Monoclonal antibodies: Principles and applications of immmunodiagnosis and immunotherapy for hepatitis C virus
Identifieur interne : 000498 ( Ncbi/Merge ); précédent : 000497; suivant : 000499Monoclonal antibodies: Principles and applications of immmunodiagnosis and immunotherapy for hepatitis C virus
Auteurs : Ashraf Tabll ; Aymn T. Abbas ; Sherif El-Kafrawy ; Ahmed WahidSource :
- World Journal of Hepatology [ 1948-5182 ] ; 2015.
Abstract
Hepatitis C virus (HCV) is a major health problem worldwide. Early detection of the infection will help better management of the infected cases. The monoclonal antibodies (mAb) of mice are predominantly used for the immunodiagnosis of several viral, bacterial, and parasitic antigens. Serological detection of HCV antigens and antibodies provide simple and rapid methods of detection but lack sensitivity specially in the window phase between the infection and antibody development. Human mAb are used in the immunotherapy of several blood malignancies, such as lymphoma and leukemia, as well as for autoimmune diseases. In this review article, we will discuss methods of mouse and human monoclonal antibody production. We will demonstrate the role of mouse mAb in the detection of HCV antigens as rapid and sensitive immunodiagnostic assays for the detection of HCV, which is a major health problem throughout the world, particularly in Egypt. We will discuss the value of HCV-neutralizing antibodies and their roles in the immunotherapy of HCV infections and in HCV vaccine development. We will also discuss the different mechanisms by which the virus escape the effect of neutralizing mAb. Finally, we will discuss available and new trends to produce antibodies, such as egg yolk-based antibodies (IgY), production in transgenic plants, and the synthetic antibody mimics approach.
Url:
DOI: 10.4254/wjh.v7.i22.2369
PubMed: 26464752
PubMed Central: 4598607
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PMC:4598607Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Hepatitis C virus (HCV) is a major health problem worldwide. Early detection of the infection will help better management of the infected cases. The monoclonal antibodies (mAb) of mice are predominantly used for the immunodiagnosis of several viral, bacterial, and parasitic antigens. Serological detection of HCV antigens and antibodies provide simple and rapid methods of detection but lack sensitivity specially in the window phase between the infection and antibody development. Human mAb are used in the immunotherapy of several blood malignancies, such as lymphoma and leukemia, as well as for autoimmune diseases. In this review article, we will discuss methods of mouse and human monoclonal antibody production. We will demonstrate the role of mouse mAb in the detection of HCV antigens as rapid and sensitive immunodiagnostic assays for the detection of HCV, which is a major health problem throughout the world, particularly in Egypt. We will discuss the value of HCV-neutralizing antibodies and their roles in the immunotherapy of HCV infections and in HCV vaccine development. We will also discuss the different mechanisms by which the virus escape the effect of neutralizing mAb. Finally, we will discuss available and new trends to produce antibodies, such as egg yolk-based antibodies (IgY), production in transgenic plants, and the synthetic antibody mimics approach.</p>
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<pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">World J Hepatol</journal-id>
<journal-id journal-id-type="publisher-id">WJH</journal-id>
<journal-title-group><journal-title>World Journal of Hepatology</journal-title>
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<issn pub-type="ppub">1948-5182</issn>
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<publisher><publisher-name>Baishideng Publishing Group Inc</publisher-name>
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<article-id pub-id-type="doi">10.4254/wjh.v7.i22.2369</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
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<title-group><article-title>Monoclonal antibodies: Principles and applications of immmunodiagnosis and immunotherapy for hepatitis C virus</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Tabll</surname>
<given-names>Ashraf</given-names>
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<contrib contrib-type="author"><name><surname>Abbas</surname>
<given-names>Aymn T</given-names>
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<contrib contrib-type="author"><name><surname>El-Kafrawy</surname>
<given-names>Sherif</given-names>
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<contrib contrib-type="author"><name><surname>Wahid</surname>
<given-names>Ahmed</given-names>
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<aff>Ashraf Tabll, Microbial Biotechnology Department (Biomedical Technology Group), Genetic Engineering and Biotechnology Division, National Research Centre, Dokki 12622, Egypt</aff>
<aff>Aymn T Abbas, Biotechnology Research Laboratories, Gastroeneterology Surgery Centre, Mansoura University, Mansoura 35516, Egypt</aff>
<aff>Aymn T Abbas, Sherif El-Kafrawy, Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 22254, Saudi Arabia</aff>
<aff>Sherif El-Kafrawy, National Liver Institute, Menoufia University, Shebin El-Kom 32511, Egypt</aff>
<aff>Ahmed Wahid, Biochemistry Department, Molecular and Cellular Biology Unit, Faculty of Pharmacy, Minia University, Minya 11432, Egypt</aff>
</contrib-group>
<author-notes><fn><p>Author contributions: All authors contributed equally in writing this review article.</p>
<p>Correspondence to: Ashraf Tabll, PhD, Head, Microbial Biotechnology Department (Biomedical Technology Group), Genetic Engineering and Biotechnology Division, National Research Centre, El Behoose Street, Dokki 12622, Egypt. <email>ashraf.tabll@yale.edu</email>
</p>
<p>Telephone: +20-23-3362609 Fax: +20-23-330931</p>
</fn>
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<pub-date pub-type="ppub"><day>8</day>
<month>10</month>
<year>2015</year>
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<pub-date pub-type="epub"><day>8</day>
<month>10</month>
<year>2015</year>
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<volume>7</volume>
<issue>22</issue>
<fpage>2369</fpage>
<lpage>2383</lpage>
<history><date date-type="received"><day>20</day>
<month>4</month>
<year>2015</year>
</date>
<date date-type="rev-recd"><day>5</day>
<month>8</month>
<year>2015</year>
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<date date-type="accepted"><day>7</day>
<month>9</month>
<year>2015</year>
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<permissions><copyright-statement>©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.</copyright-statement>
<copyright-year>2015</copyright-year>
</permissions>
<abstract><p>Hepatitis C virus (HCV) is a major health problem worldwide. Early detection of the infection will help better management of the infected cases. The monoclonal antibodies (mAb) of mice are predominantly used for the immunodiagnosis of several viral, bacterial, and parasitic antigens. Serological detection of HCV antigens and antibodies provide simple and rapid methods of detection but lack sensitivity specially in the window phase between the infection and antibody development. Human mAb are used in the immunotherapy of several blood malignancies, such as lymphoma and leukemia, as well as for autoimmune diseases. In this review article, we will discuss methods of mouse and human monoclonal antibody production. We will demonstrate the role of mouse mAb in the detection of HCV antigens as rapid and sensitive immunodiagnostic assays for the detection of HCV, which is a major health problem throughout the world, particularly in Egypt. We will discuss the value of HCV-neutralizing antibodies and their roles in the immunotherapy of HCV infections and in HCV vaccine development. We will also discuss the different mechanisms by which the virus escape the effect of neutralizing mAb. Finally, we will discuss available and new trends to produce antibodies, such as egg yolk-based antibodies (IgY), production in transgenic plants, and the synthetic antibody mimics approach.</p>
</abstract>
<kwd-group><kwd>Hepatitis C virus</kwd>
<kwd>Monoclonal antibodies</kwd>
<kwd>Immunodiagnosis</kwd>
<kwd>Immunotherapy</kwd>
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