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The ubiquity of asymptomatic respiratory viral infections in the tonsils and adenoids of children and their impact on airway obstruction.

Identifieur interne : 000577 ( Ncbi/Merge ); précédent : 000576; suivant : 000578

The ubiquity of asymptomatic respiratory viral infections in the tonsils and adenoids of children and their impact on airway obstruction.

Auteurs : Howard Faden [États-Unis] ; Vincent Callanan [États-Unis] ; Michael Pizzuto [États-Unis] ; Mark Nagy [États-Unis] ; Mark Wilby [États-Unis] ; Daryl Lamson [États-Unis] ; Brian Wrotniak [États-Unis] ; Stefan Juretschko [États-Unis] ; Kirsten St George [États-Unis]

Source :

RBID : pubmed:27729119

Descripteurs français

English descriptors

Abstract

Airway obstruction due to enlargement of tonsils and adenoids is a common pediatric problem resulting in sleep disordered breathing. The cause for the relatively abnormal growth of tonsils and adenoids is poorly understood.

DOI: 10.1016/j.ijporl.2016.09.006
PubMed: 27729119

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pubmed:27729119

Le document en format XML

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<nlm:affiliation>State University of New York, School of Medicine, Buffalo, NY, USA; Women & Children's Hospital of Buffalo/Kaleida Health, 219 Bryant St., Buffalo, NY 14222, USA. Electronic address: hfaden@upa.chob.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<name sortKey="Callanan, Vincent" sort="Callanan, Vincent" uniqKey="Callanan V" first="Vincent" last="Callanan">Vincent Callanan</name>
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<name sortKey="Pizzuto, Michael" sort="Pizzuto, Michael" uniqKey="Pizzuto M" first="Michael" last="Pizzuto">Michael Pizzuto</name>
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<name sortKey="Wilby, Mark" sort="Wilby, Mark" uniqKey="Wilby M" first="Mark" last="Wilby">Mark Wilby</name>
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<name sortKey="Juretschko, Stefan" sort="Juretschko, Stefan" uniqKey="Juretschko S" first="Stefan" last="Juretschko">Stefan Juretschko</name>
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<name sortKey="St George, Kirsten" sort="St George, Kirsten" uniqKey="St George K" first="Kirsten" last="St George">Kirsten St George</name>
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<name sortKey="Wilby, Mark" sort="Wilby, Mark" uniqKey="Wilby M" first="Mark" last="Wilby">Mark Wilby</name>
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<name sortKey="Lamson, Daryl" sort="Lamson, Daryl" uniqKey="Lamson D" first="Daryl" last="Lamson">Daryl Lamson</name>
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<nlm:affiliation>Laboratory of Viral Diseases, Wadsworth Center, New York State Department of Health, 120 New Scotland Avenue, Albany, NY 12208, USA. Electronic address: daryl.lamson@health.ny.gov.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<name sortKey="Wrotniak, Brian" sort="Wrotniak, Brian" uniqKey="Wrotniak B" first="Brian" last="Wrotniak">Brian Wrotniak</name>
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<nlm:affiliation>Women & Children's Hospital of Buffalo/Kaleida Health, 219 Bryant St., Buffalo, NY 14222, USA; D'Youville College, 320 Porter Ave., Buffalo, NY 14201, USA. Electronic address: wrotniak@dyc.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Women & Children's Hospital of Buffalo/Kaleida Health, 219 Bryant St., Buffalo, NY 14222, USA; D'Youville College, 320 Porter Ave., Buffalo, NY 14201</wicri:regionArea>
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<name sortKey="Juretschko, Stefan" sort="Juretschko, Stefan" uniqKey="Juretschko S" first="Stefan" last="Juretschko">Stefan Juretschko</name>
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<nlm:affiliation>North Shore-LIJ Health Systems and Hofstra University School of Medicine, 500 Hofstra University, Hempstead, NY 11549, USA. Electronic address: sjuretschko@nshs.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<name sortKey="St George, Kirsten" sort="St George, Kirsten" uniqKey="St George K" first="Kirsten" last="St George">Kirsten St George</name>
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<country xml:lang="fr">États-Unis</country>
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<keywords scheme="KwdEn" xml:lang="en">
<term>Adenoidectomy</term>
<term>Adenoids (pathology)</term>
<term>Adenovirus Infections, Human (epidemiology)</term>
<term>Adolescent</term>
<term>Airway Obstruction (epidemiology)</term>
<term>Airway Obstruction (etiology)</term>
<term>Airway Obstruction (surgery)</term>
<term>Asymptomatic Infections (epidemiology)</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Enterovirus Infections (epidemiology)</term>
<term>Epstein-Barr Virus Infections (epidemiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Hypertrophy</term>
<term>Infant</term>
<term>Influenza, Human (epidemiology)</term>
<term>Lymphadenitis (epidemiology)</term>
<term>Lymphadenitis (virology)</term>
<term>Male</term>
<term>Palatine Tonsil (pathology)</term>
<term>Paramyxoviridae Infections (epidemiology)</term>
<term>Picornaviridae Infections (epidemiology)</term>
<term>Polymerase Chain Reaction</term>
<term>Prospective Studies</term>
<term>Respiratory Syncytial Virus Infections (epidemiology)</term>
<term>Sleep Apnea Syndromes (epidemiology)</term>
<term>Sleep Apnea Syndromes (etiology)</term>
<term>Sleep Apnea Syndromes (surgery)</term>
<term>Tonsillectomy</term>
<term>Tonsillitis (epidemiology)</term>
<term>Tonsillitis (virology)</term>
<term>United States (epidemiology)</term>
<term>Virus Diseases (epidemiology)</term>
<term>Virus Diseases (virology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Adolescent</term>
<term>Adénoïdectomie</term>
<term>Amygdalectomie</term>
<term>Amygdalite (virologie)</term>
<term>Amygdalite (épidémiologie)</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Humains</term>
<term>Hypertrophie</term>
<term>Infections asymptomatiques (épidémiologie)</term>
<term>Infections humaines à adénovirus (épidémiologie)</term>
<term>Infections à Paramyxoviridae (épidémiologie)</term>
<term>Infections à Picornaviridae (épidémiologie)</term>
<term>Infections à coronavirus (épidémiologie)</term>
<term>Infections à entérovirus (épidémiologie)</term>
<term>Infections à virus Epstein-Barr (épidémiologie)</term>
<term>Infections à virus respiratoire syncytial (épidémiologie)</term>
<term>Lymphadénite (virologie)</term>
<term>Lymphadénite (épidémiologie)</term>
<term>Maladies virales (virologie)</term>
<term>Maladies virales (épidémiologie)</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Obstruction des voies aériennes ()</term>
<term>Obstruction des voies aériennes (épidémiologie)</term>
<term>Obstruction des voies aériennes (étiologie)</term>
<term>Réaction de polymérisation en chaîne</term>
<term>Syndromes d'apnées du sommeil ()</term>
<term>Syndromes d'apnées du sommeil (épidémiologie)</term>
<term>Syndromes d'apnées du sommeil (étiologie)</term>
<term>Tonsille palatine (anatomopathologie)</term>
<term>Tonsilles pharyngiennes (anatomopathologie)</term>
<term>États-Unis d'Amérique (épidémiologie)</term>
<term>Études prospectives</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr">
<term>Tonsille palatine</term>
<term>Tonsilles pharyngiennes</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en">
<term>Adenovirus Infections, Human</term>
<term>Airway Obstruction</term>
<term>Asymptomatic Infections</term>
<term>Coronavirus Infections</term>
<term>Enterovirus Infections</term>
<term>Epstein-Barr Virus Infections</term>
<term>Influenza, Human</term>
<term>Lymphadenitis</term>
<term>Paramyxoviridae Infections</term>
<term>Picornaviridae Infections</term>
<term>Respiratory Syncytial Virus Infections</term>
<term>Sleep Apnea Syndromes</term>
<term>Tonsillitis</term>
<term>United States</term>
<term>Virus Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en">
<term>Airway Obstruction</term>
<term>Sleep Apnea Syndromes</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>Adenoids</term>
<term>Palatine Tonsil</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en">
<term>Airway Obstruction</term>
<term>Sleep Apnea Syndromes</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr">
<term>Amygdalite</term>
<term>Lymphadénite</term>
<term>Maladies virales</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en">
<term>Lymphadenitis</term>
<term>Tonsillitis</term>
<term>Virus Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr">
<term>Amygdalite</term>
<term>Grippe humaine</term>
<term>Infections asymptomatiques</term>
<term>Infections humaines à adénovirus</term>
<term>Infections à Paramyxoviridae</term>
<term>Infections à Picornaviridae</term>
<term>Infections à coronavirus</term>
<term>Infections à entérovirus</term>
<term>Infections à virus Epstein-Barr</term>
<term>Infections à virus respiratoire syncytial</term>
<term>Lymphadénite</term>
<term>Maladies virales</term>
<term>Obstruction des voies aériennes</term>
<term>Syndromes d'apnées du sommeil</term>
<term>États-Unis d'Amérique</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr">
<term>Obstruction des voies aériennes</term>
<term>Syndromes d'apnées du sommeil</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Adenoidectomy</term>
<term>Adolescent</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>Humans</term>
<term>Hypertrophy</term>
<term>Infant</term>
<term>Male</term>
<term>Polymerase Chain Reaction</term>
<term>Prospective Studies</term>
<term>Tonsillectomy</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Adolescent</term>
<term>Adénoïdectomie</term>
<term>Amygdalectomie</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hypertrophie</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Obstruction des voies aériennes</term>
<term>Réaction de polymérisation en chaîne</term>
<term>Syndromes d'apnées du sommeil</term>
<term>Études prospectives</term>
</keywords>
</textClass>
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<front>
<div type="abstract" xml:lang="en">Airway obstruction due to enlargement of tonsils and adenoids is a common pediatric problem resulting in sleep disordered breathing. The cause for the relatively abnormal growth of tonsils and adenoids is poorly understood.</div>
</front>
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<pubmed>
<MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM">
<PMID Version="1">27729119</PMID>
<DateCompleted>
<Year>2017</Year>
<Month>03</Month>
<Day>13</Day>
</DateCompleted>
<DateRevised>
<Year>2018</Year>
<Month>12</Month>
<Day>02</Day>
</DateRevised>
<Article PubModel="Print-Electronic">
<Journal>
<ISSN IssnType="Electronic">1872-8464</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>90</Volume>
<PubDate>
<Year>2016</Year>
<Month>Nov</Month>
</PubDate>
</JournalIssue>
<Title>International journal of pediatric otorhinolaryngology</Title>
<ISOAbbreviation>Int. J. Pediatr. Otorhinolaryngol.</ISOAbbreviation>
</Journal>
<ArticleTitle>The ubiquity of asymptomatic respiratory viral infections in the tonsils and adenoids of children and their impact on airway obstruction.</ArticleTitle>
<Pagination>
<MedlinePgn>128-132</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0165-5876(16)30306-8</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ijporl.2016.09.006</ELocationID>
<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Airway obstruction due to enlargement of tonsils and adenoids is a common pediatric problem resulting in sleep disordered breathing. The cause for the relatively abnormal growth of tonsils and adenoids is poorly understood.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Non-acutely ill children undergoing tonsillectomy and adenoidectomy (T&A) for various reasons were enrolled prospectively in a study to determine the frequency of asymptomatic respiratory viral infections in each lymphoid tissue and to relate the number and types of virus to the degree of airway obstruction. Molecular techniques were used to detect 9 respiratory viruses while Brodsky scores and measurements of percentages airway obstruction were used to estimate the degree of airway compromise due to the tonsil and adenoid, respectively.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Viruses were detected in 70.9% of tonsils and 94.7% of adenoids, p < 0.001. Adenovirus was the most common virus detected at 71.1%. Adenoids had an average of 2.4 viruses compared to 0.92 for tonsils, p < 0.001. Higher Brodsky scores were only associated with EBV in tonsils, p = 0.03, while greater percentages of airway obstruction in the adenoids were associated with adenovirus, EBV, corona virus, parainfluenza virus and rhinovirus, p ≤ 0.005.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Asymptomatic viral infections are common and directly related to the degree of airway obstruction significantly more often in adenoids than tonsils.</AbstractText>
<CopyrightInformation>Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Faden</LastName>
<ForeName>Howard</ForeName>
<Initials>H</Initials>
<AffiliationInfo>
<Affiliation>State University of New York, School of Medicine, Buffalo, NY, USA; Women & Children's Hospital of Buffalo/Kaleida Health, 219 Bryant St., Buffalo, NY 14222, USA. Electronic address: hfaden@upa.chob.edu.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Callanan</LastName>
<ForeName>Vincent</ForeName>
<Initials>V</Initials>
<AffiliationInfo>
<Affiliation>Women & Children's Hospital of Buffalo/Kaleida Health, 219 Bryant St., Buffalo, NY 14222, USA. Electronic address: vcallanan@kaleidahealth.org.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Pizzuto</LastName>
<ForeName>Michael</ForeName>
<Initials>M</Initials>
<AffiliationInfo>
<Affiliation>Women & Children's Hospital of Buffalo/Kaleida Health, 219 Bryant St., Buffalo, NY 14222, USA. Electronic address: mikepizzuto@roadrunner.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Nagy</LastName>
<ForeName>Mark</ForeName>
<Initials>M</Initials>
<AffiliationInfo>
<Affiliation>Women & Children's Hospital of Buffalo/Kaleida Health, 219 Bryant St., Buffalo, NY 14222, USA. Electronic address: nagys6@verizon.net.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Wilby</LastName>
<ForeName>Mark</ForeName>
<Initials>M</Initials>
<AffiliationInfo>
<Affiliation>Women & Children's Hospital of Buffalo/Kaleida Health, 219 Bryant St., Buffalo, NY 14222, USA. Electronic address: mwilby@kaleidahealth.org.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Lamson</LastName>
<ForeName>Daryl</ForeName>
<Initials>D</Initials>
<AffiliationInfo>
<Affiliation>Laboratory of Viral Diseases, Wadsworth Center, New York State Department of Health, 120 New Scotland Avenue, Albany, NY 12208, USA. Electronic address: daryl.lamson@health.ny.gov.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Wrotniak</LastName>
<ForeName>Brian</ForeName>
<Initials>B</Initials>
<AffiliationInfo>
<Affiliation>Women & Children's Hospital of Buffalo/Kaleida Health, 219 Bryant St., Buffalo, NY 14222, USA; D'Youville College, 320 Porter Ave., Buffalo, NY 14201, USA. Electronic address: wrotniak@dyc.edu.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Juretschko</LastName>
<ForeName>Stefan</ForeName>
<Initials>S</Initials>
<AffiliationInfo>
<Affiliation>North Shore-LIJ Health Systems and Hofstra University School of Medicine, 500 Hofstra University, Hempstead, NY 11549, USA. Electronic address: sjuretschko@nshs.edu.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>St George</LastName>
<ForeName>Kirsten</ForeName>
<Initials>K</Initials>
<AffiliationInfo>
<Affiliation>Laboratory of Viral Diseases, Wadsworth Center, New York State Department of Health, 120 New Scotland Avenue, Albany, NY 12208, USA. Electronic address: kirsten.st.george@health.ny.gov.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList>
<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic">
<Year>2016</Year>
<Month>09</Month>
<Day>14</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo>
<Country>Ireland</Country>
<MedlineTA>Int J Pediatr Otorhinolaryngol</MedlineTA>
<NlmUniqueID>8003603</NlmUniqueID>
<ISSNLinking>0165-5876</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList>
<MeshHeading>
<DescriptorName UI="D000233" MajorTopicYN="Y">Adenoidectomy</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000234" MajorTopicYN="N">Adenoids</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000258" MajorTopicYN="N">Adenovirus Infections, Human</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000402" MajorTopicYN="N">Airway Obstruction</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
<QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D058345" MajorTopicYN="N">Asymptomatic Infections</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D004769" MajorTopicYN="N">Enterovirus Infections</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D020031" MajorTopicYN="N">Epstein-Barr Virus Infections</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D006984" MajorTopicYN="N">Hypertrophy</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D008199" MajorTopicYN="N">Lymphadenitis</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D014066" MajorTopicYN="N">Palatine Tonsil</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D018184" MajorTopicYN="N">Paramyxoviridae Infections</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D010850" MajorTopicYN="N">Picornaviridae Infections</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D016133" MajorTopicYN="N">Polymerase Chain Reaction</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D018357" MajorTopicYN="N">Respiratory Syncytial Virus Infections</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D012891" MajorTopicYN="N">Sleep Apnea Syndromes</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
<QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D014068" MajorTopicYN="Y">Tonsillectomy</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D014069" MajorTopicYN="N">Tonsillitis</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D014481" MajorTopicYN="N">United States</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D014777" MajorTopicYN="N">Virus Diseases</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM">
<Keyword MajorTopicYN="Y">Adenoid</Keyword>
<Keyword MajorTopicYN="Y">Airway obstruction</Keyword>
<Keyword MajorTopicYN="Y">Obstructive sleep apnea</Keyword>
<Keyword MajorTopicYN="Y">Recombinant adenovirus</Keyword>
<Keyword MajorTopicYN="Y">Respiratory virus</Keyword>
<Keyword MajorTopicYN="Y">Sleep-disordered breathing</Keyword>
<Keyword MajorTopicYN="Y">Tonsil</Keyword>
<Keyword MajorTopicYN="Y">Tonsil and adenoid hypertrophy</Keyword>
</KeywordList>
</MedlineCitation>
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<History>
<PubMedPubDate PubStatus="received">
<Year>2015</Year>
<Month>11</Month>
<Day>12</Day>
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<PubMedPubDate PubStatus="revised">
<Year>2016</Year>
<Month>09</Month>
<Day>08</Day>
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<Year>2016</Year>
<Month>09</Month>
<Day>09</Day>
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<Month>3</Month>
<Day>14</Day>
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<Minute>0</Minute>
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<ArticleId IdType="pii">S0165-5876(16)30306-8</ArticleId>
<ArticleId IdType="doi">10.1016/j.ijporl.2016.09.006</ArticleId>
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<affiliations>
<list>
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<li>États-Unis</li>
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<name sortKey="Faden, Howard" sort="Faden, Howard" uniqKey="Faden H" first="Howard" last="Faden">Howard Faden</name>
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<name sortKey="Callanan, Vincent" sort="Callanan, Vincent" uniqKey="Callanan V" first="Vincent" last="Callanan">Vincent Callanan</name>
<name sortKey="Juretschko, Stefan" sort="Juretschko, Stefan" uniqKey="Juretschko S" first="Stefan" last="Juretschko">Stefan Juretschko</name>
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<name sortKey="Nagy, Mark" sort="Nagy, Mark" uniqKey="Nagy M" first="Mark" last="Nagy">Mark Nagy</name>
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<name sortKey="St George, Kirsten" sort="St George, Kirsten" uniqKey="St George K" first="Kirsten" last="St George">Kirsten St George</name>
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<name sortKey="Wrotniak, Brian" sort="Wrotniak, Brian" uniqKey="Wrotniak B" first="Brian" last="Wrotniak">Brian Wrotniak</name>
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