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Insights into cellular factors that regulate HIV-1 replication in human cells

Identifieur interne : 000364 ( Pmc/Corpus ); précédent : 000363; suivant : 000365

Insights into cellular factors that regulate HIV-1 replication in human cells

Auteurs : Andrew Ml Lever ; Kuan-Teh Jeang

Source :

RBID : PMC:3035746

Abstract

Retroviruses integrate into the host cell’s chromosome. Accordingly, many aspects of the life cycle of retroviruses like HIV-1 are intimately linked to the functions of cellular proteins and RNAs. In this review, we discuss in brief recent genome-wide screens for the identification of cellular proteins that assist HIV-1 replication in human cells. We also review findings on other cellular moieties that help or restrict the viral life cycle.


Url:
DOI: 10.1021/bi101805f
PubMed: 21218853
PubMed Central: 3035746

Links to Exploration step

PMC:3035746

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Correspondence: KT Jeang, Building 4 room 306 ; 9000 Rockville Pike, Bethesda, MD, USA 20892, Telephone, (301) 496 6680; Fax, (301) 480 3686,
<email>kjeang@nih.gov</email>
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