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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Positional cloning of the <italic>Igl</italic> genes controlling rheumatoid factor production and allergic bronchitis in rats</title><author><name sortKey="Rintisch, Carola" sort="Rintisch, Carola" uniqKey="Rintisch C" first="Carola" last="Rintisch">Carola Rintisch</name><affiliation><nlm:aff id="aff1">*Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden;</nlm:aff></affiliation></author><author><name sortKey="Ameri, Jacqueline" sort="Ameri, Jacqueline" uniqKey="Ameri J" first="Jacqueline" last="Ameri">Jacqueline Ameri</name><affiliation><nlm:aff id="aff2">Stem Cell Center, Lund University, 22184 Lund, Sweden;</nlm:aff></affiliation></author><author><name sortKey="Olofsson, Peter" sort="Olofsson, Peter" uniqKey="Olofsson P" first="Peter" last="Olofsson">Peter Olofsson</name><affiliation><nlm:aff wicri:cut="; and" id="aff3">Redoxis, Arvid Wallgrens backe 20, SE-413 46 Göteborg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Luthman, Holger" sort="Luthman, Holger" uniqKey="Luthman H" first="Holger" last="Luthman">Holger Luthman</name><affiliation><nlm:aff id="aff4">Medical Genetics Unit, Lund University, 20502 Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Holmdahl, Rikard" sort="Holmdahl, Rikard" uniqKey="Holmdahl R" first="Rikard" last="Holmdahl">Rikard Holmdahl</name><affiliation><nlm:aff id="aff1">*Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden;</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18779593</idno><idno type="pmc">2544569</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2544569</idno><idno type="RBID">PMC:2544569</idno><idno type="doi">10.1073/pnas.0803956105</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">000469</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000469</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Positional cloning of the <italic>Igl</italic> genes controlling rheumatoid factor production and allergic bronchitis in rats</title><author><name sortKey="Rintisch, Carola" sort="Rintisch, Carola" uniqKey="Rintisch C" first="Carola" last="Rintisch">Carola Rintisch</name><affiliation><nlm:aff id="aff1">*Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden;</nlm:aff></affiliation></author><author><name sortKey="Ameri, Jacqueline" sort="Ameri, Jacqueline" uniqKey="Ameri J" first="Jacqueline" last="Ameri">Jacqueline Ameri</name><affiliation><nlm:aff id="aff2">Stem Cell Center, Lund University, 22184 Lund, Sweden;</nlm:aff></affiliation></author><author><name sortKey="Olofsson, Peter" sort="Olofsson, Peter" uniqKey="Olofsson P" first="Peter" last="Olofsson">Peter Olofsson</name><affiliation><nlm:aff wicri:cut="; and" id="aff3">Redoxis, Arvid Wallgrens backe 20, SE-413 46 Göteborg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Luthman, Holger" sort="Luthman, Holger" uniqKey="Luthman H" first="Holger" last="Luthman">Holger Luthman</name><affiliation><nlm:aff id="aff4">Medical Genetics Unit, Lund University, 20502 Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Holmdahl, Rikard" sort="Holmdahl, Rikard" uniqKey="Holmdahl R" first="Rikard" last="Holmdahl">Rikard Holmdahl</name><affiliation><nlm:aff id="aff1">*Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden;</nlm:aff></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Rheumatoid factors (RF), autoantibodies that bind the Fc region of IgG, are one of the major diagnostic marker in rheumatoid arthritis (RA) but occur with lower frequency also in other infectious and inflammatory conditions. Through positional cloning of the previously described quantitative trait locus (QTL) <italic>Rf1</italic> in congenic and advanced intercrossed rats, we identified the Ig lambda light chain locus as a locus that regulates the production of RF in rats. The congenic rats produce RF-Igλ and have significant higher levels of RF-IgG and RF-IgM in serum, while the DA rat has an impaired RF production and does not produces RF-Igλ. Thus, we could investigate the role of RF in pristane-induced arthritis (PIA) as well as ovalbumin-induced airway inflammation. We show that there was no difference in the development and severity of PIA between congenic and parental DA rats, suggesting that RF using lambda light chains have no impact on PIA. However, the RF producing congenic rats developed a more severe airway inflammation as indicated in the significantly increased number of eosinophils in bronchoalveolar lavage fluid as well as total IgE in serum. In addition, RF congenic rats had a significantly enhanced immune response toward OVA due to increased OVA-Igk but not OVA-Igl antibodies, suggesting a possible involvement of RF in the regulation of the humoral immune response.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Proc Natl Acad Sci U S A</journal-id><journal-id journal-id-type="hwp">pnas</journal-id><journal-id journal-id-type="pmc">pnas</journal-id><journal-id journal-id-type="publisher-id">PNAS</journal-id><journal-title-group><journal-title>Proceedings of the National Academy of Sciences of the United States of America</journal-title></journal-title-group><issn pub-type="ppub">0027-8424</issn><issn pub-type="epub">1091-6490</issn><publisher><publisher-name>National Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">18779593</article-id><article-id pub-id-type="pmc">2544569</article-id><article-id pub-id-type="publisher-id">4637</article-id><article-id pub-id-type="doi">10.1073/pnas.0803956105</article-id><article-categories><subj-group subj-group-type="heading"><subject>Biological Sciences</subject><subj-group><subject>Genetics</subject></subj-group></subj-group></article-categories><title-group><article-title>Positional cloning of the <italic>Igl</italic> genes controlling rheumatoid factor production and allergic bronchitis in rats</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Rintisch</surname><given-names>Carola</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Ameri</surname><given-names>Jacqueline</given-names></name><xref ref-type="aff" rid="aff2"><sup>†</sup></xref></contrib><contrib contrib-type="author"><name><surname>Olofsson</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="aff3"><sup>‡</sup></xref></contrib><contrib contrib-type="author"><name><surname>Luthman</surname><given-names>Holger</given-names></name><xref ref-type="aff" rid="aff4"><sup>§</sup></xref></contrib><contrib contrib-type="author"><name><surname>Holmdahl</surname><given-names>Rikard</given-names></name><xref ref-type="aff" rid="aff1">*</xref><xref ref-type="corresp" rid="cor1"><sup>¶</sup></xref></contrib><aff id="aff1">*Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden;</aff><aff id="aff2"><sup>†</sup>Stem Cell Center, Lund University, 22184 Lund, Sweden;</aff><aff id="aff3"><sup>‡</sup>Redoxis, Arvid Wallgrens backe 20, SE-413 46 Göteborg, Sweden; and</aff><aff id="aff4"><sup>§</sup>Medical Genetics Unit, Lund University, 20502 Malmö, Sweden</aff></contrib-group><author-notes><corresp id="cor1"><sup>¶</sup>To whom correspondence should be addressed. E-mail: <email>Rikard.Holmdahl@ki.se</email></corresp><fn fn-type="edited-by"><p>Edited by N. Avrion Mitchison, University College London Medical School, London, United Kingdom, and approved July 14, 2008</p></fn><fn fn-type="con"><p>Author contributions: C.R. and R.H. designed research; C.R. and J.A. performed research; P.O. and H.L. contributed new reagents/analytic tools; C.R. analyzed data; and C.R. and R.H. wrote the paper.</p></fn><fn fn-type="conflict"><p>The authors declare no conflict of interest.</p></fn></author-notes><pub-date pub-type="ppub"><day>16</day><month>9</month><year>2008</year></pub-date><pub-date pub-type="epub"><day>8</day><month>9</month><year>2008</year></pub-date><volume>105</volume><issue>37</issue><fpage>14005</fpage><lpage>14010</lpage><history><date date-type="received"><day>24</day><month>4</month><year>2008</year></date></history><permissions><copyright-statement>© 2008 by The National Academy of Sciences of the USA</copyright-statement></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zpq03708014005.pdf"></self-uri><abstract><p>Rheumatoid factors (RF), autoantibodies that bind the Fc region of IgG, are one of the major diagnostic marker in rheumatoid arthritis (RA) but occur with lower frequency also in other infectious and inflammatory conditions. Through positional cloning of the previously described quantitative trait locus (QTL) <italic>Rf1</italic> in congenic and advanced intercrossed rats, we identified the Ig lambda light chain locus as a locus that regulates the production of RF in rats. The congenic rats produce RF-Igλ and have significant higher levels of RF-IgG and RF-IgM in serum, while the DA rat has an impaired RF production and does not produces RF-Igλ. Thus, we could investigate the role of RF in pristane-induced arthritis (PIA) as well as ovalbumin-induced airway inflammation. We show that there was no difference in the development and severity of PIA between congenic and parental DA rats, suggesting that RF using lambda light chains have no impact on PIA. However, the RF producing congenic rats developed a more severe airway inflammation as indicated in the significantly increased number of eosinophils in bronchoalveolar lavage fluid as well as total IgE in serum. In addition, RF congenic rats had a significantly enhanced immune response toward OVA due to increased OVA-Igk but not OVA-Igl antibodies, suggesting a possible involvement of RF in the regulation of the humoral immune response.</p></abstract><kwd-group><kwd>OVA-induced airway inflammation</kwd><kwd>quantitative trait locus</kwd><kwd>rheumatoid arthritis</kwd><kwd>congenic animals</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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