Relation between genomic and capsid structures in RNA viruses.
Identifieur interne : 000773 ( Pmc/Checkpoint ); précédent : 000772; suivant : 000774Relation between genomic and capsid structures in RNA viruses.
Auteurs : K. Yamamoto ; H. YoshikuraSource :
- Nucleic Acids Research [ 0305-1048 ] ; 1986.
Abstract
We described a new computer program for calculation of RNA secondary structure. Calculation of 20 viral RNAs with this program showed that genomes of the icosahedral capsid viruses had higher folding probabilities than those of the helical capsid viruses. As this explains virus assembly quite well, the information of capsid structure must be imprinted not only in the capsid protein structures but also in the base sequence of the whole genome. We compared folding probability of the original sequence with that of the random sequence in which base composition was the same as the original. All the actual genomes of RNA viruses were more folded than the corresponding random sequences, even though most transcripts of chromosomal genes tended to be less folded. The data can be related to encapsidation of viral genomes. It was thus suggested that there exists a relation between actual sequences and random sequences with the same base ratios, and that the base ratio itself has some evolutional meaning.
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PubMed: 3753774
PubMed Central: 339422
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Nucleic Acids Res</journal-id><journal-title>Nucleic Acids Research</journal-title><issn pub-type="ppub">0305-1048</issn><issn pub-type="epub">1362-4962</issn></journal-meta><article-meta><article-id pub-id-type="pmid">3753774</article-id><article-id pub-id-type="pmc">339422</article-id><article-categories><subj-group><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Relation between genomic and capsid structures in RNA viruses.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Yamamoto</surname><given-names>K</given-names></name></contrib><contrib contrib-type="author"><name><surname>Yoshikura</surname><given-names>H</given-names></name></contrib></contrib-group><pub-date pub-type="ppub"><day>10</day><month>1</month><year>1986</year></pub-date><volume>14</volume><issue>1</issue><fpage>389</fpage><lpage>396</lpage><abstract><p>We described a new computer program for calculation of RNA secondary structure. Calculation of 20 viral RNAs with this program showed that genomes of the icosahedral capsid viruses had higher folding probabilities than those of the helical capsid viruses. As this explains virus assembly quite well, the information of capsid structure must be imprinted not only in the capsid protein structures but also in the base sequence of the whole genome. We compared folding probability of the original sequence with that of the random sequence in which base composition was the same as the original. All the actual genomes of RNA viruses were more folded than the corresponding random sequences, even though most transcripts of chromosomal genes tended to be less folded. The data can be related to encapsidation of viral genomes. It was thus suggested that there exists a relation between actual sequences and random sequences with the same base ratios, and that the base ratio itself has some evolutional meaning.</p></abstract></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Yamamoto, K" sort="Yamamoto, K" uniqKey="Yamamoto K" first="K" last="Yamamoto">K. Yamamoto</name><name sortKey="Yoshikura, H" sort="Yoshikura, H" uniqKey="Yoshikura H" first="H" last="Yoshikura">H. Yoshikura</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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