Successful Rechallenge with Imatinib in a Patient with Chronic Myeloid Leukemia Who Previously Experienced Imatinib Mesylate Induced Pneumonitis
Identifieur interne : 000366 ( Ncbi/Merge ); précédent : 000365; suivant : 000367Successful Rechallenge with Imatinib in a Patient with Chronic Myeloid Leukemia Who Previously Experienced Imatinib Mesylate Induced Pneumonitis
Auteurs : Seong Woo Go [Corée du Sud] ; Boo Kyeong Kim [Corée du Sud] ; Sung Hak Lee [Corée du Sud] ; Tae-Jung Kim [Corée du Sud] ; Joo Yeon Huh [Corée du Sud] ; Jong Min Lee [Corée du Sud] ; Jick Hwan Hah [Corée du Sud] ; Dong Whi Kim [Corée du Sud] ; Min Jung Cho [Corée du Sud] ; Tae Wan Kim [Corée du Sud] ; Ji Young Kang [Corée du Sud]Source :
- Tuberculosis and Respiratory Diseases [ 1738-3536 ] ; 2013.
Abstract
Imatinib mesylate is a targeted therapy that acts by inhibiting tyrosine kinase of the bcr-abl fusion oncoprotein, which is specific to chronic myeloid leukemia (CML), and the c-transmembrane receptor, which is specific to gastrointestinal stromal tumors. Interstitial pneumonitis is a rare adverse event of imatinib therapy. It is clinically difficult to distinguish from infectious pneumonia, which can frequently occur due to the underlying disease. The standard treatment for imatinib-induced pneumonitis is to discontinue the medication and optionally administer corticosteroids. However, there are a few cases of successful retrial with imatinib. We describe a case of successful rechallenge of imatinib in a patient with imatinib-induced interstitial pneumonitis and CML without a recurrence of the underlying disease after 3 months of follow-up.
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DOI: 10.4046/trd.2013.75.6.256
PubMed: 24416057
PubMed Central: 3884114
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T" first="Tae-Jung" last="Kim">Tae-Jung Kim</name><affiliation wicri:level="3"><nlm:aff id="A2">Department of Pathology, The Catholic University of Korea College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Pathology, The Catholic University of Korea College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Huh, Joo Yeon" sort="Huh, Joo Yeon" uniqKey="Huh J" first="Joo Yeon" last="Huh">Joo Yeon Huh</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Jong Min" sort="Lee, Jong Min" uniqKey="Lee J" first="Jong Min" last="Lee">Jong Min Lee</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Hah, Jick Hwan" sort="Hah, Jick Hwan" uniqKey="Hah J" first="Jick Hwan" last="Hah">Jick Hwan Hah</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Dong Whi" sort="Kim, Dong Whi" uniqKey="Kim D" first="Dong Whi" last="Kim">Dong Whi Kim</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Cho, Min Jung" sort="Cho, Min Jung" uniqKey="Cho M" first="Min Jung" last="Cho">Min Jung Cho</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Tae Wan" sort="Kim, Tae Wan" uniqKey="Kim T" first="Tae Wan" last="Kim">Tae Wan Kim</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kang, Ji Young" sort="Kang, Ji Young" uniqKey="Kang J" first="Ji Young" last="Kang">Ji Young Kang</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></analytic><series><title level="j">Tuberculosis and Respiratory Diseases</title><idno type="ISSN">1738-3536</idno><idno type="eISSN">2005-6184</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Imatinib mesylate is a targeted therapy that acts by inhibiting tyrosine kinase of the bcr-abl fusion oncoprotein, which is specific to chronic myeloid leukemia (CML), and the c-transmembrane receptor, which is specific to gastrointestinal stromal tumors. Interstitial pneumonitis is a rare adverse event of imatinib therapy. It is clinically difficult to distinguish from infectious pneumonia, which can frequently occur due to the underlying disease. The standard treatment for imatinib-induced pneumonitis is to discontinue the medication and optionally administer corticosteroids. However, there are a few cases of successful retrial with imatinib. We describe a case of successful rechallenge of imatinib in a patient with imatinib-induced interstitial pneumonitis and CML without a recurrence of the underlying disease after 3 months of follow-up.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Deininger, Mw" uniqKey="Deininger M">MW Deininger</name></author><author><name sortKey="Goldman, Jm" uniqKey="Goldman J">JM Goldman</name></author><author><name sortKey="Melo, Jv" uniqKey="Melo J">JV Melo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ohnishi, K" uniqKey="Ohnishi K">K Ohnishi</name></author><author><name sortKey="Sakai, F" uniqKey="Sakai F">F Sakai</name></author><author><name sortKey="Kudoh, S" uniqKey="Kudoh S">S Kudoh</name></author><author><name sortKey="Ohno, R" uniqKey="Ohno R">R Ohno</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Th" uniqKey="Kim T">TH Kim</name></author><author><name sortKey="Kim, Bg" uniqKey="Kim B">BG Kim</name></author><author><name sortKey="Cho, Sw" uniqKey="Cho S">SW Cho</name></author><author><name sortKey="Cho, Sk" uniqKey="Cho S">SK Cho</name></author><author><name sortKey="Kim, Hj" uniqKey="Kim H">HJ Kim</name></author><author><name sortKey="Yuh, Yj" uniqKey="Yuh Y">YJ Yuh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Jw" uniqKey="Lee J">JW Lee</name></author><author><name sortKey="Kim, Hj" uniqKey="Kim H">HJ Kim</name></author><author><name sortKey="Kim, Kj" uniqKey="Kim K">KJ Kim</name></author><author><name sortKey="Shin, Kc" uniqKey="Shin K">KC Shin</name></author><author><name sortKey="Hong, Yh" uniqKey="Hong Y">YH Hong</name></author><author><name sortKey="Chung, Jh" uniqKey="Chung J">JH Chung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barber, Na" uniqKey="Barber N">NA Barber</name></author><author><name sortKey="Ganti, Ak" uniqKey="Ganti A">AK Ganti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yokoyama, T" uniqKey="Yokoyama T">T Yokoyama</name></author><author><name sortKey="Miyazawa, K" uniqKey="Miyazawa K">K Miyazawa</name></author><author><name sortKey="Kurakawa, E" uniqKey="Kurakawa E">E Kurakawa</name></author><author><name sortKey="Nagate, A" uniqKey="Nagate A">A Nagate</name></author><author><name sortKey="Shimamoto, T" uniqKey="Shimamoto T">T Shimamoto</name></author><author><name sortKey="Iwaya, K" uniqKey="Iwaya K">K Iwaya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snyder, Ls" uniqKey="Snyder L">LS Snyder</name></author><author><name sortKey="Hertz, Mi" uniqKey="Hertz M">MI Hertz</name></author><author><name sortKey="Peterson, Ms" uniqKey="Peterson M">MS Peterson</name></author><author><name sortKey="Harmon, Kr" uniqKey="Harmon K">KR Harmon</name></author><author><name sortKey="Marinelli, Wa" uniqKey="Marinelli W">WA Marinelli</name></author><author><name sortKey="Henke, Ca" uniqKey="Henke C">CA Henke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walsh, J" uniqKey="Walsh J">J Walsh</name></author><author><name sortKey="Absher, M" uniqKey="Absher M">M Absher</name></author><author><name sortKey="Kelley, J" uniqKey="Kelley J">J Kelley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rossi, Se" uniqKey="Rossi S">SE Rossi</name></author><author><name sortKey="Erasmus, Jj" uniqKey="Erasmus J">JJ Erasmus</name></author><author><name sortKey="Mcadams, Hp" uniqKey="Mcadams H">HP McAdams</name></author><author><name sortKey="Sporn, Ta" uniqKey="Sporn T">TA Sporn</name></author><author><name sortKey="Goodman, Pc" uniqKey="Goodman P">PC Goodman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seki, N" uniqKey="Seki N">N Seki</name></author><author><name sortKey="Ito, A" uniqKey="Ito A">A Ito</name></author><author><name sortKey="Watanabe, K" uniqKey="Watanabe K">K Watanabe</name></author><author><name sortKey="Shibakuki, R" uniqKey="Shibakuki R">R Shibakuki</name></author><author><name sortKey="Seto, T" uniqKey="Seto T">T Seto</name></author><author><name sortKey="Uematsu, K" uniqKey="Uematsu K">K Uematsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Delomas, T" uniqKey="Delomas T">T Delomas</name></author><author><name sortKey="Darne, C" uniqKey="Darne C">C Darne</name></author><author><name sortKey="Besson, C" uniqKey="Besson C">C Besson</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="case-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Tuberc Respir Dis (Seoul)</journal-id><journal-id journal-id-type="iso-abbrev">Tuberc Respir Dis (Seoul)</journal-id><journal-id journal-id-type="publisher-id">TRD</journal-id><journal-title-group><journal-title>Tuberculosis and Respiratory Diseases</journal-title></journal-title-group><issn pub-type="ppub">1738-3536</issn><issn pub-type="epub">2005-6184</issn><publisher><publisher-name>The Korean Academy of Tuberculosis and Respiratory Diseases</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24416057</article-id><article-id pub-id-type="pmc">3884114</article-id><article-id pub-id-type="doi">10.4046/trd.2013.75.6.256</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>Successful Rechallenge with Imatinib in a Patient with Chronic Myeloid Leukemia Who Previously Experienced Imatinib Mesylate Induced Pneumonitis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Go</surname><given-names>Seong Woo</given-names></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Boo Kyeong</given-names></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Sung Hak</given-names></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Tae-Jung</given-names></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Huh</surname><given-names>Joo Yeon</given-names></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Jong Min</given-names></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Hah</surname><given-names>Jick Hwan</given-names></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Dong Whi</given-names></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Cho</surname><given-names>Min Jung</given-names></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Tae Wan</given-names></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Kang</surname><given-names>Ji Young</given-names></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.</aff><aff id="A2"><label>2</label>Department of Pathology, The Catholic University of Korea College of Medicine, Seoul, Korea.</aff><author-notes><corresp>Address for correspondence: Ji Young Kang, M.D. Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, 222 Banpo-daero, Seocho-gu, Seoul 137-701, Korea. Phone: 82-2-2258-6060, Fax: 82-2-596-2158, <email>rkdwldud@catholic.ac.kr</email></corresp></author-notes><pub-date pub-type="ppub"><month>12</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>24</day><month>12</month><year>2013</year></pub-date><volume>75</volume><issue>6</issue><fpage>256</fpage><lpage>259</lpage><history><date date-type="received"><day>29</day><month>4</month><year>2013</year></date><date date-type="rev-recd"><day>24</day><month>6</month><year>2013</year></date><date date-type="accepted"><day>16</day><month>9</month><year>2013</year></date></history><permissions><copyright-statement>Copyright©2013. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.</copyright-statement><copyright-year>2013</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p>It is identical to the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>)</license-p></license></permissions><abstract><p>Imatinib mesylate is a targeted therapy that acts by inhibiting tyrosine kinase of the bcr-abl fusion oncoprotein, which is specific to chronic myeloid leukemia (CML), and the c-transmembrane receptor, which is specific to gastrointestinal stromal tumors. Interstitial pneumonitis is a rare adverse event of imatinib therapy. It is clinically difficult to distinguish from infectious pneumonia, which can frequently occur due to the underlying disease. The standard treatment for imatinib-induced pneumonitis is to discontinue the medication and optionally administer corticosteroids. However, there are a few cases of successful retrial with imatinib. We describe a case of successful rechallenge of imatinib in a patient with imatinib-induced interstitial pneumonitis and CML without a recurrence of the underlying disease after 3 months of follow-up.</p></abstract><kwd-group><kwd>Leukemia, Myelogenous, Chronic, BCR-ABL Positive</kwd><kwd>Imatinib</kwd><kwd>Lung Diseases, Interstitial</kwd></kwd-group></article-meta></front><floats-group><fig id="F1" orientation="portrait" position="float"><label>Figure 1</label><caption><p>Chest X-ray shows bilateral reticulonodular infiltration in both lungs at admission (A) and slight regression of peribronchial patchy opacities in both lungs at 2 weeks after discontinuing imatinib and commencing steroid treatment (B).</p></caption><graphic xlink:href="trd-75-256-g001"></graphic></fig><fig id="F2" orientation="portrait" position="float"><label>Figure 2</label><caption><p>Chest high resolution computed tomography scan reveals patchy ground glass opacities with some interlobar and intralobular septal thickening in both lungs, predominantly seen in the central and upper lung zones (A), and interval improvement of the interstitial pneumonia with some remaining ground glass opacity after 12 weeks of rechallenge with imatinib (B).</p></caption><graphic xlink:href="trd-75-256-g002"></graphic></fig><fig id="F3" orientation="portrait" position="float"><label>Figure 3</label><caption><p>(A, B) Transbronchial lung biopsy specimen reveals organizing pattern of interstitial pneumonia, showing fibroblastic plug formation in the alveoli with infiltration of chronic inflammatory cells and mild fibrous thickening in the interstitium (H&E stain; A, ×40; B, ×200).</p></caption><graphic xlink:href="trd-75-256-g003"></graphic></fig></floats-group></pmc><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Go, Seong Woo" sort="Go, Seong Woo" uniqKey="Go S" first="Seong Woo" last="Go">Seong Woo Go</name></region><name sortKey="Cho, Min Jung" sort="Cho, Min Jung" uniqKey="Cho M" first="Min Jung" last="Cho">Min Jung Cho</name><name sortKey="Hah, Jick Hwan" sort="Hah, Jick Hwan" uniqKey="Hah J" first="Jick Hwan" last="Hah">Jick Hwan Hah</name><name sortKey="Huh, Joo Yeon" sort="Huh, Joo Yeon" uniqKey="Huh J" first="Joo Yeon" last="Huh">Joo Yeon Huh</name><name sortKey="Kang, Ji Young" sort="Kang, Ji Young" uniqKey="Kang J" first="Ji Young" last="Kang">Ji Young Kang</name><name sortKey="Kim, Boo Kyeong" sort="Kim, Boo Kyeong" uniqKey="Kim B" first="Boo Kyeong" last="Kim">Boo Kyeong Kim</name><name sortKey="Kim, Dong Whi" sort="Kim, Dong Whi" uniqKey="Kim D" first="Dong Whi" last="Kim">Dong Whi Kim</name><name sortKey="Kim, Tae Jung" sort="Kim, Tae Jung" uniqKey="Kim T" first="Tae-Jung" last="Kim">Tae-Jung Kim</name><name sortKey="Kim, Tae Wan" sort="Kim, Tae Wan" uniqKey="Kim T" first="Tae Wan" last="Kim">Tae Wan Kim</name><name sortKey="Lee, Jong Min" sort="Lee, Jong Min" uniqKey="Lee J" first="Jong Min" last="Lee">Jong Min Lee</name><name sortKey="Lee, Sung Hak" sort="Lee, Sung Hak" uniqKey="Lee S" first="Sung Hak" last="Lee">Sung Hak Lee</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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