Molecular mimicry between Fc receptor and S peplomer protein of mouse hepatitis virus, bovine corona virus, and transmissible gastroenteritis virus
Identifieur interne : 001300 ( Main/Merge ); précédent : 001299; suivant : 001301Molecular mimicry between Fc receptor and S peplomer protein of mouse hepatitis virus, bovine corona virus, and transmissible gastroenteritis virus
Auteurs : E. L. Oleszak [États-Unis] ; J. Kuzmak [États-Unis] ; B. Hogue ; R. Parr ; E. W. Collisson ; L. S. Rodkey ; J. L. LeibowitzSource :
- Hybridoma [ 0272-457X ] ; 1995.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
We have previously demonstrated molecular mimicry between the S peplomer protein of mouse hepatitis virus (MHV) and Fc gamma R (FcγR). A monoclonal antibody (MAb) to mouse FcγR (2.4G2 anti-FcγR MAb), purified rabbit immunoglobulin, but not their F(ab′)2 fragments, as well as mouse and rat IgG, immunoprecipitated (1) recombinant S peplomer protein expressed by a vaccinia virus recombinant in human, rabbit, and mouse cells, and (2) natural S peplomer protein from cells infected with several strains of MHV and MHV escape mutants. We report here results of studies documenting molecular mimicry between FcγR and S peplomer protein of viruses representing three distinct antigenic subgroups of the Coronaviridae. We have shown a molecular mimicry between the S peplomer protein of bovine corona virus (BCV) and FcγR. The 2.4G2 anti-FcγR MAb, rabbit IgG, but not its F(ab′)2 fragments, as well as homologous bovine serum, free of anti-BCV antibodies, immunoprecipitated S peplomer protein of BCV (Mebus strain). In contrast, we did not find molecular mimicry between S peplomer protein of human corona virus (HCV-OC43) and FcγR. Although the OC43 virus belongs to the same antigenic group as MHV and BCV, MAb specific for human FcγR I or FcγR II and purified human IgG1, IgG2, and IgG3 myeloma proteins did not immunoprecipitate the S peplomer protein from HCV-OC43-infected RD cells. In addition, we did demonstrate molecular mimicry between the S peplomer protein of porcine transmissible gastroenteritis virus (TGEV) and FcγR. TGEV belongs to the second antigenic subgroup of coronaviridae. Homologous swine IgG, but not its F(ab′)2 fragments, immunoprecipitated from TGEV-infected cells a 195-kDa polypeptide corresponding to the TGEV S peplomer protein. We have also examined whether there is a molecular mimicry between S peplomer protein of infectious bronchitis virus (IBV) and FcγR. Nonimmune chicken IgG did not immunoprecipitate the S peplomer protein from IBV-infected chicken embryo fibroblasts or Vero cells, suggesting that there is no molecular mimicry between the IBV-S and FcγR. In conclusion, we have demonstrated molecular mimicry between FcγR and S peplomer protein of three members of Coronaviridae, namely MHV, BCV, and TGEV. In contrast, the S peplomer protein of two other members of Coronaviridae, namely HCV-OC43 and IBV, did not exhibit any molecular mimicry with FcγR
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000063
- to stream PascalFrancis, to step Curation: 000067
- to stream PascalFrancis, to step Checkpoint: 000062
Links to Exploration step
Pascal:95-0193765Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Molecular mimicry between Fc receptor and S peplomer protein of mouse hepatitis virus, bovine corona virus, and transmissible gastroenteritis virus</title>
<author><name sortKey="Oleszak, E L" sort="Oleszak, E L" uniqKey="Oleszak E" first="E. L." last="Oleszak">E. L. Oleszak</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Temple univ. school medicine, Fels inst. cancer res. molecular biology</s1>
<s2>Philadelphia PA 19140</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Philadelphia PA 19140</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kuzmak, J" sort="Kuzmak, J" uniqKey="Kuzmak J" first="J." last="Kuzmak">J. Kuzmak</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Temple univ. school medicine, Fels inst. cancer res. molecular biology</s1>
<s2>Philadelphia PA 19140</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Philadelphia PA 19140</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hogue, B" sort="Hogue, B" uniqKey="Hogue B" first="B." last="Hogue">B. Hogue</name>
</author>
<author><name sortKey="Parr, R" sort="Parr, R" uniqKey="Parr R" first="R." last="Parr">R. Parr</name>
</author>
<author><name sortKey="Collisson, E W" sort="Collisson, E W" uniqKey="Collisson E" first="E. W." last="Collisson">E. W. Collisson</name>
</author>
<author><name sortKey="Rodkey, L S" sort="Rodkey, L S" uniqKey="Rodkey L" first="L. S." last="Rodkey">L. S. Rodkey</name>
</author>
<author><name sortKey="Leibowitz, J L" sort="Leibowitz, J L" uniqKey="Leibowitz J" first="J. L." last="Leibowitz">J. L. Leibowitz</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">95-0193765</idno>
<date when="1995">1995</date>
<idno type="stanalyst">PASCAL 95-0193765 INIST</idno>
<idno type="RBID">Pascal:95-0193765</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000063</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000067</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000062</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000062</idno>
<idno type="wicri:doubleKey">0272-457X:1995:Oleszak E:molecular:mimicry:between</idno>
<idno type="wicri:Area/Main/Merge">001300</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Molecular mimicry between Fc receptor and S peplomer protein of mouse hepatitis virus, bovine corona virus, and transmissible gastroenteritis virus</title>
<author><name sortKey="Oleszak, E L" sort="Oleszak, E L" uniqKey="Oleszak E" first="E. L." last="Oleszak">E. L. Oleszak</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Temple univ. school medicine, Fels inst. cancer res. molecular biology</s1>
<s2>Philadelphia PA 19140</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Philadelphia PA 19140</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kuzmak, J" sort="Kuzmak, J" uniqKey="Kuzmak J" first="J." last="Kuzmak">J. Kuzmak</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Temple univ. school medicine, Fels inst. cancer res. molecular biology</s1>
<s2>Philadelphia PA 19140</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Philadelphia PA 19140</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hogue, B" sort="Hogue, B" uniqKey="Hogue B" first="B." last="Hogue">B. Hogue</name>
</author>
<author><name sortKey="Parr, R" sort="Parr, R" uniqKey="Parr R" first="R." last="Parr">R. Parr</name>
</author>
<author><name sortKey="Collisson, E W" sort="Collisson, E W" uniqKey="Collisson E" first="E. W." last="Collisson">E. W. Collisson</name>
</author>
<author><name sortKey="Rodkey, L S" sort="Rodkey, L S" uniqKey="Rodkey L" first="L. S." last="Rodkey">L. S. Rodkey</name>
</author>
<author><name sortKey="Leibowitz, J L" sort="Leibowitz, J L" uniqKey="Leibowitz J" first="J. L." last="Leibowitz">J. L. Leibowitz</name>
</author>
</analytic>
<series><title level="j" type="main">Hybridoma</title>
<title level="j" type="abbreviated">Hybridoma</title>
<idno type="ISSN">0272-457X</idno>
<imprint><date when="1995">1995</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Hybridoma</title>
<title level="j" type="abbreviated">Hybridoma</title>
<idno type="ISSN">0272-457X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biological receptor</term>
<term>Cross reaction</term>
<term>Human</term>
<term>IgG</term>
<term>Mimetism</term>
<term>Monoclonal antibody</term>
<term>Mouse</term>
<term>Murine hepatitis virus</term>
<term>Mutation</term>
<term>Porcine transmissible gastroenteritis virus</term>
<term>Recombinant protein</term>
<term>Serology</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Souris</term>
<term>Homme</term>
<term>Virus hépatite murine</term>
<term>Virus gastroentérite transmissible porc</term>
<term>Mutation</term>
<term>Mimétisme</term>
<term>Protéine recombinante</term>
<term>Anticorps monoclonal</term>
<term>Récepteur biologique</term>
<term>Sérologie</term>
<term>Réaction croisée</term>
<term>IgG</term>
<term>Récepteur Fcγ</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We have previously demonstrated molecular mimicry between the S peplomer protein of mouse hepatitis virus (MHV) and Fc gamma R (FcγR). A monoclonal antibody (MAb) to mouse FcγR (2.4G2 anti-FcγR MAb), purified rabbit immunoglobulin, but not their F(ab′)<sub>2</sub>
fragments, as well as mouse and rat IgG, immunoprecipitated (1) recombinant S peplomer protein expressed by a vaccinia virus recombinant in human, rabbit, and mouse cells, and (2) natural S peplomer protein from cells infected with several strains of MHV and MHV escape mutants. We report here results of studies documenting molecular mimicry between FcγR and S peplomer protein of viruses representing three distinct antigenic subgroups of the Coronaviridae. We have shown a molecular mimicry between the S peplomer protein of bovine corona virus (BCV) and FcγR. The 2.4G2 anti-FcγR MAb, rabbit IgG, but not its F(ab′)<sub>2</sub>
fragments, as well as homologous bovine serum, free of anti-BCV antibodies, immunoprecipitated S peplomer protein of BCV (Mebus strain). In contrast, we did not find molecular mimicry between S peplomer protein of human corona virus (HCV-OC43) and FcγR. Although the OC43 virus belongs to the same antigenic group as MHV and BCV, MAb specific for human FcγR I or FcγR II and purified human IgG<sub>1</sub>
, IgG<sub>2</sub>
, and IgG<sub>3</sub>
myeloma proteins did not immunoprecipitate the S peplomer protein from HCV-OC43-infected RD cells. In addition, we did demonstrate molecular mimicry between the S peplomer protein of porcine transmissible gastroenteritis virus (TGEV) and FcγR. TGEV belongs to the second antigenic subgroup of coronaviridae. Homologous swine IgG, but not its F(ab′)<sub>2</sub>
fragments, immunoprecipitated from TGEV-infected cells a 195-kDa polypeptide corresponding to the TGEV S peplomer protein. We have also examined whether there is a molecular mimicry between S peplomer protein of infectious bronchitis virus (IBV) and FcγR. Nonimmune chicken IgG did not immunoprecipitate the S peplomer protein from IBV-infected chicken embryo fibroblasts or Vero cells, suggesting that there is no molecular mimicry between the IBV-S and FcγR. In conclusion, we have demonstrated molecular mimicry between FcγR and S peplomer protein of three members of Coronaviridae, namely MHV, BCV, and TGEV. In contrast, the S peplomer protein of two other members of Coronaviridae, namely HCV-OC43 and IBV, did not exhibit any molecular mimicry with FcγR</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
</list>
<tree><noCountry><name sortKey="Collisson, E W" sort="Collisson, E W" uniqKey="Collisson E" first="E. W." last="Collisson">E. W. Collisson</name>
<name sortKey="Hogue, B" sort="Hogue, B" uniqKey="Hogue B" first="B." last="Hogue">B. Hogue</name>
<name sortKey="Leibowitz, J L" sort="Leibowitz, J L" uniqKey="Leibowitz J" first="J. L." last="Leibowitz">J. L. Leibowitz</name>
<name sortKey="Parr, R" sort="Parr, R" uniqKey="Parr R" first="R." last="Parr">R. Parr</name>
<name sortKey="Rodkey, L S" sort="Rodkey, L S" uniqKey="Rodkey L" first="L. S." last="Rodkey">L. S. Rodkey</name>
</noCountry>
<country name="États-Unis"><noRegion><name sortKey="Oleszak, E L" sort="Oleszak, E L" uniqKey="Oleszak E" first="E. L." last="Oleszak">E. L. Oleszak</name>
</noRegion>
<name sortKey="Kuzmak, J" sort="Kuzmak, J" uniqKey="Kuzmak J" first="J." last="Kuzmak">J. Kuzmak</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001300 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 001300 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= CovidV1 |flux= Main |étape= Merge |type= RBID |clé= Pascal:95-0193765 |texte= Molecular mimicry between Fc receptor and S peplomer protein of mouse hepatitis virus, bovine corona virus, and transmissible gastroenteritis virus }}
This area was generated with Dilib version V0.6.33. |