Association of Seropositivity for Influenza and Coronaviruses with History of Mood Disorders and Suicide Attempts
Identifieur interne : 000375 ( Pmc/Corpus ); précédent : 000374; suivant : 000376Association of Seropositivity for Influenza and Coronaviruses with History of Mood Disorders and Suicide Attempts
Auteurs : Olaoluwa Okusaga ; Robert H. Yolken ; Patricia Langenberg ; Manana Lapidus ; Timothy A. Arling ; Faith B. Dickerson ; Debra A. Scrandis ; Emily Severance ; Johanna A. Cabassa ; Theodora Balis ; Teodor T. PostolacheSource :
- Journal of affective disorders [ 0165-0327 ] ; 2010.
Abstract
Anecdotal reports of mood disorder following infection with common respiratory viruses with neurotropic potential have been in existence since the last century. Nevertheless, systematic studies on the association between these viruses and mood disorders are lacking.
Influenza A, B and coronavirus antibody titers were measured in 257 subjects with recurrent unipolar and bipolar disorder and healthy controls, by SCID. Pearson’s χ2 tests and logistic regression models were used to analyze associations between seropositivity for coronaviruses, influenza A and B viruses and the following: a) history of recurrent mood disorders b) having attempted suicide in the past c) uni- vs. bi-polarity and d) presence of psychotic features during mood episodes.
Seropositivity for influenza A (p=0.004), B (p<0.0001) and coronaviruses (p<0.0001) were associated with history of mood disorders but not with the specific diagnosis of unipolar or bipolar depression. Seropositivity for influenza B was significantly associated with a history of suicide attempt (p =0.001) and history of psychotic features (p =0.005).
The design was cross-sectional Socioeconomic factors, inflammatory markers, and axis II psychopathology were not assessed.
The association of seropositivity for influenza and coronaviruses with a history of mood disorders, and influenza B with suicidal behavior require replication in larger longitudinal samples. The need for these studies is additionally supported by the high incidence of these viral infections, the high prevalence of mood disorders, and resilience of suicide epidemics.
Url:
DOI: 10.1016/j.jad.2010.09.029
PubMed: 21030090
PubMed Central: 3043161
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PMC:3043161Le document en format XML
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Yolken</name><affiliation><nlm:aff id="A3"> Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD USA</nlm:aff></affiliation></author><author><name sortKey="Langenberg, Patricia" sort="Langenberg, Patricia" uniqKey="Langenberg P" first="Patricia" last="Langenberg">Patricia Langenberg</name><affiliation><nlm:aff id="A4"> Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Lapidus, Manana" sort="Lapidus, Manana" uniqKey="Lapidus M" first="Manana" last="Lapidus">Manana Lapidus</name><affiliation><nlm:aff id="A1"> Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD USA</nlm:aff></affiliation></author><author><name sortKey="Arling, Timothy A" sort="Arling, Timothy A" uniqKey="Arling T" first="Timothy A." last="Arling">Timothy A. Arling</name><affiliation><nlm:aff id="A1"> Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD USA</nlm:aff></affiliation></author><author><name sortKey="Dickerson, Faith B" sort="Dickerson, Faith B" uniqKey="Dickerson F" first="Faith B." last="Dickerson">Faith B. Dickerson</name><affiliation><nlm:aff id="A5"> Stanley Research Center, Sheppard Pratt Health System, Baltimore, MD USA</nlm:aff></affiliation></author><author><name sortKey="Scrandis, Debra A" sort="Scrandis, Debra A" uniqKey="Scrandis D" first="Debra A." last="Scrandis">Debra A. Scrandis</name><affiliation><nlm:aff id="A6"> Department of Family and Community Health, University of Maryland School of Nursing, Baltimore, MD USA</nlm:aff></affiliation></author><author><name sortKey="Severance, Emily" sort="Severance, Emily" uniqKey="Severance E" first="Emily" last="Severance">Emily Severance</name><affiliation><nlm:aff id="A3"> Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD USA</nlm:aff></affiliation></author><author><name sortKey="Cabassa, Johanna A" sort="Cabassa, Johanna A" uniqKey="Cabassa J" first="Johanna A." last="Cabassa">Johanna A. Cabassa</name><affiliation><nlm:aff id="A1"> Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD USA</nlm:aff></affiliation></author><author><name sortKey="Balis, Theodora" sort="Balis, Theodora" uniqKey="Balis T" first="Theodora" last="Balis">Theodora Balis</name><affiliation><nlm:aff id="A1"> Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD USA</nlm:aff></affiliation></author><author><name sortKey="Postolache, Teodor T" sort="Postolache, Teodor T" uniqKey="Postolache T" first="Teodor T." last="Postolache">Teodor T. Postolache</name><affiliation><nlm:aff id="A1"> Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> St. Elizabeth’s Hospital, Psychiatry Residency Training Program, Washington, DC, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21030090</idno><idno type="pmc">3043161</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043161</idno><idno type="RBID">PMC:3043161</idno><idno type="doi">10.1016/j.jad.2010.09.029</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000375</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000375</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association of Seropositivity for Influenza and Coronaviruses with History of Mood Disorders and Suicide Attempts</title><author><name sortKey="Okusaga, Olaoluwa" sort="Okusaga, Olaoluwa" uniqKey="Okusaga O" first="Olaoluwa" last="Okusaga">Olaoluwa Okusaga</name><affiliation><nlm:aff id="A1"> Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> St. Elizabeth’s Hospital, Psychiatry Residency Training Program, Washington, DC, USA</nlm:aff></affiliation></author><author><name sortKey="Yolken, Robert H" sort="Yolken, Robert H" uniqKey="Yolken R" first="Robert H." last="Yolken">Robert H. Yolken</name><affiliation><nlm:aff id="A3"> Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD USA</nlm:aff></affiliation></author><author><name sortKey="Langenberg, Patricia" sort="Langenberg, Patricia" uniqKey="Langenberg P" first="Patricia" last="Langenberg">Patricia Langenberg</name><affiliation><nlm:aff id="A4"> Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Lapidus, Manana" sort="Lapidus, Manana" uniqKey="Lapidus M" first="Manana" last="Lapidus">Manana Lapidus</name><affiliation><nlm:aff id="A1"> Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD USA</nlm:aff></affiliation></author><author><name sortKey="Arling, Timothy A" sort="Arling, Timothy A" uniqKey="Arling T" first="Timothy A." last="Arling">Timothy A. Arling</name><affiliation><nlm:aff id="A1"> Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD USA</nlm:aff></affiliation></author><author><name sortKey="Dickerson, Faith B" sort="Dickerson, Faith B" uniqKey="Dickerson F" first="Faith B." last="Dickerson">Faith B. Dickerson</name><affiliation><nlm:aff id="A5"> Stanley Research Center, Sheppard Pratt Health System, Baltimore, MD USA</nlm:aff></affiliation></author><author><name sortKey="Scrandis, Debra A" sort="Scrandis, Debra A" uniqKey="Scrandis D" first="Debra A." last="Scrandis">Debra A. Scrandis</name><affiliation><nlm:aff id="A6"> Department of Family and Community Health, University of Maryland School of Nursing, Baltimore, MD USA</nlm:aff></affiliation></author><author><name sortKey="Severance, Emily" sort="Severance, Emily" uniqKey="Severance E" first="Emily" last="Severance">Emily Severance</name><affiliation><nlm:aff id="A3"> Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD USA</nlm:aff></affiliation></author><author><name sortKey="Cabassa, Johanna A" sort="Cabassa, Johanna A" uniqKey="Cabassa J" first="Johanna A." last="Cabassa">Johanna A. Cabassa</name><affiliation><nlm:aff id="A1"> Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD USA</nlm:aff></affiliation></author><author><name sortKey="Balis, Theodora" sort="Balis, Theodora" uniqKey="Balis T" first="Theodora" last="Balis">Theodora Balis</name><affiliation><nlm:aff id="A1"> Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD USA</nlm:aff></affiliation></author><author><name sortKey="Postolache, Teodor T" sort="Postolache, Teodor T" uniqKey="Postolache T" first="Teodor T." last="Postolache">Teodor T. Postolache</name><affiliation><nlm:aff id="A1"> Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> St. Elizabeth’s Hospital, Psychiatry Residency Training Program, Washington, DC, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of affective disorders</title><idno type="ISSN">0165-0327</idno><idno type="eISSN">1573-2517</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Anecdotal reports of mood disorder following infection with common respiratory viruses with neurotropic potential have been in existence since the last century. Nevertheless, systematic studies on the association between these viruses and mood disorders are lacking.</p></sec><sec sec-type="methods" id="S2"><title>Methods</title><p id="P2">Influenza A, B and coronavirus antibody titers were measured in 257 subjects with recurrent unipolar and bipolar disorder and healthy controls, by SCID. Pearson’s χ<sup>2</sup> tests and logistic regression models were used to analyze associations between seropositivity for coronaviruses, influenza A and B viruses and the following: a) history of recurrent mood disorders b) having attempted suicide in the past c) uni- vs. bi-polarity and d) presence of psychotic features during mood episodes.</p></sec><sec id="S3"><title>Results</title><p id="P3">Seropositivity for influenza A (p=0.004), B (p<0.0001) and coronaviruses (p<0.0001) were associated with history of mood disorders but not with the specific diagnosis of unipolar or bipolar depression. Seropositivity for influenza B was significantly associated with a history of suicide attempt (p =0.001) and history of psychotic features (p =0.005).</p></sec><sec id="S4"><title>Limitations</title><p id="P4">The design was cross-sectional Socioeconomic factors, inflammatory markers, and axis II psychopathology were not assessed.</p></sec><sec id="S5"><title>Conclusions</title><p id="P5">The association of seropositivity for influenza and coronaviruses with a history of mood disorders, and influenza B with suicidal behavior require replication in larger longitudinal samples. The need for these studies is additionally supported by the high incidence of these viral infections, the high prevalence of mood disorders, and resilience of suicide epidemics.</p></sec></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7906073</journal-id><journal-id journal-id-type="pubmed-jr-id">4424</journal-id><journal-id journal-id-type="nlm-ta">J Affect Disord</journal-id><journal-title>Journal of affective disorders</journal-title><issn pub-type="ppub">0165-0327</issn><issn pub-type="epub">1573-2517</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21030090</article-id><article-id pub-id-type="pmc">3043161</article-id><article-id pub-id-type="doi">10.1016/j.jad.2010.09.029</article-id><article-id pub-id-type="manuscript">NIHMS243538</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Association of Seropositivity for Influenza and Coronaviruses with History of Mood Disorders and Suicide Attempts</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Okusaga</surname><given-names>Olaoluwa</given-names></name><degrees>MD</degrees><xref rid="A1" ref-type="aff">1</xref><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Yolken</surname><given-names>Robert H.</given-names></name><degrees>MD</degrees><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Langenberg</surname><given-names>Patricia</given-names></name><degrees>PhD</degrees><xref rid="A4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>Lapidus</surname><given-names>Manana</given-names></name><degrees>MD</degrees><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Arling</surname><given-names>Timothy A.</given-names></name><degrees>BA</degrees><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Dickerson</surname><given-names>Faith B.</given-names></name><degrees>PhD</degrees><xref rid="A5" ref-type="aff">5</xref></contrib><contrib contrib-type="author"><name><surname>Scrandis</surname><given-names>Debra A.</given-names></name><degrees>PhD</degrees><xref rid="A6" ref-type="aff">6</xref></contrib><contrib contrib-type="author"><name><surname>Severance</surname><given-names>Emily</given-names></name><degrees>PhD</degrees><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Cabassa</surname><given-names>Johanna A.</given-names></name><degrees>MD</degrees><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Balis</surname><given-names>Theodora</given-names></name><degrees>MD</degrees><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Postolache</surname><given-names>Teodor T.</given-names></name><degrees>MD</degrees><xref rid="A1" ref-type="aff">1</xref><xref rid="A2" ref-type="aff">2</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib></contrib-group><aff id="A1"><label>1</label> Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD USA</aff><aff id="A2"><label>2</label> St. Elizabeth’s Hospital, Psychiatry Residency Training Program, Washington, DC, USA</aff><aff id="A3"><label>3</label> Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD USA</aff><aff id="A4"><label>4</label> Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD, USA</aff><aff id="A5"><label>5</label> Stanley Research Center, Sheppard Pratt Health System, Baltimore, MD USA</aff><aff id="A6"><label>6</label> Department of Family and Community Health, University of Maryland School of Nursing, Baltimore, MD USA</aff><author-notes><corresp id="FN1"><label>*</label>Correspondence: Teodor T Postolache, MD, Mood and Anxiety Program (MAP), Department of Psychiatry, University of Maryland School of Medicine, 685 West Baltimore Street, MSTF Building Room 930, Baltimore, MD 21201 USA. Tel: 410-706-2323; <email>tpostolache@psych.umaryland.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>9</day><month>11</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>27</day><month>10</month><year>2010</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>4</month><year>2012</year></pub-date><volume>130</volume><issue>1-2</issue><fpage>220</fpage><lpage>225</lpage><abstract><sec id="S1"><title>Background</title><p id="P1">Anecdotal reports of mood disorder following infection with common respiratory viruses with neurotropic potential have been in existence since the last century. Nevertheless, systematic studies on the association between these viruses and mood disorders are lacking.</p></sec><sec sec-type="methods" id="S2"><title>Methods</title><p id="P2">Influenza A, B and coronavirus antibody titers were measured in 257 subjects with recurrent unipolar and bipolar disorder and healthy controls, by SCID. Pearson’s χ<sup>2</sup> tests and logistic regression models were used to analyze associations between seropositivity for coronaviruses, influenza A and B viruses and the following: a) history of recurrent mood disorders b) having attempted suicide in the past c) uni- vs. bi-polarity and d) presence of psychotic features during mood episodes.</p></sec><sec id="S3"><title>Results</title><p id="P3">Seropositivity for influenza A (p=0.004), B (p<0.0001) and coronaviruses (p<0.0001) were associated with history of mood disorders but not with the specific diagnosis of unipolar or bipolar depression. Seropositivity for influenza B was significantly associated with a history of suicide attempt (p =0.001) and history of psychotic features (p =0.005).</p></sec><sec id="S4"><title>Limitations</title><p id="P4">The design was cross-sectional Socioeconomic factors, inflammatory markers, and axis II psychopathology were not assessed.</p></sec><sec id="S5"><title>Conclusions</title><p id="P5">The association of seropositivity for influenza and coronaviruses with a history of mood disorders, and influenza B with suicidal behavior require replication in larger longitudinal samples. The need for these studies is additionally supported by the high incidence of these viral infections, the high prevalence of mood disorders, and resilience of suicide epidemics.</p></sec></abstract><kwd-group><kwd>mood disorders</kwd><kwd>suicide attempts</kwd><kwd>influenza A and B</kwd><kwd>coronaviruses</kwd></kwd-group><contract-num rid="MH1">R21 MH075891-01A1
||MH</contract-num><contract-num rid="MH1">R01 MH074891-01A2
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