Apathy is associated with white matter abnormalities in anterior, medial brain regions in persons with HIV infection
Identifieur interne : 000000 ( PascalFrancis/Checkpoint ); suivant : 000001Apathy is associated with white matter abnormalities in anterior, medial brain regions in persons with HIV infection
Auteurs : Rujvi Kamat [États-Unis] ; Gregory G. Brown [États-Unis] ; Khalima Bolden [États-Unis] ; Christine Fennema-Notestein [États-Unis] ; Sarah Archibald [États-Unis] ; Thomas D. Marcotte [États-Unis] ; Scott L. Letendre [États-Unis] ; Ronald J. Ellis [États-Unis] ; Steven Paul Woods [États-Unis] ; Igor Grant [États-Unis] ; Robert K. Heaton [États-Unis]Source :
- Neuropsychology, development, and cognition. Section A, journal of clinical and experimental neuropsychology [ 1380-3395 ] ; 2014.
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Abstract
Apathy is a relatively common psychiatric syndrome in HIV infection, but little is known about its neural correlates. In the present study, we examined the associations between apathy and diffusion tensor imaging (DTI) indices in key frontal white matter regions in the thalamocorticostriatal circuit, which has been implicated in the expression of apathy. Nineteen participants with HIV infection and 19 demographically comparable seronegative comparison subjects completed the Apathy subscale of the Frontal Systems Behavioral Scale as a part of a comprehensive neuropsychiatric research evaluation. When compared to the seronegative participants, the HIV+ group had significantly more frontal white matter abnormalities. Within HIV+ persons, and as predicted, higher ratings of apathy were associated with greater white matter alterations in the anterior corona radiata, genu, and orbital medial prefrontal cortex. The associations between white matter alterations and apathy were independent of depression and were stronger among participants with lower current cluster of differentiation 4 (CD4) counts. All told, these findings indicate that apathy is independently associated with white matter abnormalities in anterior, medial brain regions in persons infected with HIV, particularly in the setting of lower current immune functioning, which may have implications for antiretroviral therapy.
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Brown</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Psychiatry, University of California</s1><s2>San Diego, La Jolla, CA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Veterans Administration San Diego Healthcare System</s1><s2>San Diego, CA</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bolden, Khalima" sort="Bolden, Khalima" uniqKey="Bolden K" first="Khalima" last="Bolden">Khalima Bolden</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>San Diego University/University of California, San Diego Joint Doctoral Program in Clinical Psychology</s1><s2>San Diego, CA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Fennema Notestein, Christine" sort="Fennema Notestein, Christine" uniqKey="Fennema Notestein C" first="Christine" last="Fennema-Notestein">Christine Fennema-Notestein</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Psychiatry, University of California</s1><s2>San Diego, La Jolla, CA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Archibald, Sarah" sort="Archibald, Sarah" uniqKey="Archibald S" first="Sarah" last="Archibald">Sarah Archibald</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Psychiatry, University of California</s1><s2>San Diego, La Jolla, CA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Marcotte, Thomas D" sort="Marcotte, Thomas D" uniqKey="Marcotte T" first="Thomas D." last="Marcotte">Thomas D. Marcotte</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Psychiatry, University of California</s1><s2>San Diego, La Jolla, CA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Letendre, Scott L" sort="Letendre, Scott L" uniqKey="Letendre S" first="Scott L." last="Letendre">Scott L. Letendre</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Medicine, University of California</s1><s2>San Diego, La Jolla, CA</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ellis, Ronald J" sort="Ellis, Ronald J" uniqKey="Ellis R" first="Ronald J." last="Ellis">Ronald J. Ellis</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Neurosciences, University of California, San Diego, School of Medicine</s1><s2>La Jolla, CA</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Woods, Steven Paul" sort="Woods, Steven Paul" uniqKey="Woods S" first="Steven Paul" last="Woods">Steven Paul Woods</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Psychiatry, University of California</s1><s2>San Diego, La Jolla, CA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Grant, Igor" sort="Grant, Igor" uniqKey="Grant I" first="Igor" last="Grant">Igor Grant</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Psychiatry, University of California</s1><s2>San Diego, La Jolla, CA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Heaton, Robert K" sort="Heaton, Robert K" uniqKey="Heaton R" first="Robert K." last="Heaton">Robert K. Heaton</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Psychiatry, University of California</s1><s2>San Diego, La Jolla, CA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Neuropsychology, development, and cognition. Section A, journal of clinical and experimental neuropsychology</title><title level="j" type="abbreviated">Neuropsychol., dev. cogn., Sect. A, j. clin. exp. neuropsychol.</title><idno type="ISSN">1380-3395</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neuropsychology, development, and cognition. Section A, journal of clinical and experimental neuropsychology</title><title level="j" type="abbreviated">Neuropsychol., dev. cogn., Sect. A, j. clin. exp. neuropsychol.</title><idno type="ISSN">1380-3395</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term><term>Apathy</term><term>Depression</term><term>Diffusion tensor imaging</term><term>Encephalon</term><term>Human</term><term>Human immunodeficiency virus</term><term>Prefrontal cortex</term><term>White matter</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Substance blanche</term><term>Encéphale</term><term>SIDA</term><term>Imagerie du tenseur de diffusion</term><term>Virus immunodéficience humaine</term><term>Cortex préfrontal</term><term>Etat dépressif</term><term>Homme</term><term>Apathie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Apathy is a relatively common psychiatric syndrome in HIV infection, but little is known about its neural correlates. In the present study, we examined the associations between apathy and diffusion tensor imaging (DTI) indices in key frontal white matter regions in the thalamocorticostriatal circuit, which has been implicated in the expression of apathy. Nineteen participants with HIV infection and 19 demographically comparable seronegative comparison subjects completed the Apathy subscale of the Frontal Systems Behavioral Scale as a part of a comprehensive neuropsychiatric research evaluation. When compared to the seronegative participants, the HIV+ group had significantly more frontal white matter abnormalities. Within HIV+ persons, and as predicted, higher ratings of apathy were associated with greater white matter alterations in the anterior corona radiata, genu, and orbital medial prefrontal cortex. The associations between white matter alterations and apathy were independent of depression and were stronger among participants with lower current cluster of differentiation 4 (CD4) counts. All told, these findings indicate that apathy is independently associated with white matter abnormalities in anterior, medial brain regions in persons infected with HIV, particularly in the setting of lower current immune functioning, which may have implications for antiretroviral therapy.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>1380-3395</s0></fA01><fA03 i2="1"><s0>Neuropsychol., dev. cogn., Sect. A, j. clin. exp. neuropsychol.</s0></fA03><fA05><s2>36</s2></fA05><fA06><s2>7-8</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Apathy is associated with white matter abnormalities in anterior, medial brain regions in persons with HIV infection</s1></fA08><fA11 i1="01" i2="1"><s1>KAMAT (Rujvi)</s1></fA11><fA11 i1="02" i2="1"><s1>BROWN (Gregory G.)</s1></fA11><fA11 i1="03" i2="1"><s1>BOLDEN (Khalima)</s1></fA11><fA11 i1="04" i2="1"><s1>FENNEMA-NOTESTEIN (Christine)</s1></fA11><fA11 i1="05" i2="1"><s1>ARCHIBALD (Sarah)</s1></fA11><fA11 i1="06" i2="1"><s1>MARCOTTE (Thomas D.)</s1></fA11><fA11 i1="07" i2="1"><s1>LETENDRE (Scott L.)</s1></fA11><fA11 i1="08" i2="1"><s1>ELLIS (Ronald J.)</s1></fA11><fA11 i1="09" i2="1"><s1>WOODS (Steven Paul)</s1></fA11><fA11 i1="10" i2="1"><s1>GRANT (Igor)</s1></fA11><fA11 i1="11" i2="1"><s1>HEATON (Robert K.)</s1></fA11><fA14 i1="01"><s1>San Diego University/University of California, San Diego Joint Doctoral Program in Clinical Psychology</s1><s2>San Diego, CA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Psychiatry, University of California</s1><s2>San Diego, La Jolla, CA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></fA14><fA14 i1="03"><s1>Veterans Administration San Diego Healthcare System</s1><s2>San Diego, CA</s2><s3>USA</s3><sZ>2 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Medicine, University of California</s1><s2>San Diego, La Jolla, CA</s2><s3>USA</s3><sZ>7 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Neurosciences, University of California, San Diego, School of Medicine</s1><s2>La Jolla, CA</s2><s3>USA</s3><sZ>8 aut.</sZ></fA14><fA17 i1="01" i2="1"><s1>TMARC Group</s1><s3>USA</s3></fA17><fA20><s1>854-866</s1></fA20><fA21><s1>2014</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>19365A</s2><s5>354000503561620170</s5></fA43><fA44><s0>0000</s0><s1>© 2015 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>2 p.1/4</s0></fA45><fA47 i1="01" i2="1"><s0>15-0016983</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Neuropsychology, development, and cognition. Section A, journal of clinical and experimental neuropsychology</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>Apathy is a relatively common psychiatric syndrome in HIV infection, but little is known about its neural correlates. In the present study, we examined the associations between apathy and diffusion tensor imaging (DTI) indices in key frontal white matter regions in the thalamocorticostriatal circuit, which has been implicated in the expression of apathy. Nineteen participants with HIV infection and 19 demographically comparable seronegative comparison subjects completed the Apathy subscale of the Frontal Systems Behavioral Scale as a part of a comprehensive neuropsychiatric research evaluation. When compared to the seronegative participants, the HIV+ group had significantly more frontal white matter abnormalities. Within HIV+ persons, and as predicted, higher ratings of apathy were associated with greater white matter alterations in the anterior corona radiata, genu, and orbital medial prefrontal cortex. The associations between white matter alterations and apathy were independent of depression and were stronger among participants with lower current cluster of differentiation 4 (CD4) counts. All told, these findings indicate that apathy is independently associated with white matter abnormalities in anterior, medial brain regions in persons infected with HIV, particularly in the setting of lower current immune functioning, which may have implications for antiretroviral therapy.</s0></fC01><fC02 i1="01" i2="X"><s0>002B05C02D</s0></fC02><fC02 i1="02" i2="X"><s0>002B18C07A</s0></fC02><fC02 i1="03" i2="X"><s0>002B06D01</s0></fC02><fC02 i1="04" i2="X"><s0>002B18C07D</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Substance blanche</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>White matter</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Substancia blanca</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Encéphale</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Encephalon</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Encéfalo</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>SIDA</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>AIDS</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>SIDA</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Imagerie du tenseur de diffusion</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Diffusion tensor imaging</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Imágen de tensor de difusión</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Virus immunodéficience humaine</s0><s2>NW</s2><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Human immunodeficiency virus</s0><s2>NW</s2><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Human immunodeficiency virus</s0><s2>NW</s2><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Cortex préfrontal</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Prefrontal cortex</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Corteza prefrontal</s0><s5>06</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Etat dépressif</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Depression</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Estado depresivo</s0><s5>07</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Homme</s0><s5>18</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Human</s0><s5>18</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Hombre</s0><s5>18</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Apathie</s0><s4>CD</s4><s5>96</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Apathy</s0><s4>CD</s4><s5>96</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Apatía</s0><s4>CD</s4><s5>96</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Virose</s0></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Viral disease</s0></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Virosis</s0></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Infection</s0></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Infection</s0></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Infección</s0></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Lentivirus</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Lentivirus</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Lentivirus</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Retroviridae</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Retroviridae</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Retroviridae</s0><s2>NW</s2></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Système nerveux central</s0><s5>37</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system</s0><s5>37</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervioso central</s0><s5>37</s5></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Immunodéficit</s0><s5>38</s5></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Immune deficiency</s0><s5>38</s5></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Inmunodeficiencia</s0><s5>38</s5></fC07><fC07 i1="08" i2="X" l="FRE"><s0>Immunopathologie</s0><s5>40</s5></fC07><fC07 i1="08" i2="X" l="ENG"><s0>Immunopathology</s0><s5>40</s5></fC07><fC07 i1="08" i2="X" l="SPA"><s0>Inmunopatología</s0><s5>40</s5></fC07><fC07 i1="09" i2="X" l="FRE"><s0>Trouble de l'humeur</s0><s5>41</s5></fC07><fC07 i1="09" i2="X" l="ENG"><s0>Mood disorder</s0><s5>41</s5></fC07><fC07 i1="09" i2="X" l="SPA"><s0>Trastorno humor</s0><s5>41</s5></fC07><fN21><s1>019</s1></fN21></pA></standard></inist><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Kamat, Rujvi" sort="Kamat, Rujvi" uniqKey="Kamat R" first="Rujvi" last="Kamat">Rujvi Kamat</name></region><name sortKey="Archibald, Sarah" sort="Archibald, Sarah" uniqKey="Archibald S" first="Sarah" last="Archibald">Sarah Archibald</name><name sortKey="Bolden, Khalima" sort="Bolden, Khalima" uniqKey="Bolden K" first="Khalima" last="Bolden">Khalima Bolden</name><name sortKey="Brown, Gregory G" sort="Brown, Gregory G" uniqKey="Brown G" first="Gregory G." last="Brown">Gregory G. Brown</name><name sortKey="Brown, Gregory G" sort="Brown, Gregory G" uniqKey="Brown G" first="Gregory G." last="Brown">Gregory G. Brown</name><name sortKey="Ellis, Ronald J" sort="Ellis, Ronald J" uniqKey="Ellis R" first="Ronald J." last="Ellis">Ronald J. Ellis</name><name sortKey="Fennema Notestein, Christine" sort="Fennema Notestein, Christine" uniqKey="Fennema Notestein C" first="Christine" last="Fennema-Notestein">Christine Fennema-Notestein</name><name sortKey="Grant, Igor" sort="Grant, Igor" uniqKey="Grant I" first="Igor" last="Grant">Igor Grant</name><name sortKey="Heaton, Robert K" sort="Heaton, Robert K" uniqKey="Heaton R" first="Robert K." last="Heaton">Robert K. Heaton</name><name sortKey="Letendre, Scott L" sort="Letendre, Scott L" uniqKey="Letendre S" first="Scott L." last="Letendre">Scott L. Letendre</name><name sortKey="Marcotte, Thomas D" sort="Marcotte, Thomas D" uniqKey="Marcotte T" first="Thomas D." last="Marcotte">Thomas D. Marcotte</name><name sortKey="Woods, Steven Paul" sort="Woods, Steven Paul" uniqKey="Woods S" first="Steven Paul" last="Woods">Steven Paul Woods</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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