Case of the Index Patient Who Caused Tertiary Transmission of Coronavirus Disease 2019 in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Pneumonia Monitored by Quantitative RT-PCR
Identifieur interne : 000634 ( Pmc/Corpus ); précédent : 000633; suivant : 000635Case of the Index Patient Who Caused Tertiary Transmission of Coronavirus Disease 2019 in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Pneumonia Monitored by Quantitative RT-PCR
Auteurs : Jaegyun Lim ; Seunghyun Jeon ; Hyun-Young Shin ; Moon Jung Kim ; Yu Min Seong ; Wang Jun Lee ; Kang-Won Choe ; Yu Min Kang ; Baeckseung Lee ; Sang-Joon ParkSource :
- Journal of Korean Medical Science [ 1011-8934 ] ; 2020.
Abstract
Since mid-December of 2019, coronavirus disease 2019 (COVID-19) has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the speed of transmission is accelerating, there are rising concerns about community infections. The 54-year old male is the third patient diagnosed with COVID-19 in Korea. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. This patient caused one case of secondary transmission and three cases of tertiary transmission. Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed.
Url:
DOI: 10.3346/jkms.2020.35.e79
PubMed: 32056407
PubMed Central: 7025910
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Case of the Index Patient Who Caused Tertiary Transmission of Coronavirus Disease 2019 in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Pneumonia Monitored by Quantitative RT-PCR</title><author><name sortKey="Lim, Jaegyun" sort="Lim, Jaegyun" uniqKey="Lim J" first="Jaegyun" last="Lim">Jaegyun Lim</name><affiliation><nlm:aff id="A1">Department of Laboratory Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang,<country>Korea</country>.</nlm:aff></affiliation></author><author><name sortKey="Jeon, Seunghyun" sort="Jeon, Seunghyun" uniqKey="Jeon S" first="Seunghyun" last="Jeon">Seunghyun Jeon</name><affiliation><nlm:aff id="A2">New Horizon Cancer Institute, Myongji Hospital, Goyang,<country>Korea</country>.</nlm:aff></affiliation></author><author><name sortKey="Shin, Hyun Young" sort="Shin, Hyun Young" uniqKey="Shin H" first="Hyun-Young" last="Shin">Hyun-Young Shin</name><affiliation><nlm:aff id="A3">Department of Family Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang,<country>Korea</country>.</nlm:aff></affiliation></author><author><name sortKey="Kim, Moon Jung" sort="Kim, Moon Jung" uniqKey="Kim M" first="Moon Jung" last="Kim">Moon Jung Kim</name><affiliation><nlm:aff id="A1">Department of Laboratory Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang,<country>Korea</country>.</nlm:aff></affiliation></author><author><name sortKey="Seong, Yu Min" sort="Seong, Yu Min" uniqKey="Seong Y" first="Yu Min" last="Seong">Yu Min Seong</name><affiliation><nlm:aff id="A4">Department of Internal Medicine, Myongji Hospital, Goyang,<country>Korea</country>.</nlm:aff></affiliation></author><author><name sortKey="Lee, Wang Jun" sort="Lee, Wang Jun" uniqKey="Lee W" first="Wang Jun" last="Lee">Wang Jun Lee</name><affiliation><nlm:aff id="A5">Office of Chief Executive Officer and Chairman, Department of General Surgery, Myongji Hospital, Goyang,<country>Korea</country>.</nlm:aff></affiliation></author><author><name sortKey="Choe, Kang Won" sort="Choe, Kang Won" uniqKey="Choe K" first="Kang-Won" last="Choe">Kang-Won Choe</name><affiliation><nlm:aff id="A6">Department of Infectious Diseases, Myongji Hospital, Goyang,<country>Korea</country>.</nlm:aff></affiliation></author><author><name sortKey="Kang, Yu Min" sort="Kang, Yu Min" uniqKey="Kang Y" first="Yu Min" last="Kang">Yu Min Kang</name><affiliation><nlm:aff id="A6">Department of Infectious Diseases, Myongji Hospital, Goyang,<country>Korea</country>.</nlm:aff></affiliation></author><author><name sortKey="Lee, Baeckseung" sort="Lee, Baeckseung" uniqKey="Lee B" first="Baeckseung" last="Lee">Baeckseung Lee</name><affiliation><nlm:aff id="A7">CancerROP, Seoul,<country>Korea</country>.</nlm:aff></affiliation></author><author><name sortKey="Park, Sang Joon" sort="Park, Sang Joon" uniqKey="Park S" first="Sang-Joon" last="Park">Sang-Joon Park</name><affiliation><nlm:aff id="A8">Department of Pulmonary and Critical Care Medicine, Myongji Hospital, Goyang,<country>Korea</country>.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32056407</idno><idno type="pmc">7025910</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025910</idno><idno type="RBID">PMC:7025910</idno><idno type="doi">10.3346/jkms.2020.35.e79</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000634</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000634</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Case of the Index Patient Who Caused Tertiary Transmission of Coronavirus Disease 2019 in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Pneumonia Monitored by Quantitative RT-PCR</title><author><name sortKey="Lim, Jaegyun" sort="Lim, Jaegyun" uniqKey="Lim J" first="Jaegyun" last="Lim">Jaegyun Lim</name><affiliation><nlm:aff id="A1">Department of Laboratory Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang,<country>Korea</country>.</nlm:aff></affiliation></author><author><name sortKey="Jeon, Seunghyun" sort="Jeon, Seunghyun" uniqKey="Jeon S" first="Seunghyun" last="Jeon">Seunghyun Jeon</name><affiliation><nlm:aff id="A2">New Horizon Cancer Institute, Myongji Hospital, Goyang,<country>Korea</country>.</nlm:aff></affiliation></author><author><name sortKey="Shin, Hyun Young" sort="Shin, Hyun Young" uniqKey="Shin H" first="Hyun-Young" last="Shin">Hyun-Young Shin</name><affiliation><nlm:aff id="A3">Department of Family Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang,<country>Korea</country>.</nlm:aff></affiliation></author><author><name sortKey="Kim, Moon Jung" sort="Kim, Moon Jung" uniqKey="Kim M" first="Moon Jung" last="Kim">Moon Jung Kim</name><affiliation><nlm:aff id="A1">Department of Laboratory Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang,<country>Korea</country>.</nlm:aff></affiliation></author><author><name sortKey="Seong, Yu Min" sort="Seong, Yu Min" uniqKey="Seong Y" first="Yu Min" last="Seong">Yu Min Seong</name><affiliation><nlm:aff id="A4">Department of Internal Medicine, Myongji Hospital, Goyang,<country>Korea</country>.</nlm:aff></affiliation></author><author><name sortKey="Lee, Wang Jun" sort="Lee, Wang Jun" uniqKey="Lee W" first="Wang Jun" last="Lee">Wang Jun Lee</name><affiliation><nlm:aff id="A5">Office of Chief Executive Officer and Chairman, Department of General Surgery, Myongji Hospital, Goyang,<country>Korea</country>.</nlm:aff></affiliation></author><author><name sortKey="Choe, Kang Won" sort="Choe, Kang Won" uniqKey="Choe K" first="Kang-Won" last="Choe">Kang-Won Choe</name><affiliation><nlm:aff id="A6">Department of Infectious Diseases, Myongji Hospital, Goyang,<country>Korea</country>.</nlm:aff></affiliation></author><author><name sortKey="Kang, Yu Min" sort="Kang, Yu Min" uniqKey="Kang Y" first="Yu Min" last="Kang">Yu Min Kang</name><affiliation><nlm:aff id="A6">Department of Infectious Diseases, Myongji Hospital, Goyang,<country>Korea</country>.</nlm:aff></affiliation></author><author><name sortKey="Lee, Baeckseung" sort="Lee, Baeckseung" uniqKey="Lee B" first="Baeckseung" last="Lee">Baeckseung Lee</name><affiliation><nlm:aff id="A7">CancerROP, Seoul,<country>Korea</country>.</nlm:aff></affiliation></author><author><name sortKey="Park, Sang Joon" sort="Park, Sang Joon" uniqKey="Park S" first="Sang-Joon" last="Park">Sang-Joon Park</name><affiliation><nlm:aff id="A8">Department of Pulmonary and Critical Care Medicine, Myongji Hospital, Goyang,<country>Korea</country>.</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Korean Medical Science</title><idno type="ISSN">1011-8934</idno><idno type="eISSN">1598-6357</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Since mid-December of 2019, coronavirus disease 2019 (COVID-19) has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the speed of transmission is accelerating, there are rising concerns about community infections. The 54-year old male is the third patient diagnosed with COVID-19 in Korea. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. This patient caused one case of secondary transmission and three cases of tertiary transmission. Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kim, Jy" uniqKey="Kim J">JY Kim</name></author><author><name sortKey="Choe, Pg" uniqKey="Choe P">PG Choe</name></author><author><name sortKey="Oh, Y" uniqKey="Oh Y">Y Oh</name></author><author><name sortKey="Oh, Kj" uniqKey="Oh K">KJ Oh</name></author><author><name sortKey="Kim, J" uniqKey="Kim J">J Kim</name></author><author><name sortKey="Park, Sj" uniqKey="Park S">SJ Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamer, M" uniqKey="Hamer M">M Hamer</name></author><author><name sortKey="Kivimaki, M" uniqKey="Kivimaki M">M Kivimaki</name></author><author><name sortKey="Stamatakis, E" uniqKey="Stamatakis E">E Stamatakis</name></author><author><name sortKey="Batty, Gd" uniqKey="Batty G">GD Batty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name></author><author><name sortKey="Guan, X" uniqKey="Guan X">X Guan</name></author><author><name sortKey="Wu, P" uniqKey="Wu P">P Wu</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author><author><name sortKey="Zhou, L" uniqKey="Zhou L">L Zhou</name></author><author><name sortKey="Tong, Y" uniqKey="Tong Y">Y Tong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rothe, C" uniqKey="Rothe C">C Rothe</name></author><author><name sortKey="Schunk, M" uniqKey="Schunk M">M Schunk</name></author><author><name sortKey="Sothmann, P" uniqKey="Sothmann P">P Sothmann</name></author><author><name sortKey="Bretzel, G" uniqKey="Bretzel G">G Bretzel</name></author><author><name sortKey="Froeschl, G" uniqKey="Froeschl G">G Froeschl</name></author><author><name sortKey="Wallrauch, C" uniqKey="Wallrauch C">C Wallrauch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chang, D" uniqKey="Chang D">D Chang</name></author><author><name sortKey="Lin, M" uniqKey="Lin M">M Lin</name></author><author><name sortKey="Wei, L" uniqKey="Wei L">L Wei</name></author><author><name sortKey="Xie, L" uniqKey="Xie L">L Xie</name></author><author><name sortKey="Zhu, G" uniqKey="Zhu G">G Zhu</name></author><author><name sortKey="Dela Cruz, Cs" uniqKey="Dela Cruz C">CS Dela Cruz</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Korean Med Sci</journal-id><journal-id journal-id-type="iso-abbrev">J. Korean Med. Sci</journal-id><journal-id journal-id-type="publisher-id">JKMS</journal-id><journal-title-group><journal-title>Journal of Korean Medical Science</journal-title></journal-title-group><issn pub-type="ppub">1011-8934</issn><issn pub-type="epub">1598-6357</issn><publisher><publisher-name>The Korean Academy of Medical Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32056407</article-id><article-id pub-id-type="pmc">7025910</article-id><article-id pub-id-type="doi">10.3346/jkms.2020.35.e79</article-id><article-categories><subj-group subj-group-type="heading"><subject>Brief Communication</subject><subj-group subj-group-type="subheading"><subject>Infectious Diseases, Microbiology & Parasitology</subject></subj-group></subj-group></article-categories><title-group><article-title>Case of the Index Patient Who Caused Tertiary Transmission of Coronavirus Disease 2019 in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Pneumonia Monitored by Quantitative RT-PCR</article-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-3553-0058</contrib-id><name><surname>Lim</surname><given-names>Jaegyun</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-4320-2644</contrib-id><name><surname>Jeon</surname><given-names>Seunghyun</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0001-7261-3365</contrib-id><name><surname>Shin</surname><given-names>Hyun-Young</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0003-4148-9116</contrib-id><name><surname>Kim</surname><given-names>Moon Jung</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0001-9650-6353</contrib-id><name><surname>Seong</surname><given-names>Yu Min</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-3042-1557</contrib-id><name><surname>Lee</surname><given-names>Wang Jun</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0003-2003-6492</contrib-id><name><surname>Choe</surname><given-names>Kang-Won</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-4368-9878</contrib-id><name><surname>Kang</surname><given-names>Yu Min</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0001-7867-8434</contrib-id><name><surname>Lee</surname><given-names>Baeckseung</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0003-3178-6272</contrib-id><name><surname>Park</surname><given-names>Sang-Joon</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Laboratory Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang,<country>Korea</country>.</aff><aff id="A2"><label>2</label>New Horizon Cancer Institute, Myongji Hospital, Goyang,<country>Korea</country>.</aff><aff id="A3"><label>3</label>Department of Family Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang,<country>Korea</country>.</aff><aff id="A4"><label>4</label>Department of Internal Medicine, Myongji Hospital, Goyang,<country>Korea</country>.</aff><aff id="A5"><label>5</label>Office of Chief Executive Officer and Chairman, Department of General Surgery, Myongji Hospital, Goyang,<country>Korea</country>.</aff><aff id="A6"><label>6</label>Department of Infectious Diseases, Myongji Hospital, Goyang,<country>Korea</country>.</aff><aff id="A7"><label>7</label>CancerROP, Seoul,<country>Korea</country>.</aff><aff id="A8"><label>8</label>Department of Pulmonary and Critical Care Medicine, Myongji Hospital, Goyang,<country>Korea</country>.</aff><author-notes><corresp>Address for Correspondence: Sang-Joon Park, MD, PhD. Department of Pulmonary and Critical Care Medicine, Myongji Hospital, 55 Hwasu-ro 14-beon-gil, Deogyang-gu, Goyang 10475, Republic of Korea. <email>drjoseph@mjh.or.kr</email></corresp><corresp>Address for Correspondence: Baeckseung Lee, PhD. CancerROP, 173 Digital-ro, Geumcheon-gu, Seoul 08511, Republic of Korea. <email>baeckseung@gmail.com</email></corresp></author-notes><pub-date pub-type="epub"><day>14</day><month>2</month><year>2020</year></pub-date><pub-date pub-type="collection"><day>17</day><month>2</month><year>2020</year></pub-date><volume>35</volume><issue>6</issue><elocation-id>e79</elocation-id><history><date date-type="received"><day>10</day><month>2</month><year>2020</year></date><date date-type="accepted"><day>11</day><month>2</month><year>2020</year></date></history><permissions><copyright-statement>© 2020 The Korean Academy of Medical Sciences.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder>The Korean Academy of Medical Sciences</copyright-holder><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by-nc/4.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by-nc/4.0/">https://creativecommons.org/licenses/by-nc/4.0/</ext-link>) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Since mid-December of 2019, coronavirus disease 2019 (COVID-19) has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the speed of transmission is accelerating, there are rising concerns about community infections. The 54-year old male is the third patient diagnosed with COVID-19 in Korea. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. This patient caused one case of secondary transmission and three cases of tertiary transmission. Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed.</p></abstract><abstract abstract-type="graphical"><title>Graphical Abstract</title><p><graphic xlink:href="jkms-35-e79-abf001.jpg" position="float" orientation="portrait"></graphic></p></abstract><kwd-group kwd-group-type="author"><kwd>Coronavirus</kwd><kwd>COVID-19</kwd><kwd>Pneumonia</kwd><kwd>Tertiary Infection</kwd><kwd>Viral Load</kwd><kwd>Real-Time Reverse-Transcriptase Polymerase Chain Reaction</kwd></kwd-group></article-meta></front><body><p>A 54-year-old Korean man living in Wuhan, China entered Korea on January 20, 2020 and felt the first symptoms of chills and muscle pain on January 22. After contacting a public health center on January 25, he was isolated in a negative pressure room at Myongji Hospital and confirmed to have COVID-19 on January 26.</p><p>At that time the initial confirmation of COVID-19 was made by pan-coronavirus conventional polymerase chain reaction assay and sequencing of the polymerase chain reaction (PCR) amplicons using a throat swab.</p><p>The index patient transmitted the virus to his friend (patient A) at a restaurant on the 1st day of the symptoms. And then patient A (confirmed on January 30, 2020) transmitted COVID-19 to his spouse and son (confirmed on January 31, 2020), and a church colleague (confirmed on February 6, 2020). Those were the first cases of tertiary transmission of COVID-19 outside China.</p><p>The index patient was a clothing worker at the Wuhan Fashion Center, with a height of 193 cm and weight of 96 kg (body mass index, 25.7), and had no major illness. He denied any smoking and drinking history. On admission day, he had no respiratory symptoms and blood pressure of 152/93 mmHg, pulse rate of 73 beats per minute, respiratory rate of 20 breaths per minute, and a body temperature of 37.0°C. On physical examination, no pharyngeal injection, clear lung sounds, and no haziness on chest X-ray were observed. Tests for Leptospira, Hantan virus, Tsutsugamushi, Malaria, <italic>M tuberculosis</italic>, human immunodeficiency virus (HIV) Ag/Ab, and venereal disease research laboratory (VDRL) test were all negative.</p><p>He developed fever and dry cough on days 5 and 7 of illness, respectively, but he had no serious respiratory symptoms such as shortness of breath, productive sputum or chest pain. Small consolidation in right upper lobe and ground-glass opacities in both lower lobes were observed on high-resolution computed tomography scan (<xref ref-type="fig" rid="F1">Figs. 1</xref> and <xref ref-type="fig" rid="F2">2</xref>, <xref rid="T1" ref-type="table">Table 1</xref>).</p><p>The initial viral load could not be measured because real-time PCR was not available when the patient was diagnosed. So we measured viral loads using quantitative reverse transcription (RT)-PCR since Jan. 31, 2020. Viral RNA was extracted from the sputum using QIAamp viral RNA mini kit (Qiagen, Hilden, Germany) according to the manufacturer's instructions. All quantitative real-time PCR amplifications were performed using Quantstudio 1 (Applied Biosystems, Foster City, CA, USA) and PowerCheck™ SARS-CoV-2 Real-Time PCR kit (KogeneBiotech, Seoul, Korea).</p><p>There were some reports about lopinavir/ritonavir (Kaletra, AbbVie) for the treatment of COVID-19.<xref rid="B1" ref-type="bibr">1</xref> Lopinavir/ritonavir was started from the hospital day 8 (day 10 of illness); 2 tablets (lopinavir 200 mg/ritonavir 50 mg) were given per oral bid. Interestingly, from the next day of lopinavir/ritonavir administration, β-coronavirus viral load started to decrease and no detectable or little coronavirus titers have been observed since then (<xref ref-type="fig" rid="F2">Fig. 2</xref> and <xref ref-type="supplementary-material" rid="S1">Supplementary Fig. 1</xref>).</p><p>It is possible that the decreased load of SARS-CoV-2 resulted from the natural course of the healing process rather than administration of lopinavir/ritonavir, or both. Therefore, more data need to be collected to figure out the direct effect of lopinavir/ritonavir on treatment with COVID-19.</p><p>The patient also complained of psychiatric symptoms such as depression, insomnia and suicidal thoughts after isolation. The patient experienced stress regarding people's reactions from the media reports about the COVID-19 patients. In addition, despite mild symptoms of COVID-19 in his case, isolation in the negative pressure room during treatment might be one of the reasons provoking psychological symptoms. Counseling and related medications were provided under the consult of a psychiatrist.<xref rid="B2" ref-type="bibr">2</xref></p><p>This case shows that the COVID-19 may induce relatively mild symptoms and a patient can recover when early diagnosis of pneumonia was made.<xref rid="B3" ref-type="bibr">3</xref><xref rid="B4" ref-type="bibr">4</xref><xref rid="B5" ref-type="bibr">5</xref> When lopinavir/ritonavir was used, we found reduced viral loads and improved clinical symptoms during the treatment. So lopinavir/ritonavir can be recommended to relatively high-risk groups of COVID-19 pneumonia (elderly patients or patients with underlying diseases) from the early stage. But we need more evidence to prove the clinical efficacy of lopinavir/ritonavir based on well controlled clinical trials.</p><p>The images are published under agreement of the patient.</p><sec sec-type="other1"><title>Ethics statement</title><p>Myongji Hospital Institutional Review Board (IRB) approved this study (No. IRB 2020-01-027) and written informed consent was given by the patient.</p></sec></body><back><ack><title>ACKNOWLEDGMENTS</title><p>We thank to Myongji Hospital staffs for their efforts to cope with COVID-19 and CancerROP Co., Ltd., for providing a test diagnostic kit to measure SARS-CoV-2 virus titers.</p></ack><fn-group><fn fn-type="COI-statement"><p><bold>Disclosure:</bold> The authors have no potential conflicts of interest to disclose.</p></fn><fn fn-type="con"><p><bold>Author Contributions:</bold><list list-type="simple"><list-item><p><bold>Conceptualization:</bold> Lim J.</p></list-item><list-item><p><bold>Data curation:</bold> Kim MJ, Lee B, Shin HY, Seong YM.</p></list-item><list-item><p><bold>Formal analysis:</bold> Jeon S, Kim MJ, Shin HY, Lee B.</p></list-item><list-item><p><bold>Methodology:</bold> Lee B.</p></list-item><list-item><p><bold>Project administration:</bold> Park SJ.</p></list-item><list-item><p><bold>Supervision:</bold> Lee WJ, Choe KW.</p></list-item><list-item><p><bold>Validation:</bold> Lee WJ.</p></list-item><list-item><p><bold>Writing - original draft:</bold> Park SJ.</p></list-item><list-item><p><bold>Writing - review & editing:</bold> Choe KW, Kang YM.</p></list-item></list></p></fn></fn-group><ref-list><ref id="B1"><label>1</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kim</surname><given-names>JY</given-names></name><name><surname>Choe</surname><given-names>PG</given-names></name><name><surname>Oh</surname><given-names>Y</given-names></name><name><surname>Oh</surname><given-names>KJ</given-names></name><name><surname>Kim</surname><given-names>J</given-names></name><name><surname>Park</surname><given-names>SJ</given-names></name><etal></etal></person-group><article-title>The first case of 2019 novel coronavirus pneumonia imported into Korea from Wuhan, China: implication for infection prevention and control measures</article-title><source>J Korean Med Sci</source><year>2020</year><volume>35</volume><issue>5</issue><elocation-id>e61</elocation-id><pub-id pub-id-type="pmid">32030925</pub-id></element-citation></ref><ref id="B2"><label>2</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hamer</surname><given-names>M</given-names></name><name><surname>Kivimaki</surname><given-names>M</given-names></name><name><surname>Stamatakis</surname><given-names>E</given-names></name><name><surname>Batty</surname><given-names>GD</given-names></name></person-group><article-title>Psychological distress and infectious disease mortality in the general population</article-title><source>Brain Behav Immun</source><year>2019</year><volume>76</volume><fpage>280</fpage><lpage>283</lpage><pub-id pub-id-type="pmid">30579940</pub-id></element-citation></ref><ref id="B3"><label>3</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li</surname><given-names>Q</given-names></name><name><surname>Guan</surname><given-names>X</given-names></name><name><surname>Wu</surname><given-names>P</given-names></name><name><surname>Wang</surname><given-names>X</given-names></name><name><surname>Zhou</surname><given-names>L</given-names></name><name><surname>Tong</surname><given-names>Y</given-names></name><etal></etal></person-group><article-title>Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia</article-title><source>N Engl J Med</source><year>2020</year><pub-id pub-id-type="doi">10.1056/NEJMoa2001316</pub-id></element-citation></ref><ref id="B4"><label>4</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rothe</surname><given-names>C</given-names></name><name><surname>Schunk</surname><given-names>M</given-names></name><name><surname>Sothmann</surname><given-names>P</given-names></name><name><surname>Bretzel</surname><given-names>G</given-names></name><name><surname>Froeschl</surname><given-names>G</given-names></name><name><surname>Wallrauch</surname><given-names>C</given-names></name><etal></etal></person-group><article-title>Transmission of 2019-nCoV Infection from an asymptomatic contact in Germany</article-title><source>N Engl J Med</source><year>2020</year><pub-id pub-id-type="doi">10.1056/NEJMc2001468</pub-id></element-citation></ref><ref id="B5"><label>5</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chang</surname><given-names>D</given-names></name><name><surname>Lin</surname><given-names>M</given-names></name><name><surname>Wei</surname><given-names>L</given-names></name><name><surname>Xie</surname><given-names>L</given-names></name><name><surname>Zhu</surname><given-names>G</given-names></name><name><surname>Dela Cruz</surname><given-names>CS</given-names></name><etal></etal></person-group><article-title>Epidemiologic and clinical characteristics of novel coronavirus infections involving 13 patients outside Wuhan, China</article-title><source>JAMA</source><year>2020</year><pub-id pub-id-type="doi">10.1001/jama.2020.1623</pub-id></element-citation></ref></ref-list><sec sec-type="supplementary-material"><title>SUPPLEMENTARY MATERIAL</title><supplementary-material content-type="local-data" id="S1"><caption><title>Supplementary Fig. 1</title><p>Time course quantification of SARS-CoV-2 by real-time RT-PCR. (<bold>A</bold>) Quantitative RT-PCR analysis of beta CoV. (<bold>B</bold>) SARS-CoV-2 in sputum samples collected from the patient. The results showed decline of virus titers with time and no detectable RdRP titer at illness days 12 and 13.</p></caption><media mimetype="application" mime-subtype="ppt" xlink:href="jkms-35-e79-s001.ppt" orientation="portrait" id="d35e624" position="anchor"></media></supplementary-material></sec></back><floats-group><fig id="F1" fig-type="figure" orientation="portrait" position="float"><label>Fig. 1</label><caption><title>Radiologic findings of the patient.</title><p>(<bold>A</bold>) Chest X-ray of illness day 3, hospital day 1. (<bold>B</bold>) Chest X-ray of illness day 9, hospital day 7. (<bold>C</bold>) Chest X-ray of illness day 15, hospital day 13. (<bold>D</bold>) HRCT scan of illness day 9, hospital day 7. (<bold>E</bold>) HRCT scan of illness day 15, hospital day 13.</p><p>AP(P) = Anteroposterior (Portable X-ray), HRCT = high-resolution computed tomography.</p></caption><graphic xlink:href="jkms-35-e79-g001"></graphic></fig><fig id="F2" fig-type="figure" orientation="portrait" position="float"><label>Fig. 2</label><caption><title>Clinical course, treatment and viral load of the patient.</title><p>RdRP = RNA-dependent RNA polymerase, Posi = positive, Nega = negative, UD = undeteced, Ct = cycle threshold.</p></caption><graphic xlink:href="jkms-35-e79-g002"></graphic></fig><table-wrap id="T1" orientation="portrait" position="float"><label>Table 1</label><caption><title>Serial laboratory results of the patient</title></caption><alternatives><graphic xlink:href="jkms-35-e79-i001"></graphic><table frame="hsides" rules="rows"><col width="24.19%" span="1"></col><col width="9.48%" span="1"></col><col width="9.48%" span="1"></col><col width="9.48%" span="1"></col><col width="9.48%" span="1"></col><col width="9.48%" span="1"></col><col width="9.48%" span="1"></col><col width="9.48%" span="1"></col><col width="9.48%" span="1"></col><thead><tr><th valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(211,212,235)">Variables</th><th valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(211,212,235)">Illness day 3 (HD 1)</th><th valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(211,212,235)">Illness day 6 (HD 4)</th><th valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(211,212,235)">Illness day 7 (HD 5)</th><th valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(211,212,235)">Illness day 8 (HD 6)</th><th valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(211,212,235)">Illness day 10 (HD 8)</th><th valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(211,212,235)">Illness day 12 (HD 10)</th><th valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(211,212,235)">Illness day 14 (HD 12)</th><th valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(211,212,235)">Illness day 16 (HD 14)</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">White blood cell count, ×10<sup>3</sup>/µL</td><td valign="top" align="center" rowspan="1" colspan="1">7,200</td><td valign="top" align="center" rowspan="1" colspan="1">5,800</td><td valign="top" align="center" rowspan="1" colspan="1">5,200</td><td valign="top" align="center" rowspan="1" colspan="1">6,700</td><td valign="top" align="center" rowspan="1" colspan="1">6,000</td><td valign="top" align="center" rowspan="1" colspan="1">6,700</td><td valign="top" align="center" rowspan="1" colspan="1">8,600</td><td valign="top" align="center" rowspan="1" colspan="1">9,100</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">Segment neutrophil, %</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">59.0</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">64.2</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">50.3</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">69.3</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">58.8</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">55.5</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">63.1</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">63.0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Lymphocyte, %</td><td valign="top" align="center" rowspan="1" colspan="1">28.5</td><td valign="top" align="center" rowspan="1" colspan="1">24.0</td><td valign="top" align="center" rowspan="1" colspan="1">36.5</td><td valign="top" align="center" rowspan="1" colspan="1">19.1</td><td valign="top" align="center" rowspan="1" colspan="1">30.9</td><td valign="top" align="center" rowspan="1" colspan="1">29.4</td><td valign="top" align="center" rowspan="1" colspan="1">24.4</td><td valign="top" align="center" rowspan="1" colspan="1">24.9</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">Monocyte, %</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">11.5</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">11.0</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">11.6</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">10.7</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">9.2</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">13.5</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">10.9</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">10.2</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Eosinophil, %</td><td valign="top" align="center" rowspan="1" colspan="1">0.6</td><td valign="top" align="center" rowspan="1" colspan="1">0.3</td><td valign="top" align="center" rowspan="1" colspan="1">1.0</td><td valign="top" align="center" rowspan="1" colspan="1">0.6</td><td valign="top" align="center" rowspan="1" colspan="1">0.8</td><td valign="top" align="center" rowspan="1" colspan="1">1.3</td><td valign="top" align="center" rowspan="1" colspan="1">1.3</td><td valign="top" align="center" rowspan="1" colspan="1">1.5</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">Hemoglobin, g/dL</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">16.3</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">15.4</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">16.1</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">15.3</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">15.2</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">14.9</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">14.2</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">13.9</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Platelets, ×10<sup>3</sup>/µL</td><td valign="top" align="center" rowspan="1" colspan="1">301</td><td valign="top" align="center" rowspan="1" colspan="1">176</td><td valign="top" align="center" rowspan="1" colspan="1">212</td><td valign="top" align="center" rowspan="1" colspan="1">225</td><td valign="top" align="center" rowspan="1" colspan="1">229</td><td valign="top" align="center" rowspan="1" colspan="1">287</td><td valign="top" align="center" rowspan="1" colspan="1">358</td><td valign="top" align="center" rowspan="1" colspan="1">507</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">Glucose, mg/dL</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">97</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">114</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">-</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">-</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">-</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">-</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">-</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">103</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">BUN, mg/dL</td><td valign="top" align="center" rowspan="1" colspan="1">13.0</td><td valign="top" align="center" rowspan="1" colspan="1">7.0</td><td valign="top" align="center" rowspan="1" colspan="1">10.1</td><td valign="top" align="center" rowspan="1" colspan="1">9.1</td><td valign="top" align="center" rowspan="1" colspan="1">9.6</td><td valign="top" align="center" rowspan="1" colspan="1">7.9</td><td valign="top" align="center" rowspan="1" colspan="1">6.3</td><td valign="top" align="center" rowspan="1" colspan="1">8.1</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">Creatinine, mg/dL</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">1.0</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">0.8</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">1.2</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">0.8</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">1.0</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">0.8</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">0.8</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">0.9</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Total bilirubin, mg/dL</td><td valign="top" align="center" rowspan="1" colspan="1">0.50</td><td valign="top" align="center" rowspan="1" colspan="1">0.47</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">0.35</td><td valign="top" align="center" rowspan="1" colspan="1">0.61</td><td valign="top" align="center" rowspan="1" colspan="1">0.74</td><td valign="top" align="center" rowspan="1" colspan="1">0.85</td><td valign="top" align="center" rowspan="1" colspan="1">1.09</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">AST, U/L</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">27</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">31</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">-</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">22</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">127</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">54</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">19</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">17</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">ALT, U/L</td><td valign="top" align="center" rowspan="1" colspan="1">29</td><td valign="top" align="center" rowspan="1" colspan="1">37</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">29</td><td valign="top" align="center" rowspan="1" colspan="1">106</td><td valign="top" align="center" rowspan="1" colspan="1">83</td><td valign="top" align="center" rowspan="1" colspan="1">45</td><td valign="top" align="center" rowspan="1" colspan="1">30</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">Uric acid, mg/dL</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">8.6</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">7.0</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">-</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">-</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">-</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">-</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">-</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">-</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">CK, U/L</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">43</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">31</td><td valign="top" align="center" rowspan="1" colspan="1">30</td><td valign="top" align="center" rowspan="1" colspan="1">28</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">ALP, U/L</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">-</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">62</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">-</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">-</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">-</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">140</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">113</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">95</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">LDH, U/L</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">332</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">351</td><td valign="top" align="center" rowspan="1" colspan="1">329</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">Sodium, mmol/L</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">138</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">135</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">138</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">137</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">138</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">138</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">138</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">139</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Potassium, mmol/L</td><td valign="top" align="center" rowspan="1" colspan="1">4.3</td><td valign="top" align="center" rowspan="1" colspan="1">4.1</td><td valign="top" align="center" rowspan="1" colspan="1">4.8</td><td valign="top" align="center" rowspan="1" colspan="1">4.2</td><td valign="top" align="center" rowspan="1" colspan="1">4.2</td><td valign="top" align="center" rowspan="1" colspan="1">4.3</td><td valign="top" align="center" rowspan="1" colspan="1">4.2</td><td valign="top" align="center" rowspan="1" colspan="1">4.3</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">Chloride, mmol/L</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">104</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">104</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">105</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">104</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">102</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">103</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">103</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">103</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Total protein, g/dL</td><td valign="top" align="center" rowspan="1" colspan="1">7.4</td><td valign="top" align="center" rowspan="1" colspan="1">6.4</td><td valign="top" align="center" rowspan="1" colspan="1">6.8</td><td valign="top" align="center" rowspan="1" colspan="1">6.3</td><td valign="top" align="center" rowspan="1" colspan="1">6.3</td><td valign="top" align="center" rowspan="1" colspan="1">6.4</td><td valign="top" align="center" rowspan="1" colspan="1">6.3</td><td valign="top" align="center" rowspan="1" colspan="1">6.5</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">Albumin, g/dL</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">4.5</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">3.9</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">4.1</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">3.8</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">3.8</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">3.8</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">3.7</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">3.7</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">ESR, mm/hr</td><td valign="top" align="center" rowspan="1" colspan="1">26</td><td valign="top" align="center" rowspan="1" colspan="1">27</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">66</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">82</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">CRP, mg/dL</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">0.43</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">1.23</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">-</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">4.51</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">10.94</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">9.11</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">11.20</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">3.60</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Pro-Calcitonin, ng/mL</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">0.06</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">-</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">PT, sec</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">12.5</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">12.9</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">-</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">-</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">13.2</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">13.1</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">13.6</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">13.6</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">PT INR</td><td valign="top" align="center" rowspan="1" colspan="1">0.96</td><td valign="top" align="center" rowspan="1" colspan="1">1.00</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">1.03</td><td valign="top" align="center" rowspan="1" colspan="1">1.02</td><td valign="top" align="center" rowspan="1" colspan="1">1.07</td><td valign="top" align="center" rowspan="1" colspan="1">1.07</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">aPTT, sec</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">40.4</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">38.5</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">-</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">-</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">38.8</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">38.0</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">40.1</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">40.7</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">D-dimer, µg/mL (FEU)</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">0.28</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">-</td><td valign="top" align="center" rowspan="1" colspan="1">1.22</td><td valign="top" align="center" rowspan="1" colspan="1">-</td></tr></tbody></table></alternatives><table-wrap-foot><p>HD = hospital day, AST = aspartate aminotransferase, ALT = alanine aminotransferase, CK = creatine kinase, ALP = alkaline phosphatase, LDH = lactate dehydrogenase, ESR = erythrocyte sedimentation rate, CRP = C-reactive protein, PT = prothrombin time, INR = international normalized ratio, aPTT = activated partial thromboplastin time, FEU = fibrinogen equivalent units.</p></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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