The iddm4 Locus Segregates With Diabetes Susceptibility in Congenic WF.iddm4 Rats
Identifieur interne : 001110 ( Main/Exploration ); précédent : 001109; suivant : 001111The iddm4 Locus Segregates With Diabetes Susceptibility in Congenic WF.iddm4 Rats
Auteurs : John P. Mordes [États-Unis] ; Jean Leif [États-Unis] ; Stephen Novak ; Cheryl Descipio ; Dale L. Greiner [États-Unis] ; Elizabeth P. BlankenhornSource :
- Diabetes [ 0012-1797 ] ; 2002.
Abstract
Viral antibody–free BBDR and WF rats never develop spontaneous diabetes. BBDR rats, however, develop autoimmune diabetes after perturbation of the immune system, e.g., by viral infection. We previously identified a disease-susceptibility locus in the BBDR rat,
Url:
PubMed: 12401717
PubMed Central: 4034451
Affiliations:
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Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The <italic>iddm4</italic>
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<author><name sortKey="Mordes, John P" sort="Mordes, John P" uniqKey="Mordes J" first="John P." last="Mordes">John P. Mordes</name>
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<placeName><region type="state">Massachusetts</region>
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<wicri:cityArea>Department of Medicine, University of Massachusetts Medical School, Worcester</wicri:cityArea>
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<author><name sortKey="Leif, Jean" sort="Leif, Jean" uniqKey="Leif J" first="Jean" last="Leif">Jean Leif</name>
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<author><name sortKey="Greiner, Dale L" sort="Greiner, Dale L" uniqKey="Greiner D" first="Dale L." last="Greiner">Dale L. Greiner</name>
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<author><name sortKey="Blankenhorn, Elizabeth P" sort="Blankenhorn, Elizabeth P" uniqKey="Blankenhorn E" first="Elizabeth P." last="Blankenhorn">Elizabeth P. Blankenhorn</name>
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<series><title level="j">Diabetes</title>
<idno type="ISSN">0012-1797</idno>
<idno type="eISSN">1939-327X</idno>
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<front><div type="abstract" xml:lang="en"><p id="P1">Viral antibody–free BBDR and WF rats never develop spontaneous diabetes. BBDR rats, however, develop autoimmune diabetes after perturbation of the immune system, e.g., by viral infection. We previously identified a disease-susceptibility locus in the BBDR rat, <italic>iddm4</italic>
, which is associated with the development of autoimmune diabetes after treatment with polyinosinic:polycytidylic acid and an antibody that depletes ART2<sup>+</sup>
regulatory cells. We have now developed lines of congenic WF.<italic>iddm4</italic>
rats and report that in an intercross of N5 generation WF.<italic>iddm4</italic>
rats, ∼70% of animals either homozygous or heterozygous for the BBDR origin allele of <italic>iddm4</italic>
became hyperglycemic after treatment to induce diabetes. Fewer than 20% of rats expressing the WF origin allele of <italic>iddm4</italic>
became diabetic. Testing the progeny of various recombinant N5 WF.<italic>iddm4</italic>
congenic rats for susceptibility to diabetes suggests that <italic>iddm4</italic>
is centered on a small segment of chromosome 4 bounded by the proximal marker <italic>D4Rat135</italic>
and the distal marker <italic>D4Got51</italic>
, an interval of <2.8 cM. The allele at <italic>iddm4</italic>
has 79% sensitivity and 80% specificity in prediction of diabetes in rats that are segregating for this locus. These characteristics suggest that <italic>iddm4</italic>
is one of the most powerful non–major histocompatibility complex determinants of susceptibility to autoimmune diabetes described to date.</p>
</div>
</front>
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<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Massachusetts</li>
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<tree><noCountry><name sortKey="Blankenhorn, Elizabeth P" sort="Blankenhorn, Elizabeth P" uniqKey="Blankenhorn E" first="Elizabeth P." last="Blankenhorn">Elizabeth P. Blankenhorn</name>
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<name sortKey="Novak, Stephen" sort="Novak, Stephen" uniqKey="Novak S" first="Stephen" last="Novak">Stephen Novak</name>
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<country name="États-Unis"><region name="Massachusetts"><name sortKey="Mordes, John P" sort="Mordes, John P" uniqKey="Mordes J" first="John P." last="Mordes">John P. Mordes</name>
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