Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models
Identifieur interne : 000035 ( PascalFrancis/Checkpoint ); précédent : 000034; suivant : 000036Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models
Auteurs : Masaji Okada [Japon] ; Yoshinobu Okuno [Japon] ; Satomi Hashimoto [Japon] ; Yoko Kita [Japon] ; Noriko Kanamaru [Japon] ; Yasuko Nishida [Japon] ; Yoshie Tsunai [Japon] ; Ruriko Inoue [Japon] ; Hitoshi Nakatani [Japon] ; Reiko Fukamizu [Japon] ; Yumi Namie [Japon] ; Junko Yamada [Japon] ; Kyoko Takao [Japon] ; Ritsuko Asai [Japon] ; Ryoko Asaki [Japon] ; Tetsuo Kase [Japon] ; Yuji Takemoto [Japon] ; Shigeto Yoshida [Japon] ; J. S. M. Peiris [Hong Kong] ; Pei-Jer Chen [Taïwan] ; Naoki Yamamoto [Japon] ; Tatsuji Nomura [Japon] ; Isao Ishida [Japon] ; Shigeru Morikawa [Japon] ; Masato Tashiro [Japon] ; Mitsunori Sakatani [Japon]Source :
- Vaccine [ 0264-410X ] ; 2007.
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Abstract
We have investigated novel vaccine strategies against severe acute respiratory syndrome (SARS) CoV using cDNA constructs encoding the structural antigens: (S), (M), (E), or (N) protein, derived from SARS CoV. PBL from healthy human volunteers were administered i.p. into IL-2 receptor γ-chain disrupted SCID mice, and SCID-PBL/hu mice were constructed. These mice can be used to analyze the human immune response in vivo. SARS M DNA vaccine and N DNA vaccine induced human CTL specific for SARS CoV antigens. Alternatively, SARS M DNA vaccines inducing human neutralizing antibodies and human monoclonal antibodies against SARS CoV are now being developed. These results show that these vaccines can induce virus-specific immune responses and should provide a useful tool for development of protective and therapeutic vaccines.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models</title><author><name sortKey="Okada, Masaji" sort="Okada, Masaji" uniqKey="Okada M" first="Masaji" last="Okada">Masaji Okada</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Okuno, Yoshinobu" sort="Okuno, Yoshinobu" uniqKey="Okuno Y" first="Yoshinobu" last="Okuno">Yoshinobu Okuno</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, 3-69 Nakamichi 1-chome</s1><s2>Higashinari-ku, Osaka 537-0025</s2><s3>JPN</s3><sZ>2 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Higashinari-ku, Osaka 537-0025</wicri:noRegion></affiliation></author><author><name sortKey="Hashimoto, Satomi" sort="Hashimoto, Satomi" uniqKey="Hashimoto S" first="Satomi" last="Hashimoto">Satomi Hashimoto</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Kita, Yoko" sort="Kita, Yoko" uniqKey="Kita Y" first="Yoko" last="Kita">Yoko Kita</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Kanamaru, Noriko" sort="Kanamaru, Noriko" uniqKey="Kanamaru N" first="Noriko" last="Kanamaru">Noriko Kanamaru</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Nishida, Yasuko" sort="Nishida, Yasuko" uniqKey="Nishida Y" first="Yasuko" last="Nishida">Yasuko Nishida</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Tsunai, Yoshie" sort="Tsunai, Yoshie" uniqKey="Tsunai Y" first="Yoshie" last="Tsunai">Yoshie Tsunai</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Inoue, Ruriko" sort="Inoue, Ruriko" uniqKey="Inoue R" first="Ruriko" last="Inoue">Ruriko Inoue</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Nakatani, Hitoshi" sort="Nakatani, Hitoshi" uniqKey="Nakatani H" first="Hitoshi" last="Nakatani">Hitoshi Nakatani</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Fukamizu, Reiko" sort="Fukamizu, Reiko" uniqKey="Fukamizu R" first="Reiko" last="Fukamizu">Reiko Fukamizu</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Namie, Yumi" sort="Namie, Yumi" uniqKey="Namie Y" first="Yumi" last="Namie">Yumi Namie</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Yamada, Junko" sort="Yamada, Junko" uniqKey="Yamada J" first="Junko" last="Yamada">Junko Yamada</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Takao, Kyoko" sort="Takao, Kyoko" uniqKey="Takao K" first="Kyoko" last="Takao">Kyoko Takao</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Asai, Ritsuko" sort="Asai, Ritsuko" uniqKey="Asai R" first="Ritsuko" last="Asai">Ritsuko Asai</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Asaki, Ryoko" sort="Asaki, Ryoko" uniqKey="Asaki R" first="Ryoko" last="Asaki">Ryoko Asaki</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Kase, Tetsuo" sort="Kase, Tetsuo" uniqKey="Kase T" first="Tetsuo" last="Kase">Tetsuo Kase</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, 3-69 Nakamichi 1-chome</s1><s2>Higashinari-ku, Osaka 537-0025</s2><s3>JPN</s3><sZ>2 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Higashinari-ku, Osaka 537-0025</wicri:noRegion></affiliation></author><author><name sortKey="Takemoto, Yuji" sort="Takemoto, Yuji" uniqKey="Takemoto Y" first="Yuji" last="Takemoto">Yuji Takemoto</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Yoshida, Shigeto" sort="Yoshida, Shigeto" uniqKey="Yoshida S" first="Shigeto" last="Yoshida">Shigeto Yoshida</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Infection and Immunity, Jichi Medical School, 3311-1 Yakushiji</s1><s2>Minamikawachi-machi, Tochigi 329-0498</s2><s3>JPN</s3><sZ>18 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Minamikawachi-machi, Tochigi 329-0498</wicri:noRegion></affiliation></author><author><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J. S. M." last="Peiris">J. S. M. Peiris</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology, The University of Hong Kong, Prokfulam Road</s1><s3>HKG</s3><sZ>19 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Microbiology, The University of Hong Kong, Prokfulam Road</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Pei Jer" sort="Chen, Pei Jer" uniqKey="Chen P" first="Pei-Jer" last="Chen">Pei-Jer Chen</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Hapatitis Research Center, National Taiwan University College of Medicine, Room 328, 3F, No. 1, Sec. 1, Ren-ai Rd</s1><s2>Jhongjheng District 100, Taipei</s2><s3>TWN</s3><sZ>20 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Jhongjheng District 100, Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Yamamoto, Naoki" sort="Yamamoto, Naoki" uniqKey="Yamamoto N" first="Naoki" last="Yamamoto">Naoki Yamamoto</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama</s1><s2>Shinjyuku, Tokyo 162-8640</s2><s3>JPN</s3><sZ>21 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Nomura, Tatsuji" sort="Nomura, Tatsuji" uniqKey="Nomura T" first="Tatsuji" last="Nomura">Tatsuji Nomura</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Central Institute for Experimental Animals, 1430 Nogawa, Miyamae</s1><s2>Kawasaki, Kanagawa 216-0001</s2><s3>JPN</s3><sZ>22 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Kawasaki, Kanagawa 216-0001</wicri:noRegion></affiliation></author><author><name sortKey="Ishida, Isao" sort="Ishida, Isao" uniqKey="Ishida I" first="Isao" last="Ishida">Isao Ishida</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Pharmaceutical Frontier Laboratory, Pharmaceutical Division, Kirin Brewery Co., 3 Miyahara</s1><s2>Takasaki, Gunma 370-1295</s2><s3>JPN</s3><sZ>23 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Takasaki, Gunma 370-1295</wicri:noRegion></affiliation></author><author><name sortKey="Morikawa, Shigeru" sort="Morikawa, Shigeru" uniqKey="Morikawa S" first="Shigeru" last="Morikawa">Shigeru Morikawa</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>National Institute of Infectious Diseases, 1-23-1 Toyama</s1><s2>Shinjuku-ku, Tokyo 162-8640</s2><s3>JPN</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>National Institute of Infectious Diseases, 1-23-1 Toyama</s1><s2>Shinjuku-ku, Tokyo 162-8640</s2><s3>JPN</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Sakatani, Mitsunori" sort="Sakatani, Mitsunori" uniqKey="Sakatani M" first="Mitsunori" last="Sakatani">Mitsunori Sakatani</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">07-0226642</idno><date when="2007">2007</date><idno type="stanalyst">PASCAL 07-0226642 INIST</idno><idno type="RBID">Pascal:07-0226642</idno><idno type="wicri:Area/PascalFrancis/Corpus">000036</idno><idno type="wicri:Area/PascalFrancis/Curation">000023</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000035</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000035</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models</title><author><name sortKey="Okada, Masaji" sort="Okada, Masaji" uniqKey="Okada M" first="Masaji" last="Okada">Masaji Okada</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Okuno, Yoshinobu" sort="Okuno, Yoshinobu" uniqKey="Okuno Y" first="Yoshinobu" last="Okuno">Yoshinobu Okuno</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, 3-69 Nakamichi 1-chome</s1><s2>Higashinari-ku, Osaka 537-0025</s2><s3>JPN</s3><sZ>2 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Higashinari-ku, Osaka 537-0025</wicri:noRegion></affiliation></author><author><name sortKey="Hashimoto, Satomi" sort="Hashimoto, Satomi" uniqKey="Hashimoto S" first="Satomi" last="Hashimoto">Satomi Hashimoto</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Kita, Yoko" sort="Kita, Yoko" uniqKey="Kita Y" first="Yoko" last="Kita">Yoko Kita</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Kanamaru, Noriko" sort="Kanamaru, Noriko" uniqKey="Kanamaru N" first="Noriko" last="Kanamaru">Noriko Kanamaru</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Nishida, Yasuko" sort="Nishida, Yasuko" uniqKey="Nishida Y" first="Yasuko" last="Nishida">Yasuko Nishida</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Tsunai, Yoshie" sort="Tsunai, Yoshie" uniqKey="Tsunai Y" first="Yoshie" last="Tsunai">Yoshie Tsunai</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Inoue, Ruriko" sort="Inoue, Ruriko" uniqKey="Inoue R" first="Ruriko" last="Inoue">Ruriko Inoue</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Nakatani, Hitoshi" sort="Nakatani, Hitoshi" uniqKey="Nakatani H" first="Hitoshi" last="Nakatani">Hitoshi Nakatani</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Fukamizu, Reiko" sort="Fukamizu, Reiko" uniqKey="Fukamizu R" first="Reiko" last="Fukamizu">Reiko Fukamizu</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Namie, Yumi" sort="Namie, Yumi" uniqKey="Namie Y" first="Yumi" last="Namie">Yumi Namie</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Yamada, Junko" sort="Yamada, Junko" uniqKey="Yamada J" first="Junko" last="Yamada">Junko Yamada</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Takao, Kyoko" sort="Takao, Kyoko" uniqKey="Takao K" first="Kyoko" last="Takao">Kyoko Takao</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Asai, Ritsuko" sort="Asai, Ritsuko" uniqKey="Asai R" first="Ritsuko" last="Asai">Ritsuko Asai</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Asaki, Ryoko" sort="Asaki, Ryoko" uniqKey="Asaki R" first="Ryoko" last="Asaki">Ryoko Asaki</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Kase, Tetsuo" sort="Kase, Tetsuo" uniqKey="Kase T" first="Tetsuo" last="Kase">Tetsuo Kase</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, 3-69 Nakamichi 1-chome</s1><s2>Higashinari-ku, Osaka 537-0025</s2><s3>JPN</s3><sZ>2 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Higashinari-ku, Osaka 537-0025</wicri:noRegion></affiliation></author><author><name sortKey="Takemoto, Yuji" sort="Takemoto, Yuji" uniqKey="Takemoto Y" first="Yuji" last="Takemoto">Yuji Takemoto</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author><author><name sortKey="Yoshida, Shigeto" sort="Yoshida, Shigeto" uniqKey="Yoshida S" first="Shigeto" last="Yoshida">Shigeto Yoshida</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Infection and Immunity, Jichi Medical School, 3311-1 Yakushiji</s1><s2>Minamikawachi-machi, Tochigi 329-0498</s2><s3>JPN</s3><sZ>18 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Minamikawachi-machi, Tochigi 329-0498</wicri:noRegion></affiliation></author><author><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J. S. M." last="Peiris">J. S. M. Peiris</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology, The University of Hong Kong, Prokfulam Road</s1><s3>HKG</s3><sZ>19 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Microbiology, The University of Hong Kong, Prokfulam Road</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Pei Jer" sort="Chen, Pei Jer" uniqKey="Chen P" first="Pei-Jer" last="Chen">Pei-Jer Chen</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Hapatitis Research Center, National Taiwan University College of Medicine, Room 328, 3F, No. 1, Sec. 1, Ren-ai Rd</s1><s2>Jhongjheng District 100, Taipei</s2><s3>TWN</s3><sZ>20 aut.</sZ></inist:fA14><country>Taïwan</country><wicri:noRegion>Jhongjheng District 100, Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Yamamoto, Naoki" sort="Yamamoto, Naoki" uniqKey="Yamamoto N" first="Naoki" last="Yamamoto">Naoki Yamamoto</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama</s1><s2>Shinjyuku, Tokyo 162-8640</s2><s3>JPN</s3><sZ>21 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Nomura, Tatsuji" sort="Nomura, Tatsuji" uniqKey="Nomura T" first="Tatsuji" last="Nomura">Tatsuji Nomura</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Central Institute for Experimental Animals, 1430 Nogawa, Miyamae</s1><s2>Kawasaki, Kanagawa 216-0001</s2><s3>JPN</s3><sZ>22 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Kawasaki, Kanagawa 216-0001</wicri:noRegion></affiliation></author><author><name sortKey="Ishida, Isao" sort="Ishida, Isao" uniqKey="Ishida I" first="Isao" last="Ishida">Isao Ishida</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Pharmaceutical Frontier Laboratory, Pharmaceutical Division, Kirin Brewery Co., 3 Miyahara</s1><s2>Takasaki, Gunma 370-1295</s2><s3>JPN</s3><sZ>23 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Takasaki, Gunma 370-1295</wicri:noRegion></affiliation></author><author><name sortKey="Morikawa, Shigeru" sort="Morikawa, Shigeru" uniqKey="Morikawa S" first="Shigeru" last="Morikawa">Shigeru Morikawa</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>National Institute of Infectious Diseases, 1-23-1 Toyama</s1><s2>Shinjuku-ku, Tokyo 162-8640</s2><s3>JPN</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>National Institute of Infectious Diseases, 1-23-1 Toyama</s1><s2>Shinjuku-ku, Tokyo 162-8640</s2><s3>JPN</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Sakatani, Mitsunori" sort="Sakatani, Mitsunori" uniqKey="Sakatani M" first="Mitsunori" last="Sakatani">Mitsunori Sakatani</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sakai, Osaka 591-8555</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Vaccine</title><title level="j" type="abbreviated">Vaccine</title><idno type="ISSN">0264-410X</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Vaccine</title><title level="j" type="abbreviated">Vaccine</title><idno type="ISSN">0264-410X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal model</term><term>Combined immune deficiency</term><term>Genetic vaccine</term><term>Human</term><term>Immunotherapy</term><term>Neutralizing antibody</term><term>Severe</term><term>Severe acute respiratory syndrome</term><term>Severe acute respiratory syndrome virus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Virus syndrome respiratoire aigu sévère</term><term>Homme</term><term>Vaccin génétique</term><term>Immunothérapie</term><term>Grave</term><term>Modèle animal</term><term>Anticorps neutralisant</term><term>Immunodéficit mixte</term><term>Syndrome respiratoire aigu sévère</term><term>Mutation severe combined immunodeficiency (scid)</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have investigated novel vaccine strategies against severe acute respiratory syndrome (SARS) CoV using cDNA constructs encoding the structural antigens: (S), (M), (E), or (N) protein, derived from SARS CoV. PBL from healthy human volunteers were administered i.p. into IL-2 receptor γ-chain disrupted SCID mice, and SCID-PBL/hu mice were constructed. These mice can be used to analyze the human immune response in vivo. SARS M DNA vaccine and N DNA vaccine induced human CTL specific for SARS CoV antigens. Alternatively, SARS M DNA vaccines inducing human neutralizing antibodies and human monoclonal antibodies against SARS CoV are now being developed. These results show that these vaccines can induce virus-specific immune responses and should provide a useful tool for development of protective and therapeutic vaccines.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0264-410X</s0></fA01><fA02 i1="01"><s0>VACCDE</s0></fA02><fA03 i2="1"><s0>Vaccine</s0></fA03><fA05><s2>25</s2></fA05><fA06><s2>16</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models</s1></fA08><fA09 i1="01" i2="1" l="ENG"><s1>Vaccines, immunisation and immunotherapy. Based on the Fifth World Congress on Vaccines, Immunisation and Immunotherapy, Montreal, 6-9 November 2006</s1></fA09><fA11 i1="01" i2="1"><s1>OKADA (Masaji)</s1></fA11><fA11 i1="02" i2="1"><s1>OKUNO (Yoshinobu)</s1></fA11><fA11 i1="03" i2="1"><s1>HASHIMOTO (Satomi)</s1></fA11><fA11 i1="04" i2="1"><s1>KITA (Yoko)</s1></fA11><fA11 i1="05" i2="1"><s1>KANAMARU (Noriko)</s1></fA11><fA11 i1="06" i2="1"><s1>NISHIDA (Yasuko)</s1></fA11><fA11 i1="07" i2="1"><s1>TSUNAI (Yoshie)</s1></fA11><fA11 i1="08" i2="1"><s1>INOUE (Ruriko)</s1></fA11><fA11 i1="09" i2="1"><s1>NAKATANI (Hitoshi)</s1></fA11><fA11 i1="10" i2="1"><s1>FUKAMIZU (Reiko)</s1></fA11><fA11 i1="11" i2="1"><s1>NAMIE (Yumi)</s1></fA11><fA11 i1="12" i2="1"><s1>YAMADA (Junko)</s1></fA11><fA11 i1="13" i2="1"><s1>TAKAO (Kyoko)</s1></fA11><fA11 i1="14" i2="1"><s1>ASAI (Ritsuko)</s1></fA11><fA11 i1="15" i2="1"><s1>ASAKI (Ryoko)</s1></fA11><fA11 i1="16" i2="1"><s1>KASE (Tetsuo)</s1></fA11><fA11 i1="17" i2="1"><s1>TAKEMOTO (Yuji)</s1></fA11><fA11 i1="18" i2="1"><s1>YOSHIDA (Shigeto)</s1></fA11><fA11 i1="19" i2="1"><s1>PEIRIS (J. S. M.)</s1></fA11><fA11 i1="20" i2="1"><s1>CHEN (Pei-Jer)</s1></fA11><fA11 i1="21" i2="1"><s1>YAMAMOTO (Naoki)</s1></fA11><fA11 i1="22" i2="1"><s1>NOMURA (Tatsuji)</s1></fA11><fA11 i1="23" i2="1"><s1>ISHIDA (Isao)</s1></fA11><fA11 i1="24" i2="1"><s1>MORIKAWA (Shigeru)</s1></fA11><fA11 i1="25" i2="1"><s1>TASHIRO (Masato)</s1></fA11><fA11 i1="26" i2="1"><s1>SAKATANI (Mitsunori)</s1></fA11><fA12 i1="01" i2="1"><s1>KURSTAK (Edouard)</s1><s9>ed.</s9></fA12><fA14 i1="01"><s1>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Kitaku</s1><s2>Sakai, Osaka 591-8555</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>26 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, 3-69 Nakamichi 1-chome</s1><s2>Higashinari-ku, Osaka 537-0025</s2><s3>JPN</s3><sZ>2 aut.</sZ><sZ>16 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Infection and Immunity, Jichi Medical School, 3311-1 Yakushiji</s1><s2>Minamikawachi-machi, Tochigi 329-0498</s2><s3>JPN</s3><sZ>18 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Microbiology, The University of Hong Kong, Prokfulam Road</s1><s3>HKG</s3><sZ>19 aut.</sZ></fA14><fA14 i1="05"><s1>Hapatitis Research Center, National Taiwan University College of Medicine, Room 328, 3F, No. 1, Sec. 1, Ren-ai Rd</s1><s2>Jhongjheng District 100, Taipei</s2><s3>TWN</s3><sZ>20 aut.</sZ></fA14><fA14 i1="06"><s1>AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama</s1><s2>Shinjyuku, Tokyo 162-8640</s2><s3>JPN</s3><sZ>21 aut.</sZ></fA14><fA14 i1="07"><s1>Central Institute for Experimental Animals, 1430 Nogawa, Miyamae</s1><s2>Kawasaki, Kanagawa 216-0001</s2><s3>JPN</s3><sZ>22 aut.</sZ></fA14><fA14 i1="08"><s1>Pharmaceutical Frontier Laboratory, Pharmaceutical Division, Kirin Brewery Co., 3 Miyahara</s1><s2>Takasaki, Gunma 370-1295</s2><s3>JPN</s3><sZ>23 aut.</sZ></fA14><fA14 i1="09"><s1>National Institute of Infectious Diseases, 1-23-1 Toyama</s1><s2>Shinjuku-ku, Tokyo 162-8640</s2><s3>JPN</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ></fA14><fA15 i1="01"><s1>Infections Control World Organization (ICWO), Faculty of Medicine, University of Montreal</s1><s2>Montreal, Que. H3C 3J7</s2><s3>CAN</s3><sZ>1 aut.</sZ></fA15><fA18 i1="01" i2="1"><s1>Infections Control World Organization</s1><s2>Montreal, PQ</s2><s3>CAN</s3><s9>org-cong.</s9></fA18><fA20><s1>3038-3040</s1></fA20><fA21><s1>2007</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20289</s2><s5>354000149378260120</s5></fA43><fA44><s0>0000</s0><s1>© 2007 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>10 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>07-0226642</s0></fA47><fA60><s1>P</s1><s2>C</s2></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Vaccine</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>We have investigated novel vaccine strategies against severe acute respiratory syndrome (SARS) CoV using cDNA constructs encoding the structural antigens: (S), (M), (E), or (N) protein, derived from SARS CoV. PBL from healthy human volunteers were administered i.p. into IL-2 receptor γ-chain disrupted SCID mice, and SCID-PBL/hu mice were constructed. These mice can be used to analyze the human immune response in vivo. SARS M DNA vaccine and N DNA vaccine induced human CTL specific for SARS CoV antigens. Alternatively, SARS M DNA vaccines inducing human neutralizing antibodies and human monoclonal antibodies against SARS CoV are now being developed. These results show that these vaccines can induce virus-specific immune responses and should provide a useful tool for development of protective and therapeutic vaccines.</s0></fC01><fC02 i1="01" i2="X"><s0>002A05F04</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Virus syndrome respiratoire aigu sévère</s0><s2>NW</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Severe acute respiratory syndrome virus</s0><s2>NW</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Severe acute respiratory syndrome virus</s0><s2>NW</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Homme</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Human</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Hombre</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Vaccin génétique</s0><s5>05</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Genetic vaccine</s0><s5>05</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Vaccina genética</s0><s5>05</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Immunothérapie</s0><s5>06</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Immunotherapy</s0><s5>06</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Inmunoterapia</s0><s5>06</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Grave</s0><s5>07</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Severe</s0><s5>07</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Grave</s0><s5>07</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Modèle animal</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Animal model</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Modelo animal</s0><s5>08</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Anticorps neutralisant</s0><s5>09</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Neutralizing antibody</s0><s5>09</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>anticuerpo neutralizante</s0><s5>09</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Immunodéficit mixte</s0><s2>NM</s2><s5>14</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Combined immune deficiency</s0><s2>NM</s2><s5>14</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Inmunodeficiencia mixta</s0><s2>NM</s2><s5>14</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0><s2>NM</s2><s5>15</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0><s2>NM</s2><s5>15</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0><s2>NM</s2><s5>15</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Mutation severe combined immunodeficiency (scid)</s0><s4>INC</s4><s5>79</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Coronavirus</s0><s2>NW</s2></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Coronavirus</s0><s2>NW</s2></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Coronavirus</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0><s5>13</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Respiratory disease</s0><s5>13</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0><s5>13</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Virose</s0></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Viral disease</s0></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Virosis</s0></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Infection</s0></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Infection</s0></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Infección</s0></fC07><fC07 i1="08" i2="X" l="FRE"><s0>Poumon pathologie</s0><s5>16</s5></fC07><fC07 i1="08" i2="X" l="ENG"><s0>Lung disease</s0><s5>16</s5></fC07><fC07 i1="08" i2="X" l="SPA"><s0>Pulmón patología</s0><s5>16</s5></fC07><fN21><s1>155</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA><pR><fA30 i1="01" i2="1" l="ENG"><s1>World Congress on Vaccines, Immunisation and Immunotherapy</s1><s2>5</s2><s3>Montreal, PQ CAN</s3><s4>2006-11-06</s4></fA30></pR></standard></inist><affiliations><list><country><li>Hong Kong</li><li>Japon</li><li>Taïwan</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><noRegion><name sortKey="Okada, Masaji" sort="Okada, Masaji" uniqKey="Okada M" first="Masaji" last="Okada">Masaji Okada</name></noRegion><name sortKey="Asai, Ritsuko" sort="Asai, Ritsuko" uniqKey="Asai R" first="Ritsuko" last="Asai">Ritsuko Asai</name><name sortKey="Asaki, Ryoko" sort="Asaki, Ryoko" uniqKey="Asaki R" first="Ryoko" last="Asaki">Ryoko Asaki</name><name sortKey="Fukamizu, Reiko" sort="Fukamizu, Reiko" uniqKey="Fukamizu R" first="Reiko" last="Fukamizu">Reiko Fukamizu</name><name sortKey="Hashimoto, Satomi" sort="Hashimoto, Satomi" uniqKey="Hashimoto S" first="Satomi" last="Hashimoto">Satomi Hashimoto</name><name sortKey="Inoue, Ruriko" sort="Inoue, Ruriko" uniqKey="Inoue R" first="Ruriko" last="Inoue">Ruriko Inoue</name><name sortKey="Ishida, Isao" sort="Ishida, Isao" uniqKey="Ishida I" first="Isao" last="Ishida">Isao Ishida</name><name sortKey="Kanamaru, Noriko" sort="Kanamaru, Noriko" uniqKey="Kanamaru N" first="Noriko" last="Kanamaru">Noriko Kanamaru</name><name sortKey="Kase, Tetsuo" sort="Kase, Tetsuo" uniqKey="Kase T" first="Tetsuo" last="Kase">Tetsuo Kase</name><name sortKey="Kita, Yoko" sort="Kita, Yoko" uniqKey="Kita Y" first="Yoko" last="Kita">Yoko Kita</name><name sortKey="Morikawa, Shigeru" sort="Morikawa, Shigeru" uniqKey="Morikawa S" first="Shigeru" last="Morikawa">Shigeru Morikawa</name><name sortKey="Nakatani, Hitoshi" sort="Nakatani, Hitoshi" uniqKey="Nakatani H" first="Hitoshi" last="Nakatani">Hitoshi Nakatani</name><name sortKey="Namie, Yumi" sort="Namie, Yumi" uniqKey="Namie Y" first="Yumi" last="Namie">Yumi Namie</name><name sortKey="Nishida, Yasuko" sort="Nishida, Yasuko" uniqKey="Nishida Y" first="Yasuko" last="Nishida">Yasuko Nishida</name><name sortKey="Nomura, Tatsuji" sort="Nomura, Tatsuji" uniqKey="Nomura T" first="Tatsuji" last="Nomura">Tatsuji Nomura</name><name sortKey="Okuno, Yoshinobu" sort="Okuno, Yoshinobu" uniqKey="Okuno Y" first="Yoshinobu" last="Okuno">Yoshinobu Okuno</name><name sortKey="Sakatani, Mitsunori" sort="Sakatani, Mitsunori" uniqKey="Sakatani M" first="Mitsunori" last="Sakatani">Mitsunori Sakatani</name><name sortKey="Takao, Kyoko" sort="Takao, Kyoko" uniqKey="Takao K" first="Kyoko" last="Takao">Kyoko Takao</name><name sortKey="Takemoto, Yuji" sort="Takemoto, Yuji" uniqKey="Takemoto Y" first="Yuji" last="Takemoto">Yuji Takemoto</name><name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name><name sortKey="Tsunai, Yoshie" sort="Tsunai, Yoshie" uniqKey="Tsunai Y" first="Yoshie" last="Tsunai">Yoshie Tsunai</name><name sortKey="Yamada, Junko" sort="Yamada, Junko" uniqKey="Yamada J" first="Junko" last="Yamada">Junko Yamada</name><name sortKey="Yamamoto, Naoki" sort="Yamamoto, Naoki" uniqKey="Yamamoto N" first="Naoki" last="Yamamoto">Naoki Yamamoto</name><name sortKey="Yoshida, Shigeto" sort="Yoshida, Shigeto" uniqKey="Yoshida S" first="Shigeto" last="Yoshida">Shigeto Yoshida</name></country><country name="Hong Kong"><noRegion><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J. S. M." last="Peiris">J. S. M. Peiris</name></noRegion></country><country name="Taïwan"><noRegion><name sortKey="Chen, Pei Jer" sort="Chen, Pei Jer" uniqKey="Chen P" first="Pei-Jer" last="Chen">Pei-Jer Chen</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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