Field trial to evaluate the effect of an intranasal respiratory vaccine protocol on bovine respiratory disease incidence and growth in a commercial calf rearing unit
Identifieur interne : 000034 ( Pmc/Checkpoint ); précédent : 000033; suivant : 000035Field trial to evaluate the effect of an intranasal respiratory vaccine protocol on bovine respiratory disease incidence and growth in a commercial calf rearing unit
Auteurs : Atte Sandelin [Finlande] ; Heidi H Rtel ; Leena Sepp Lassila [Finlande] ; Liisa Kaartinen [Finlande] ; Helena Rautala [Finlande] ; Timo Soveri [Finlande] ; Heli Simojoki [Finlande]Source :
- BMC Veterinary Research [ 1746-6148 ] ; 2020.
Abstract
Bovine respiratory disease (BRD) continues to be great challenge in calf rearing units. The urgent need to decrease the use of antibiotics and increase animal welfare in beef production has forced us to introduce new preventive methods. Vaccinations could contribute to the solution, but the high incidence of BRD already at an early age has made it difficult to introduce suitable vaccination programs. Challenge studies have shown promising results in 3–14 day old calves vaccinated with intranasal BRD vaccine, but very few field trials are available to assess the efficacy of the intranasal vaccines in field conditions. We evaluated the effect of one dose of commercial intranasal vaccination on calf mortality, daily gain, and treatment incidence for BRD in one calf rearing unit. In total, 497 calves (mean age 19 days) were included in our study, 247 of which were vaccinated at the time of arrival to the unit and 250 served as negative controls (unvaccinated). Vaccinated and unvaccinated calves were situated in separate compartments until weaning. Daily gain, treatment incidence, and mortality were recorded until the calves were transported to the finishing unit, which averaged 154.5 days from arrival.
Average daily gain over the complete study period was 1151.9 g/day (SD 137.9) for the vaccinated calves and 1139.5 g/day (SD 135.9) for the unvaccinated calves. Intranasal vaccination combined with older arrival age (17 days or older) resulted in a higher daily gain (47.8 g/day) compared with unvaccinated calves (coef. 0.0478,
Vaccinating arriving calves with intranasal vaccine in the calf rearing unit did not decrease the mortality or treatment incidence for BRD, but it significantly improved the weight gain in calves transported to the unit at the age of 17 days or older.
Url:
DOI: 10.1186/s12917-020-02294-7
PubMed: 32131825
PubMed Central: 7055024
Affiliations:
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sortKey="Sandelin, Atte" sort="Sandelin, Atte" uniqKey="Sandelin A" first="Atte" last="Sandelin">Atte Sandelin</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.7737.4</institution-id><institution-id institution-id-type="ISNI">0000 0004 0410 2071</institution-id><institution>Department of Production Animal Medicine, Faculty of Veterinary Medicine,</institution><institution>University of Helsinki,</institution></institution-wrap>Paroninkuja 20, 04920 Saarentaus, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Paroninkuja 20, 04920 Saarentaus, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="H Rtel, Heidi" sort="H Rtel, Heidi" uniqKey="H Rtel H" first="Heidi" last="H Rtel">Heidi H Rtel</name><affiliation><nlm:aff id="Aff2">HKScan Finland Oy, 50, 20521 Turku, PL Finland</nlm:aff><wicri:noCountry code="subfield">PL Finland</wicri:noCountry></affiliation></author><author><name sortKey="Sepp Lassila, Leena" sort="Sepp Lassila, Leena" uniqKey="Sepp Lassila L" first="Leena" last="Sepp Lassila">Leena Sepp Lassila</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.7737.4</institution-id><institution-id institution-id-type="ISNI">0000 0004 0410 2071</institution-id><institution>Department of Production Animal Medicine, Faculty of Veterinary Medicine,</institution><institution>University of Helsinki,</institution></institution-wrap>Paroninkuja 20, 04920 Saarentaus, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Paroninkuja 20, 04920 Saarentaus, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Kaartinen, Liisa" sort="Kaartinen, Liisa" uniqKey="Kaartinen L" first="Liisa" last="Kaartinen">Liisa Kaartinen</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Finnish Food Authority Ruokavirasto, Mustialankatu 3, 00790 Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Finnish Food Authority Ruokavirasto, Mustialankatu 3, 00790 Helsinki</wicri:regionArea><wicri:noRegion>00790 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Rautala, Helena" sort="Rautala, Helena" uniqKey="Rautala H" first="Helena" last="Rautala">Helena Rautala</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.7737.4</institution-id><institution-id institution-id-type="ISNI">0000 0004 0410 2071</institution-id><institution>Department of Production Animal Medicine, Faculty of Veterinary Medicine,</institution><institution>University of Helsinki,</institution></institution-wrap>Paroninkuja 20, 04920 Saarentaus, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Paroninkuja 20, 04920 Saarentaus, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Soveri, Timo" sort="Soveri, Timo" uniqKey="Soveri T" first="Timo" last="Soveri">Timo Soveri</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.7737.4</institution-id><institution-id institution-id-type="ISNI">0000 0004 0410 2071</institution-id><institution>Department of Production Animal Medicine, Faculty of Veterinary Medicine,</institution><institution>University of Helsinki,</institution></institution-wrap>Paroninkuja 20, 04920 Saarentaus, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Paroninkuja 20, 04920 Saarentaus, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Simojoki, Heli" sort="Simojoki, Heli" uniqKey="Simojoki H" first="Heli" last="Simojoki">Heli Simojoki</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.7737.4</institution-id><institution-id institution-id-type="ISNI">0000 0004 0410 2071</institution-id><institution>Department of Production Animal Medicine, Faculty of Veterinary Medicine,</institution><institution>University of Helsinki,</institution></institution-wrap>Paroninkuja 20, 04920 Saarentaus, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Paroninkuja 20, 04920 Saarentaus, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC Veterinary Research</title><idno type="eISSN">1746-6148</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">Bovine respiratory disease (BRD) continues to be great challenge in calf rearing units. The urgent need to decrease the use of antibiotics and increase animal welfare in beef production has forced us to introduce new preventive methods. Vaccinations could contribute to the solution, but the high incidence of BRD already at an early age has made it difficult to introduce suitable vaccination programs. Challenge studies have shown promising results in 3–14 day old calves vaccinated with intranasal BRD vaccine, but very few field trials are available to assess the efficacy of the intranasal vaccines in field conditions. We evaluated the effect of one dose of commercial intranasal vaccination on calf mortality, daily gain, and treatment incidence for BRD in one calf rearing unit. In total, 497 calves (mean age 19 days) were included in our study, 247 of which were vaccinated at the time of arrival to the unit and 250 served as negative controls (unvaccinated). Vaccinated and unvaccinated calves were situated in separate compartments until weaning. Daily gain, treatment incidence, and mortality were recorded until the calves were transported to the finishing unit, which averaged 154.5 days from arrival.</p></sec><sec><title>Results</title><p id="Par2">Average daily gain over the complete study period was 1151.9 g/day (SD 137.9) for the vaccinated calves and 1139.5 g/day (SD 135.9) for the unvaccinated calves. Intranasal vaccination combined with older arrival age (17 days or older) resulted in a higher daily gain (47.8 g/day) compared with unvaccinated calves (coef. 0.0478, <italic>p</italic> = 0.003). This association was not recorded in calves that were younger than 17 days upon arrival. Intranasal vaccination was not significantly associated either with mortality (OR 0.976, <italic>p</italic> = 0.968) or treatment incidence for BRD (OR 1.341, <italic>p</italic> = 0.120). In total, six vaccinated calves (2.43%) and six unvaccinated calves (2.40%) died during the study period.</p></sec><sec><title>Conclusions</title><p id="Par3">Vaccinating arriving calves with intranasal vaccine in the calf rearing unit did not decrease the mortality or treatment incidence for BRD, but it significantly improved the weight gain in calves transported to the unit at the age of 17 days or older.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Sargeant, Jm" uniqKey="Sargeant J">JM Sargeant</name></author><author><name sortKey="Blackwell, Te" uniqKey="Blackwell T">TE Blackwell</name></author><author><name sortKey="Martin, Sw" uniqKey="Martin S">SW Martin</name></author><author><name sortKey="Tremblay, Rr" uniqKey="Tremblay R">RR Tremblay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sepp Lassila, L" uniqKey="Sepp Lassila L">L Seppä-Lassila</name></author><author><name sortKey="Oksanen, J" uniqKey="Oksanen J">J Oksanen</name></author><author><name sortKey="Herva, T" uniqKey="Herva T">T Herva</name></author><author><name sortKey="Dorbek Kolin, E" uniqKey="Dorbek Kolin E">E Dorbek-Kolin</name></author><author><name sortKey="Kosunen, H" uniqKey="Kosunen H">H Kosunen</name></author><author><name sortKey="Parviainen, L" uniqKey="Parviainen L">L Parviainen</name></author><author><name sortKey="Soveri, T" uniqKey="Soveri T">T Soveri</name></author><author><name sortKey="Orro, T" uniqKey="Orro T">T Orro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pardon, B" uniqKey="Pardon B">B Pardon</name></author><author><name sortKey="De Bleecker, K" uniqKey="De Bleecker K">K De Bleecker</name></author><author><name sortKey="Hostens, M" uniqKey="Hostens M">M Hostens</name></author><author><name sortKey="Callens, J" uniqKey="Callens J">J Callens</name></author><author><name sortKey="Dewulf, J" uniqKey="Dewulf J">J Dewulf</name></author><author><name sortKey="Deprez, P" uniqKey="Deprez P">P Deprez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ortiz Pelaez, A" uniqKey="Ortiz Pelaez A">A Ortiz-Pelaez</name></author><author><name sortKey="Pritchard, Dg" uniqKey="Pritchard D">DG Pritchard</name></author><author><name sortKey="Pfeiffer, Du" uniqKey="Pfeiffer D">DU Pfeiffer</name></author><author><name sortKey="Jones, E" uniqKey="Jones E">E Jones</name></author><author><name sortKey="Honeyman, P" uniqKey="Honeyman P">P Honeyman</name></author><author><name sortKey="Mawdsley, Jj" uniqKey="Mawdsley J">JJ Mawdsley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cusack, Pm" uniqKey="Cusack P">PM Cusack</name></author><author><name sortKey="Mcmeniman, Np" uniqKey="Mcmeniman N">NP McMeniman</name></author><author><name sortKey="Lean, Ij" uniqKey="Lean I">IJ Lean</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thompson, Pn" uniqKey="Thompson P">PN Thompson</name></author><author><name sortKey="Stone, A" uniqKey="Stone A">A Stone</name></author><author><name sortKey="Schultheiss, Wa" uniqKey="Schultheiss W">WA Schultheiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pardon, B" uniqKey="Pardon B">B Pardon</name></author><author><name sortKey="Hostens, M" uniqKey="Hostens M">M Hostens</name></author><author><name sortKey="Duchateau, L" uniqKey="Duchateau L">L Duchateau</name></author><author><name sortKey="Dewulf, J" uniqKey="Dewulf J">J Dewulf</name></author><author><name sortKey="De Bleecker, K" uniqKey="De Bleecker K">K De Bleecker</name></author><author><name sortKey="Deprez, P" uniqKey="Deprez P">P Deprez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Catry, Boudewijn" uniqKey="Catry B">Boudewijn Catry</name></author><author><name sortKey="Dewulf, Jeroen" uniqKey="Dewulf J">Jeroen Dewulf</name></author><author><name sortKey="Maes, Dominiek" uniqKey="Maes D">Dominiek Maes</name></author><author><name sortKey="Pardon, Bart" uniqKey="Pardon B">Bart Pardon</name></author><author><name sortKey="Callens, Benedicte" uniqKey="Callens B">Benedicte Callens</name></author><author><name sortKey="Vanrobaeys, Mia" uniqKey="Vanrobaeys M">Mia Vanrobaeys</name></author><author><name sortKey="Opsomer, Geert" uniqKey="Opsomer G">Geert Opsomer</name></author><author><name sortKey="De Kruif, Aart" uniqKey="De Kruif A">Aart de Kruif</name></author><author><name sortKey="Haesebrouck, Freddy" uniqKey="Haesebrouck F">Freddy Haesebrouck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bos, Marian E H" uniqKey="Bos M">Marian E. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Vet Res</journal-id><journal-id journal-id-type="iso-abbrev">BMC Vet. Res</journal-id><journal-title-group><journal-title>BMC Veterinary Research</journal-title></journal-title-group><issn pub-type="epub">1746-6148</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32131825</article-id><article-id pub-id-type="pmc">7055024</article-id><article-id pub-id-type="publisher-id">2294</article-id><article-id pub-id-type="doi">10.1186/s12917-020-02294-7</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Field trial to evaluate the effect of an intranasal respiratory vaccine protocol on bovine respiratory disease incidence and growth in a commercial calf rearing unit</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-8761-9062</contrib-id><name><surname>Sandelin</surname><given-names>Atte</given-names></name><address><email>atte.sandelin@helsinki.fi</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Härtel</surname><given-names>Heidi</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Seppä-Lassila</surname><given-names>Leena</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kaartinen</surname><given-names>Liisa</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Rautala</surname><given-names>Helena</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Soveri</surname><given-names>Timo</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Simojoki</surname><given-names>Heli</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.7737.4</institution-id><institution-id institution-id-type="ISNI">0000 0004 0410 2071</institution-id><institution>Department of Production Animal Medicine, Faculty of Veterinary Medicine,</institution><institution>University of Helsinki,</institution></institution-wrap>Paroninkuja 20, 04920 Saarentaus, Helsinki, Finland</aff><aff id="Aff2"><label>2</label>HKScan Finland Oy, 50, 20521 Turku, PL Finland</aff><aff id="Aff3"><label>3</label>Finnish Food Authority Ruokavirasto, Mustialankatu 3, 00790 Helsinki, Finland</aff></contrib-group><pub-date pub-type="epub"><day>4</day><month>3</month><year>2020</year></pub-date><pub-date pub-type="pmc-release"><day>4</day><month>3</month><year>2020</year></pub-date><pub-date pub-type="collection"><year>2020</year></pub-date><volume>16</volume><elocation-id>73</elocation-id><history><date date-type="received"><day>2</day><month>11</month><year>2019</year></date><date date-type="accepted"><day>20</day><month>2</month><year>2020</year></date></history><permissions><copyright-statement>© The Author(s) 2020</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated in a credit line to the data.</license-p></license></permissions><abstract id="Abs1"><sec><title>Background</title><p id="Par1">Bovine respiratory disease (BRD) continues to be great challenge in calf rearing units. The urgent need to decrease the use of antibiotics and increase animal welfare in beef production has forced us to introduce new preventive methods. Vaccinations could contribute to the solution, but the high incidence of BRD already at an early age has made it difficult to introduce suitable vaccination programs. Challenge studies have shown promising results in 3–14 day old calves vaccinated with intranasal BRD vaccine, but very few field trials are available to assess the efficacy of the intranasal vaccines in field conditions. We evaluated the effect of one dose of commercial intranasal vaccination on calf mortality, daily gain, and treatment incidence for BRD in one calf rearing unit. In total, 497 calves (mean age 19 days) were included in our study, 247 of which were vaccinated at the time of arrival to the unit and 250 served as negative controls (unvaccinated). Vaccinated and unvaccinated calves were situated in separate compartments until weaning. Daily gain, treatment incidence, and mortality were recorded until the calves were transported to the finishing unit, which averaged 154.5 days from arrival.</p></sec><sec><title>Results</title><p id="Par2">Average daily gain over the complete study period was 1151.9 g/day (SD 137.9) for the vaccinated calves and 1139.5 g/day (SD 135.9) for the unvaccinated calves. Intranasal vaccination combined with older arrival age (17 days or older) resulted in a higher daily gain (47.8 g/day) compared with unvaccinated calves (coef. 0.0478, <italic>p</italic> = 0.003). This association was not recorded in calves that were younger than 17 days upon arrival. Intranasal vaccination was not significantly associated either with mortality (OR 0.976, <italic>p</italic> = 0.968) or treatment incidence for BRD (OR 1.341, <italic>p</italic> = 0.120). In total, six vaccinated calves (2.43%) and six unvaccinated calves (2.40%) died during the study period.</p></sec><sec><title>Conclusions</title><p id="Par3">Vaccinating arriving calves with intranasal vaccine in the calf rearing unit did not decrease the mortality or treatment incidence for BRD, but it significantly improved the weight gain in calves transported to the unit at the age of 17 days or older.</p></sec></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Intranasal vaccination</kwd><kwd>Bovine respiratory disease</kwd><kwd>BRD</kwd><kwd>Morbidity</kwd><kwd>Mortality</kwd><kwd>Calf rearing unit</kwd></kwd-group><funding-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100006697</institution-id><institution>Maa- ja MetsätalousministeriÖ</institution></institution-wrap></funding-source><award-id>2212/03.01.02/2015</award-id><principal-award-recipient><name><surname>Simojoki</surname><given-names>Heli</given-names></name></principal-award-recipient></award-group></funding-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2020</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>Finlande</li></country></list><tree><noCountry><name sortKey="H Rtel, Heidi" sort="H Rtel, Heidi" uniqKey="H Rtel H" first="Heidi" last="H Rtel">Heidi H Rtel</name></noCountry><country name="Finlande"><noRegion><name sortKey="Sandelin, Atte" sort="Sandelin, Atte" uniqKey="Sandelin A" first="Atte" last="Sandelin">Atte Sandelin</name></noRegion><name sortKey="Kaartinen, Liisa" sort="Kaartinen, Liisa" uniqKey="Kaartinen L" first="Liisa" last="Kaartinen">Liisa Kaartinen</name><name sortKey="Rautala, Helena" sort="Rautala, Helena" uniqKey="Rautala H" first="Helena" last="Rautala">Helena Rautala</name><name sortKey="Sepp Lassila, Leena" sort="Sepp Lassila, Leena" uniqKey="Sepp Lassila L" first="Leena" last="Sepp Lassila">Leena Sepp Lassila</name><name sortKey="Simojoki, Heli" sort="Simojoki, Heli" uniqKey="Simojoki H" first="Heli" last="Simojoki">Heli Simojoki</name><name sortKey="Soveri, Timo" sort="Soveri, Timo" uniqKey="Soveri T" first="Timo" last="Soveri">Timo Soveri</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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