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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Use of humanized severe combined immunodeficient mice for human vaccine development</title><author><name sortKey="Koo, Gloria C" sort="Koo, Gloria C" uniqKey="Koo G" first="Gloria C" last="Koo">Gloria C. Koo</name></author><author><name sortKey="Hasan, Aisha" sort="Hasan, Aisha" uniqKey="Hasan A" first="Aisha" last="Hasan">Aisha Hasan</name></author><author><name sortKey="O Eilly, Richard J" sort="O Eilly, Richard J" uniqKey="O Eilly R" first="Richard J" last="O Eilly">Richard J. O Eilly</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19093778</idno><idno type="pmc">2677709</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677709</idno><idno type="RBID">PMC:2677709</idno><idno type="doi">10.1586/14760584.8.1.113</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000370</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000370</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Use of humanized severe combined immunodeficient mice for human vaccine development</title><author><name sortKey="Koo, Gloria C" sort="Koo, Gloria C" uniqKey="Koo G" first="Gloria C" last="Koo">Gloria C. Koo</name></author><author><name sortKey="Hasan, Aisha" sort="Hasan, Aisha" uniqKey="Hasan A" first="Aisha" last="Hasan">Aisha Hasan</name></author><author><name sortKey="O Eilly, Richard J" sort="O Eilly, Richard J" uniqKey="O Eilly R" first="Richard J" last="O Eilly">Richard J. O Eilly</name></author></analytic><series><title level="j">Expert review of vaccines</title><idno type="ISSN">1476-0584</idno><idno type="eISSN">1744-8395</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The severe combined immunodeficient (SCID) mouse has no adaptive immunity, lacking mature T and B cells in the peripheral blood or the lymphoid organs. It has been used extensively in biomedical research as a valuable translational model for xeno-engraftment of human tissues and cells. This review focuses on the engraftment of human peripheral blood cells and tissues in SCID mice, as well as in the newly established and more permissive SCID mice deficient in the IL-2 receptor γ-chain. Human immune responses could be elicited and assessed in these humanized SCID mice upon vaccination or sensitization with allogeneic tissues. A translational model is proposed to attain preclinical data for testing human vaccines.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101155475</journal-id><journal-id journal-id-type="pubmed-jr-id">30416</journal-id><journal-id journal-id-type="nlm-ta">Expert Rev Vaccines</journal-id><journal-title>Expert review of vaccines</journal-title><issn pub-type="ppub">1476-0584</issn><issn pub-type="epub">1744-8395</issn></journal-meta><article-meta><article-id pub-id-type="pmid">19093778</article-id><article-id pub-id-type="pmc">2677709</article-id><article-id pub-id-type="manuscript">NIHMS87792</article-id><article-id pub-id-type="doi">10.1586/14760584.8.1.113</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Use of humanized severe combined immunodeficient mice for human vaccine development</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Koo</surname><given-names>Gloria C</given-names></name><degrees>PhD</degrees><xref ref-type="corresp" rid="cor1">†</xref><aff id="A1">Department of Pediatrics, Memorial Sloan Kettering Cancer Center, NY 10021, USA and Lupus Research 3rd Floor, Hospital of Special Surgery, 535 East 70th Street, NY 10021, USA, Tel.: +1 212 774 7307,<email>koog@hss.edu</email>/<email>koog@mskcc.org</email></aff></contrib><contrib contrib-type="author"><name><surname>Hasan</surname><given-names>Aisha</given-names></name><degrees>MD</degrees><aff id="A2">Department of Pediatrics, Memorial Sloan Kettering Cancer Center, NY 10021, USA, Tel.: +1 646 888 2116,<email>hasana@mskcc.org</email></aff></contrib><contrib contrib-type="author"><name><surname>O’Reilly</surname><given-names>Richard J</given-names></name><degrees>MD</degrees><role>Chairman</role><aff id="A3">Department of Pediatrics, Memorial Sloan Kettering Cancer Center, NY 10021, USA, Tel.: +1 212 639 5957,<email>oreillyr@mskcc.org</email></aff></contrib></contrib-group><author-notes><corresp id="cor1"><label>†</label>Author for correspondence Lupus Research 3rd Floor, Hospital of Special Surgery, 535 East 70th Street, New York, NY 10021, USA, Tel.: +1 212 774 7307, <email>koog@hss.edu</email>; <email>koog@mskcc.org</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>2</day><month>2</month><year>2009</year></pub-date><pub-date pub-type="ppub"><month>1</month><year>2009</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>11</month><year>2009</year></pub-date><volume>8</volume><issue>1</issue><fpage>113</fpage><lpage>120</lpage><abstract><p id="P1">The severe combined immunodeficient (SCID) mouse has no adaptive immunity, lacking mature T and B cells in the peripheral blood or the lymphoid organs. It has been used extensively in biomedical research as a valuable translational model for xeno-engraftment of human tissues and cells. This review focuses on the engraftment of human peripheral blood cells and tissues in SCID mice, as well as in the newly established and more permissive SCID mice deficient in the IL-2 receptor γ-chain. Human immune responses could be elicited and assessed in these humanized SCID mice upon vaccination or sensitization with allogeneic tissues. A translational model is proposed to attain preclinical data for testing human vaccines.</p></abstract><kwd-group><kwd>preclinical model</kwd><kwd>severe combined immunodeficient mice</kwd><kwd>vaccine development</kwd></kwd-group><contract-num rid="CA1">P01 CA059350-150005</contract-num><contract-num rid="CA1">P01 CA059350-140005</contract-num><contract-num rid="CA1">P01 CA059350-13A20005</contract-num><contract-num rid="CA1">P01 CA023766-26</contract-num><contract-num rid="CA1">P01 CA023766-23</contract-num><contract-num rid="CA1">P01 CA023766-22</contract-num><contract-sponsor id="CA1">National Cancer Institute : NCI</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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