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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Autoimmune disease triggered by infection with alphaproteobacteria</title><author><name sortKey="Mohammed, Javid P" sort="Mohammed, Javid P" uniqKey="Mohammed J" first="Javid P" last="Mohammed">Javid P. Mohammed</name></author><author><name sortKey="Mattner, Jochen" sort="Mattner, Jochen" uniqKey="Mattner J" first="Jochen" last="Mattner">Jochen Mattner</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20161124</idno><idno type="pmc">2742979</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742979</idno><idno type="RBID">PMC:2742979</idno><idno type="doi">10.1586/ECI.09.23</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000371</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000371</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Autoimmune disease triggered by infection with alphaproteobacteria</title><author><name sortKey="Mohammed, Javid P" sort="Mohammed, Javid P" uniqKey="Mohammed J" first="Javid P" last="Mohammed">Javid P. Mohammed</name></author><author><name sortKey="Mattner, Jochen" sort="Mattner, Jochen" uniqKey="Mattner J" first="Jochen" last="Mattner">Jochen Mattner</name></author></analytic><series><title level="j">Expert review of clinical immunology</title><idno type="ISSN">1744-666X</idno><idno type="eISSN">1744-8409</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Despite having long been postulated, compelling evidence for the theory that microbial triggers drive autoimmunity has only recently been reported. A specific association between <italic>Novosphingobium aromaticivorans</italic>, an ubiquitous alphaproteobacterium, and primary biliary cirrhosis (PBC) has been uncovered in patients with PBC. Notably, the association between <italic>Novosphingobium</italic> infection and PBC has been confirmed in a mouse model in which infection leads to the development of liver lesions resembling PBC concomitant with the production of anti-PDC-E2 antibodies that cross-react with conserved PDC-E2 epitopes shared by <italic>Novosphingobium</italic>. The discovery of infectious triggers of autoimmunity is likely to change our current concepts about the etiology of various autoimmune syndromes and may suggest new and simpler ways to diagnose and treat these debilitating diseases.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101271248</journal-id><journal-id journal-id-type="pubmed-jr-id">36076</journal-id><journal-id journal-id-type="nlm-ta">Expert Rev Clin Immunol</journal-id><journal-title>Expert review of clinical immunology</journal-title><issn pub-type="ppub">1744-666X</issn><issn pub-type="epub">1744-8409</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20161124</article-id><article-id pub-id-type="pmc">2742979</article-id><article-id pub-id-type="doi">10.1586/ECI.09.23</article-id><article-id pub-id-type="manuscript">NIHMS139342</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Autoimmune disease triggered by infection with alphaproteobacteria</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Mohammed</surname><given-names>Javid P</given-names></name><aff id="A1">Division of Immunobiology, Cincinnati Children’s Hospital, Cincinnati, OH 45229, USA</aff></contrib><contrib contrib-type="author"><name><surname>Mattner</surname><given-names>Jochen</given-names></name><xref ref-type="corresp" rid="cor1">†</xref><aff id="A2">Division of Immunobiology, Cincinnati Children’s Hospital, Cincinnati, OH 45229, USA Tel.: +1 513 803 0768, Fax: +1 513 636 5355,<email>jochen.mattner@cchmc.org</email></aff></contrib></contrib-group><author-notes><corresp id="cor1"><label>†</label>Author for correspondence Division of Immunobiology, Cincinnati Children’s Hospital, Cincinnati, OH 45229, USA Tel.: +1 513 803 0768, Fax: +1 513 636 5355, <email>jochen.mattner@cchmc.org</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>20</day><month>8</month><year>2009</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>7</month><year>2009</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>5</month><year>2010</year></pub-date><volume>5</volume><issue>4</issue><fpage>369</fpage><lpage>379</lpage><permissions><copyright-statement>© 2009 Expert Reviews Ltd</copyright-statement><copyright-year>2009</copyright-year></permissions><abstract><p id="P1">Despite having long been postulated, compelling evidence for the theory that microbial triggers drive autoimmunity has only recently been reported. A specific association between <italic>Novosphingobium aromaticivorans</italic>, an ubiquitous alphaproteobacterium, and primary biliary cirrhosis (PBC) has been uncovered in patients with PBC. Notably, the association between <italic>Novosphingobium</italic> infection and PBC has been confirmed in a mouse model in which infection leads to the development of liver lesions resembling PBC concomitant with the production of anti-PDC-E2 antibodies that cross-react with conserved PDC-E2 epitopes shared by <italic>Novosphingobium</italic>. The discovery of infectious triggers of autoimmunity is likely to change our current concepts about the etiology of various autoimmune syndromes and may suggest new and simpler ways to diagnose and treat these debilitating diseases.</p></abstract><kwd-group><kwd>alphaproteobacteria</kwd><kwd>antibiotics</kwd><kwd>autoimmunity</kwd><kwd>E2 subunit of the pyruvate dehydrogenase complex</kwd><kwd>mitochondrial enzymes</kwd><kwd>molecular mimicry</kwd><kwd><italic>Novosphingobium spp.</italic></kwd><kwd>primary biliary cirrhosis</kwd></kwd-group><contract-num rid="DK1">R01 DK084054-01
||DK</contract-num><contract-sponsor id="DK1">National Institute of Diabetes and Digestive and Kidney Diseases : NIDDK</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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