Development of a cytotoxic T-lymphocyte-based, broadly protective influenza vaccine.
Identifieur interne : 000201 ( Ncbi/Checkpoint ); précédent : 000200; suivant : 000202Development of a cytotoxic T-lymphocyte-based, broadly protective influenza vaccine.
Auteurs : Tetsuya Uchida [Japon]Source :
- Microbiology and immunology [ 0385-5600 ] ; 2011.
Descripteurs français
- KwdFr :
- MESH :
- administration et posologie : Liposomes.
- immunologie : Lymphocytes T cytotoxiques, Vaccins antigrippaux.
- physiologie : Cellules présentatrices d'antigène.
- Animaux, Déterminants antigéniques des lymphocytes T, Grippe humaine, Humains, Mémoire immunologique.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Liposomes.
- chemical , immunology : Influenza Vaccines.
- chemical : Epitopes, T-Lymphocyte.
- immunology : T-Lymphocytes, Cytotoxic.
- physiology : Antigen-Presenting Cells.
- prevention & control : Influenza, Human.
- Animals, Humans, Immunologic Memory.
Abstract
The current vaccination strategy against influenza is to induce production of antibodies directed against the surface antigens of these viruses. However, frequent changes in the surface antigens of influenza viruses allow them to avoid antibody-mediated immunity. On the other hand, it is known that cytotoxic T-lymphocyte (CTL) populations directed against internal antigens of influenza A virus are broadly cross-reactive to influenza virus subtypes. The present authors have previously demonstrated that antigens chemically coupled to the surface of liposomes made using unsaturated fatty acids are cross-presented by APCs via MHC class I to CD8(+) T cells and induce antigen-specific CTLs. Based on this finding, a liposome vaccine that is capable of inducing CTL response against internal antigens of influenza viruses and removing virus-infected cells in the host has been developed. The CTL-based liposomal technique might be applicable for developing vaccines against influenza and other viruses, such as hepatitis C, HIV, and severe acute respiratory syndrome corona virus, which frequently change their surface antigenic molecules.
DOI: 10.1111/j.1348-0421.2010.00273.x
PubMed: 21175770
Affiliations:
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pubmed:21175770Le document en format XML
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scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Liposomes</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Lymphocytes T cytotoxiques</term><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>T-Lymphocytes, Cytotoxic</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Cellules présentatrices d'antigène</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Antigen-Presenting Cells</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Immunologic Memory</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Déterminants antigéniques des lymphocytes T</term><term>Grippe humaine</term><term>Humains</term><term>Mémoire immunologique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The current vaccination strategy against influenza is to induce production of antibodies directed against the surface antigens of these viruses. However, frequent changes in the surface antigens of influenza viruses allow them to avoid antibody-mediated immunity. On the other hand, it is known that cytotoxic T-lymphocyte (CTL) populations directed against internal antigens of influenza A virus are broadly cross-reactive to influenza virus subtypes. The present authors have previously demonstrated that antigens chemically coupled to the surface of liposomes made using unsaturated fatty acids are cross-presented by APCs via MHC class I to CD8(+) T cells and induce antigen-specific CTLs. Based on this finding, a liposome vaccine that is capable of inducing CTL response against internal antigens of influenza viruses and removing virus-infected cells in the host has been developed. The CTL-based liposomal technique might be applicable for developing vaccines against influenza and other viruses, such as hepatitis C, HIV, and severe acute respiratory syndrome corona virus, which frequently change their surface antigenic molecules.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><region name="Région de Kantō"><name sortKey="Uchida, Tetsuya" sort="Uchida, Tetsuya" uniqKey="Uchida T" first="Tetsuya" last="Uchida">Tetsuya Uchida</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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