></element-citation></ref><ref id="B2-viruses-04-03452"><label>2.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wellemans</surname><given-names>G.</given-names></name><name><surname>Leunen</surname><given-names>J.</given-names></name><name><surname>Luchsinger</surname><given-names>E.</given-names></name></person-group><article-title>Respiratory ailments of cattle: isolation of a virus (220/69) with serologic resemblance to the human respiratory syncytial virus</article-title><source>Ann. Med. Vet.</source><year>1970</year><volume>114</volume><fpage>89</fpage><lpage>93</lpage></element-citation></ref><ref id="B3-viruses-04-03452"><label>3.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Smith</surname><given-names>R.A.</given-names></name></person-group><article-title>Effects of feedlot disease on economics, production and carcass value</article-title><source>The American Association of Bovine Practitioners Proceedings</source><year>2000</year><volume>33</volume><fpage>125</fpage><lpage>128</lpage></element-citation></ref><ref id="B4-viruses-04-03452"><label>4.</label><element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Lamb</surname><given-names>R.A.</given-names></name><name><surname>Parks</surname><given-names>G.D.</given-names></name></person-group><article-title><italic>Paramyxoviridae</italic>: The Viruses and their Replication</article-title><source>Fields Virology</source><edition>5th</edition><person-group person-group-type="editor"><name><surname>Knipe</surname><given-names>D.M.</given-names></name><name><surname>Howley</surname><given-names>P.M.</given-names></name></person-group><publisher-name>Lippincott Williams & Williams</publisher-name><publisher-loc>Philadelphia, PA, USA</publisher-loc><year>2007</year><volume>2</volume><fpage>1449</fpage><lpage>1496</lpage></element-citation></ref><ref id="B5-viruses-04-03452"><label>5.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Van der Poel</surname><given-names>W.H.</given-names></name><name><surname>Brand</surname><given-names>A.</given-names></name><name><surname>Kramps</surname><given-names>J.A.</given-names></name><name><surname>Van Oirschot</surname><given-names>J.T.</given-names></name></person-group><article-title>Respiratory syncytial virus infections in human beings and in cattle</article-title><source>J. Infection</source><year>1994</year><volume>29</volume><fpage>215</fpage><lpage>228</lpage><pub-id pub-id-type="doi">10.1016/S0163-4453(94)90866-4</pub-id></element-citation></ref><ref id="B6-viruses-04-03452"><label>6.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ames</surname><given-names>T.R.</given-names></name></person-group><article-title>The epidemiology of BRSV infection</article-title><source>Vet. Med.</source><year>1993</year><volume>88</volume><fpage>881</fpage><lpage>885</lpage></element-citation></ref><ref id="B7-viruses-04-03452"><label>7.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Masot</surname><given-names>A.J.</given-names></name><name><surname>Kelling</surname><given-names>C.L.</given-names></name><name><surname>Lopez</surname><given-names>O.</given-names></name><name><surname>Sur</surname><given-names>J.H.</given-names></name><name><surname>Redondo</surname><given-names>E.</given-names></name></person-group><article-title>In situ hybridization detection of bovine respiratory syncytial virus in the lung of experimentally infected lambs</article-title><source>Vet. Pathol.</source><year>2000</year><volume>37</volume><fpage>618</fpage><lpage>625</lpage><pub-id pub-id-type="doi">10.1354/vp.37-6-618</pub-id><pub-id pub-id-type="pmid">11105951</pub-id></element-citation></ref><ref id="B8-viruses-04-03452"><label>8.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ohlson</surname><given-names>A.</given-names></name><name><surname>Emanuelson</surname><given-names>U.</given-names></name><name><surname>Traven</surname><given-names>M.</given-names></name><name><surname>Alenius</surname><given-names>S.</given-names></name></person-group><article-title>The relationship between antibody status to bovine corona virus and bovine respiratory syncytial virus and disease incidence, reproduction and herd characteristics in dairy herds</article-title><source>Acta Vet. Scand.</source><year>2010</year><volume>52</volume><fpage>37</fpage><pub-id pub-id-type="doi">10.1186/1751-0147-52-37</pub-id><pub-id pub-id-type="pmid">20525326</pub-id></element-citation></ref><ref id="B9-viruses-04-03452"><label>9.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ohlson</surname><given-names>A.</given-names></name><name><surname>Heuer</surname><given-names>C.</given-names></name><name><surname>Lockhart</surname><given-names>C.</given-names></name><name><surname>Traven</surname><given-names>M.</given-names></name><name><surname>Emanuelson</surname><given-names>U.</given-names></name><name><surname>Alenius</surname><given-names>S.</given-names></name></person-group><article-title>Risk factors for seropositivity to bovine coronavirus and bovine respiratory syncytial virus in dairy herds</article-title><source>Vet. Rec.</source><year>2010</year><volume>167</volume><fpage>201</fpage><lpage>266</lpage><pub-id pub-id-type="doi">10.1136/vr.c4119</pub-id><pub-id pub-id-type="pmid">20693503</pub-id></element-citation></ref><ref id="B10-viruses-04-03452"><label>10.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Saa</surname><given-names>L.R.</given-names></name><name><surname>Perea</surname><given-names>A.</given-names></name><name><surname>Jara</surname><given-names>D.V.</given-names></name><name><surname>Arenas</surname><given-names>A.J.</given-names></name><name><surname>Garcia-Bocanegra</surname><given-names>I.</given-names></name><name><surname>Borge</surname><given-names>C.</given-names></name><name><surname>Carbonero</surname><given-names>A.</given-names></name></person-group><article-title>Prevalence of and risk factors for bovine respiratory syncytial virus (BRSV) infection in non-vaccinated dairy and dual-purpose cattle herds in Ecuador</article-title><source>Trop. Anim. Health Prod.</source><year>2012</year><volume>44</volume><fpage>1423</fpage><lpage>1427</lpage><pub-id pub-id-type="doi">10.1007/s11250-012-0082-8</pub-id><pub-id pub-id-type="pmid">22270243</pub-id></element-citation></ref><ref id="B11-viruses-04-03452"><label>11.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Valarcher</surname><given-names>J.F.</given-names></name><name><surname>Taylor</surname><given-names>G.</given-names></name></person-group><article-title>Bovine respiratory syncytial virus infection</article-title><source>Vet. Res.</source><year>2007</year><volume>38</volume><fpage>153</fpage><lpage>180</lpage><pub-id pub-id-type="pmid">17257568</pub-id></element-citation></ref><ref id="B12-viruses-04-03452"><label>12.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bidokhti</surname><given-names>M.R.</given-names></name><name><surname>Traven</surname><given-names>M.</given-names></name><name><surname>Ohlson</surname><given-names>A.</given-names></name><name><surname>Zarnegar</surname><given-names>B.</given-names></name><name><surname>Baule</surname><given-names>C.</given-names></name><name><surname>Belak</surname><given-names>S.</given-names></name><name><surname>Alenius</surname><given-names>S.</given-names></name><name><surname>Liu</surname><given-names>L.</given-names></name></person-group><article-title>Phylogenetic analysis of bovine respiratory syncytial viruses from recent outbreaks in feedlot and dairy cattle herds</article-title><source>Arch. Virol.</source><year>2012</year><volume>157</volume><fpage>601</fpage><lpage>607</lpage><pub-id pub-id-type="doi">10.1007/s00705-011-1209-3</pub-id><pub-id pub-id-type="pmid">22209787</pub-id></element-citation></ref><ref id="B13-viruses-04-03452"><label>13.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Elvander</surname><given-names>M.</given-names></name></person-group><article-title>Severe respiratory disease in dairy cows caused by infection with bovine respiratory syncytial virus</article-title><source>Vet. Rec.</source><year>1996</year><volume>138</volume><fpage>101</fpage><lpage>105</lpage><pub-id pub-id-type="doi">10.1136/vr.138.5.101</pub-id><pub-id pub-id-type="pmid">8650902</pub-id></element-citation></ref><ref id="B14-viruses-04-03452"><label>14.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Woldemeskel</surname><given-names>M.</given-names></name><name><surname>Kebede</surname><given-names>E.</given-names></name><name><surname>Yigezu</surname><given-names>L.</given-names></name><name><surname>Potgieter</surname><given-names>L.N.</given-names></name></person-group><article-title>Prevalence of bovine respiratory syncytial virus (BRSV) and bovine herpesvirus-4 (BHV-4) in cattle from Ethiopia</article-title><source>Dtsch. Tierarztl. Wochenschr.</source><year>2000</year><volume>107</volume><fpage>464</fpage><lpage>466</lpage><pub-id pub-id-type="pmid">11153233</pub-id></element-citation></ref><ref id="B15-viruses-04-03452"><label>15.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Collins</surname><given-names>J.K.</given-names></name><name><surname>Teegarden</surname><given-names>R.M.</given-names></name><name><surname>MacVean</surname><given-names>D.W.</given-names></name><name><surname>Salman</surname></name><name><surname>Smith</surname><given-names>G.H.</given-names></name><name><surname>Frank</surname><given-names>G.R.</given-names></name></person-group><article-title>Prevalence and specificity of antibodies to bovine respiratory syncytial virus in sera from feedlot and range cattle</article-title><source>Am. J. Vet. Res.</source><year>1988</year><volume>49</volume><fpage>1316</fpage><lpage>1319</lpage><pub-id pub-id-type="pmid">3178027</pub-id></element-citation></ref><ref id="B16-viruses-04-03452"><label>16.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Elazhary</surname><given-names>M.A.</given-names></name><name><surname>Silim</surname><given-names>A.</given-names></name><name><surname>Dea</surname><given-names>S.</given-names></name></person-group><article-title>Prevalence of antibodies to bovine respiratory syncytial virus, bovine viral diarrhea virus, bovine herpesvirus-1, and bovine parainfluenza-3 virus in sheep and goats in Quebec</article-title><source>Am. J. Vet. Res.</source><year>1984</year><volume>45</volume><fpage>1660</fpage><lpage>1662</lpage><pub-id pub-id-type="pmid">6089626</pub-id></element-citation></ref><ref id="B17-viruses-04-03452"><label>17.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Elazhary</surname><given-names>M.A.</given-names></name><name><surname>Roy</surname><given-names>R.S.</given-names></name><name><surname>Champlin</surname><given-names>R.</given-names></name><name><surname>Higgins</surname><given-names>R.</given-names></name><name><surname>Marsolais</surname><given-names>G.</given-names></name></person-group><article-title>Bovine respiratory syncytial virus in Quebec: antibody prevalence and disease outbreak</article-title><source>Can. J. Comp. Med.</source><year>1980</year><volume>44</volume><fpage>299</fpage><lpage>303</lpage><pub-id pub-id-type="pmid">7000320</pub-id></element-citation></ref><ref id="B18-viruses-04-03452"><label>18.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Baker</surname><given-names>J.C.</given-names></name><name><surname>Ames</surname><given-names>T.R.</given-names></name><name><surname>Markham</surname><given-names>R.J.</given-names></name></person-group><article-title>Seroepizootiologic study of bovine respiratory syncytial virus in a dairy herd</article-title><source>Am. J. Vet. Res.</source><year>1986</year><volume>47</volume><fpage>240</fpage><lpage>245</lpage><pub-id pub-id-type="pmid">3954198</pub-id></element-citation></ref><ref id="B19-viruses-04-03452"><label>19.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kimman</surname><given-names>T.G.</given-names></name><name><surname>Zimmer</surname><given-names>G.M.</given-names></name><name><surname>Westenbrink</surname><given-names>F.</given-names></name><name><surname>Mars</surname><given-names>J.</given-names></name><name><surname>van Leeuwen</surname><given-names>E.</given-names></name></person-group><article-title>Epidemiological study of bovine respiratory syncytial virus infections in calves: influence of maternal antibodies on the outcome of disease</article-title><source>Vet. Rec.</source><year>1988</year><volume>123</volume><fpage>104</fpage><lpage>109</lpage><pub-id pub-id-type="pmid">3413952</pub-id></element-citation></ref><ref id="B20-viruses-04-03452"><label>20.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hagglund</surname><given-names>S.</given-names></name><name><surname>Svensson</surname><given-names>C.</given-names></name><name><surname>Emanuelson</surname><given-names>U.</given-names></name><name><surname>Valarcher</surname><given-names>J.F.</given-names></name><name><surname>Alenius</surname><given-names>S.</given-names></name></person-group><article-title>Dynamics of virus infections involved in the bovine respiratory disease complex in Swedish dairy herds</article-title><source>Vet. J.</source><year>2006</year><volume>172</volume><fpage>320</fpage><lpage>328</lpage><pub-id pub-id-type="pmid">15964774</pub-id></element-citation></ref><ref id="B21-viruses-04-03452"><label>21.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Raaperi</surname><given-names>K.</given-names></name><name><surname>Bougeard</surname><given-names>S.</given-names></name><name><surname>Aleksejev</surname><given-names>A.</given-names></name><name><surname>Orro</surname><given-names>T.</given-names></name><name><surname>Viltrop</surname><given-names>A.</given-names></name></person-group><article-title>Association of herd BRSV and BHV-1 seroprevalence with respiratory disease and reproductive performance in adult dairy cattle</article-title><source>Acta Vet. Scand.</source><year>2012</year><volume>54</volume><fpage>4</fpage><pub-id pub-id-type="doi">10.1186/1751-0147-54-4</pub-id><pub-id pub-id-type="pmid">22289165</pub-id></element-citation></ref><ref id="B22-viruses-04-03452"><label>22.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bidokhti</surname><given-names>M.R.</given-names></name><name><surname>Traven</surname><given-names>M.</given-names></name><name><surname>Fall</surname><given-names>N.</given-names></name><name><surname>Emanuelson</surname><given-names>U.</given-names></name><name><surname>Alenius</surname><given-names>S.</given-names></name></person-group><article-title>Reduced likelihood of bovine coronavirus and bovine respiratory syncytial virus infection on organic compared to conventional dairy farms</article-title><source>Vet. J.</source><year>2009</year><volume>182</volume><fpage>436</fpage><lpage>440</lpage><pub-id pub-id-type="doi">10.1016/j.tvjl.2008.08.010</pub-id><pub-id pub-id-type="pmid">18835795</pub-id></element-citation></ref><ref id="B23-viruses-04-03452"><label>23.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Stott</surname><given-names>E.J.</given-names></name><name><surname>Thomas</surname><given-names>L.H.</given-names></name><name><surname>Collins</surname><given-names>A.P.</given-names></name><name><surname>Crouch</surname><given-names>S.</given-names></name><name><surname>Jebbett</surname><given-names>J.</given-names></name><name><surname>Smith</surname><given-names>G.S.</given-names></name><name><surname>Luther</surname><given-names>P.D.</given-names></name><name><surname>Caswell</surname><given-names>R.</given-names></name></person-group><article-title>A survey of virus infections of the respiratory tract of cattle and their association with disease</article-title><source>J. Hyg. (Lond.)</source><year>1980</year><volume>85</volume><fpage>257</fpage><lpage>270</lpage><pub-id pub-id-type="doi">10.1017/S0022172400063294</pub-id><pub-id pub-id-type="pmid">6256435</pub-id></element-citation></ref><ref id="B24-viruses-04-03452"><label>24.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Brodersen</surname><given-names>B.W.</given-names></name></person-group><article-title>Bovine respiratory syncytial virus</article-title><source>Vet. Clin. North. Am. Food Anim. Pract.</source><year>2010</year><volume>26</volume><fpage>323</fpage><lpage>333</lpage><pub-id pub-id-type="doi">10.1016/j.cvfa.2010.04.010</pub-id><pub-id pub-id-type="pmid">20619187</pub-id></element-citation></ref><ref id="B25-viruses-04-03452"><label>25.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Baker</surname><given-names>J.C.</given-names></name><name><surname>Werdin</surname><given-names>R.E.</given-names></name><name><surname>Ames</surname><given-names>T.R.</given-names></name><name><surname>Markham</surname><given-names>R.J.</given-names></name><name><surname>Larson</surname><given-names>V.L.</given-names></name></person-group><article-title>Study on the etiologic role of bovine respiratory syncytial virus in pneumonia of dairy calves</article-title><source>J. Am. Vet. Med. Assoc.</source><year>1986</year><volume>189</volume><fpage>66</fpage><lpage>70</lpage><pub-id pub-id-type="pmid">3733504</pub-id></element-citation></ref><ref id="B26-viruses-04-03452"><label>26.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>De Jong</surname><given-names>M.C.</given-names></name><name><surname>van der Poel</surname><given-names>W.H.</given-names></name><name><surname>Kramps</surname><given-names>J.A.</given-names></name><name><surname>Brand</surname><given-names>A.</given-names></name><name><surname>van Oirschot</surname><given-names>J.T.</given-names></name></person-group><article-title>Quantitative investigation of population persistence and recurrent outbreaks of bovine respiratory syncytial virus on dairy farms</article-title><source>Am. J. Vet. Res.</source><year>1996</year><volume>57</volume><fpage>628</fpage><lpage>633</lpage><pub-id pub-id-type="pmid">8723872</pub-id></element-citation></ref><ref id="B27-viruses-04-03452"><label>27.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rossi</surname><given-names>C.R.</given-names></name><name><surname>Kiesel</surname><given-names>G.K.</given-names></name></person-group><article-title>Serological evidence for the association of bovine respiratory syncytial virus with respiratory tract disease in Alabama cattle</article-title><source>Infect. Immun.</source><year>1974</year><volume>10</volume><fpage>293</fpage><lpage>298</lpage><pub-id pub-id-type="pmid">4854249</pub-id></element-citation></ref><ref id="B28-viruses-04-03452"><label>28.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Smith</surname><given-names>M.H.</given-names></name><name><surname>Frey</surname><given-names>M.L.</given-names></name><name><surname>Dierks</surname><given-names>R.E.</given-names></name></person-group><article-title>Isolation, characterization, and pathogenicity studies of a bovine respiratory syncytial virus</article-title><source>Arch. Virol.</source><year>1975</year><volume>47</volume><fpage>237</fpage><lpage>247</lpage><pub-id pub-id-type="doi">10.1007/BF01317811</pub-id><pub-id pub-id-type="pmid">1119944</pub-id></element-citation></ref><ref id="B29-viruses-04-03452"><label>29.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Baker</surname><given-names>J.C.</given-names></name><name><surname>Ames</surname><given-names>T.R.</given-names></name><name><surname>Markham</surname><given-names>R.J.</given-names></name></person-group><article-title>Serologic studies of bovine respiratory syncytial virus in Minnesota cattle</article-title><source>Am. J. Vet. Res.</source><year>1985</year><volume>46</volume><fpage>891</fpage><lpage>892</lpage><pub-id pub-id-type="pmid">4014838</pub-id></element-citation></ref><ref id="B30-viruses-04-03452"><label>30.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lehmkuhl</surname><given-names>H.D.</given-names></name><name><surname>Gough</surname><given-names>P.M.</given-names></name></person-group><article-title>Investigation of causative agents of bovine respiratory tract disease in a beef cow-calf herd with an early weaning program</article-title><source>Am. J. Vet. Res.</source><year>1977</year><volume>38</volume><fpage>1717</fpage><lpage>1720</lpage><pub-id pub-id-type="pmid">201196</pub-id></element-citation></ref><ref id="B31-viruses-04-03452"><label>31.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Grubbs</surname><given-names>S.T.</given-names></name><name><surname>Kania</surname><given-names>S.A.</given-names></name><name><surname>Potgieter</surname><given-names>L.N.</given-names></name></person-group><article-title>Prevalence of ovine and bovine respiratory syncytial virus infections in cattle determined with a synthetic peptide-based immunoassay</article-title><source>J. Vet. Diagn. Invest.</source><year>2001</year><volume>13</volume><fpage>128</fpage><lpage>132</lpage><pub-id pub-id-type="doi">10.1177/104063870101300206</pub-id><pub-id pub-id-type="pmid">11289208</pub-id></element-citation></ref><ref id="B32-viruses-04-03452"><label>32.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fulton</surname><given-names>R.W.</given-names></name><name><surname>Purdy</surname><given-names>C.W.</given-names></name><name><surname>Confer</surname><given-names>A.W.</given-names></name><name><surname>Saliki</surname><given-names>J.T.</given-names></name><name><surname>Loan</surname><given-names>R.W.</given-names></name><name><surname>Briggs</surname><given-names>R.E.</given-names></name><name><surname>Burge</surname><given-names>L.J.</given-names></name></person-group><article-title>Bovine viral diarrhea viral infections in feeder calves with respiratory disease: interactions with Pasteurella spp., parainfluenza-3 virus, and bovine respiratory syncytial virus</article-title><source>Can. J. Vet. Res.</source><year>2000</year><volume>64</volume><fpage>151</fpage><lpage>159</lpage><pub-id pub-id-type="pmid">10935880</pub-id></element-citation></ref><ref id="B33-viruses-04-03452"><label>33.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Martin</surname><given-names>S.W.</given-names></name><name><surname>Bateman</surname><given-names>K.G.</given-names></name><name><surname>Shewen</surname><given-names>P.E.</given-names></name><name><surname>Rosendal</surname><given-names>S.</given-names></name><name><surname>Bohac</surname><given-names>J.E.</given-names></name></person-group><article-title>The frequency, distribution and effects of antibodies, to seven putative respiratory pathogens, on respiratory disease and weight gain in feedlot calves in Ontario</article-title><source>Can. J. Vet. Res.</source><year>1989</year><volume>53</volume><fpage>355</fpage><lpage>362</lpage><pub-id pub-id-type="pmid">2766158</pub-id></element-citation></ref><ref id="B34-viruses-04-03452"><label>34.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gagea</surname><given-names>M.I.</given-names></name><name><surname>Bateman</surname><given-names>K.G.</given-names></name><name><surname>van Dreumel</surname><given-names>T.</given-names></name><name><surname>McEwen</surname><given-names>B.J.</given-names></name><name><surname>Carman</surname><given-names>S.</given-names></name><name><surname>Archambault</surname><given-names>M.</given-names></name><name><surname>Shanahan</surname><given-names>R.A.</given-names></name><name><surname>Caswell</surname><given-names>J.L.</given-names></name></person-group><article-title>Diseases and pathogens associated with mortality in Ontario beef feedlots</article-title><source>J. Vet. Diagn. Invest.</source><year>2006</year><volume>18</volume><fpage>18</fpage><lpage>28</lpage><pub-id pub-id-type="pmid">16566254</pub-id></element-citation></ref><ref id="B35-viruses-04-03452"><label>35.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Figueroa-Chavez</surname><given-names>D.</given-names></name><name><surname>Segura-Correa</surname><given-names>J.C.</given-names></name><name><surname>Garcia-Marquez</surname><given-names>L.J.</given-names></name><name><surname>Pescador-Rubio</surname><given-names>A.</given-names></name><name><surname>Valdivia-Flores</surname><given-names>A.G.</given-names></name></person-group><article-title>Detection of antibodies and risk factors for infection with bovine respiratory syncytial virus and parainfluenza virus 3 in dual-purpose farms in Colima, Mexico</article-title><source>Trop. Anim. Health Prod.</source><year>2012</year><volume>44</volume><fpage>1417</fpage><lpage>1421</lpage><pub-id pub-id-type="doi">10.1007/s11250-012-0081-9</pub-id><pub-id pub-id-type="pmid">22270242</pub-id></element-citation></ref><ref id="B36-viruses-04-03452"><label>36.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Solis-Calderon</surname><given-names>J.J.</given-names></name><name><surname>Segura-Correa</surname><given-names>J.C.</given-names></name><name><surname>Aguilar-Romero</surname><given-names>F.</given-names></name><name><surname>Segura-Correa</surname><given-names>V.M.</given-names></name></person-group><article-title>Detection of antibodies and risk factors for infection with bovine respiratory syncytial virus and parainfluenza virus-3 in beef cattle of Yucatan, Mexico</article-title><source>Prev. Vet. Med.</source><year>2007</year><volume>82</volume><fpage>102</fpage><lpage>110</lpage><pub-id pub-id-type="doi">10.1016/j.prevetmed.2007.05.013</pub-id><pub-id pub-id-type="pmid">17590461</pub-id></element-citation></ref><ref id="B37-viruses-04-03452"><label>37.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Almeida</surname><given-names>R.S.</given-names></name><name><surname>Domingues</surname><given-names>H.G.</given-names></name><name><surname>Spilki</surname><given-names>F.R.</given-names></name><name><surname>Larsen</surname><given-names>L.E.</given-names></name><name><surname>Hagglund</surname><given-names>S.</given-names></name><name><surname>Belak</surname><given-names>S.</given-names></name><name><surname>Arns</surname><given-names>C.W.</given-names></name></person-group><article-title>Circulation of bovine respiratory syncytial virus in Brazil</article-title><source>Vet. Rec.</source><year>2006</year><volume>158</volume><fpage>632</fpage><lpage>634</lpage><pub-id pub-id-type="doi">10.1136/vr.158.18.632</pub-id><pub-id pub-id-type="pmid">16679483</pub-id></element-citation></ref><ref id="B38-viruses-04-03452"><label>38.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Arns</surname><given-names>C.W.</given-names></name><name><surname>Campalans</surname><given-names>J.</given-names></name><name><surname>Costa</surname><given-names>S.C.</given-names></name><name><surname>Domingues</surname><given-names>H.G.</given-names></name><name><surname>D'Arce</surname><given-names>R.C.</given-names></name><name><surname>Almeida</surname><given-names>R.S.</given-names></name><name><surname>Coswig</surname><given-names>L.T.</given-names></name></person-group><article-title>Characterization of bovine respiratory syncytial virus isolated in Brazil</article-title><source>Braz. J. Med. Biol. Res.</source><year>2003</year><volume>36</volume><fpage>213</fpage><lpage>218</lpage><pub-id pub-id-type="pmid">12563523</pub-id></element-citation></ref><ref id="B39-viruses-04-03452"><label>39.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jacobs</surname><given-names>J.W.</given-names></name><name><surname>Edington</surname><given-names>N.</given-names></name></person-group><article-title>Isolation of respiratory syncytial virus from cattle in Britain</article-title><source>Vet. Rec.</source><year>1971</year><volume>88</volume><fpage>694</fpage><pub-id pub-id-type="pmid">5091097</pub-id></element-citation></ref><ref id="B40-viruses-04-03452"><label>40.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Beaudeau</surname><given-names>F.</given-names></name><name><surname>Bjorkman</surname><given-names>C.</given-names></name><name><surname>Alenius</surname><given-names>S.</given-names></name><name><surname>Frossling</surname><given-names>J.</given-names></name></person-group><article-title>Spatial patterns of bovine corona virus and bovine respiratory syncytial virus in the Swedish beef cattle population</article-title><source>Acta Vet. Scand.</source><year>2010</year><volume>52</volume><fpage>33</fpage><pub-id pub-id-type="pmid">20492637</pub-id></element-citation></ref><ref id="B41-viruses-04-03452"><label>41.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Uttenthal</surname><given-names>A.</given-names></name><name><surname>Larsen</surname><given-names>L.E.</given-names></name><name><surname>Philipsen</surname><given-names>J.S.</given-names></name><name><surname>Tjornehoj</surname><given-names>K.</given-names></name><name><surname>Viuff</surname><given-names>B.</given-names></name><name><surname>Nielsen</surname><given-names>K.H.</given-names></name><name><surname>Nielsen</surname><given-names>T.K.</given-names></name></person-group><article-title>Antibody dynamics in BRSV-infected Danish dairy herds as determined by isotype-specific immunoglobulins</article-title><source>Vet. Microbiol.</source><year>2000</year><volume>76</volume><fpage>329</fpage><lpage>341</lpage><pub-id pub-id-type="doi">10.1016/S0378-1135(00)00261-3</pub-id><pub-id pub-id-type="pmid">11000530</pub-id></element-citation></ref><ref id="B42-viruses-04-03452"><label>42.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pardon</surname><given-names>B.</given-names></name><name><surname>De Bleecker</surname><given-names>K.</given-names></name><name><surname>Dewulf</surname><given-names>J.</given-names></name><name><surname>Callens</surname><given-names>J.</given-names></name><name><surname>Boyen</surname><given-names>F.</given-names></name><name><surname>Catry</surname><given-names>B.</given-names></name><name><surname>Deprez</surname><given-names>P.</given-names></name></person-group><article-title>Prevalence of respiratory pathogens in diseased, non-vaccinated, routinely medicated veal calves</article-title><source>Vet. Rec.</source><year>2011</year><volume>169</volume><fpage>278</fpage><pub-id pub-id-type="doi">10.1136/vr.d4406</pub-id><pub-id pub-id-type="pmid">21831999</pub-id></element-citation></ref><ref id="B43-viruses-04-03452"><label>43.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hotchkiss</surname><given-names>E.J.</given-names></name><name><surname>Dagleish</surname><given-names>M.P.</given-names></name><name><surname>Willoughby</surname><given-names>K.</given-names></name><name><surname>McKendrick</surname><given-names>I.J.</given-names></name><name><surname>Finlayson</surname><given-names>J.</given-names></name><name><surname>Zadoks</surname><given-names>R.N.</given-names></name><name><surname>Newsome</surname><given-names>E.</given-names></name><name><surname>Brulisauer</surname><given-names>F.</given-names></name><name><surname>Gunn</surname><given-names>G.J.</given-names></name><name><surname>Hodgson</surname><given-names>J.C.</given-names></name></person-group><article-title>Prevalence of Pasteurella multocida and other respiratory pathogens in the nasal tract of Scottish calves</article-title><source>Vet. Rec.</source><year>2010</year><volume>167</volume><fpage>555</fpage><lpage>560</lpage><pub-id pub-id-type="doi">10.1136/vr.c4827</pub-id><pub-id pub-id-type="pmid">21257416</pub-id></element-citation></ref><ref id="B44-viruses-04-03452"><label>44.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Paton</surname><given-names>D.J.</given-names></name><name><surname>Christiansen</surname><given-names>K.H.</given-names></name><name><surname>Alenius</surname><given-names>S.</given-names></name><name><surname>Cranwell</surname><given-names>M.P.</given-names></name><name><surname>Pritchard</surname><given-names>G.C.</given-names></name><name><surname>Drew</surname><given-names>T.W.</given-names></name></person-group><article-title>Prevalence of antibodies to bovine virus diarrhoea virus and other viruses in bulk tank milk in England and Wales</article-title><source>Vet. Rec.</source><year>1998</year><volume>142</volume><fpage>385</fpage><lpage>391</lpage><pub-id pub-id-type="doi">10.1136/vr.142.15.385</pub-id><pub-id pub-id-type="pmid">9586130</pub-id></element-citation></ref><ref id="B45-viruses-04-03452"><label>45.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Raaperi</surname><given-names>K.</given-names></name><name><surname>Bougeard</surname><given-names>S.</given-names></name><name><surname>Aleksejev</surname><given-names>A.</given-names></name><name><surname>Orro</surname><given-names>T.</given-names></name><name><surname>Viltrop</surname><given-names>A.</given-names></name></person-group><article-title>Association of herd BHV-1 seroprevalence with respiratory disease in youngstock in Estonian dairy cattle</article-title><source>Res. Vet. Sci.</source><year>2012</year><volume>93</volume><fpage>641</fpage><lpage>648</lpage><pub-id pub-id-type="pmid">22100246</pub-id></element-citation></ref><ref id="B46-viruses-04-03452"><label>46.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Van Vuuren</surname><given-names>M.</given-names></name></person-group><article-title>Serological studies of bovine respiratory syncytial virus in feedlot cattle in South Africa</article-title><source>J. S. Afr. Vet. Assoc.</source><year>1990</year><volume>61</volume><fpage>168</fpage><lpage>169</lpage><pub-id pub-id-type="pmid">9022846</pub-id></element-citation></ref><ref id="B47-viruses-04-03452"><label>47.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mahin</surname><given-names>L.</given-names></name><name><surname>Wellemans</surname><given-names>G.</given-names></name><name><surname>Shimi</surname><given-names>A.</given-names></name></person-group><article-title>Prevalence of antibodies to bovid herpesvirus 1 (IBR-IPV), bovine virus diarrhoea, bovine respiratory syncytial parainfluenza 3, adeno A and adeno B viruses in indigenous and imported Moroccan cattle</article-title><source>Ann. Rech. Vet.</source><year>1985</year><volume>16</volume><fpage>279</fpage><lpage>283</lpage><pub-id pub-id-type="pmid">2998260</pub-id></element-citation></ref><ref id="B48-viruses-04-03452"><label>48.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mahin</surname><given-names>L.</given-names></name><name><surname>Wellemans</surname><given-names>G.</given-names></name></person-group><article-title>Serological evidence for the intervention of bovine respiratory syncytial virus in a respiratory disease outbreak in Moroccan cattle</article-title><source>Zentralbl. Veterinarmed. B</source><year>1982</year><volume>29</volume><fpage>76</fpage><lpage>79</lpage><pub-id pub-id-type="pmid">7090648</pub-id></element-citation></ref><ref id="B49-viruses-04-03452"><label>49.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yesilbag</surname><given-names>K.</given-names></name><name><surname>Gungor</surname><given-names>B.</given-names></name></person-group><article-title>Seroprevalence of bovine respiratory viruses in North-Western Turkey</article-title><source>Trop. Anim. Health Prod.</source><year>2008</year><volume>40</volume><fpage>55</fpage><lpage>60</lpage><pub-id pub-id-type="doi">10.1007/s11250-007-9053-x</pub-id><pub-id pub-id-type="pmid">18551779</pub-id></element-citation></ref><ref id="B50-viruses-04-03452"><label>50.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Valarcher</surname><given-names>J.F.</given-names></name><name><surname>Schelcher</surname><given-names>F.</given-names></name><name><surname>Bourhy</surname><given-names>H.</given-names></name></person-group><article-title>Evolution of bovine respiratory syncytial virus</article-title><source>J. Virol.</source><year>2000</year><volume>74</volume><fpage>10714</fpage><lpage>10728</lpage><pub-id pub-id-type="pmid">11044116</pub-id></element-citation></ref><ref id="B51-viruses-04-03452"><label>51.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Deplanche</surname><given-names>M.</given-names></name><name><surname>Lemaire</surname><given-names>M.</given-names></name><name><surname>Mirandette</surname><given-names>C.</given-names></name><name><surname>Bonnet</surname><given-names>M.</given-names></name><name><surname>Schelcher</surname><given-names>F.</given-names></name><name><surname>Meyer</surname><given-names>G.</given-names></name></person-group><article-title><italic>In vivo</italic> evidence for quasispecies distributions in the bovine respiratory syncytial virus genome</article-title><source>J. Gen. Virol.</source><year>2007</year><volume>88</volume><fpage>1260</fpage><lpage>1265</lpage><pub-id pub-id-type="doi">10.1099/vir.0.82668-0</pub-id><pub-id pub-id-type="pmid">17374770</pub-id></element-citation></ref><ref id="B52-viruses-04-03452"><label>52.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lam</surname><given-names>T.T.</given-names></name><name><surname>Hon</surname><given-names>C.C.</given-names></name><name><surname>Tang</surname><given-names>J.W.</given-names></name></person-group><article-title>Use of phylogenetics in the molecular epidemiology and evolutionary studies of viral infections</article-title><source>Critical reviews in clinical laboratory sciences</source><year>2010</year><volume>47</volume><fpage>5</fpage><lpage>49</lpage><pub-id pub-id-type="doi">10.3109/10408361003633318</pub-id><pub-id pub-id-type="pmid">20367503</pub-id></element-citation></ref><ref id="B53-viruses-04-03452"><label>53.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Khudyakov</surname><given-names>Y.</given-names></name></person-group><article-title>Coevolution and HBV drug resistance</article-title><source>Antivir. Ther.</source><year>2010</year><volume>15</volume><fpage>505</fpage><lpage>515</lpage><pub-id pub-id-type="pmid">20516572</pub-id></element-citation></ref><ref id="B54-viruses-04-03452"><label>54.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Spilki</surname><given-names>F.R.</given-names></name><name><surname>Almeida</surname><given-names>R.S.</given-names></name><name><surname>Domingues</surname><given-names>H.G.</given-names></name><name><surname>D'Arce</surname><given-names>R.C.F.</given-names></name><name><surname>Ferreira</surname><given-names>H.L.</given-names></name><name><surname>Campalans</surname><given-names>J.</given-names></name><name><surname>Costa</surname><given-names>S.C.B.</given-names></name><name><surname>Arns</surname><given-names>C.W.</given-names></name></person-group><article-title>Phylogenetic relationships of Brazilian bovine respiratory syncytial virus isolates and molecular homology modeling of attachment glycoprotein</article-title><source>Virus Res.</source><year>2006</year><volume>116</volume><fpage>30</fpage><lpage>37</lpage><pub-id pub-id-type="doi">10.1016/j.virusres.2005.08.010</pub-id><pub-id pub-id-type="pmid">16387381</pub-id></element-citation></ref><ref id="B55-viruses-04-03452"><label>55.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Samal</surname><given-names>S.K.</given-names></name><name><surname>Zamora</surname><given-names>M.</given-names></name><name><surname>McPhillips</surname><given-names>T.H.</given-names></name><name><surname>Mohanty</surname><given-names>S.B.</given-names></name></person-group><article-title>Molecular cloning and sequence analysis of bovine respiratory syncytial virus mRNA encoding the major nucleocapsid protein</article-title><source>Virology</source><year>1991</year><volume>180</volume><fpage>453</fpage><lpage>456</lpage><pub-id pub-id-type="doi">10.1016/0042-6822(91)90057-I</pub-id><pub-id pub-id-type="pmid">1984667</pub-id></element-citation></ref><ref id="B56-viruses-04-03452"><label>56.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kovarcik</surname><given-names>K.</given-names></name><name><surname>Valentova</surname><given-names>V.</given-names></name></person-group><article-title>Bovine respiratory syncytial virus strains currently circulating in the Czech Republic are most closely related to Danish strains from 1995</article-title><source>Acta Virol.</source><year>2004</year><volume>48</volume><fpage>57</fpage><lpage>62</lpage><pub-id pub-id-type="pmid">15230477</pub-id></element-citation></ref><ref id="B57-viruses-04-03452"><label>57.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lerch</surname><given-names>R.A.</given-names></name><name><surname>Stott</surname><given-names>E.J.</given-names></name><name><surname>Wertz</surname><given-names>G.W.</given-names></name></person-group><article-title>Characterization of bovine respiratory syncytial virus proteins and mRNAs and generation of cDNA clones to the viral mRNAs</article-title><source>J. Virol.</source><year>1989</year><volume>63</volume><fpage>833</fpage><lpage>840</lpage><pub-id pub-id-type="pmid">2911122</pub-id></element-citation></ref><ref id="B58-viruses-04-03452"><label>58.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Baker</surname><given-names>J.C.</given-names></name><name><surname>Wilson</surname><given-names>E.G.</given-names></name><name><surname>McKay</surname><given-names>G.L.</given-names></name><name><surname>Stanek</surname><given-names>R.J.</given-names></name><name><surname>Underwood</surname><given-names>W.J.</given-names></name><name><surname>Velicer</surname><given-names>L.F.</given-names></name><name><surname>Mufson</surname><given-names>M.A.</given-names></name></person-group><article-title>Identification of subgroups of bovine respiratory syncytial virus</article-title><source>J. Clin. Microbiol.</source><year>1992</year><volume>30</volume><fpage>1120</fpage><lpage>1126</lpage><pub-id pub-id-type="pmid">1583108</pub-id></element-citation></ref><ref id="B59-viruses-04-03452"><label>59.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mallipeddi</surname><given-names>S.K.</given-names></name><name><surname>Samal</surname><given-names>S.K.</given-names></name></person-group><article-title>Structural difference in the fusion protein among strains of bovine respiratory syncytial virus</article-title><source>Vet. Microbiol.</source><year>1993</year><volume>36</volume><fpage>359</fpage><lpage>367</lpage><pub-id pub-id-type="doi">10.1016/0378-1135(93)90102-D</pub-id><pub-id pub-id-type="pmid">8273280</pub-id></element-citation></ref><ref id="B60-viruses-04-03452"><label>60.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Prozzi</surname><given-names>D.</given-names></name><name><surname>Walravens</surname><given-names>K.</given-names></name><name><surname>Langedijk</surname><given-names>J.P.</given-names></name><name><surname>Daus</surname><given-names>F.</given-names></name><name><surname>Kramps</surname><given-names>J.A.</given-names></name><name><surname>Letesson</surname><given-names>J.J.</given-names></name></person-group><article-title>Antigenic and molecular analyses of the variability of bovine respiratory syncytial virus G glycoprotein</article-title><source>J. Gen. Virol.</source><year>1997</year><volume>78</volume><fpage>359</fpage><lpage>366</lpage><pub-id pub-id-type="pmid">9018058</pub-id></element-citation></ref><ref id="B61-viruses-04-03452"><label>61.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Furze</surname><given-names>J.</given-names></name><name><surname>Wertz</surname><given-names>G.</given-names></name><name><surname>Lerch</surname><given-names>R.</given-names></name><name><surname>Taylor</surname><given-names>G.</given-names></name></person-group><article-title>Antigenic heterogeneity of the attachment protein of bovine respiratory syncytial virus</article-title><source>J. Gen. Virol.</source><year>1994</year><volume>75</volume><fpage>363</fpage><lpage>370</lpage><pub-id pub-id-type="doi">10.1099/0022-1317-75-2-363</pub-id><pub-id pub-id-type="pmid">8113757</pub-id></element-citation></ref><ref id="B62-viruses-04-03452"><label>62.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Meyer</surname><given-names>G.</given-names></name><name><surname>Deplanche</surname><given-names>M.</given-names></name><name><surname>Schelcher</surname><given-names>F.</given-names></name></person-group><article-title>Human and bovine respiratory syncytial virus vaccine research and development</article-title><source>Comp. Immunol. Microbiol. Infect. Dis.</source><year>2008</year><volume>31</volume><fpage>191</fpage><lpage>225</lpage><pub-id pub-id-type="doi">10.1016/j.cimid.2007.07.008</pub-id><pub-id pub-id-type="pmid">17720245</pub-id></element-citation></ref><ref id="B63-viruses-04-03452"><label>63.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lerch</surname><given-names>R.A.</given-names></name><name><surname>Anderson</surname><given-names>K.</given-names></name><name><surname>Wertz</surname><given-names>G.W.</given-names></name></person-group><article-title>Nucleotide sequence analysis and expression from recombinant vectors demonstrate that the attachment protein G of bovine respiratory syncytial virus is distinct from that of human respiratory syncytial virus</article-title><source>J. Virol.</source><year>1990</year><volume>64</volume><fpage>5559</fpage><lpage>5569</lpage><pub-id pub-id-type="pmid">2214024</pub-id></element-citation></ref><ref id="B64-viruses-04-03452"><label>64.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Walravens</surname><given-names>K.</given-names></name><name><surname>Kettmann</surname><given-names>R.</given-names></name><name><surname>Collard</surname><given-names>A.</given-names></name><name><surname>Coppe</surname><given-names>P.</given-names></name><name><surname>Burny</surname><given-names>A.</given-names></name></person-group><article-title>Sequence comparison between the fusion protein of human and bovine respiratory syncytial viruses</article-title><source>J. Gen. Virol.</source><year>1990</year><volume>71</volume><fpage>3009</fpage><lpage>3014</lpage><pub-id pub-id-type="doi">10.1099/0022-1317-71-12-3009</pub-id><pub-id pub-id-type="pmid">1703214</pub-id></element-citation></ref><ref id="B65-viruses-04-03452"><label>65.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Samal</surname><given-names>S.K.</given-names></name><name><surname>Zamora</surname><given-names>M.</given-names></name></person-group><article-title>Nucleotide sequence analysis of a matrix and small hydrophobic protein dicistronic mRNA of bovine respiratory syncytial virus demonstrates extensive sequence divergence of the small hydrophobic protein from that of human respiratory syncytial virus</article-title><source>J. Gen. Virol.</source><year>1991</year><volume>72</volume><fpage>1715</fpage><lpage>1720</lpage><pub-id pub-id-type="pmid">1856698</pub-id></element-citation></ref><ref id="B66-viruses-04-03452"><label>66.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zamora</surname><given-names>M.</given-names></name><name><surname>Samal</surname><given-names>S.K.</given-names></name></person-group><article-title>Sequence analysis of M2 mRNA of bovine respiratory syncytial virus obtained from an F-M2 dicistronic mRNA suggests structural homology with that of human respiratory syncytial virus</article-title><source>J. Gen. Virol.</source><year>1992</year><volume>73</volume><fpage>737</fpage><lpage>741</lpage><pub-id pub-id-type="doi">10.1099/0022-1317-73-3-737</pub-id><pub-id pub-id-type="pmid">1312130</pub-id></element-citation></ref><ref id="B67-viruses-04-03452"><label>67.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mallipeddi</surname><given-names>S.K.</given-names></name><name><surname>Samal</surname><given-names>S.K.</given-names></name></person-group><article-title>Sequence comparison between the phosphoprotein mRNAs of human and bovine respiratory syncytial viruses identifies a divergent domain in the predicted protein</article-title><source>J. Gen. Virol.</source><year>1992</year><volume>73</volume><fpage>2441</fpage><lpage>2444</lpage><pub-id pub-id-type="doi">10.1099/0022-1317-73-9-2441</pub-id><pub-id pub-id-type="pmid">1402819</pub-id></element-citation></ref><ref id="B68-viruses-04-03452"><label>68.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mallipeddi</surname><given-names>S.K.</given-names></name><name><surname>Samal</surname><given-names>S.K.</given-names></name></person-group><article-title>Sequence variability of the glycoprotein gene of bovine respiratory syncytial virus</article-title><source>J. Gen. Virol.</source><year>1993</year><volume>74</volume><fpage>2001</fpage><lpage>2004</lpage><pub-id pub-id-type="pmid">8376974</pub-id></element-citation></ref><ref id="B69-viruses-04-03452"><label>69.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Langedijk</surname><given-names>J.P.</given-names></name><name><surname>Meloen</surname><given-names>R.H.</given-names></name><name><surname>Taylor</surname><given-names>G.</given-names></name><name><surname>Furze</surname><given-names>J.M.</given-names></name><name><surname>van Oirschot</surname><given-names>J.T.</given-names></name></person-group><article-title>Antigenic structure of the central conserved region of protein G of bovine respiratory syncytial virus</article-title><source>J. Virol.</source><year>1997</year><volume>71</volume><fpage>4055</fpage><lpage>4061</lpage><pub-id pub-id-type="pmid">9094683</pub-id></element-citation></ref><ref id="B70-viruses-04-03452"><label>70.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Stine</surname><given-names>L.C.</given-names></name><name><surname>Hoppe</surname><given-names>D.K.</given-names></name><name><surname>Kelling</surname><given-names>C.L.</given-names></name></person-group><article-title>Sequence conservation in the attachment glycoprotein and antigenic diversity among bovine respiratory syncytial virus isolates</article-title><source>Vet. Microbiol.</source><year>1997</year><volume>54</volume><fpage>201</fpage><lpage>221</lpage><pub-id pub-id-type="doi">10.1016/S0378-1135(96)01288-6</pub-id><pub-id pub-id-type="pmid">9100323</pub-id></element-citation></ref><ref id="B71-viruses-04-03452"><label>71.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Elvander</surname><given-names>M.</given-names></name><name><surname>Vilcek</surname><given-names>S.</given-names></name><name><surname>Baule</surname><given-names>C.</given-names></name><name><surname>Uttenthal</surname><given-names>A.</given-names></name><name><surname>Ballagi-Pordany</surname><given-names>A.</given-names></name><name><surname>Belak</surname><given-names>S.</given-names></name></person-group><article-title>Genetic and antigenic analysis of the G attachment protein of bovine respiratory syncytial virus strains</article-title><source>J. Gen. Virol.</source><year>1998</year><volume>79</volume><fpage>2939</fpage><lpage>2946</lpage><pub-id pub-id-type="pmid">9880007</pub-id></element-citation></ref><ref id="B72-viruses-04-03452"><label>72.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Larsen</surname><given-names>L.E.</given-names></name><name><surname>Uttenthal</surname><given-names>A.</given-names></name><name><surname>Arctander</surname><given-names>P.</given-names></name><name><surname>Tjornehoj</surname><given-names>K.</given-names></name><name><surname>Viuff</surname><given-names>B.</given-names></name><name><surname>Rontved</surname><given-names>C.</given-names></name><name><surname>Ronsholt</surname><given-names>L.</given-names></name><name><surname>Alexandersen</surname><given-names>S.</given-names></name><name><surname>Blixenkrone-Moller</surname><given-names>M.</given-names></name></person-group><article-title>Serological and genetic characterisation of bovine respiratory syncytial virus (BRSV) indicates that Danish isolates belong to the intermediate subgroup: no evidence of a selective effect on the variability of G protein nucleotide sequence by prior cell culture adaption and passages in cell culture or calves</article-title><source>Vet. Microbiol.</source><year>1998</year><volume>62</volume><fpage>265</fpage><lpage>279</lpage><pub-id pub-id-type="doi">10.1016/S0378-1135(98)00226-0</pub-id><pub-id pub-id-type="pmid">9791873</pub-id></element-citation></ref><ref id="B73-viruses-04-03452"><label>73.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kovarcik</surname><given-names>K.</given-names></name><name><surname>Valentova</surname><given-names>V.</given-names></name></person-group><article-title>Bovine respiratory syncytial virus strains currently circulating in the Czech Republic are most closely related to Danish strains from 1995</article-title><source>Acta Virol.</source><year>2004</year><volume>48</volume><fpage>57</fpage><lpage>62</lpage><pub-id pub-id-type="pmid">15230477</pub-id></element-citation></ref><ref id="B74-viruses-04-03452"><label>74.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Larsen</surname><given-names>L.E.</given-names></name><name><surname>Tjornehoj</surname><given-names>K.</given-names></name><name><surname>Viuff</surname><given-names>B.</given-names></name></person-group><article-title>Extensive sequence divergence among bovine respiratory syncytial viruses isolated during recurrent outbreaks in closed herds</article-title><source>J. Clin. Microbiol.</source><year>2000</year><volume>38</volume><fpage>4222</fpage><lpage>4227</lpage><pub-id pub-id-type="pmid">11060095</pub-id></element-citation></ref><ref id="B75-viruses-04-03452"><label>75.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Valentova</surname><given-names>V.</given-names></name><name><surname>Antonis</surname><given-names>A.F.</given-names></name><name><surname>Kovarcik</surname><given-names>K.</given-names></name></person-group><article-title>Restriction enzyme analysis of RT-PCR amplicons as a rapid method for detection of genetic diversity among bovine respiratory syncytial virus isolates</article-title><source>Vet. Microbiol.</source><year>2005</year><volume>108</volume><fpage>1</fpage><lpage>12</lpage><pub-id pub-id-type="doi">10.1016/j.vetmic.2005.02.008</pub-id><pub-id pub-id-type="pmid">15917131</pub-id></element-citation></ref><ref id="B76-viruses-04-03452"><label>76.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yaegashi</surname><given-names>G.</given-names></name><name><surname>Seimiya</surname><given-names>Y.M.</given-names></name><name><surname>Seki</surname><given-names>Y.</given-names></name><name><surname>Tsunemitsu</surname><given-names>H.</given-names></name></person-group><article-title>Genetic and antigenic analyses of bovine respiratory syncytial virus detected in Japan</article-title><source>J. Vet. Med. Sci.</source><year>2005</year><volume>67</volume><fpage>145</fpage><lpage>150</lpage><pub-id pub-id-type="pmid">15750309</pub-id></element-citation></ref><ref id="B77-viruses-04-03452"><label>77.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Spilki</surname><given-names>F.R.</given-names></name><name><surname>Almeida</surname><given-names>R.S.</given-names></name><name><surname>Domingues</surname><given-names>H.G.</given-names></name><name><surname>D'Arce</surname><given-names>R.C.</given-names></name><name><surname>Ferreira</surname><given-names>H.L.</given-names></name><name><surname>Campalans</surname><given-names>J.</given-names></name><name><surname>Costa</surname><given-names>S.C.</given-names></name><name><surname>Arns</surname><given-names>C.W.</given-names></name></person-group><article-title>Phylogenetic relationships of Brazilian bovine respiratory syncytial virus isolates and molecular homology modeling of attachment glycoprotein</article-title><source>Virus. Res.</source><year>2006</year><volume>116</volume><fpage>30</fpage><lpage>37</lpage><pub-id pub-id-type="doi">10.1016/j.virusres.2005.08.010</pub-id><pub-id pub-id-type="pmid">16387381</pub-id></element-citation></ref><ref id="B78-viruses-04-03452"><label>78.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nettleton</surname><given-names>P.F.</given-names></name><name><surname>Gilray</surname><given-names>J.A.</given-names></name><name><surname>Caldow</surname><given-names>G.</given-names></name><name><surname>Gidlow</surname><given-names>J.R.</given-names></name><name><surname>Durkovic</surname><given-names>B.</given-names></name><name><surname>Vilcek</surname><given-names>S.</given-names></name></person-group><article-title>Recent isolates of bovine respiratory syncytial virus from Britain are more closely related to isolates from USA than to earlier British and current mainland European isolates</article-title><source>J. Vet. Med. B Infect. Dis. Vet. Public Health</source><year>2003</year><volume>50</volume><fpage>196</fpage><lpage>199</lpage><pub-id pub-id-type="doi">10.1046/j.1439-0450.2003.00647.x</pub-id><pub-id pub-id-type="pmid">12916694</pub-id></element-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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