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Duration of challenge immunity to coronavirus JHM in mice

Identifieur interne : 001512 ( Main/Merge ); précédent : 001511; suivant : 001513

Duration of challenge immunity to coronavirus JHM in mice

Auteurs : S. W. Barthold [États-Unis] ; Abigail L. Smith [États-Unis]

Source :

RBID : ISTEX:0A92D565FBC57699E16D52F3EC7499CD1AFA1349

English descriptors

Abstract

Summary: The duration of challenge resistance in mice immunized with mouse hepatitis virus (MHV) strain JHM was examined as a model of immunity to corona-virus infection. Genetically susceptible BALB/cByJ mice were immunized by intranasal (i.n.) or per os (p.o.) inoculation with MHV-JHM or sterile tissue culture fluid (sham) then challenged i.n. with MHV-JHM or sterile tissue culture fluid 1, 6, or 12 months later. Four days after challenge, virus in nasal turbinates and liver was quantified, and prevalance of microscopic lesions in liver and gut-associated lymphoid tissue was tabulated as indices of challenge resistance. MHV-immunized and challenged groups were compared to sham-immunized and challenged groups. Mice immunized by i.n. inoculation were strongly resistant to challenge at 1, 6, and 12 months. Mice immunized by p.o. inoculation were resistant at 1 month, but became partially susceptible to reinfection at 6 and 12 months, based upon all indices. These data indicate that, depending upon route of immunization, mice can become susceptible to reinfection with the same coronavirus strain over time.

Url:
DOI: 10.1007/BF01317914

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ISTEX:0A92D565FBC57699E16D52F3EC7499CD1AFA1349

Le document en format XML

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<term>Absolute challenge resistance</term>
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<term>Brain infection</term>
<term>Challenge immunity</term>
<term>Challenge infection</term>
<term>Challenge resistance</term>
<term>Comparative medicine</term>
<term>Coronavirus</term>
<term>Detectable liver virus</term>
<term>Detectable virus</term>
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<term>Galt</term>
<term>High prevalence</term>
<term>High titers</term>
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<term>Immunizing infection</term>
<term>Infection</term>
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<term>Intranasal</term>
<term>Intranasal challenge inoculation</term>
<term>Intranasal inoculation</term>
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<term>Lymphoid tissue</term>
<term>Month interval</term>
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<term>Mouse hepatitis virus</term>
<term>Nasal</term>
<term>Nasal mucosa</term>
<term>Nasal turbinates</term>
<term>Olfactory mucosa</term>
<term>Rodent coronaviruses</term>
<term>Same coronavirus strain</term>
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<term>Serum antibody</term>
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<term>Sham inoculation</term>
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<term>Sterile tissue culture fluid</term>
<term>Susceptible mice</term>
<term>Tissue culture fluid</term>
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<div type="abstract" xml:lang="en">Summary: The duration of challenge resistance in mice immunized with mouse hepatitis virus (MHV) strain JHM was examined as a model of immunity to corona-virus infection. Genetically susceptible BALB/cByJ mice were immunized by intranasal (i.n.) or per os (p.o.) inoculation with MHV-JHM or sterile tissue culture fluid (sham) then challenged i.n. with MHV-JHM or sterile tissue culture fluid 1, 6, or 12 months later. Four days after challenge, virus in nasal turbinates and liver was quantified, and prevalance of microscopic lesions in liver and gut-associated lymphoid tissue was tabulated as indices of challenge resistance. MHV-immunized and challenged groups were compared to sham-immunized and challenged groups. Mice immunized by i.n. inoculation were strongly resistant to challenge at 1, 6, and 12 months. Mice immunized by p.o. inoculation were resistant at 1 month, but became partially susceptible to reinfection at 6 and 12 months, based upon all indices. These data indicate that, depending upon route of immunization, mice can become susceptible to reinfection with the same coronavirus strain over time.</div>
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