Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Baculovirus Stimulates Antiviral Effects in Mammalian Cells</title><author><name sortKey="Gronowski, Ann M" sort="Gronowski, Ann M" uniqKey="Gronowski A" first="Ann M." last="Gronowski">Ann M. Gronowski</name><affiliation><nlm:aff id="N0x9f902d0.0x9ef2b10"></nlm:aff></affiliation></author><author><name sortKey="Hilbert, David M" sort="Hilbert, David M" uniqKey="Hilbert D" first="David M." last="Hilbert">David M. Hilbert</name><affiliation><nlm:aff id="N0x9f902d0.0x9ef2b10"></nlm:aff></affiliation></author><author><name sortKey="Sheehan, Kathleen C F" sort="Sheehan, Kathleen C F" uniqKey="Sheehan K" first="Kathleen C. F." last="Sheehan">Kathleen C. F. Sheehan</name><affiliation><nlm:aff id="N0x9f902d0.0x9ef2b10"></nlm:aff></affiliation></author><author><name sortKey="Garotta, Gianni" sort="Garotta, Gianni" uniqKey="Garotta G" first="Gianni" last="Garotta">Gianni Garotta</name><affiliation><nlm:aff id="N0x9f902d0.0x9ef2b10"></nlm:aff></affiliation></author><author><name sortKey="Schreiber, Robert D" sort="Schreiber, Robert D" uniqKey="Schreiber R" first="Robert D." last="Schreiber">Robert D. Schreiber</name><affiliation><nlm:aff id="N0x9f902d0.0x9ef2b10"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">10559307</idno><idno type="pmc">113044</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC113044</idno><idno type="RBID">PMC:113044</idno><date when="1999">1999</date><idno type="wicri:Area/Pmc/Corpus">000088</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000088</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Baculovirus Stimulates Antiviral Effects in Mammalian Cells</title><author><name sortKey="Gronowski, Ann M" sort="Gronowski, Ann M" uniqKey="Gronowski A" first="Ann M." last="Gronowski">Ann M. Gronowski</name><affiliation><nlm:aff id="N0x9f902d0.0x9ef2b10"></nlm:aff></affiliation></author><author><name sortKey="Hilbert, David M" sort="Hilbert, David M" uniqKey="Hilbert D" first="David M." last="Hilbert">David M. Hilbert</name><affiliation><nlm:aff id="N0x9f902d0.0x9ef2b10"></nlm:aff></affiliation></author><author><name sortKey="Sheehan, Kathleen C F" sort="Sheehan, Kathleen C F" uniqKey="Sheehan K" first="Kathleen C. F." last="Sheehan">Kathleen C. F. Sheehan</name><affiliation><nlm:aff id="N0x9f902d0.0x9ef2b10"></nlm:aff></affiliation></author><author><name sortKey="Garotta, Gianni" sort="Garotta, Gianni" uniqKey="Garotta G" first="Gianni" last="Garotta">Gianni Garotta</name><affiliation><nlm:aff id="N0x9f902d0.0x9ef2b10"></nlm:aff></affiliation></author><author><name sortKey="Schreiber, Robert D" sort="Schreiber, Robert D" uniqKey="Schreiber R" first="Robert D." last="Schreiber">Robert D. Schreiber</name><affiliation><nlm:aff id="N0x9f902d0.0x9ef2b10"></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="1999">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Herein, we report that <italic>Autographa californica</italic> nucleopolyhedrovirus, a member of the <italic>Baculoviridae</italic> family, is capable of stimulating antiviral activity in mammalian cells. Baculoviruses are not pathogenic to mammalian cells. Nevertheless, live baculovirus is shown here to induce interferons (IFN) from murine and human cell lines and induces in vivo protection of mice from encephalomyocarditis virus infection. Monoclonal antibodies specific for the baculovirus envelope gp67 neutralize baculovirus-dependent IFN production. Moreover, UV treatment of baculovirus eliminates both infectivity and IFN-inducing activity. In contrast, the IFN-inducing activity of the baculovirus was unaffected by DNase or RNase treatment. These data demonstrate that IFN production can be induced in mammalian cells by baculovirus even though the cells fail to serve as a natural host for an active viral infection. Baculoviruses, therefore, provide a novel model in which to study at least one alternative mechanism for IFN induction in mammalian cells.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id><journal-id journal-id-type="publisher-id">J VIROL</journal-id><journal-title>Journal of Virology</journal-title><issn pub-type="ppub">0022-538X</issn><issn pub-type="epub">1098-5514</issn><publisher><publisher-name>American Society for Microbiology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">10559307</article-id><article-id pub-id-type="pmc">113044</article-id><article-id pub-id-type="publisher-id">0528</article-id><article-categories><subj-group subj-group-type="heading"><subject>Pathogenesis and Immunity</subject></subj-group></article-categories><title-group><article-title>Baculovirus Stimulates Antiviral Effects in Mammalian Cells</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Gronowski</surname><given-names>Ann M.</given-names></name><xref ref-type="aff" rid="N0x9f902d0.0x9ef2b10">1</xref></contrib><contrib contrib-type="author"><name><surname>Hilbert</surname><given-names>David M.</given-names></name><xref ref-type="aff" rid="N0x9f902d0.0x9ef2b10">2</xref></contrib><contrib contrib-type="author"><name><surname>Sheehan</surname><given-names>Kathleen C. F.</given-names></name><xref ref-type="aff" rid="N0x9f902d0.0x9ef2b10">1</xref></contrib><contrib contrib-type="author"><name><surname>Garotta</surname><given-names>Gianni</given-names></name><xref ref-type="aff" rid="N0x9f902d0.0x9ef2b10">2</xref><xref ref-type="author-notes" rid="FN151">†</xref></contrib><contrib contrib-type="author"><name><surname>Schreiber</surname><given-names>Robert D.</given-names></name><xref ref-type="aff" rid="N0x9f902d0.0x9ef2b10">1</xref><xref ref-type="author-notes" rid="FN150">*</xref></contrib></contrib-group><aff id="N0x9f902d0.0x9ef2b10"> Department of Pathology and Center for Immunology, Washington University School of Medicine, Saint Louis, Missouri 63110,<sup>1</sup> and Human Genome Sciences Inc., Rockville, Maryland 20850<sup>2</sup></aff><author-notes><fn id="FN150"><label>*</label><p>Corresponding author. Mailing address: Dept. of Pathology, Washington University School of Medicine, Box 8118, 660 S. Euclid Ave., St. Louis, MO 63110. Phone: (314) 362-8747. Fax: (314) 747-4888. E-mail: <email>schreiber@immunology.wustl.edu</email>.</p></fn><fn id="FN151"><label>†</label><p>Present address: Ares-Serono, 2 Chemin des Mines, Case Postale 54, CH-1211 Geneva 20, Switzerland.</p></fn></author-notes><pub-date pub-type="ppub"><month>12</month><year>1999</year></pub-date><volume>73</volume><issue>12</issue><fpage>9944</fpage><lpage>9951</lpage><history><date date-type="received"><day>30</day><month>3</month><year>1999</year></date><date date-type="accepted"><day>14</day><month>9</month><year>1999</year></date></history><copyright-statement>Copyright © 1999, American Society for Microbiology</copyright-statement><copyright-year>1999</copyright-year><abstract><p>Herein, we report that <italic>Autographa californica</italic> nucleopolyhedrovirus, a member of the <italic>Baculoviridae</italic> family, is capable of stimulating antiviral activity in mammalian cells. Baculoviruses are not pathogenic to mammalian cells. Nevertheless, live baculovirus is shown here to induce interferons (IFN) from murine and human cell lines and induces in vivo protection of mice from encephalomyocarditis virus infection. Monoclonal antibodies specific for the baculovirus envelope gp67 neutralize baculovirus-dependent IFN production. Moreover, UV treatment of baculovirus eliminates both infectivity and IFN-inducing activity. In contrast, the IFN-inducing activity of the baculovirus was unaffected by DNase or RNase treatment. These data demonstrate that IFN production can be induced in mammalian cells by baculovirus even though the cells fail to serve as a natural host for an active viral infection. Baculoviruses, therefore, provide a novel model in which to study at least one alternative mechanism for IFN induction in mammalian cells.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000088 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000088 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.33. |  |