CovidV1, Ncbi, Curation, bibRecord, 000507

Design, Synthesis, and Antiviral Activity of Novel Ribonucleosides of 1,2,3‐Triazolylbenzyl‐aminophosphonates

Identifieur interne : 000507 ( Ncbi/Curation ); précédent : 000506; suivant : 000508

Design, Synthesis, and Antiviral Activity of Novel Ribonucleosides of 1,2,3‐Triazolylbenzyl‐aminophosphonates

Auteurs : Abdelaaziz Ouahrouch ; Moha Taourirte ; Dominique Schols ; Robert Snoeck ; Graciela Andrei ; Joachim W. Engels ; Hassan B. Lazrek

Source :

Archiv Der Pharmazie [ 0365-6233 ] ; 2015.

RBID : PMC:4832832

Abstract

A novel series of ribonucleosides of 1,2,3‐triazolylbenzyl‐aminophosphonates was synthesized through the Kabachnik–Fields reaction using I₂ as catalyst followed by copper‐catalyzed cycloaddition of the azide–alkyne reaction (CuAAC). All structures of the newly prepared compounds were characterized by ¹H NMR, ¹³C NMR, and HRMS spectra. The structures of 2e, 2f, 3d, and 3g were further confirmed by X‐ray diffraction analysis. These compounds were tested against various strains of DNA and RNA viruses; compounds 4b and 4c showed a modest inhibitory activity against respiratory syncytial virus (RSV) and compound 4h displayed modest inhibitory activity against Coxsackie virus B4.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832832

DOI: 10.1002/ardp.201500292
PubMed: 26575425
PubMed Central: 4832832

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PMC:4832832

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Design, Synthesis, and Antiviral Activity of Novel Ribonucleosides of 1,2,3‐Triazolylbenzyl‐aminophosphonates

Design, Synthesis, and Antiviral Activity of Novel Ribonucleosides of 1,2,3‐Triazolylbenzyl‐aminophosphonates

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Abstract

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