α4-integrins control viral meningoencephalitis through differential recruitment of T helper cell subsets
Identifieur interne : 000997 ( Main/Exploration ); précédent : 000996; suivant : 000998α4-integrins control viral meningoencephalitis through differential recruitment of T helper cell subsets
Auteurs : Veit Rothhammer [Allemagne] ; Andreas Muschaweckh [Allemagne] ; Georg Gasteiger [États-Unis] ; Franziska Petermann [Allemagne] ; Sylvia Heink [Allemagne] ; Dirk H. Busch [Allemagne] ; Mathias Heikenw Lder [Allemagne] ; Bernhard Hemmer [Allemagne] ; Ingo Drexler [Allemagne] ; Thomas Korn [Allemagne]Source :
- Acta Neuropathologica Communications [ 2051-5960 ] ; 2014.
Abstract
Natalizumab blocks α4-integrins and is a prototypic agent for a series of anti-inflammatory drugs that impair trafficking of immune cells into the CNS. However, modulation of the access of immune cells to the CNS is associated with impaired immune surveillance and detrimental viral infections of the CNS. Here, we explored the potency of cellular immune responses within the CNS to protect against viral encephalitis in mice with T cell conditional disruption of VLA-4 integrin (α4β1) expression.
While VLA-4 expression in virus specific Th1 cells is non-redundant for their ability to access the CNS, α4-integrin deficient Th17 cells enter the CNS compartment and generate an inflammatory milieu upon intrathecal vaccinia virus (VV) infection. However, in contrast to Th1 cells that can adopt direct cytotoxic properties, Th17 cells fail to clear the virus due to insufficient Eomes induced perforin-1 expression.
The quality of the intrathecal cellular antiviral response under conditions of impaired VLA-4 function jeopardizes host protection. Our functional
Url:
DOI: 10.1186/2051-5960-2-27
PubMed: 24606807
PubMed Central: 4029267
Affiliations:
- Allemagne, États-Unis
- Bavière, District de Düsseldorf, District de Haute-Bavière, Rhénanie-du-Nord-Westphalie
- Düsseldorf, Munich
- Université technique de Munich
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000389
- to stream Pmc, to step Curation: 000389
- to stream Pmc, to step Checkpoint: 000380
- to stream Ncbi, to step Merge: 000375
- to stream Ncbi, to step Curation: 000375
- to stream Ncbi, to step Checkpoint: 000375
- to stream Main, to step Merge: 000999
- to stream Main, to step Curation: 000997
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">α4-integrins control viral meningoencephalitis through differential recruitment of T helper cell subsets</title><author><name sortKey="Rothhammer, Veit" sort="Rothhammer, Veit" uniqKey="Rothhammer V" first="Veit" last="Rothhammer">Veit Rothhammer</name><affiliation wicri:level="4"><nlm:aff id="I1">Klinikum rechts der Isar, Department of Neurology, Technische Universität München, Ismaninger Str. 22, 81675 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinikum rechts der Isar, Department of Neurology, Technische Universität München, Ismaninger Str. 22, 81675 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Muschaweckh, Andreas" sort="Muschaweckh, Andreas" uniqKey="Muschaweckh A" first="Andreas" last="Muschaweckh">Andreas Muschaweckh</name><affiliation wicri:level="4"><nlm:aff id="I2">Institute of Virology, Helmholtz Zentrum München, Technische Universität München, Schneckenburger Str. 8, 81675 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, Helmholtz Zentrum München, Technische Universität München, Schneckenburger Str. 8, 81675 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Gasteiger, Georg" sort="Gasteiger, Georg" uniqKey="Gasteiger G" first="Georg" last="Gasteiger">Georg Gasteiger</name><affiliation wicri:level="1"><nlm:aff id="I3">Howard Hughes Medical Institute and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Howard Hughes Medical Institute and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065</wicri:regionArea><wicri:noRegion>NY 10065</wicri:noRegion></affiliation></author><author><name sortKey="Petermann, Franziska" sort="Petermann, Franziska" uniqKey="Petermann F" first="Franziska" last="Petermann">Franziska Petermann</name><affiliation wicri:level="4"><nlm:aff id="I1">Klinikum rechts der Isar, Department of Neurology, Technische Universität München, Ismaninger Str. 22, 81675 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinikum rechts der Isar, Department of Neurology, Technische Universität München, Ismaninger Str. 22, 81675 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Heink, Sylvia" sort="Heink, Sylvia" uniqKey="Heink S" first="Sylvia" last="Heink">Sylvia Heink</name><affiliation wicri:level="4"><nlm:aff id="I1">Klinikum rechts der Isar, Department of Neurology, Technische Universität München, Ismaninger Str. 22, 81675 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinikum rechts der Isar, Department of Neurology, Technische Universität München, Ismaninger Str. 22, 81675 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Busch, Dirk H" sort="Busch, Dirk H" uniqKey="Busch D" first="Dirk H" last="Busch">Dirk H. Busch</name><affiliation wicri:level="4"><nlm:aff id="I4">Institute for Medical Microbiology, Immunology, and Hygiene, Technische Universität München, Trogerstr. 30, 81675 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Medical Microbiology, Immunology, and Hygiene, Technische Universität München, Trogerstr. 30, 81675 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Heikenw Lder, Mathias" sort="Heikenw Lder, Mathias" uniqKey="Heikenw Lder M" first="Mathias" last="Heikenw Lder">Mathias Heikenw Lder</name><affiliation wicri:level="4"><nlm:aff id="I2">Institute of Virology, Helmholtz Zentrum München, Technische Universität München, Schneckenburger Str. 8, 81675 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, Helmholtz Zentrum München, Technische Universität München, Schneckenburger Str. 8, 81675 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Hemmer, Bernhard" sort="Hemmer, Bernhard" uniqKey="Hemmer B" first="Bernhard" last="Hemmer">Bernhard Hemmer</name><affiliation wicri:level="4"><nlm:aff id="I1">Klinikum rechts der Isar, Department of Neurology, Technische Universität München, Ismaninger Str. 22, 81675 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinikum rechts der Isar, Department of Neurology, Technische Universität München, Ismaninger Str. 22, 81675 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="I5">Munich Cluster for Systems Neurology (SyNergy), Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Munich Cluster for Systems Neurology (SyNergy), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Drexler, Ingo" sort="Drexler, Ingo" uniqKey="Drexler I" first="Ingo" last="Drexler">Ingo Drexler</name><affiliation wicri:level="3"><nlm:aff id="I6">Institute for Virology, Düsseldorf University Hospital, Heinrich-Heine-University, Universitätsstr. 1, 40225 Düsseldorf, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Virology, Düsseldorf University Hospital, Heinrich-Heine-University, Universitätsstr. 1, 40225 Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Korn, Thomas" sort="Korn, Thomas" uniqKey="Korn T" first="Thomas" last="Korn">Thomas Korn</name><affiliation wicri:level="4"><nlm:aff id="I1">Klinikum rechts der Isar, Department of Neurology, Technische Universität München, Ismaninger Str. 22, 81675 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinikum rechts der Isar, Department of Neurology, Technische Universität München, Ismaninger Str. 22, 81675 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="I5">Munich Cluster for Systems Neurology (SyNergy), Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Munich Cluster for Systems Neurology (SyNergy), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24606807</idno><idno type="pmc">4029267</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029267</idno><idno type="RBID">PMC:4029267</idno><idno type="doi">10.1186/2051-5960-2-27</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000389</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000389</idno><idno type="wicri:Area/Pmc/Curation">000389</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000389</idno><idno type="wicri:Area/Pmc/Checkpoint">000380</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000380</idno><idno type="wicri:Area/Ncbi/Merge">000375</idno><idno type="wicri:Area/Ncbi/Curation">000375</idno><idno type="wicri:Area/Ncbi/Checkpoint">000375</idno><idno type="wicri:Area/Main/Merge">000999</idno><idno type="wicri:Area/Main/Curation">000997</idno><idno type="wicri:Area/Main/Exploration">000997</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">α4-integrins control viral meningoencephalitis through differential recruitment of T helper cell subsets</title><author><name sortKey="Rothhammer, Veit" sort="Rothhammer, Veit" uniqKey="Rothhammer V" first="Veit" last="Rothhammer">Veit Rothhammer</name><affiliation wicri:level="4"><nlm:aff id="I1">Klinikum rechts der Isar, Department of Neurology, Technische Universität München, Ismaninger Str. 22, 81675 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinikum rechts der Isar, Department of Neurology, Technische Universität München, Ismaninger Str. 22, 81675 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Muschaweckh, Andreas" sort="Muschaweckh, Andreas" uniqKey="Muschaweckh A" first="Andreas" last="Muschaweckh">Andreas Muschaweckh</name><affiliation wicri:level="4"><nlm:aff id="I2">Institute of Virology, Helmholtz Zentrum München, Technische Universität München, Schneckenburger Str. 8, 81675 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, Helmholtz Zentrum München, Technische Universität München, Schneckenburger Str. 8, 81675 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Gasteiger, Georg" sort="Gasteiger, Georg" uniqKey="Gasteiger G" first="Georg" last="Gasteiger">Georg Gasteiger</name><affiliation wicri:level="1"><nlm:aff id="I3">Howard Hughes Medical Institute and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Howard Hughes Medical Institute and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065</wicri:regionArea><wicri:noRegion>NY 10065</wicri:noRegion></affiliation></author><author><name sortKey="Petermann, Franziska" sort="Petermann, Franziska" uniqKey="Petermann F" first="Franziska" last="Petermann">Franziska Petermann</name><affiliation wicri:level="4"><nlm:aff id="I1">Klinikum rechts der Isar, Department of Neurology, Technische Universität München, Ismaninger Str. 22, 81675 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinikum rechts der Isar, Department of Neurology, Technische Universität München, Ismaninger Str. 22, 81675 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Heink, Sylvia" sort="Heink, Sylvia" uniqKey="Heink S" first="Sylvia" last="Heink">Sylvia Heink</name><affiliation wicri:level="4"><nlm:aff id="I1">Klinikum rechts der Isar, Department of Neurology, Technische Universität München, Ismaninger Str. 22, 81675 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinikum rechts der Isar, Department of Neurology, Technische Universität München, Ismaninger Str. 22, 81675 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Busch, Dirk H" sort="Busch, Dirk H" uniqKey="Busch D" first="Dirk H" last="Busch">Dirk H. Busch</name><affiliation wicri:level="4"><nlm:aff id="I4">Institute for Medical Microbiology, Immunology, and Hygiene, Technische Universität München, Trogerstr. 30, 81675 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Medical Microbiology, Immunology, and Hygiene, Technische Universität München, Trogerstr. 30, 81675 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Heikenw Lder, Mathias" sort="Heikenw Lder, Mathias" uniqKey="Heikenw Lder M" first="Mathias" last="Heikenw Lder">Mathias Heikenw Lder</name><affiliation wicri:level="4"><nlm:aff id="I2">Institute of Virology, Helmholtz Zentrum München, Technische Universität München, Schneckenburger Str. 8, 81675 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, Helmholtz Zentrum München, Technische Universität München, Schneckenburger Str. 8, 81675 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Hemmer, Bernhard" sort="Hemmer, Bernhard" uniqKey="Hemmer B" first="Bernhard" last="Hemmer">Bernhard Hemmer</name><affiliation wicri:level="4"><nlm:aff id="I1">Klinikum rechts der Isar, Department of Neurology, Technische Universität München, Ismaninger Str. 22, 81675 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinikum rechts der Isar, Department of Neurology, Technische Universität München, Ismaninger Str. 22, 81675 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="I5">Munich Cluster for Systems Neurology (SyNergy), Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Munich Cluster for Systems Neurology (SyNergy), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Drexler, Ingo" sort="Drexler, Ingo" uniqKey="Drexler I" first="Ingo" last="Drexler">Ingo Drexler</name><affiliation wicri:level="3"><nlm:aff id="I6">Institute for Virology, Düsseldorf University Hospital, Heinrich-Heine-University, Universitätsstr. 1, 40225 Düsseldorf, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Virology, Düsseldorf University Hospital, Heinrich-Heine-University, Universitätsstr. 1, 40225 Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Korn, Thomas" sort="Korn, Thomas" uniqKey="Korn T" first="Thomas" last="Korn">Thomas Korn</name><affiliation wicri:level="4"><nlm:aff id="I1">Klinikum rechts der Isar, Department of Neurology, Technische Universität München, Ismaninger Str. 22, 81675 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinikum rechts der Isar, Department of Neurology, Technische Universität München, Ismaninger Str. 22, 81675 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="I5">Munich Cluster for Systems Neurology (SyNergy), Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Munich Cluster for Systems Neurology (SyNergy), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author></analytic><series><title level="j">Acta Neuropathologica Communications</title><idno type="eISSN">2051-5960</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction</title><p>Natalizumab blocks α4-integrins and is a prototypic agent for a series of anti-inflammatory drugs that impair trafficking of immune cells into the CNS. However, modulation of the access of immune cells to the CNS is associated with impaired immune surveillance and detrimental viral infections of the CNS. Here, we explored the potency of cellular immune responses within the CNS to protect against viral encephalitis in mice with T cell conditional disruption of VLA-4 integrin (α4β1) expression.</p></sec><sec><title>Results</title><p>While VLA-4 expression in virus specific Th1 cells is non-redundant for their ability to access the CNS, α4-integrin deficient Th17 cells enter the CNS compartment and generate an inflammatory milieu upon intrathecal vaccinia virus (VV) infection. However, in contrast to Th1 cells that can adopt direct cytotoxic properties, Th17 cells fail to clear the virus due to insufficient Eomes induced perforin-1 expression.</p></sec><sec><title>Conclusion</title><p>The quality of the intrathecal cellular antiviral response under conditions of impaired VLA-4 function jeopardizes host protection. Our functional <italic>in vivo</italic> data extend our mechanistic understanding of anti-viral immunity in the CNS and help to estimate the risk potential of upcoming therapeutic agents that target the trafficking of immune cells into distinct anatomical compartments.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Domingues, Hs" uniqKey="Domingues H">HS Domingues</name></author><author><name sortKey="Mues, M" uniqKey="Mues M">M Mues</name></author><author><name sortKey="Lassmann, H" uniqKey="Lassmann H">H Lassmann</name></author><author><name sortKey="Wekerle, H" uniqKey="Wekerle H">H Wekerle</name></author><author><name sortKey="Krishnamoorthy, G" uniqKey="Krishnamoorthy G">G Krishnamoorthy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yednock, Ta" uniqKey="Yednock T">TA Yednock</name></author><author><name sortKey="Cannon, C" uniqKey="Cannon C">C Cannon</name></author><author><name sortKey="Fritz, Lc" uniqKey="Fritz L">LC Fritz</name></author><author><name sortKey="Sanchez Madrid, F" uniqKey="Sanchez Madrid F">F Sanchez-Madrid</name></author><author><name sortKey="Steinman, L" uniqKey="Steinman L">L Steinman</name></author><author><name sortKey="Karin, N" uniqKey="Karin N">N Karin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Polman, Ch" uniqKey="Polman C">CH Polman</name></author><author><name sortKey="O Onnor, Pw" uniqKey="O Onnor P">PW O’Connor</name></author><author><name sortKey="Havrdova, E" uniqKey="Havrdova E">E Havrdova</name></author><author><name sortKey="Hutchinson, M" uniqKey="Hutchinson M">M Hutchinson</name></author><author><name sortKey="Kappos, L" uniqKey="Kappos L">L Kappos</name></author><author><name sortKey="Miller, Dh" uniqKey="Miller D">DH Miller</name></author><author><name sortKey="Phillips, Jt" uniqKey="Phillips J">JT Phillips</name></author><author><name sortKey="Lublin, Fd" uniqKey="Lublin F">FD Lublin</name></author><author><name sortKey="Giovannoni, G" uniqKey="Giovannoni G">G Giovannoni</name></author><author><name sortKey="Wajgt, A" uniqKey="Wajgt A">A Wajgt</name></author><author><name sortKey="Toal, M" uniqKey="Toal M">M Toal</name></author><author><name sortKey="Lynn, F" uniqKey="Lynn F">F Lynn</name></author><author><name sortKey="Panzara, Ma" uniqKey="Panzara M">MA Panzara</name></author><author><name sortKey="Sandrock, Aw" uniqKey="Sandrock A">AW Sandrock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rothhammer, V" uniqKey="Rothhammer V">V Rothhammer</name></author><author><name sortKey="Heink, S" uniqKey="Heink S">S Heink</name></author><author><name sortKey="Petermann, F" uniqKey="Petermann F">F Petermann</name></author><author><name sortKey="Srivastava, R" uniqKey="Srivastava R">R Srivastava</name></author><author><name sortKey="Claussen, Mc" uniqKey="Claussen M">MC Claussen</name></author><author><name sortKey="Hemmer, B" uniqKey="Hemmer B">B Hemmer</name></author><author><name sortKey="Korn, T" uniqKey="Korn T">T Korn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ransohoff, Rm" uniqKey="Ransohoff R">RM Ransohoff</name></author><author><name sortKey="Engelhardt, B" uniqKey="Engelhardt B">B Engelhardt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gebhardt, T" uniqKey="Gebhardt T">T Gebhardt</name></author><author><name sortKey="Whitney, Pg" uniqKey="Whitney P">PG Whitney</name></author><author><name sortKey="Zaid, A" uniqKey="Zaid A">A Zaid</name></author><author><name sortKey="Mackay, Lk" uniqKey="Mackay L">LK Mackay</name></author><author><name sortKey="Brooks, Ag" uniqKey="Brooks A">AG Brooks</name></author><author><name sortKey="Heath, Wr" uniqKey="Heath W">WR Heath</name></author><author><name sortKey="Carbone, Fr" uniqKey="Carbone F">FR Carbone</name></author><author><name sortKey="Mueller, Sn" uniqKey="Mueller S">SN Mueller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lebwohl, M" uniqKey="Lebwohl M">M Lebwohl</name></author><author><name sortKey="Tyring, Sk" uniqKey="Tyring S">SK Tyring</name></author><author><name sortKey="Hamilton, Tk" uniqKey="Hamilton T">TK Hamilton</name></author><author><name sortKey="Toth, D" uniqKey="Toth D">D Toth</name></author><author><name sortKey="Glazer, S" uniqKey="Glazer S">S Glazer</name></author><author><name sortKey="Tawfik, Nh" uniqKey="Tawfik N">NH Tawfik</name></author><author><name sortKey="Walicke, P" uniqKey="Walicke P">P Walicke</name></author><author><name sortKey="Dummer, W" uniqKey="Dummer W">W Dummer</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author><author><name sortKey="Garovoy, Mr" uniqKey="Garovoy M">MR Garovoy</name></author><author><name sortKey="Pariser, D" uniqKey="Pariser D">D Pariser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kappos, L" uniqKey="Kappos L">L Kappos</name></author><author><name sortKey="Radue, E W" uniqKey="Radue E">E-W Radue</name></author><author><name sortKey="O Onnor, P" uniqKey="O Onnor P">P O’Connor</name></author><author><name sortKey="Polman, C" uniqKey="Polman C">C Polman</name></author><author><name sortKey="Hohlfeld, R" uniqKey="Hohlfeld R">R Hohlfeld</name></author><author><name sortKey="Calabresi, P" uniqKey="Calabresi P">P Calabresi</name></author><author><name sortKey="Selmaj, K" uniqKey="Selmaj K">K Selmaj</name></author><author><name sortKey="Agoropoulou, C" uniqKey="Agoropoulou C">C Agoropoulou</name></author><author><name sortKey="Leyk, M" uniqKey="Leyk M">M Leyk</name></author><author><name sortKey="Zhang Auberson, L" uniqKey="Zhang Auberson L">L Zhang-Auberson</name></author><author><name sortKey="Burtin, P" uniqKey="Burtin P">P Burtin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Selmaj, K" uniqKey="Selmaj K">K Selmaj</name></author><author><name sortKey="Li, Dk" uniqKey="Li D">DK Li</name></author><author><name sortKey="Hartung, H P" uniqKey="Hartung H">H-P Hartung</name></author><author><name sortKey="Hemmer, B" uniqKey="Hemmer B">B Hemmer</name></author><author><name sortKey="Kappos, L" uniqKey="Kappos L">L Kappos</name></author><author><name sortKey="Freedman, Ms" uniqKey="Freedman M">MS Freedman</name></author><author><name sortKey="Stuve, O" uniqKey="Stuve O">O Stüve</name></author><author><name sortKey="Rieckmann, P" uniqKey="Rieckmann P">P Rieckmann</name></author><author><name sortKey="Montalban, X" uniqKey="Montalban X">X Montalban</name></author><author><name sortKey="Ziemssen, T" uniqKey="Ziemssen T">T Ziemssen</name></author><author><name sortKey="Auberson, Lz" uniqKey="Auberson L">LZ Auberson</name></author><author><name sortKey="Pohlmann, H" uniqKey="Pohlmann H">H Pohlmann</name></author><author><name sortKey="Mercier, F" uniqKey="Mercier F">F Mercier</name></author><author><name sortKey="Dahlke, F" uniqKey="Dahlke F">F Dahlke</name></author><author><name sortKey="Wallstrom, E" uniqKey="Wallstrom E">E Wallström</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, Dh" uniqKey="Miller D">DH Miller</name></author><author><name sortKey="Weber, T" uniqKey="Weber T">T Weber</name></author><author><name sortKey="Grove, R" uniqKey="Grove R">R Grove</name></author><author><name sortKey="Wardell, C" uniqKey="Wardell C">C Wardell</name></author><author><name sortKey="Horrigan, J" uniqKey="Horrigan J">J Horrigan</name></author><author><name sortKey="Graff, O" uniqKey="Graff O">O Graff</name></author><author><name sortKey="Atkinson, G" uniqKey="Atkinson G">G Atkinson</name></author><author><name sortKey="Dua, P" uniqKey="Dua P">P Dua</name></author><author><name sortKey="Yousry, T" uniqKey="Yousry T">T Yousry</name></author><author><name sortKey="Macmanus, D" uniqKey="Macmanus D">D Macmanus</name></author><author><name sortKey="Montalban, X" uniqKey="Montalban X">X Montalban</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hueber, W" uniqKey="Hueber W">W Hueber</name></author><author><name sortKey="Patel, Dd" uniqKey="Patel D">DD Patel</name></author><author><name sortKey="Dryja, T" uniqKey="Dryja T">T Dryja</name></author><author><name sortKey="Wright, Am" uniqKey="Wright A">AM Wright</name></author><author><name sortKey="Koroleva, I" uniqKey="Koroleva I">I Koroleva</name></author><author><name sortKey="Bruin, G" uniqKey="Bruin G">G Bruin</name></author><author><name sortKey="Antoni, C" uniqKey="Antoni C">C Antoni</name></author><author><name sortKey="Draelos, Z" uniqKey="Draelos Z">Z Draelos</name></author><author><name sortKey="Gold, Mh" uniqKey="Gold M">MH Gold</name></author><author><name sortKey="Durez, P" uniqKey="Durez P">P Durez</name></author><author><name sortKey="Tak, Pp" uniqKey="Tak P">PP Tak</name></author><author><name sortKey="Gomez Reino, Jj" uniqKey="Gomez Reino J">JJ Gomez-Reino</name></author><author><name sortKey="Foster, Cs" uniqKey="Foster C">CS Foster</name></author><author><name sortKey="Kim, Ry" uniqKey="Kim R">RY Kim</name></author><author><name sortKey="Samson, Cm" uniqKey="Samson C">CM Samson</name></author><author><name sortKey="Falk, Ns" uniqKey="Falk N">NS Falk</name></author><author><name sortKey="Chu, Ds" uniqKey="Chu D">DS Chu</name></author><author><name sortKey="Callanan, D" uniqKey="Callanan D">D Callanan</name></author><author><name sortKey="Nguyen, Qd" uniqKey="Nguyen Q">QD Nguyen</name></author><author><name sortKey="Rose, K" uniqKey="Rose K">K Rose</name></author><author><name sortKey="Haider, A" uniqKey="Haider A">A Haider</name></author><author><name sortKey="Di Padova, F" uniqKey="Di Padova F">F Di Padova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leonardi, C" uniqKey="Leonardi C">C Leonardi</name></author><author><name sortKey="Matheson, R" uniqKey="Matheson R">R Matheson</name></author><author><name sortKey="Zachariae, C" uniqKey="Zachariae C">C Zachariae</name></author><author><name sortKey="Cameron, G" uniqKey="Cameron G">G Cameron</name></author><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author><author><name sortKey="Edson Heredia, E" uniqKey="Edson Heredia E">E Edson-Heredia</name></author><author><name sortKey="Braun, D" uniqKey="Braun D">D Braun</name></author><author><name sortKey="Banerjee, S" uniqKey="Banerjee S">S Banerjee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yazici, Y" uniqKey="Yazici Y">Y Yazici</name></author><author><name sortKey="Curtis, Jr" uniqKey="Curtis J">JR Curtis</name></author><author><name sortKey="Ince, A" uniqKey="Ince A">A Ince</name></author><author><name sortKey="Baraf, H" uniqKey="Baraf H">H Baraf</name></author><author><name sortKey="Malamet, Rl" uniqKey="Malamet R">RL Malamet</name></author><author><name sortKey="Teng, Ll" uniqKey="Teng L">LL Teng</name></author><author><name sortKey="Kavanaugh, A" uniqKey="Kavanaugh A">A Kavanaugh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Major, Eo" uniqKey="Major E">EO Major</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sette, A" uniqKey="Sette A">A Sette</name></author><author><name sortKey="Moutaftsi, M" uniqKey="Moutaftsi M">M Moutaftsi</name></author><author><name sortKey="Moyron Quiroz, J" uniqKey="Moyron Quiroz J">J Moyron-Quiroz</name></author><author><name sortKey="Mccausland, Mm" uniqKey="Mccausland M">MM McCausland</name></author><author><name sortKey="Davies, Dh" uniqKey="Davies D">DH Davies</name></author><author><name sortKey="Johnston, Rj" uniqKey="Johnston R">RJ Johnston</name></author><author><name sortKey="Peters, B" uniqKey="Peters B">B Peters</name></author><author><name sortKey="Rafii El Idrissi Benhnia, M" uniqKey="Rafii El Idrissi Benhnia M">M Rafii-El-Idrissi Benhnia</name></author><author><name sortKey="Hoffmann, J" uniqKey="Hoffmann J">J Hoffmann</name></author><author><name sortKey="Su, H P" uniqKey="Su H">H-P Su</name></author><author><name sortKey="Singh, K" uniqKey="Singh K">K Singh</name></author><author><name sortKey="Garboczi, Dn" uniqKey="Garboczi D">DN Garboczi</name></author><author><name sortKey="Head, S" uniqKey="Head S">S Head</name></author><author><name sortKey="Grey, H" uniqKey="Grey H">H Grey</name></author><author><name sortKey="Felgner, Pl" uniqKey="Felgner P">PL Felgner</name></author><author><name sortKey="Crotty, S" uniqKey="Crotty S">S Crotty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moutaftsi, M" uniqKey="Moutaftsi M">M Moutaftsi</name></author><author><name sortKey="Bui, H H" uniqKey="Bui H">H-H Bui</name></author><author><name sortKey="Peters, B" uniqKey="Peters B">B Peters</name></author><author><name sortKey="Sidney, J" uniqKey="Sidney J">J Sidney</name></author><author><name sortKey="Salek Ardakani, S" uniqKey="Salek Ardakani S">S Salek-Ardakani</name></author><author><name sortKey="Oseroff, C" uniqKey="Oseroff C">C Oseroff</name></author><author><name sortKey="Pasquetto, V" uniqKey="Pasquetto V">V Pasquetto</name></author><author><name sortKey="Crotty, S" uniqKey="Crotty S">S Crotty</name></author><author><name sortKey="Croft, M" uniqKey="Croft M">M Croft</name></author><author><name sortKey="Lefkowitz, Ej" uniqKey="Lefkowitz E">EJ Lefkowitz</name></author><author><name sortKey="Grey, H" uniqKey="Grey H">H Grey</name></author><author><name sortKey="Sette, A" uniqKey="Sette A">A Sette</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bettelli, E" uniqKey="Bettelli E">E Bettelli</name></author><author><name sortKey="Carrier, Y" uniqKey="Carrier Y">Y Carrier</name></author><author><name sortKey="Gao, W" uniqKey="Gao W">W Gao</name></author><author><name sortKey="Korn, T" uniqKey="Korn T">T Korn</name></author><author><name sortKey="Strom, Tb" uniqKey="Strom T">TB Strom</name></author><author><name sortKey="Oukka, M" uniqKey="Oukka M">M Oukka</name></author><author><name sortKey="Weiner, Hl" uniqKey="Weiner H">HL Weiner</name></author><author><name sortKey="Kuchroo, Vk" uniqKey="Kuchroo V">VK Kuchroo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Korn, T" uniqKey="Korn T">T Korn</name></author><author><name sortKey="Reddy, J" uniqKey="Reddy J">J Reddy</name></author><author><name sortKey="Gao, W" uniqKey="Gao W">W Gao</name></author><author><name sortKey="Bettelli, E" uniqKey="Bettelli E">E Bettelli</name></author><author><name sortKey="Awasthi, A" uniqKey="Awasthi A">A Awasthi</name></author><author><name sortKey="Petersen, Tr" uniqKey="Petersen T">TR Petersen</name></author><author><name sortKey="B Ckstrom, Bt" uniqKey="B Ckstrom B">BT Bäckström</name></author><author><name sortKey="Sobel, Ra" uniqKey="Sobel R">RA Sobel</name></author><author><name sortKey="Wucherpfennig, Kw" uniqKey="Wucherpfennig K">KW Wucherpfennig</name></author><author><name sortKey="Strom, Tb" uniqKey="Strom T">TB Strom</name></author><author><name sortKey="Oukka, M" uniqKey="Oukka M">M Oukka</name></author><author><name sortKey="Kuchroo, Vk" uniqKey="Kuchroo V">VK Kuchroo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scott, Lm" uniqKey="Scott L">LM Scott</name></author><author><name sortKey="Priestley, Gv" uniqKey="Priestley G">GV Priestley</name></author><author><name sortKey="Papayannopoulou, T" uniqKey="Papayannopoulou T">T Papayannopoulou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koedel, U" uniqKey="Koedel U">U Koedel</name></author><author><name sortKey="Rupprecht, T" uniqKey="Rupprecht T">T Rupprecht</name></author><author><name sortKey="Angele, B" uniqKey="Angele B">B Angele</name></author><author><name sortKey="Heesemann, J" uniqKey="Heesemann J">J Heesemann</name></author><author><name sortKey="Wagner, H" uniqKey="Wagner H">H Wagner</name></author><author><name sortKey="Pfister, H W" uniqKey="Pfister H">H-W Pfister</name></author><author><name sortKey="Kirschning, Cj" uniqKey="Kirschning C">CJ Kirschning</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Staib, C" uniqKey="Staib C">C Staib</name></author><author><name sortKey="Drexler, I" uniqKey="Drexler I">I Drexler</name></author><author><name sortKey="Sutter, G" uniqKey="Sutter G">G Sutter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hickman, Hd" uniqKey="Hickman H">HD Hickman</name></author><author><name sortKey="Reynoso, Gv" uniqKey="Reynoso G">GV Reynoso</name></author><author><name sortKey="Ngudiankama, Bf" uniqKey="Ngudiankama B">BF Ngudiankama</name></author><author><name sortKey="Rubin, Ej" uniqKey="Rubin E">EJ Rubin</name></author><author><name sortKey="Magadan, Jg" uniqKey="Magadan J">JG Magadán</name></author><author><name sortKey="Cush, Ss" uniqKey="Cush S">SS Cush</name></author><author><name sortKey="Gibbs, J" uniqKey="Gibbs J">J Gibbs</name></author><author><name sortKey="Molon, B" uniqKey="Molon B">B Molon</name></author><author><name sortKey="Bronte, V" uniqKey="Bronte V">V Bronte</name></author><author><name sortKey="Bennink, Jr" uniqKey="Bennink J">JR Bennink</name></author><author><name sortKey="Yewdell, Jw" uniqKey="Yewdell J">JW Yewdell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stuve, O" uniqKey="Stuve O">O Stüve</name></author><author><name sortKey="Marra, Cm" uniqKey="Marra C">CM Marra</name></author><author><name sortKey="Bar Or, A" uniqKey="Bar Or A">A Bar-Or</name></author><author><name sortKey="Niino, M" uniqKey="Niino M">M Niino</name></author><author><name sortKey="Cravens, Pd" uniqKey="Cravens P">PD Cravens</name></author><author><name sortKey="Cepok, S" uniqKey="Cepok S">S Cepok</name></author><author><name sortKey="Frohman, Em" uniqKey="Frohman E">EM Frohman</name></author><author><name sortKey="Phillips, Jt" uniqKey="Phillips J">JT Phillips</name></author><author><name sortKey="Arendt, G" uniqKey="Arendt G">G Arendt</name></author><author><name sortKey="Jerome, Kr" uniqKey="Jerome K">KR Jerome</name></author><author><name sortKey="Cook, L" uniqKey="Cook L">L Cook</name></author><author><name sortKey="Grand Aison, F" uniqKey="Grand Aison F">F Grand’Maison</name></author><author><name sortKey="Hemmer, B" uniqKey="Hemmer B">B Hemmer</name></author><author><name sortKey="Monson, Nl" uniqKey="Monson N">NL Monson</name></author><author><name sortKey="Racke, Mk" uniqKey="Racke M">MK Racke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kowarik, Mc" uniqKey="Kowarik M">MC Kowarik</name></author><author><name sortKey="Pellkofer, Hl" uniqKey="Pellkofer H">HL Pellkofer</name></author><author><name sortKey="Cepok, S" uniqKey="Cepok S">S Cepok</name></author><author><name sortKey="Korn, T" uniqKey="Korn T">T Korn</name></author><author><name sortKey="Kumpfel, T" uniqKey="Kumpfel T">T Kümpfel</name></author><author><name sortKey="Buck, D" uniqKey="Buck D">D Buck</name></author><author><name sortKey="Hohlfeld, R" uniqKey="Hohlfeld R">R Hohlfeld</name></author><author><name sortKey="Berthele, A" uniqKey="Berthele A">A Berthele</name></author><author><name sortKey="Hemmer, B" uniqKey="Hemmer B">B Hemmer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jelcic, I" uniqKey="Jelcic I">I Jelcic</name></author><author><name sortKey="Aly, L" uniqKey="Aly L">L Aly</name></author><author><name sortKey="Binder, Tmc" uniqKey="Binder T">TMC Binder</name></author><author><name sortKey="Jelcic, I" uniqKey="Jelcic I">I Jelcic</name></author><author><name sortKey="Bofill Mas, S" uniqKey="Bofill Mas S">S Bofill-Mas</name></author><author><name sortKey="Planas, R" uniqKey="Planas R">R Planas</name></author><author><name sortKey="Demina, V" uniqKey="Demina V">V Demina</name></author><author><name sortKey="Eiermann, Th" uniqKey="Eiermann T">TH Eiermann</name></author><author><name sortKey="Weber, T" uniqKey="Weber T">T Weber</name></author><author><name sortKey="Girones, R" uniqKey="Girones R">R Girones</name></author><author><name sortKey="Sospedra, M" uniqKey="Sospedra M">M Sospedra</name></author><author><name sortKey="Martin, R" uniqKey="Martin R">R Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eshima, K" uniqKey="Eshima K">K Eshima</name></author><author><name sortKey="Chiba, S" uniqKey="Chiba S">S Chiba</name></author><author><name sortKey="Suzuki, H" uniqKey="Suzuki H">H Suzuki</name></author><author><name sortKey="Kokubo, K" uniqKey="Kokubo K">K Kokubo</name></author><author><name sortKey="Kobayashi, H" uniqKey="Kobayashi H">H Kobayashi</name></author><author><name sortKey="Iizuka, M" uniqKey="Iizuka M">M Iizuka</name></author><author><name sortKey="Iwabuchi, K" uniqKey="Iwabuchi K">K Iwabuchi</name></author><author><name sortKey="Shinohara, N" uniqKey="Shinohara N">N Shinohara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jellison, Er" uniqKey="Jellison E">ER Jellison</name></author><author><name sortKey="Kim, S K" uniqKey="Kim S">S-K Kim</name></author><author><name sortKey="Welsh, Rm" uniqKey="Welsh R">RM Welsh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fang, M" uniqKey="Fang M">M Fang</name></author><author><name sortKey="Siciliano, Na" uniqKey="Siciliano N">NA Siciliano</name></author><author><name sortKey="Hersperger, Ar" uniqKey="Hersperger A">AR Hersperger</name></author><author><name sortKey="Roscoe, F" uniqKey="Roscoe F">F Roscoe</name></author><author><name sortKey="Hu, A" uniqKey="Hu A">A Hu</name></author><author><name sortKey="Ma, X" uniqKey="Ma X">X Ma</name></author><author><name sortKey="Shamsedeen, Ar" uniqKey="Shamsedeen A">AR Shamsedeen</name></author><author><name sortKey="Eisenlohr, Lc" uniqKey="Eisenlohr L">LC Eisenlohr</name></author><author><name sortKey="Sigal, Lj" uniqKey="Sigal L">LJ Sigal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, Jc" uniqKey="Sun J">JC Sun</name></author><author><name sortKey="Bevan, Mj" uniqKey="Bevan M">MJ Bevan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, R" uniqKey="Xu R">R Xu</name></author><author><name sortKey="Johnson, Aj" uniqKey="Johnson A">AJ Johnson</name></author><author><name sortKey="Liggitt, D" uniqKey="Liggitt D">D Liggitt</name></author><author><name sortKey="Bevan, Mj" uniqKey="Bevan M">MJ Bevan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bachmann, Mf" uniqKey="Bachmann M">MF Bachmann</name></author><author><name sortKey="Wolint, P" uniqKey="Wolint P">P Wolint</name></author><author><name sortKey="Schwarz, K" uniqKey="Schwarz K">K Schwarz</name></author><author><name sortKey="Oxenius, A" uniqKey="Oxenius A">A Oxenius</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Glass, Wg" uniqKey="Glass W">WG Glass</name></author><author><name sortKey="Lim, Jk" uniqKey="Lim J">JK Lim</name></author><author><name sortKey="Cholera, R" uniqKey="Cholera R">R Cholera</name></author><author><name sortKey="Pletnev, Ag" uniqKey="Pletnev A">AG Pletnev</name></author><author><name sortKey="Gao, J L" uniqKey="Gao J">J-L Gao</name></author><author><name sortKey="Murphy, Pm" uniqKey="Murphy P">PM Murphy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Glass, Wg" uniqKey="Glass W">WG Glass</name></author><author><name sortKey="Liu, Mt" uniqKey="Liu M">MT Liu</name></author><author><name sortKey="Kuziel, Wa" uniqKey="Kuziel W">WA Kuziel</name></author><author><name sortKey="Lane, Te" uniqKey="Lane T">TE Lane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nansen, A" uniqKey="Nansen A">A Nansen</name></author><author><name sortKey="Christensen, Jp" uniqKey="Christensen J">JP Christensen</name></author><author><name sortKey="Andreasen, S" uniqKey="Andreasen S">SØ Andreasen</name></author><author><name sortKey="Bartholdy, C" uniqKey="Bartholdy C">C Bartholdy</name></author><author><name sortKey="Christensen, Je" uniqKey="Christensen J">JE Christensen</name></author><author><name sortKey="Thomsen, Ar" uniqKey="Thomsen A">AR Thomsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Christensen, Je" uniqKey="Christensen J">JE Christensen</name></author><author><name sortKey="Nansen, A" uniqKey="Nansen A">A Nansen</name></author><author><name sortKey="Moos, T" uniqKey="Moos T">T Moos</name></author><author><name sortKey="Lu, B" uniqKey="Lu B">B Lu</name></author><author><name sortKey="Gerard, C" uniqKey="Gerard C">C Gerard</name></author><author><name sortKey="Christensen, Jp" uniqKey="Christensen J">JP Christensen</name></author><author><name sortKey="Thomsen, Ar" uniqKey="Thomsen A">AR Thomsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Engelhardt, B" uniqKey="Engelhardt B">B Engelhardt</name></author><author><name sortKey="Ransohoff, Rm" uniqKey="Ransohoff R">RM Ransohoff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Irani, Dn" uniqKey="Irani D">DN Irani</name></author><author><name sortKey="Griffin, De" uniqKey="Griffin D">DE Griffin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reboldi, A" uniqKey="Reboldi A">A Reboldi</name></author><author><name sortKey="Coisne, C" uniqKey="Coisne C">C Coisne</name></author><author><name sortKey="Baumjohann, D" uniqKey="Baumjohann D">D Baumjohann</name></author><author><name sortKey="Benvenuto, F" uniqKey="Benvenuto F">F Benvenuto</name></author><author><name sortKey="Bottinelli, D" uniqKey="Bottinelli D">D Bottinelli</name></author><author><name sortKey="Lira, S" uniqKey="Lira S">S Lira</name></author><author><name sortKey="Uccelli, A" uniqKey="Uccelli A">A Uccelli</name></author><author><name sortKey="Lanzavecchia, A" uniqKey="Lanzavecchia A">A Lanzavecchia</name></author><author><name sortKey="Engelhardt, B" uniqKey="Engelhardt B">B Engelhardt</name></author><author><name sortKey="Sallusto, F" uniqKey="Sallusto F">F Sallusto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Veldhoen, M" uniqKey="Veldhoen M">M Veldhoen</name></author><author><name sortKey="Hocking, Rj" uniqKey="Hocking R">RJ Hocking</name></author><author><name sortKey="Atkins, Cj" uniqKey="Atkins C">CJ Atkins</name></author><author><name sortKey="Locksley, Rm" uniqKey="Locksley R">RM Locksley</name></author><author><name sortKey="Stockinger, B" uniqKey="Stockinger B">B Stockinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mangan, Pr" uniqKey="Mangan P">PR Mangan</name></author><author><name sortKey="Harrington, Le" uniqKey="Harrington L">LE Harrington</name></author><author><name sortKey="O Uinn, Db" uniqKey="O Uinn D">DB O’quinn</name></author><author><name sortKey="Helms, Ws" uniqKey="Helms W">WS Helms</name></author><author><name sortKey="Bullard, Dc" uniqKey="Bullard D">DC Bullard</name></author><author><name sortKey="Elson, Co" uniqKey="Elson C">CO Elson</name></author><author><name sortKey="Hatton, Rd" uniqKey="Hatton R">RD Hatton</name></author><author><name sortKey="Wahl, Sm" uniqKey="Wahl S">SM Wahl</name></author><author><name sortKey="Schoeb, Tr" uniqKey="Schoeb T">TR Schoeb</name></author><author><name sortKey="Weaver, Ct" uniqKey="Weaver C">CT Weaver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, N" uniqKey="Zhang N">N Zhang</name></author><author><name sortKey="Bevan, Mj" uniqKey="Bevan M">MJ Bevan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ifergan, I" uniqKey="Ifergan I">I Ifergan</name></author><author><name sortKey="Kebir, H" uniqKey="Kebir H">H Kebir</name></author><author><name sortKey="Alvarez, Ji" uniqKey="Alvarez J">JI Alvarez</name></author><author><name sortKey="Marceau, G" uniqKey="Marceau G">G Marceau</name></author><author><name sortKey="Bernard, M" uniqKey="Bernard M">M Bernard</name></author><author><name sortKey="Bourbonniere, L" uniqKey="Bourbonniere L">L Bourbonnière</name></author><author><name sortKey="Poirier, J" uniqKey="Poirier J">J Poirier</name></author><author><name sortKey="Duquette, P" uniqKey="Duquette P">P Duquette</name></author><author><name sortKey="Talbot, Pj" uniqKey="Talbot P">PJ Talbot</name></author><author><name sortKey="Arbour, N" uniqKey="Arbour N">N Arbour</name></author><author><name sortKey="Prat, A" uniqKey="Prat A">A Prat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oxenius, A" uniqKey="Oxenius A">A Oxenius</name></author><author><name sortKey="Bachmann, Mf" uniqKey="Bachmann M">MF Bachmann</name></author><author><name sortKey="Zinkernagel, Rm" uniqKey="Zinkernagel R">RM Zinkernagel</name></author><author><name sortKey="Hengartner, H" uniqKey="Hengartner H">H Hengartner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laurence, A" uniqKey="Laurence A">A Laurence</name></author><author><name sortKey="Tato, Cm" uniqKey="Tato C">CM Tato</name></author><author><name sortKey="Davidson, Ts" uniqKey="Davidson T">TS Davidson</name></author><author><name sortKey="Kanno, Y" uniqKey="Kanno Y">Y Kanno</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z Chen</name></author><author><name sortKey="Yao, Z" uniqKey="Yao Z">Z Yao</name></author><author><name sortKey="Blank, Rb" uniqKey="Blank R">RB Blank</name></author><author><name sortKey="Meylan, F" uniqKey="Meylan F">F Meylan</name></author><author><name sortKey="Siegel, R" uniqKey="Siegel R">R Siegel</name></author><author><name sortKey="Hennighausen, L" uniqKey="Hennighausen L">L Hennighausen</name></author><author><name sortKey="Shevach, Em" uniqKey="Shevach E">EM Shevach</name></author><author><name sortKey="O Shea, Jj" uniqKey="O Shea J">JJ O'Shea</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brown, Dm" uniqKey="Brown D">DM Brown</name></author><author><name sortKey="Kamperschroer, C" uniqKey="Kamperschroer C">C Kamperschroer</name></author><author><name sortKey="Dilzer, Am" uniqKey="Dilzer A">AM Dilzer</name></author><author><name sortKey="Roberts, Dm" uniqKey="Roberts D">DM Roberts</name></author><author><name sortKey="Swain, Sl" uniqKey="Swain S">SL Swain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pipkin, Me" uniqKey="Pipkin M">ME Pipkin</name></author><author><name sortKey="Sacks, Ja" uniqKey="Sacks J">JA Sacks</name></author><author><name sortKey="Cruz Guilloty, F" uniqKey="Cruz Guilloty F">F Cruz-Guilloty</name></author><author><name sortKey="Lichtenheld, Mg" uniqKey="Lichtenheld M">MG Lichtenheld</name></author><author><name sortKey="Bevan, Mj" uniqKey="Bevan M">MJ Bevan</name></author><author><name sortKey="Rao, A" uniqKey="Rao A">A Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mckinstry, Kk" uniqKey="Mckinstry K">KK McKinstry</name></author><author><name sortKey="Strutt, Tm" uniqKey="Strutt T">TM Strutt</name></author><author><name sortKey="Buck, A" uniqKey="Buck A">A Buck</name></author><author><name sortKey="Curtis, Jd" uniqKey="Curtis J">JD Curtis</name></author><author><name sortKey="Dibble, Jp" uniqKey="Dibble J">JP Dibble</name></author><author><name sortKey="Huston, G" uniqKey="Huston G">G Huston</name></author><author><name sortKey="Tighe, M" uniqKey="Tighe M">M Tighe</name></author><author><name sortKey="Hamada, H" uniqKey="Hamada H">H Hamada</name></author><author><name sortKey="Sell, S" uniqKey="Sell S">S Sell</name></author><author><name sortKey="Dutton, Rw" uniqKey="Dutton R">RW Dutton</name></author><author><name sortKey="Swain, Sl" uniqKey="Swain S">SL Swain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hou, W" uniqKey="Hou W">W Hou</name></author><author><name sortKey="Kang, Hs" uniqKey="Kang H">HS Kang</name></author><author><name sortKey="Kim, Bs" uniqKey="Kim B">BS Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tate, Md" uniqKey="Tate M">MD Tate</name></author><author><name sortKey="Deng, Y M" uniqKey="Deng Y">Y-M Deng</name></author><author><name sortKey="Jones, Je" uniqKey="Jones J">JE Jones</name></author><author><name sortKey="Anderson, Gp" uniqKey="Anderson G">GP Anderson</name></author><author><name sortKey="Brooks, Ag" uniqKey="Brooks A">AG Brooks</name></author><author><name sortKey="Reading, Pc" uniqKey="Reading P">PC Reading</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barker, Br" uniqKey="Barker B">BR Barker</name></author><author><name sortKey="Gladstone, Mn" uniqKey="Gladstone M">MN Gladstone</name></author><author><name sortKey="Gillard, Go" uniqKey="Gillard G">GO Gillard</name></author><author><name sortKey="Panas, Mw" uniqKey="Panas M">MW Panas</name></author><author><name sortKey="Letvin, Nl" uniqKey="Letvin N">NL Letvin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oyoshi, Mk" uniqKey="Oyoshi M">MK Oyoshi</name></author><author><name sortKey="Elkhal, A" uniqKey="Elkhal A">A Elkhal</name></author><author><name sortKey="Kumar, L" uniqKey="Kumar L">L Kumar</name></author><author><name sortKey="Scott, Je" uniqKey="Scott J">JE Scott</name></author><author><name sortKey="Koduru, S" uniqKey="Koduru S">S Koduru</name></author><author><name sortKey="He, R" uniqKey="He R">R He</name></author><author><name sortKey="Leung, Dym" uniqKey="Leung D">DYM Leung</name></author><author><name sortKey="Howell, Md" uniqKey="Howell M">MD Howell</name></author><author><name sortKey="Oettgen, Hc" uniqKey="Oettgen H">HC Oettgen</name></author><author><name sortKey="Murphy, Gf" uniqKey="Murphy G">GF Murphy</name></author><author><name sortKey="Geha, Rs" uniqKey="Geha R">RS Geha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suryawanshi, A" uniqKey="Suryawanshi A">A Suryawanshi</name></author><author><name sortKey="Veiga Parga, T" uniqKey="Veiga Parga T">T Veiga-Parga</name></author><author><name sortKey="Rajasagi, Nk" uniqKey="Rajasagi N">NK Rajasagi</name></author><author><name sortKey="Reddy, Pbj" uniqKey="Reddy P">PBJ Reddy</name></author><author><name sortKey="Sehrawat, S" uniqKey="Sehrawat S">S Sehrawat</name></author><author><name sortKey="Sharma, S" uniqKey="Sharma S">S Sharma</name></author><author><name sortKey="Rouse, Bt" uniqKey="Rouse B">BT Rouse</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aly, L" uniqKey="Aly L">L Aly</name></author><author><name sortKey="Yousef, S" uniqKey="Yousef S">S Yousef</name></author><author><name sortKey="Schippling, S" uniqKey="Schippling S">S Schippling</name></author><author><name sortKey="Jelcic, I" uniqKey="Jelcic I">I Jelcic</name></author><author><name sortKey="Breiden, P" uniqKey="Breiden P">P Breiden</name></author><author><name sortKey="Matschke, J" uniqKey="Matschke J">J Matschke</name></author><author><name sortKey="Schulz, R" uniqKey="Schulz R">R Schulz</name></author><author><name sortKey="Bofill Mas, S" uniqKey="Bofill Mas S">S Bofill-Mas</name></author><author><name sortKey="Jones, L" uniqKey="Jones L">L Jones</name></author><author><name sortKey="Demina, V" uniqKey="Demina V">V Demina</name></author><author><name sortKey="Linnebank, M" uniqKey="Linnebank M">M Linnebank</name></author><author><name sortKey="Ogg, G" uniqKey="Ogg G">G Ogg</name></author><author><name sortKey="Girones, R" uniqKey="Girones R">R Girones</name></author><author><name sortKey="Weber, T" uniqKey="Weber T">T Weber</name></author><author><name sortKey="Sospedra, M" uniqKey="Sospedra M">M Sospedra</name></author><author><name sortKey="Martin, R" uniqKey="Martin R">R Martin</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>États-Unis</li></country><region><li>Bavière</li><li>District de Düsseldorf</li><li>District de Haute-Bavière</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Düsseldorf</li><li>Munich</li></settlement><orgName><li>Université technique de Munich</li></orgName></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="Rothhammer, Veit" sort="Rothhammer, Veit" uniqKey="Rothhammer V" first="Veit" last="Rothhammer">Veit Rothhammer</name></region><name sortKey="Busch, Dirk H" sort="Busch, Dirk H" uniqKey="Busch D" first="Dirk H" last="Busch">Dirk H. Busch</name><name sortKey="Drexler, Ingo" sort="Drexler, Ingo" uniqKey="Drexler I" first="Ingo" last="Drexler">Ingo Drexler</name><name sortKey="Heikenw Lder, Mathias" sort="Heikenw Lder, Mathias" uniqKey="Heikenw Lder M" first="Mathias" last="Heikenw Lder">Mathias Heikenw Lder</name><name sortKey="Heink, Sylvia" sort="Heink, Sylvia" uniqKey="Heink S" first="Sylvia" last="Heink">Sylvia Heink</name><name sortKey="Hemmer, Bernhard" sort="Hemmer, Bernhard" uniqKey="Hemmer B" first="Bernhard" last="Hemmer">Bernhard Hemmer</name><name sortKey="Hemmer, Bernhard" sort="Hemmer, Bernhard" uniqKey="Hemmer B" first="Bernhard" last="Hemmer">Bernhard Hemmer</name><name sortKey="Korn, Thomas" sort="Korn, Thomas" uniqKey="Korn T" first="Thomas" last="Korn">Thomas Korn</name><name sortKey="Korn, Thomas" sort="Korn, Thomas" uniqKey="Korn T" first="Thomas" last="Korn">Thomas Korn</name><name sortKey="Muschaweckh, Andreas" sort="Muschaweckh, Andreas" uniqKey="Muschaweckh A" first="Andreas" last="Muschaweckh">Andreas Muschaweckh</name><name sortKey="Petermann, Franziska" sort="Petermann, Franziska" uniqKey="Petermann F" first="Franziska" last="Petermann">Franziska Petermann</name></country><country name="États-Unis"><noRegion><name sortKey="Gasteiger, Georg" sort="Gasteiger, Georg" uniqKey="Gasteiger G" first="Georg" last="Gasteiger">Georg Gasteiger</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000997 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000997 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4029267
|texte= α4-integrins control viral meningoencephalitis through differential recruitment of T helper cell subsets
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24606807" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidV1
| This area was generated with Dilib version V0.6.33. |  |