Cis-acting RNA elements in human and animal plus-strand RNA viruses
Identifieur interne : 000150 ( Ncbi/Merge ); précédent : 000149; suivant : 000151Cis-acting RNA elements in human and animal plus-strand RNA viruses
Auteurs : Ying Liu ; Eckard Wimmer ; Aniko V. PaulSource :
- Biochimica et biophysica acta [ 0006-3002 ] ; 2009.
Abstract
The RNA genomes of plus-strand RNA viruses have the ability to form secondary and higher-order structures that contribute to their stability and to their participation in inter- and intramolecular interactions. Those structures that are functionally important are called
Url:
DOI: 10.1016/j.bbagrm.2009.09.007
PubMed: 19781674
PubMed Central: 2783963
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PMC:2783963Le document en format XML
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-acting RNA elements in human and animal plus-strand RNA viruses</title>
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<author><name sortKey="Paul, Aniko V" sort="Paul, Aniko V" uniqKey="Paul A" first="Aniko V." last="Paul">Aniko V. Paul</name>
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-acting RNA elements in human and animal plus-strand RNA viruses</title>
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<front><div type="abstract" xml:lang="en"><p id="P2">The RNA genomes of plus-strand RNA viruses have the ability to form secondary and higher-order structures that contribute to their stability and to their participation in inter- and intramolecular interactions. Those structures that are functionally important are called <italic>cis</italic>
-acting RNA elements because their functions cannot be complemented in <italic>trans</italic>
. They can be involved not only in RNA/RNA interactions but also in binding of viral and cellular proteins during the complex processes of translation, RNA replication and encapsidation. Most viral <italic>cis</italic>
-acting RNA elements are located in the highly structured 5′- and 3′-nontranslated regions of the genomes but sometimes they also extend into the adjacent coding sequences. In addition, some <italic>cis</italic>
-acting RNA elements are embedded within the coding sequences far away from the genomic ends. Although the functional importance of many of these structures have been confirmed by genetic and biochemical analyses their precise roles are not yet fully understood. In this review we have summarized what is known about <italic>cis</italic>
-acting RNA elements in nine families of human and animal plus-strand RNA viruses with an emphasis on the most thoroughly characterized virus families, the <italic>Picornaviridae</italic>
and <italic>Flaviviridae</italic>
.</p>
</div>
</front>
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<title-group><article-title><italic>Cis</italic>
-acting RNA elements in human and animal plus-strand RNA viruses</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Liu</surname>
<given-names>Ying</given-names>
</name>
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<contrib contrib-type="author"><name><surname>Wimmer</surname>
<given-names>Eckard</given-names>
</name>
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<contrib contrib-type="author"><name><surname>Paul</surname>
<given-names>Aniko V.</given-names>
</name>
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<aff id="A1">Dept. of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, N. Y. 11790</aff>
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<author-notes><corresp id="FN1">Corresponding author: Aniko V. Paul. Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, N. Y. 11794. <email>apaul@notes.cc.sunysb.edu</email>
. Tel: 631-632-9777. Fax:631-632-8891</corresp>
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<pub-date pub-type="nihms-submitted"><day>6</day>
<month>10</month>
<year>2009</year>
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<pub-date pub-type="epub"><day>23</day>
<month>9</month>
<year>2009</year>
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<pub-date pub-type="ppub"><season>Sep–Oct</season>
<year>2009</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>23</day>
<month>9</month>
<year>2010</year>
</pub-date>
<volume>1789</volume>
<issue>9-10</issue>
<fpage>495</fpage>
<lpage>517</lpage>
<abstract><p id="P2">The RNA genomes of plus-strand RNA viruses have the ability to form secondary and higher-order structures that contribute to their stability and to their participation in inter- and intramolecular interactions. Those structures that are functionally important are called <italic>cis</italic>
-acting RNA elements because their functions cannot be complemented in <italic>trans</italic>
. They can be involved not only in RNA/RNA interactions but also in binding of viral and cellular proteins during the complex processes of translation, RNA replication and encapsidation. Most viral <italic>cis</italic>
-acting RNA elements are located in the highly structured 5′- and 3′-nontranslated regions of the genomes but sometimes they also extend into the adjacent coding sequences. In addition, some <italic>cis</italic>
-acting RNA elements are embedded within the coding sequences far away from the genomic ends. Although the functional importance of many of these structures have been confirmed by genetic and biochemical analyses their precise roles are not yet fully understood. In this review we have summarized what is known about <italic>cis</italic>
-acting RNA elements in nine families of human and animal plus-strand RNA viruses with an emphasis on the most thoroughly characterized virus families, the <italic>Picornaviridae</italic>
and <italic>Flaviviridae</italic>
.</p>
</abstract>
<contract-num rid="AI1">R01 AI015122-35A1
||AI</contract-num>
<contract-sponsor id="AI1">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</contract-sponsor>
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<name sortKey="Wimmer, Eckard" sort="Wimmer, Eckard" uniqKey="Wimmer E" first="Eckard" last="Wimmer">Eckard Wimmer</name>
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