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Respiratory Viruses in Adults With Community-Acquired Pneumonia

Identifieur interne : 000043 ( PascalFrancis/Curation ); précédent : 000042; suivant : 000044

Respiratory Viruses in Adults With Community-Acquired Pneumonia

Auteurs : David Lieberman [Israël] ; Avi Shimoni [Israël] ; Yonat Shemer-Avni [Israël] ; Ayelet Keren-Naos [Israël] ; Rachel Shtainberg [Israël] ; Devora Lieberman [Israël]

Source :

RBID : Pascal:10-0485663

Descripteurs français

English descriptors

Abstract

Background: Use of nucleic acid amplification techniques has increased the identification of respiratory viruses (RVs) in adult patients with community-acquired pneumonia (CAP). The objectives of the present study were to identify RV in patients with CAP using three different sampling methods and to compare CAP virus proportions and types with two comparison groups. Methods: The study population included 183 adult patients with CAP, 450 control subjects, and 201 patients with nonpneumonic lower respiratory tract infection (NPLRTI). Each participant was sampled by oropharyngeal swab, nasopharyngeal swab, and nasopharyngeal washing, and the samples were tested for detection of 12 RVs by multiplex TaqMan Hydrolysis probe-based real-time polymerase chain reaction (Integrated DNA Technology; Coralville, IA). Results: At least one RV was identified in 58 patients with CAP (31.7%) compared with 32 (7.1%) in control subjects and 104 (51.7%) in patients with NPLRTI (P < .01 and P < .01, respectively). Corona-viruses were identified in 24 (13.1%) patients with CAP, compared with 17 (3.8%) in control subjects, and 21 (10.4%) patients with NPLRTI. Respiratory syncytial virus was identified in 13 (7.1%), four (0.9%), and seven (3.5%); rhinovirus in nine (4.9%), nine (2.0%), and 15 (7.5%); and influenza virus in eight (4.4%), two (0.4%), and 63 (31.3%) patients with CAP, control subjects, and patients with NPLRTI, respectively. Conclusions: The proportion of RV involvement in CAP is higher than previously reported. The proportion of RV identified in healthy subjects is significantly lower than in CAP, but it is not zero and should be weighed when interpreting corresponding proportions among patients.
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A08 01  1  ENG  @1 Respiratory Viruses in Adults With Community-Acquired Pneumonia
A11 01  1    @1 LIEBERMAN (David)
A11 02  1    @1 SHIMONI (Avi)
A11 03  1    @1 SHEMER-AVNI (Yonat)
A11 04  1    @1 KEREN-NAOS (Ayelet)
A11 05  1    @1 SHTAINBERG (Rachel)
A11 06  1    @1 LIEBERMAN (Devora)
A14 01      @1 Pulmonary Unit, Soroka Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev @2 Beer-Sheva @3 ISR @Z 1 aut. @Z 3 aut.
A14 02      @1 Division of Internal Medicine, Soroka Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev @2 Beer-Sheva @3 ISR @Z 1 aut. @Z 2 aut. @Z 6 aut.
A14 03      @1 Clinical Virology Laboratory, Soroka Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev @2 Beer-Sheva @3 ISR @Z 2 aut. @Z 4 aut. @Z 5 aut.
A14 04      @1 Department of Geriatric Medicine, Soroka Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev @2 Beer-Sheva @3 ISR @Z 6 aut.
A20       @1 811-816
A21       @1 2010
A23 01      @0 ENG
A43 01      @1 INIST @2 7627 @5 354000193278410110
A44       @0 0000 @1 © 2010 INIST-CNRS. All rights reserved.
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C01 01    ENG  @0 Background: Use of nucleic acid amplification techniques has increased the identification of respiratory viruses (RVs) in adult patients with community-acquired pneumonia (CAP). The objectives of the present study were to identify RV in patients with CAP using three different sampling methods and to compare CAP virus proportions and types with two comparison groups. Methods: The study population included 183 adult patients with CAP, 450 control subjects, and 201 patients with nonpneumonic lower respiratory tract infection (NPLRTI). Each participant was sampled by oropharyngeal swab, nasopharyngeal swab, and nasopharyngeal washing, and the samples were tested for detection of 12 RVs by multiplex TaqMan Hydrolysis probe-based real-time polymerase chain reaction (Integrated DNA Technology; Coralville, IA). Results: At least one RV was identified in 58 patients with CAP (31.7%) compared with 32 (7.1%) in control subjects and 104 (51.7%) in patients with NPLRTI (P < .01 and P < .01, respectively). Corona-viruses were identified in 24 (13.1%) patients with CAP, compared with 17 (3.8%) in control subjects, and 21 (10.4%) patients with NPLRTI. Respiratory syncytial virus was identified in 13 (7.1%), four (0.9%), and seven (3.5%); rhinovirus in nine (4.9%), nine (2.0%), and 15 (7.5%); and influenza virus in eight (4.4%), two (0.4%), and 63 (31.3%) patients with CAP, control subjects, and patients with NPLRTI, respectively. Conclusions: The proportion of RV involvement in CAP is higher than previously reported. The proportion of RV identified in healthy subjects is significantly lower than in CAP, but it is not zero and should be weighed when interpreting corresponding proportions among patients.
C02 01  X    @0 002B11
C02 02  X    @0 002B12
C03 01  X  FRE  @0 Pneumonie @5 01
C03 01  X  ENG  @0 Pneumonia @5 01
C03 01  X  SPA  @0 Neumonía @5 01
C03 02  X  FRE  @0 Infection communautaire @2 NM @5 02
C03 02  X  ENG  @0 Community acquired infection @2 NM @5 02
C03 02  X  SPA  @0 Infección comunitaria @2 NM @5 02
C03 03  X  FRE  @0 Voie respiratoire @5 09
C03 03  X  ENG  @0 Respiratory tract @5 09
C03 03  X  SPA  @0 Vía respiratoria @5 09
C03 04  X  FRE  @0 Adulte @5 10
C03 04  X  ENG  @0 Adult @5 10
C03 04  X  SPA  @0 Adulto @5 10
C03 05  X  FRE  @0 Anesthésie @5 11
C03 05  X  ENG  @0 Anesthesia @5 11
C03 05  X  SPA  @0 Anestesia @5 11
C03 06  X  FRE  @0 Appareil circulatoire @5 12
C03 06  X  ENG  @0 Circulatory system @5 12
C03 06  X  SPA  @0 Aparato circulatorio @5 12
C03 07  X  FRE  @0 Cardiologie @5 13
C03 07  X  ENG  @0 Cardiology @5 13
C03 07  X  SPA  @0 Cardiología @5 13
C07 01  X  FRE  @0 Homme
C07 01  X  ENG  @0 Human
C07 01  X  SPA  @0 Hombre
C07 02  X  FRE  @0 Pathologie de l'appareil respiratoire @5 37
C07 02  X  ENG  @0 Respiratory disease @5 37
C07 02  X  SPA  @0 Aparato respiratorio patología @5 37
C07 03  X  FRE  @0 Pathologie des poumons @5 38
C07 03  X  ENG  @0 Lung disease @5 38
C07 03  X  SPA  @0 Pulmón patología @5 38
N21       @1 319
N44 01      @1 OTO
N82       @1 OTO

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Pascal:10-0485663

Le document en format XML

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<div type="abstract" xml:lang="en">Background: Use of nucleic acid amplification techniques has increased the identification of respiratory viruses (RVs) in adult patients with community-acquired pneumonia (CAP). The objectives of the present study were to identify RV in patients with CAP using three different sampling methods and to compare CAP virus proportions and types with two comparison groups. Methods: The study population included 183 adult patients with CAP, 450 control subjects, and 201 patients with nonpneumonic lower respiratory tract infection (NPLRTI). Each participant was sampled by oropharyngeal swab, nasopharyngeal swab, and nasopharyngeal washing, and the samples were tested for detection of 12 RVs by multiplex TaqMan Hydrolysis probe-based real-time polymerase chain reaction (Integrated DNA Technology; Coralville, IA). Results: At least one RV was identified in 58 patients with CAP (31.7%) compared with 32 (7.1%) in control subjects and 104 (51.7%) in patients with NPLRTI (P < .01 and P < .01, respectively). Corona-viruses were identified in 24 (13.1%) patients with CAP, compared with 17 (3.8%) in control subjects, and 21 (10.4%) patients with NPLRTI. Respiratory syncytial virus was identified in 13 (7.1%), four (0.9%), and seven (3.5%); rhinovirus in nine (4.9%), nine (2.0%), and 15 (7.5%); and influenza virus in eight (4.4%), two (0.4%), and 63 (31.3%) patients with CAP, control subjects, and patients with NPLRTI, respectively. Conclusions: The proportion of RV involvement in CAP is higher than previously reported. The proportion of RV identified in healthy subjects is significantly lower than in CAP, but it is not zero and should be weighed when interpreting corresponding proportions among patients.</div>
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<fA44>
<s0>0000</s0>
<s1>© 2010 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45>
<s0>19 ref.</s0>
</fA45>
<fA47 i1="01" i2="1">
<s0>10-0485663</s0>
</fA47>
<fA60>
<s1>P</s1>
</fA60>
<fA61>
<s0>A</s0>
</fA61>
<fA64 i1="01" i2="1">
<s0>Chest : (American College of Chest Physicians)</s0>
</fA64>
<fA66 i1="01">
<s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG">
<s0>Background: Use of nucleic acid amplification techniques has increased the identification of respiratory viruses (RVs) in adult patients with community-acquired pneumonia (CAP). The objectives of the present study were to identify RV in patients with CAP using three different sampling methods and to compare CAP virus proportions and types with two comparison groups. Methods: The study population included 183 adult patients with CAP, 450 control subjects, and 201 patients with nonpneumonic lower respiratory tract infection (NPLRTI). Each participant was sampled by oropharyngeal swab, nasopharyngeal swab, and nasopharyngeal washing, and the samples were tested for detection of 12 RVs by multiplex TaqMan Hydrolysis probe-based real-time polymerase chain reaction (Integrated DNA Technology; Coralville, IA). Results: At least one RV was identified in 58 patients with CAP (31.7%) compared with 32 (7.1%) in control subjects and 104 (51.7%) in patients with NPLRTI (P < .01 and P < .01, respectively). Corona-viruses were identified in 24 (13.1%) patients with CAP, compared with 17 (3.8%) in control subjects, and 21 (10.4%) patients with NPLRTI. Respiratory syncytial virus was identified in 13 (7.1%), four (0.9%), and seven (3.5%); rhinovirus in nine (4.9%), nine (2.0%), and 15 (7.5%); and influenza virus in eight (4.4%), two (0.4%), and 63 (31.3%) patients with CAP, control subjects, and patients with NPLRTI, respectively. Conclusions: The proportion of RV involvement in CAP is higher than previously reported. The proportion of RV identified in healthy subjects is significantly lower than in CAP, but it is not zero and should be weighed when interpreting corresponding proportions among patients.</s0>
</fC01>
<fC02 i1="01" i2="X">
<s0>002B11</s0>
</fC02>
<fC02 i1="02" i2="X">
<s0>002B12</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE">
<s0>Pneumonie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG">
<s0>Pneumonia</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA">
<s0>Neumonía</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE">
<s0>Infection communautaire</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG">
<s0>Community acquired infection</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA">
<s0>Infección comunitaria</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE">
<s0>Voie respiratoire</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG">
<s0>Respiratory tract</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA">
<s0>Vía respiratoria</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE">
<s0>Adulte</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG">
<s0>Adult</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA">
<s0>Adulto</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE">
<s0>Anesthésie</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG">
<s0>Anesthesia</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA">
<s0>Anestesia</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE">
<s0>Appareil circulatoire</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG">
<s0>Circulatory system</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA">
<s0>Aparato circulatorio</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE">
<s0>Cardiologie</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG">
<s0>Cardiology</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA">
<s0>Cardiología</s0>
<s5>13</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE">
<s0>Homme</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG">
<s0>Human</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA">
<s0>Hombre</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE">
<s0>Pathologie de l'appareil respiratoire</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG">
<s0>Respiratory disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA">
<s0>Aparato respiratorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE">
<s0>Pathologie des poumons</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG">
<s0>Lung disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>Pulmón patología</s0>
<s5>38</s5>
</fC07>
<fN21>
<s1>319</s1>
</fN21>
<fN44 i1="01">
<s1>OTO</s1>
</fN44>
<fN82>
<s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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