Coronaviruses: An Overview of Their Replication and Pathogenesis
Identifieur interne : 000443 ( Ncbi/Merge ); précédent : 000442; suivant : 000444Coronaviruses: An Overview of Their Replication and Pathogenesis
Auteurs : Anthony R. Fehr ; Stanley PerlmanSource :
- Methods in molecular biology (Clifton, N.J.) [ 1064-3745 ] ; 2015.
Abstract
Coronaviruses (CoVs), enveloped positive-sense RNA viruses, are characterized by club-like spikes that project from their surface, an unusually large RNA genome, and a unique replication strategy. Coronaviruses cause a variety of diseases in mammals and birds ranging from enteritis in cows and pigs and upper respiratory disease chickens to potentially lethal human respiratory infections. Here we provide a brief introduction to coronaviruses discussing their replication and pathogenicity, and current prevention and treatment strategies. We will also discuss the outbreaks of the highly pathogenic Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and the recently identified Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV).
Url:
DOI: 10.1007/978-1-4939-2438-7_1
PubMed: 25720466
PubMed Central: 4369385
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<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9214969</journal-id><journal-id journal-id-type="pubmed-jr-id">2488</journal-id><journal-id journal-id-type="nlm-ta">Methods Mol Biol</journal-id><journal-id journal-id-type="iso-abbrev">Methods Mol. Biol.</journal-id><journal-title-group><journal-title>Methods in molecular biology (Clifton, N.J.)</journal-title></journal-title-group><issn pub-type="ppub">1064-3745</issn><issn pub-type="epub">1940-6029</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25720466</article-id><article-id pub-id-type="pmc">4369385</article-id><article-id pub-id-type="doi">10.1007/978-1-4939-2438-7_1</article-id><article-id pub-id-type="manuscript">NIHMS671207</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Coronaviruses: An Overview of Their Replication and Pathogenesis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Fehr</surname><given-names>Anthony R.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Perlman</surname><given-names>Stanley</given-names></name></contrib><aff id="A1">Department of Microbiology, University of Iowa Carver College of Medicine, Iowa City, IA 52242</aff></contrib-group><author-notes><corresp id="cor1">Corresponding Author Stanley Perlman M.D., Ph.D., Professor of Microbiology University of Iowa Carver College of Medicine, <email>stanley-perlman@uiowa.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>13</day><month>3</month><year>2015</year></pub-date><pub-date pub-type="ppub"><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>1</month><year>2016</year></pub-date><volume>1282</volume><fpage>1</fpage><lpage>23</lpage><pmc-comment>elocation-id from pubmed: 10.1007/978-1-4939-2438-7_1</pmc-comment>
<abstract><p id="P1">Coronaviruses (CoVs), enveloped positive-sense RNA viruses, are characterized by club-like spikes that project from their surface, an unusually large RNA genome, and a unique replication strategy. Coronaviruses cause a variety of diseases in mammals and birds ranging from enteritis in cows and pigs and upper respiratory disease chickens to potentially lethal human respiratory infections. Here we provide a brief introduction to coronaviruses discussing their replication and pathogenicity, and current prevention and treatment strategies. We will also discuss the outbreaks of the highly pathogenic Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and the recently identified Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV).</p></abstract><kwd-group><kwd>Nidovirales</kwd><kwd>Coronavirus</kwd><kwd>positive-sense RNA viruses</kwd><kwd>SARS-CoV</kwd><kwd>MERS-CoV</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Fehr, Anthony R" sort="Fehr, Anthony R" uniqKey="Fehr A" first="Anthony R." last="Fehr">Anthony R. Fehr</name><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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