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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Bovine Fetal Inoculations with Calf Rotavirus</title><author><name sortKey="Schlafer, D H" sort="Schlafer, D H" uniqKey="Schlafer D" first="D. H." last="Schlafer">D. H. Schlafer</name></author><author><name sortKey="Schultz, R D" sort="Schultz, R D" uniqKey="Schultz R" first="R. D." last="Schultz">R. D. Schultz</name></author><author><name sortKey="Scott, F W" sort="Scott, F W" uniqKey="Scott F" first="F. W." last="Scott">F. W. Scott</name></author><author><name sortKey="Duncan, J R" sort="Duncan, J R" uniqKey="Duncan J" first="J. R." last="Duncan">J. R. Duncan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">232853</idno><idno type="pmc">1320013</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1320013</idno><idno type="RBID">PMC:1320013</idno><date when="1979">1979</date><idno type="wicri:Area/Pmc/Corpus">000206</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000206</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Bovine Fetal Inoculations with Calf Rotavirus</title><author><name sortKey="Schlafer, D H" sort="Schlafer, D H" uniqKey="Schlafer D" first="D. H." last="Schlafer">D. H. Schlafer</name></author><author><name sortKey="Schultz, R D" sort="Schultz, R D" uniqKey="Schultz R" first="R. D." last="Schultz">R. D. Schultz</name></author><author><name sortKey="Scott, F W" sort="Scott, F W" uniqKey="Scott F" first="F. W." last="Scott">F. W. Scott</name></author><author><name sortKey="Duncan, J R" sort="Duncan, J R" uniqKey="Duncan J" first="J. R." last="Duncan">J. R. Duncan</name></author></analytic><series><title level="j">Canadian Journal of Comparative Medicine</title><idno type="ISSN">0008-4050</idno><imprint><date when="1979">1979</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The serological and histopathological responses of bovine fetuses to <bold>in utero</bold> inoculation with virulent and attenuated strains of the calf rotavirus (reovirus-like agent of neonatal calf diarrhea) are described. Thirteen bovine fetuses, 63 to 190 days of gestation, were inoculated <bold>in utero</bold> with attenuated (three fetuses) or field strain virus (nine fetuses) or both (one fetus).</p><p>Serum-neutralizing antibody titers ranging from 1:16 to > 1:256 were detected in six of eight fetuses tested, demonstrating the ability of the bovine fetus to respond immunologically to this agent. The youngest fetus in the series was inoculated at 63 days of gestation and developed a titer of 128 in 64 days. This represents the earliest stage of gestation at which a bovine fetus has been inoculated with a bovine virus and found to produce antibody to it. Serum neutralizing titers in six of the eight dams tested increased significantly following the inoculations of their fetuses <bold>in utero</bold>.</p><p>Histological changes associated with viral replication and antigenic stimulation of the lymphoreticular system were observed. Pneumonic lesions consisting of both local and diffuse lymphoreticular proliferation were present in five of the nine fetuses that were alive at slaughter. Gliosis and perivascular cuffing were noted in the brains of two of these fetuses and meningitis was seen in one. No evidence of teratogenic change was found.</p><sec sec-type="scanned-figures"><title>Images</title><fig id="F1"><label>Fig. 2.</label><graphic xlink:href="compmed00028-0070-a" xlink:role="408"></graphic></fig><fig id="F2"><label>Fig. 3.</label><graphic xlink:href="compmed00028-0071-a" xlink:role="409"></graphic></fig><fig id="F3"><label>Fig. 4.</label><graphic xlink:href="compmed00028-0071-b" xlink:role="409"></graphic></fig><fig id="F4"><label>Fig. 5.</label><graphic xlink:href="compmed00028-0072-a" xlink:role="410"></graphic></fig><fig id="F5"><label>Fig. 6.</label><graphic xlink:href="compmed00028-0072-b" xlink:role="410"></graphic></fig><fig id="F6"><label>Fig. 7.</label><graphic xlink:href="compmed00028-0073-a" xlink:role="411"></graphic></fig></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Can J Comp Med</journal-id><journal-title>Canadian Journal of Comparative Medicine</journal-title><issn pub-type="ppub">0008-4050</issn></journal-meta><article-meta><article-id pub-id-type="pmid">232853</article-id><article-id pub-id-type="pmc">1320013</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Bovine Fetal Inoculations with Calf Rotavirus</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Schlafer</surname><given-names>D. H.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Schultz</surname><given-names>R. D.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Scott</surname><given-names>F. W.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Duncan</surname><given-names>J. R.</given-names></name></contrib></contrib-group><author-notes><fn id="au1"><label></label><p>Department of Microbiology, New York State College of Veterinary Medicine, Cornell University, Ithaca, New York 14853.</p></fn></author-notes><pub-date pub-type="ppub"><month>10</month><year>1979</year></pub-date><volume>43</volume><issue>4</issue><fpage>405</fpage><lpage>414</lpage><abstract><p>The serological and histopathological responses of bovine fetuses to <bold>in utero</bold> inoculation with virulent and attenuated strains of the calf rotavirus (reovirus-like agent of neonatal calf diarrhea) are described. Thirteen bovine fetuses, 63 to 190 days of gestation, were inoculated <bold>in utero</bold> with attenuated (three fetuses) or field strain virus (nine fetuses) or both (one fetus).</p><p>Serum-neutralizing antibody titers ranging from 1:16 to > 1:256 were detected in six of eight fetuses tested, demonstrating the ability of the bovine fetus to respond immunologically to this agent. The youngest fetus in the series was inoculated at 63 days of gestation and developed a titer of 128 in 64 days. This represents the earliest stage of gestation at which a bovine fetus has been inoculated with a bovine virus and found to produce antibody to it. Serum neutralizing titers in six of the eight dams tested increased significantly following the inoculations of their fetuses <bold>in utero</bold>.</p><p>Histological changes associated with viral replication and antigenic stimulation of the lymphoreticular system were observed. Pneumonic lesions consisting of both local and diffuse lymphoreticular proliferation were present in five of the nine fetuses that were alive at slaughter. Gliosis and perivascular cuffing were noted in the brains of two of these fetuses and meningitis was seen in one. No evidence of teratogenic change was found.</p><sec sec-type="scanned-figures"><title>Images</title><fig id="F1"><label>Fig. 2.</label><graphic xlink:href="compmed00028-0070-a" xlink:role="408"></graphic></fig><fig id="F2"><label>Fig. 3.</label><graphic xlink:href="compmed00028-0071-a" xlink:role="409"></graphic></fig><fig id="F3"><label>Fig. 4.</label><graphic xlink:href="compmed00028-0071-b" xlink:role="409"></graphic></fig><fig id="F4"><label>Fig. 5.</label><graphic xlink:href="compmed00028-0072-a" xlink:role="410"></graphic></fig><fig id="F5"><label>Fig. 6.</label><graphic xlink:href="compmed00028-0072-b" xlink:role="410"></graphic></fig><fig id="F6"><label>Fig. 7.</label><graphic xlink:href="compmed00028-0073-a" xlink:role="411"></graphic></fig></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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