IMMUNITY AND IMMUNOPATHOLOGY TO VIRUSES: what decides the outcome?
Identifieur interne : 000600 ( Pmc/Checkpoint ); précédent : 000599; suivant : 000601IMMUNITY AND IMMUNOPATHOLOGY TO VIRUSES: what decides the outcome?
Auteurs : Barry T. Rouse [États-Unis] ; Sharvan Sehrawat [États-Unis]Source :
- Nature reviews. Immunology [ 1474-1733 ] ; 2010.
Abstract
Many viruses infect humans and most are controlled satisfactorily by the immune system with limited damage to host tissues. Some viruses, however, do cause overt damage to the host, either in isolated cases or as a reaction that commonly occurs after infection. The outcome is influenced by properties of the infecting virus, the circumstances of infection and multiple factors controlled by the host. In this Review, we focus on host factors that influence the outcome of viral infection, including genetic susceptibility, the age of the host when infected, the dose and route of infection, the induction of anti-inflammatory cells and proteins as well as the presence of concurrent infections and past exposure to cross-reactive agents.
Url:
DOI: 10.1038/nri2802
PubMed: 20577268
PubMed Central: 3899649
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101124169</journal-id><journal-id journal-id-type="pubmed-jr-id">27017</journal-id><journal-id journal-id-type="nlm-ta">Nat Rev Immunol</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Rev. Immunol.</journal-id><journal-title-group><journal-title>Nature reviews. Immunology</journal-title></journal-title-group><issn pub-type="ppub">1474-1733</issn><issn pub-type="epub">1474-1741</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20577268</article-id><article-id pub-id-type="pmc">3899649</article-id><article-id pub-id-type="doi">10.1038/nri2802</article-id><article-id pub-id-type="manuscript">NIHMS541562</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>IMMUNITY AND IMMUNOPATHOLOGY TO VIRUSES: what decides the outcome?</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Rouse</surname><given-names>Barry T.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Sehrawat</surname><given-names>Sharvan</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996-0845, USA</aff><aff id="A2"><label>2</label>Whitehead Institute of Biomedical Research, 9 Cambridge center, Cambridge, Massachusetts 02142, USA</aff><author-notes><corresp id="FN1">Correspondence to B.T.R. <email>btr@utk.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>6</day><month>1</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>23</day><month>1</month><year>2014</year></pub-date><volume>10</volume><issue>7</issue><fpage>514</fpage><lpage>526</lpage><pmc-comment>elocation-id from pubmed: 10.1038/nri2802</pmc-comment>
<abstract><title>PREFACE</title><p id="P1">Many viruses infect humans and most are controlled satisfactorily by the immune system with limited damage to host tissues. Some viruses, however, do cause overt damage to the host, either in isolated cases or as a reaction that commonly occurs after infection. The outcome is influenced by properties of the infecting virus, the circumstances of infection and multiple factors controlled by the host. In this Review, we focus on host factors that influence the outcome of viral infection, including genetic susceptibility, the age of the host when infected, the dose and route of infection, the induction of anti-inflammatory cells and proteins as well as the presence of concurrent infections and past exposure to cross-reactive agents.</p></abstract><funding-group><award-group><funding-source country="United States">National Eye Institute : NEI</funding-source><award-id>R01 EY005093 || EY</award-id></award-group><award-group><funding-source country="United States">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</funding-source><award-id>R01 AI063365 || AI</award-id></award-group></funding-group></article-meta></front></pmc><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Rouse, Barry T" sort="Rouse, Barry T" uniqKey="Rouse B" first="Barry T." last="Rouse">Barry T. Rouse</name></noRegion><name sortKey="Sehrawat, Sharvan" sort="Sehrawat, Sharvan" uniqKey="Sehrawat S" first="Sharvan" last="Sehrawat">Sharvan Sehrawat</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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