Spectrum of respiratory viral infections in liver disease patients with cirrhosis admitted in critical care unit
Identifieur interne : 000634 ( Main/Exploration ); précédent : 000633; suivant : 000635Spectrum of respiratory viral infections in liver disease patients with cirrhosis admitted in critical care unit
Auteurs : Vijeta Bajpai ; Ekta Gupta ; Lalita Gauri Mitra ; Hemant Kumar ; Rakhi Maiwall ; Kapil Dev Soni ; Amit GuptaSource :
- Journal of Laboratory Physicians [ 0974-2727 ] ; 2019.
Abstract
Clinical significance of respiratory viruses (RVs) as an etiology of pneumonia in liver disease patients with cirrhosis is usually underestimated. Therefore, the aim of this study was to evaluate the spectrum of RVs in cirrhotic patients with pneumonia admitted in critical care units (CCUs) and its impact on the clinical outcome of cirrhotic patients.
A prospective study was conducted in a tertiary care CCU, and consecutive cirrhotic patients with pneumonia were included. Bronchoalveolar lavage or throat swab/nasal swab was collected in viral transport medium for analysis of RVs by multiplex real-time polymerase chain reaction. A total of 135 cirrhotic patients were included, viral and bacterial etiology of pneumonia was identified, and analysis was done with the clinical outcome.
Overall, RVs were detected in 30 (22.2%) cirrhotic patients and viral–bacterial coinfection in 16 (11.8%) cirrhotic patients. The most common virus detected was rhinovirus in 9 (30%) patients. Mortality in cirrhotic patients with RV infection was significantly higher in comparison to cirrhotic patients with no RV infection (25 [83.3%] and 11 [12.3%], respectively,
Respiratory viruses in cirrhotic patients with pneumonia are associated with poor clinical outcome.
Url:
DOI: 10.4103/JLP.JLP_6_19
PubMed: 31929704
PubMed Central: 6943874
Affiliations:
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Kumar</name><affiliation><nlm:aff id="aff3"><italic>Pulmonary Medicine, JPNATC, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Maiwall, Rakhi" sort="Maiwall, Rakhi" uniqKey="Maiwall R" first="Rakhi" last="Maiwall">Rakhi Maiwall</name><affiliation><nlm:aff id="aff4"><italic>Hepatology, Institute of Liver and Biliary Sciences, JPNATC, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Soni, Kapil Dev" sort="Soni, Kapil Dev" uniqKey="Soni K" first="Kapil Dev" last="Soni">Kapil Dev Soni</name><affiliation><nlm:aff id="aff5"><italic>Department of Trauma and Critical Intensive Care Unit, JPNATC, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Gupta, Amit" sort="Gupta, Amit" uniqKey="Gupta A" first="Amit" last="Gupta">Amit Gupta</name><affiliation><nlm:aff 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type="wicri:Area/Ncbi/Checkpoint">000805</idno><idno type="wicri:doubleKey">0974-2727:2019:Bajpai V:spectrum:of:respiratory</idno><idno type="wicri:Area/Main/Merge">000636</idno><idno type="wicri:Area/Main/Curation">000634</idno><idno type="wicri:Area/Main/Exploration">000634</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Spectrum of respiratory viral infections in liver disease patients with cirrhosis admitted in critical care unit</title><author><name sortKey="Bajpai, Vijeta" sort="Bajpai, Vijeta" uniqKey="Bajpai V" first="Vijeta" last="Bajpai">Vijeta Bajpai</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Gupta, Ekta" sort="Gupta, Ekta" uniqKey="Gupta E" first="Ekta" last="Gupta">Ekta Gupta</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Mitra, Lalita Gauri" sort="Mitra, Lalita Gauri" uniqKey="Mitra L" first="Lalita Gauri" last="Mitra">Lalita Gauri Mitra</name><affiliation><nlm:aff id="aff2"><italic>Critical Care and Anaesthesia, JPNATC, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Kumar, Hemant" sort="Kumar, Hemant" uniqKey="Kumar H" first="Hemant" last="Kumar">Hemant Kumar</name><affiliation><nlm:aff id="aff3"><italic>Pulmonary Medicine, JPNATC, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Maiwall, Rakhi" sort="Maiwall, Rakhi" uniqKey="Maiwall R" first="Rakhi" last="Maiwall">Rakhi Maiwall</name><affiliation><nlm:aff id="aff4"><italic>Hepatology, Institute of Liver and Biliary Sciences, JPNATC, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Soni, Kapil Dev" sort="Soni, Kapil Dev" uniqKey="Soni K" first="Kapil Dev" last="Soni">Kapil Dev Soni</name><affiliation><nlm:aff id="aff5"><italic>Department of Trauma and Critical Intensive Care Unit, JPNATC, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Gupta, Amit" sort="Gupta, Amit" uniqKey="Gupta A" first="Amit" last="Gupta">Amit Gupta</name><affiliation><nlm:aff id="aff6"><italic>Department of Surgery, JPNATC, All India Institute of Medical Sciences, New Delhi, India</italic></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Laboratory Physicians</title><idno type="ISSN">0974-2727</idno><idno type="eISSN">0974-7826</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>BACKGROUND:</title><p>Clinical significance of respiratory viruses (RVs) as an etiology of pneumonia in liver disease patients with cirrhosis is usually underestimated. Therefore, the aim of this study was to evaluate the spectrum of RVs in cirrhotic patients with pneumonia admitted in critical care units (CCUs) and its impact on the clinical outcome of cirrhotic patients.</p></sec><sec id="st2"><title>MATERIAL AND METHOD:</title><p>A prospective study was conducted in a tertiary care CCU, and consecutive cirrhotic patients with pneumonia were included. Bronchoalveolar lavage or throat swab/nasal swab was collected in viral transport medium for analysis of RVs by multiplex real-time polymerase chain reaction. A total of 135 cirrhotic patients were included, viral and bacterial etiology of pneumonia was identified, and analysis was done with the clinical outcome.</p></sec><sec id="st3"><title>RESULTS:</title><p>Overall, RVs were detected in 30 (22.2%) cirrhotic patients and viral–bacterial coinfection in 16 (11.8%) cirrhotic patients. The most common virus detected was rhinovirus in 9 (30%) patients. Mortality in cirrhotic patients with RV infection was significantly higher in comparison to cirrhotic patients with no RV infection (25 [83.3%] and 11 [12.3%], respectively, <italic>P</italic> < 0.001).</p></sec><sec id="st4"><title>CONCLUSION:</title><p>Respiratory viruses in cirrhotic patients with pneumonia are associated with poor clinical outcome.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Xu, L" uniqKey="Xu L">L Xu</name></author><author><name sortKey="Ying, S" uniqKey="Ying S">S Ying</name></author><author><name sortKey="Hu, J" uniqKey="Hu J">J Hu</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Yang, M" uniqKey="Yang M">M Yang</name></author><author><name sortKey="Ge, T" uniqKey="Ge T">T Ge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Viasus, D" uniqKey="Viasus D">D Viasus</name></author><author><name 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Basualdo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bellinghausen, C" uniqKey="Bellinghausen C">C Bellinghausen</name></author><author><name sortKey="Rohde, Gg" uniqKey="Rohde G">GG Rohde</name></author><author><name sortKey="Savelkoul, Ph" uniqKey="Savelkoul P">PH Savelkoul</name></author><author><name sortKey="Wouters, Ef" uniqKey="Wouters E">EF Wouters</name></author><author><name sortKey="Stassen, Fr" uniqKey="Stassen F">FR Stassen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morris, De" uniqKey="Morris D">DE Morris</name></author><author><name sortKey="Cleary, Dw" uniqKey="Cleary D">DW Cleary</name></author><author><name sortKey="Clarke, Sc" uniqKey="Clarke S">SC Clarke</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bajpai, Vijeta" sort="Bajpai, Vijeta" uniqKey="Bajpai V" first="Vijeta" last="Bajpai">Vijeta Bajpai</name><name sortKey="Gupta, Amit" sort="Gupta, Amit" uniqKey="Gupta A" first="Amit" last="Gupta">Amit Gupta</name><name sortKey="Gupta, Ekta" sort="Gupta, Ekta" uniqKey="Gupta E" first="Ekta" last="Gupta">Ekta Gupta</name><name sortKey="Kumar, Hemant" sort="Kumar, Hemant" uniqKey="Kumar H" first="Hemant" last="Kumar">Hemant Kumar</name><name sortKey="Maiwall, Rakhi" sort="Maiwall, Rakhi" uniqKey="Maiwall R" first="Rakhi" last="Maiwall">Rakhi Maiwall</name><name sortKey="Mitra, Lalita Gauri" sort="Mitra, Lalita Gauri" uniqKey="Mitra L" first="Lalita Gauri" last="Mitra">Lalita Gauri Mitra</name><name sortKey="Soni, Kapil Dev" sort="Soni, Kapil Dev" uniqKey="Soni K" first="Kapil Dev" last="Soni">Kapil Dev Soni</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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