Enantioselective syntheses of carbocyclic nuleosides 5′-homocarbovir, epi-4′-homocarbovir and their cyclopropylamine analogs using facially selective Pd-mediated allylations
Identifieur interne : 000C56 ( Main/Exploration ); précédent : 000C55; suivant : 000C57Enantioselective syntheses of carbocyclic nuleosides 5′-homocarbovir, epi-4′-homocarbovir and their cyclopropylamine analogs using facially selective Pd-mediated allylations
Auteurs : Lawrence P. Tardibono [États-Unis] ; Marvin J. Miller [États-Unis] ; Jan Balzarini [Belgique]Source :
- Tetrahedron [ 0040-4020 ] ; 2011.
Abstract
Carbocyclic nucleosides (−)-5′-homocarbovir and (+)-
Url:
DOI: 10.1016/j.tet.2010.11.097
PubMed: 21399715
PubMed Central: 3050557
Affiliations:
- Belgique, États-Unis
- Province du Brabant flamand, Région flamande
- Louvain
- Katholieke Universiteit Leuven
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000374
- to stream Pmc, to step Curation: 000374
- to stream Pmc, to step Checkpoint: 000564
- to stream Ncbi, to step Merge: 000211
- to stream Ncbi, to step Curation: 000211
- to stream Ncbi, to step Checkpoint: 000211
- to stream Main, to step Merge: 000C58
- to stream Main, to step Curation: 000C56
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Enantioselective syntheses of carbocyclic nuleosides 5′-homocarbovir, <italic>epi</italic>
-4′-homocarbovir and their cyclopropylamine analogs using facially selective Pd-mediated allylations</title>
<author><name sortKey="Tardibono, Lawrence P" sort="Tardibono, Lawrence P" uniqKey="Tardibono L" first="Lawrence P." last="Tardibono">Lawrence P. Tardibono</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556</wicri:regionArea>
<wicri:noRegion>IN 46556</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Miller, Marvin J" sort="Miller, Marvin J" uniqKey="Miller M" first="Marvin J." last="Miller">Marvin J. Miller</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556</wicri:regionArea>
<wicri:noRegion>IN 46556</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Balzarini, Jan" sort="Balzarini, Jan" uniqKey="Balzarini J" first="Jan" last="Balzarini">Jan Balzarini</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000, Leuven, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000, Leuven</wicri:regionArea>
<orgName type="university">Katholieke Universiteit Leuven</orgName>
<placeName><settlement type="city">Louvain</settlement>
<region>Région flamande</region>
<region type="district" nuts="2">Province du Brabant flamand</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">21399715</idno>
<idno type="pmc">3050557</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050557</idno>
<idno type="RBID">PMC:3050557</idno>
<idno type="doi">10.1016/j.tet.2010.11.097</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">000374</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000374</idno>
<idno type="wicri:Area/Pmc/Curation">000374</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000374</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000564</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000564</idno>
<idno type="wicri:Area/Ncbi/Merge">000211</idno>
<idno type="wicri:Area/Ncbi/Curation">000211</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000211</idno>
<idno type="wicri:doubleKey">0040-4020:2011:Tardibono L:enantioselective:syntheses:of</idno>
<idno type="wicri:Area/Main/Merge">000C58</idno>
<idno type="wicri:Area/Main/Curation">000C56</idno>
<idno type="wicri:Area/Main/Exploration">000C56</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Enantioselective syntheses of carbocyclic nuleosides 5′-homocarbovir, <italic>epi</italic>
-4′-homocarbovir and their cyclopropylamine analogs using facially selective Pd-mediated allylations</title>
<author><name sortKey="Tardibono, Lawrence P" sort="Tardibono, Lawrence P" uniqKey="Tardibono L" first="Lawrence P." last="Tardibono">Lawrence P. Tardibono</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556</wicri:regionArea>
<wicri:noRegion>IN 46556</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Miller, Marvin J" sort="Miller, Marvin J" uniqKey="Miller M" first="Marvin J." last="Miller">Marvin J. Miller</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556</wicri:regionArea>
<wicri:noRegion>IN 46556</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Balzarini, Jan" sort="Balzarini, Jan" uniqKey="Balzarini J" first="Jan" last="Balzarini">Jan Balzarini</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000, Leuven, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000, Leuven</wicri:regionArea>
<orgName type="university">Katholieke Universiteit Leuven</orgName>
<placeName><settlement type="city">Louvain</settlement>
<region>Région flamande</region>
<region type="district" nuts="2">Province du Brabant flamand</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Tetrahedron</title>
<idno type="ISSN">0040-4020</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Carbocyclic nucleosides (−)-5′-homocarbovir and (+)-<italic>epi</italic>
-4′-homocarbovir were prepared from an acylnitroso-derived hetero Diels–Alder cycloadduct. A kinetic enzymatic resolution generated an enantiopure aminocyclopentenol and Pd(0)-mediated decarboxylative allylations of allyl 2,2,2-trifluoroethyl malonates were used to install the 4′-hydroxyethyl groups. Late stage derivatization gave access to the cyclopropylamine congenors, (−)-5′-homoabacavir and (+)-<italic>epi</italic>
-4′-homoabacavir. All carbonucleoside target molecules were evaluated for antiviral activity.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Belgique</li>
<li>États-Unis</li>
</country>
<region><li>Province du Brabant flamand</li>
<li>Région flamande</li>
</region>
<settlement><li>Louvain</li>
</settlement>
<orgName><li>Katholieke Universiteit Leuven</li>
</orgName>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Tardibono, Lawrence P" sort="Tardibono, Lawrence P" uniqKey="Tardibono L" first="Lawrence P." last="Tardibono">Lawrence P. Tardibono</name>
</noRegion>
<name sortKey="Miller, Marvin J" sort="Miller, Marvin J" uniqKey="Miller M" first="Marvin J." last="Miller">Marvin J. Miller</name>
</country>
<country name="Belgique"><region name="Région flamande"><name sortKey="Balzarini, Jan" sort="Balzarini, Jan" uniqKey="Balzarini J" first="Jan" last="Balzarini">Jan Balzarini</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C56 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000C56 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= CovidV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:3050557 |texte= Enantioselective syntheses of carbocyclic nuleosides 5′-homocarbovir, epi-4′-homocarbovir and their cyclopropylamine analogs using facially selective Pd-mediated allylations }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:21399715" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a CovidV1
This area was generated with Dilib version V0.6.33. |