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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Interferon alfacon 1 inhibits SARS-CoV infection In human bronchial epithelial Calu-3 cells</title><author><name sortKey="Kumaki, Yohichi" sort="Kumaki, Yohichi" uniqKey="Kumaki Y" first="Yohichi" last="Kumaki">Yohichi Kumaki</name><affiliation><nlm:aff id="A1">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, Utah State University, 5600 Old Main Hill, Logan, Utah 84322-5600, USA</nlm:aff></affiliation></author><author><name sortKey="Day, Craig W" sort="Day, Craig W" uniqKey="Day C" first="Craig W." last="Day">Craig W. Day</name><affiliation><nlm:aff id="A1">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, Utah State University, 5600 Old Main Hill, Logan, Utah 84322-5600, USA</nlm:aff></affiliation></author><author><name sortKey="Wandersee, Miles K" sort="Wandersee, Miles K" uniqKey="Wandersee M" first="Miles K." last="Wandersee">Miles K. Wandersee</name><affiliation><nlm:aff id="A1">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, Utah State University, 5600 Old Main Hill, Logan, Utah 84322-5600, USA</nlm:aff></affiliation></author><author><name sortKey="Schow, Bradley P" sort="Schow, Bradley P" uniqKey="Schow B" first="Bradley P." last="Schow">Bradley P. Schow</name><affiliation><nlm:aff id="A1">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, Utah State University, 5600 Old Main Hill, Logan, Utah 84322-5600, USA</nlm:aff></affiliation></author><author><name sortKey="Madsen, Justin S" sort="Madsen, Justin S" uniqKey="Madsen J" first="Justin S." last="Madsen">Justin S. Madsen</name><affiliation><nlm:aff id="A1">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, Utah State University, 5600 Old Main Hill, Logan, Utah 84322-5600, USA</nlm:aff></affiliation></author><author><name sortKey="Grant, Dixon" sort="Grant, Dixon" uniqKey="Grant D" first="Dixon" last="Grant">Dixon Grant</name><affiliation><nlm:aff id="A1">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, Utah State University, 5600 Old Main Hill, Logan, Utah 84322-5600, USA</nlm:aff></affiliation></author><author><name sortKey="Blatt, Lawrence M" sort="Blatt, Lawrence M" uniqKey="Blatt L" first="Lawrence M." last="Blatt">Lawrence M. Blatt</name><affiliation><nlm:aff id="A2">Research Laboratories, InterMune Inc., Brisbane, San Diego, CA 94005, USA</nlm:aff></affiliation></author><author><name sortKey="Barnard, Dale L" sort="Barnard, Dale L" uniqKey="Barnard D" first="Dale L." last="Barnard">Dale L. Barnard</name><affiliation><nlm:aff id="A1">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, Utah State University, 5600 Old Main Hill, Logan, Utah 84322-5600, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18406349</idno><idno type="pmc">2441846</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441846</idno><idno type="RBID">PMC:2441846</idno><idno type="doi">10.1016/j.bbrc.2008.04.006</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">000365</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000365</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Interferon alfacon 1 inhibits SARS-CoV infection In human bronchial epithelial Calu-3 cells</title><author><name sortKey="Kumaki, Yohichi" sort="Kumaki, Yohichi" uniqKey="Kumaki Y" first="Yohichi" last="Kumaki">Yohichi Kumaki</name><affiliation><nlm:aff id="A1">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, Utah State University, 5600 Old Main Hill, Logan, Utah 84322-5600, USA</nlm:aff></affiliation></author><author><name sortKey="Day, Craig W" sort="Day, Craig W" uniqKey="Day C" first="Craig W." last="Day">Craig W. Day</name><affiliation><nlm:aff id="A1">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, Utah State University, 5600 Old Main Hill, Logan, Utah 84322-5600, USA</nlm:aff></affiliation></author><author><name sortKey="Wandersee, Miles K" sort="Wandersee, Miles K" uniqKey="Wandersee M" first="Miles K." last="Wandersee">Miles K. Wandersee</name><affiliation><nlm:aff id="A1">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, Utah State University, 5600 Old Main Hill, Logan, Utah 84322-5600, USA</nlm:aff></affiliation></author><author><name sortKey="Schow, Bradley P" sort="Schow, Bradley P" uniqKey="Schow B" first="Bradley P." last="Schow">Bradley P. Schow</name><affiliation><nlm:aff id="A1">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, Utah State University, 5600 Old Main Hill, Logan, Utah 84322-5600, USA</nlm:aff></affiliation></author><author><name sortKey="Madsen, Justin S" sort="Madsen, Justin S" uniqKey="Madsen J" first="Justin S." last="Madsen">Justin S. Madsen</name><affiliation><nlm:aff id="A1">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, Utah State University, 5600 Old Main Hill, Logan, Utah 84322-5600, USA</nlm:aff></affiliation></author><author><name sortKey="Grant, Dixon" sort="Grant, Dixon" uniqKey="Grant D" first="Dixon" last="Grant">Dixon Grant</name><affiliation><nlm:aff id="A1">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, Utah State University, 5600 Old Main Hill, Logan, Utah 84322-5600, USA</nlm:aff></affiliation></author><author><name sortKey="Blatt, Lawrence M" sort="Blatt, Lawrence M" uniqKey="Blatt L" first="Lawrence M." last="Blatt">Lawrence M. Blatt</name><affiliation><nlm:aff id="A2">Research Laboratories, InterMune Inc., Brisbane, San Diego, CA 94005, USA</nlm:aff></affiliation></author><author><name sortKey="Barnard, Dale L" sort="Barnard, Dale L" uniqKey="Barnard D" first="Dale L." last="Barnard">Dale L. Barnard</name><affiliation><nlm:aff id="A1">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, Utah State University, 5600 Old Main Hill, Logan, Utah 84322-5600, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Biochemical and biophysical research communications</title><idno type="ISSN">0006-291X</idno><idno type="eISSN">1090-2104</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The primary targets for SARS-CoV infection are the epithelial cells in the respiratory and intestinal tract. The angiotensin-converting enzyme 2 (ACE-2) has been identified as a functional receptor for SARS-CoV. ACE-2 has been shown to be expressed at the apical domain of polarized Calu-3 cells. In this report, interferon alfacon 1 was examined for inhibitory activities against SARS-CoV on human lung carcinoma epithelial Calu-3 cell line and the other three African green monkey kidney epithelial cell lines. Interferon alfacon 1 demonstrated significant antiviral activity in neutral red uptake assay and virus yield reduction assay. The data might provide an important insight into the mechanism of pathogenesis of SARS-CoV allowing further development of antiviral therapies for treating SARS infections.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0372516</journal-id><journal-id journal-id-type="pubmed-jr-id">1008</journal-id><journal-id journal-id-type="nlm-ta">Biochem Biophys Res Commun</journal-id><journal-title>Biochemical and biophysical research communications</journal-title><issn pub-type="ppub">0006-291X</issn><issn pub-type="epub">1090-2104</issn></journal-meta><article-meta><article-id pub-id-type="pmid">18406349</article-id><article-id pub-id-type="pmc">2441846</article-id><article-id pub-id-type="manuscript">NIHMS51641</article-id><article-id pub-id-type="doi">10.1016/j.bbrc.2008.04.006</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Interferon alfacon 1 inhibits SARS-CoV infection In human bronchial epithelial Calu-3 cells</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kumaki</surname><given-names>Yohichi</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Day</surname><given-names>Craig W.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Wandersee</surname><given-names>Miles K.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Schow</surname><given-names>Bradley P.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Madsen</surname><given-names>Justin S.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Grant</surname><given-names>Dixon</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Blatt</surname><given-names>Lawrence M.</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Barnard</surname><given-names>Dale L.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib></contrib-group><aff id="A1"><label>a</label>Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, Utah State University, 5600 Old Main Hill, Logan, Utah 84322-5600, USA</aff><aff id="A2"><label>b</label>Research Laboratories, InterMune Inc., Brisbane, San Diego, CA 94005, USA</aff><author-notes><corresp id="cor1"><label>*</label>Corresponding author: Tel: 435-797-1885; Fax: 435-797-3959; Email: <email>ykumaki@cc.usu.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>28</day><month>5</month><year>2008</year></pub-date><pub-date pub-type="epub"><day>10</day><month>4</month><year>2008</year></pub-date><pub-date pub-type="ppub"><day>20</day><month>6</month><year>2008</year></pub-date><pub-date pub-type="pmc-release"><day>20</day><month>6</month><year>2009</year></pub-date><volume>371</volume><issue>1</issue><fpage>110</fpage><lpage>113</lpage><abstract><p id="P1">The primary targets for SARS-CoV infection are the epithelial cells in the respiratory and intestinal tract. The angiotensin-converting enzyme 2 (ACE-2) has been identified as a functional receptor for SARS-CoV. ACE-2 has been shown to be expressed at the apical domain of polarized Calu-3 cells. In this report, interferon alfacon 1 was examined for inhibitory activities against SARS-CoV on human lung carcinoma epithelial Calu-3 cell line and the other three African green monkey kidney epithelial cell lines. Interferon alfacon 1 demonstrated significant antiviral activity in neutral red uptake assay and virus yield reduction assay. The data might provide an important insight into the mechanism of pathogenesis of SARS-CoV allowing further development of antiviral therapies for treating SARS infections.</p></abstract><kwd-group><kwd>angiotensin-converting enzyme 2</kwd><kwd>ACE-2</kwd><kwd>Calu-3 cells</kwd><kwd>IFN-alfacon 1</kwd><kwd>neutral red uptake assay</kwd><kwd>SARS-CoV</kwd><kwd>severe acute respiratory syndrome</kwd><kwd>virus yield reduction assay</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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