Peritoneal macrophage alterations caused by naturally occurring mouse hepatitis virus.
Identifieur interne : 001677 ( Main/Exploration ); précédent : 001676; suivant : 001678Peritoneal macrophage alterations caused by naturally occurring mouse hepatitis virus.
Auteurs : G. A. Boorman ; M. I. Luster ; J. H. Dean ; M. L. Campbell ; L. A. Lauer ; F. A. Talley ; R. E. Wilson ; M. J. CollinsSource :
- The American Journal of Pathology [ 0002-9440 ] ; 1982.
Descripteurs français
- KwdFr :
- Animaux, Femelle, Foie (anatomopathologie), Humains, Hépatite virale animale (), Hépatite virale animale (anatomopathologie), Hépatite virale animale (immunologie), Infections à Coronaviridae (anatomopathologie), Infections à Coronaviridae (immunologie), Macrophages (anatomopathologie), Macrophages (physiologie), Péritonite (), Souris, Test ELISA.
- MESH :
- anatomopathologie : Foie, Hépatite virale animale, Infections à Coronaviridae, Macrophages.
- immunologie : Hépatite virale animale, Infections à Coronaviridae.
- physiologie : Macrophages.
- Animaux, Femelle, Humains, Hépatite virale animale, Péritonite, Souris, Test ELISA.
English descriptors
- KwdEn :
- Animals, Coronaviridae Infections (immunology), Coronaviridae Infections (pathology), Enzyme-Linked Immunosorbent Assay, Female, Hepatitis, Viral, Animal (complications), Hepatitis, Viral, Animal (immunology), Hepatitis, Viral, Animal (pathology), Humans, Liver (pathology), Macrophages (pathology), Macrophages (physiology), Mice, Peritonitis (complications).
- MESH :
- complications : Hepatitis, Viral, Animal, Peritonitis.
- immunology : Coronaviridae Infections, Hepatitis, Viral, Animal.
- pathology : Coronaviridae Infections, Hepatitis, Viral, Animal, Liver, Macrophages.
- physiology : Macrophages.
- Animals, Enzyme-Linked Immunosorbent Assay, Female, Humans, Mice.
Abstract
During routine harvest of murine resident peritoneal cells for macrophage function assays the authors recently noted that mice showed a 3-4-fold spontaneous increase in number of peritoneal cells within 1 week of being placed in one of their animal rooms. While the mice appeared clinically normal, the collected macrophages had highly convoluted membranes, showed enhanced spontaneous tumor cell killing, and showed increased erythrophagocytosis. Histopathologic findings included mild peritonitis and occasional foci of individual hepatocyte necrosis. The results of routine murine serologic studies and bacterial cultures of the peritoneal cavity were negative. Immunosuppressed mice placed in this room showed severe hepatic necrosis within 4 days, and ultrastructural particles characteristic of corona virus could be demonstrated in the necrotic foci. Mouse hepatitis virus (MHV) was isolated from these livers. Untreated mice showed positive MHV titers, as detected by the enzyme-linked immunoabsorbent assay (ELISA) after 21 days in the room. This episode demonstrates that MHV have profound effects on macrophage parameters while causing few clinical signs or histopathologic alterations. Secondly, the complement fixation assay for MHV as included in routine viral screens appears relatively insensitive for detecting outbreaks of MHV.
Url:
PubMed: 6275707
PubMed Central: 1915970
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000188
- to stream Pmc, to step Curation: 000188
- to stream Pmc, to step Checkpoint: 000787
- to stream PubMed, to step Corpus: 000754
- to stream PubMed, to step Curation: 000754
- to stream PubMed, to step Checkpoint: 000743
- to stream Ncbi, to step Merge: 000E45
- to stream Ncbi, to step Curation: 000E45
- to stream Ncbi, to step Checkpoint: 000E45
- to stream Main, to step Merge: 001705
- to stream Main, to step Curation: 001677
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Peritoneal macrophage alterations caused by naturally occurring mouse hepatitis virus.</title>
<author><name sortKey="Boorman, G A" sort="Boorman, G A" uniqKey="Boorman G" first="G. A." last="Boorman">G. A. Boorman</name>
</author>
<author><name sortKey="Luster, M I" sort="Luster, M I" uniqKey="Luster M" first="M. I." last="Luster">M. I. Luster</name>
</author>
<author><name sortKey="Dean, J H" sort="Dean, J H" uniqKey="Dean J" first="J. H." last="Dean">J. H. Dean</name>
</author>
<author><name sortKey="Campbell, M L" sort="Campbell, M L" uniqKey="Campbell M" first="M. L." last="Campbell">M. L. Campbell</name>
</author>
<author><name sortKey="Lauer, L A" sort="Lauer, L A" uniqKey="Lauer L" first="L. A." last="Lauer">L. A. Lauer</name>
</author>
<author><name sortKey="Talley, F A" sort="Talley, F A" uniqKey="Talley F" first="F. A." last="Talley">F. A. Talley</name>
</author>
<author><name sortKey="Wilson, R E" sort="Wilson, R E" uniqKey="Wilson R" first="R. E." last="Wilson">R. E. Wilson</name>
</author>
<author><name sortKey="Collins, M J" sort="Collins, M J" uniqKey="Collins M" first="M. J." last="Collins">M. J. Collins</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">6275707</idno>
<idno type="pmc">1915970</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1915970</idno>
<idno type="RBID">PMC:1915970</idno>
<date when="1982">1982</date>
<idno type="wicri:Area/Pmc/Corpus">000188</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000188</idno>
<idno type="wicri:Area/Pmc/Curation">000188</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000188</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000787</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000787</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000754</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000754</idno>
<idno type="wicri:Area/PubMed/Curation">000754</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000754</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000743</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000743</idno>
<idno type="wicri:Area/Ncbi/Merge">000E45</idno>
<idno type="wicri:Area/Ncbi/Curation">000E45</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000E45</idno>
<idno type="wicri:doubleKey">0002-9440:1982:Boorman G:peritoneal:macrophage:alterations</idno>
<idno type="wicri:Area/Main/Merge">001705</idno>
<idno type="wicri:Area/Main/Curation">001677</idno>
<idno type="wicri:Area/Main/Exploration">001677</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Peritoneal macrophage alterations caused by naturally occurring mouse hepatitis virus.</title>
<author><name sortKey="Boorman, G A" sort="Boorman, G A" uniqKey="Boorman G" first="G. A." last="Boorman">G. A. Boorman</name>
</author>
<author><name sortKey="Luster, M I" sort="Luster, M I" uniqKey="Luster M" first="M. I." last="Luster">M. I. Luster</name>
</author>
<author><name sortKey="Dean, J H" sort="Dean, J H" uniqKey="Dean J" first="J. H." last="Dean">J. H. Dean</name>
</author>
<author><name sortKey="Campbell, M L" sort="Campbell, M L" uniqKey="Campbell M" first="M. L." last="Campbell">M. L. Campbell</name>
</author>
<author><name sortKey="Lauer, L A" sort="Lauer, L A" uniqKey="Lauer L" first="L. A." last="Lauer">L. A. Lauer</name>
</author>
<author><name sortKey="Talley, F A" sort="Talley, F A" uniqKey="Talley F" first="F. A." last="Talley">F. A. Talley</name>
</author>
<author><name sortKey="Wilson, R E" sort="Wilson, R E" uniqKey="Wilson R" first="R. E." last="Wilson">R. E. Wilson</name>
</author>
<author><name sortKey="Collins, M J" sort="Collins, M J" uniqKey="Collins M" first="M. J." last="Collins">M. J. Collins</name>
</author>
</analytic>
<series><title level="j">The American Journal of Pathology</title>
<idno type="ISSN">0002-9440</idno>
<idno type="eISSN">1525-2191</idno>
<imprint><date when="1982">1982</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Coronaviridae Infections (immunology)</term>
<term>Coronaviridae Infections (pathology)</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Female</term>
<term>Hepatitis, Viral, Animal (complications)</term>
<term>Hepatitis, Viral, Animal (immunology)</term>
<term>Hepatitis, Viral, Animal (pathology)</term>
<term>Humans</term>
<term>Liver (pathology)</term>
<term>Macrophages (pathology)</term>
<term>Macrophages (physiology)</term>
<term>Mice</term>
<term>Peritonitis (complications)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Femelle</term>
<term>Foie (anatomopathologie)</term>
<term>Humains</term>
<term>Hépatite virale animale ()</term>
<term>Hépatite virale animale (anatomopathologie)</term>
<term>Hépatite virale animale (immunologie)</term>
<term>Infections à Coronaviridae (anatomopathologie)</term>
<term>Infections à Coronaviridae (immunologie)</term>
<term>Macrophages (anatomopathologie)</term>
<term>Macrophages (physiologie)</term>
<term>Péritonite ()</term>
<term>Souris</term>
<term>Test ELISA</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Foie</term>
<term>Hépatite virale animale</term>
<term>Infections à Coronaviridae</term>
<term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Hepatitis, Viral, Animal</term>
<term>Peritonitis</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Hépatite virale animale</term>
<term>Infections à Coronaviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronaviridae Infections</term>
<term>Hepatitis, Viral, Animal</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronaviridae Infections</term>
<term>Hepatitis, Viral, Animal</term>
<term>Liver</term>
<term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Macrophages</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Female</term>
<term>Humans</term>
<term>Mice</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hépatite virale animale</term>
<term>Péritonite</term>
<term>Souris</term>
<term>Test ELISA</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>During routine harvest of murine resident peritoneal cells for macrophage function assays the authors recently noted that mice showed a 3-4-fold spontaneous increase in number of peritoneal cells within 1 week of being placed in one of their animal rooms. While the mice appeared clinically normal, the collected macrophages had highly convoluted membranes, showed enhanced spontaneous tumor cell killing, and showed increased erythrophagocytosis. Histopathologic findings included mild peritonitis and occasional foci of individual hepatocyte necrosis. The results of routine murine serologic studies and bacterial cultures of the peritoneal cavity were negative. Immunosuppressed mice placed in this room showed severe hepatic necrosis within 4 days, and ultrastructural particles characteristic of corona virus could be demonstrated in the necrotic foci. Mouse hepatitis virus (MHV) was isolated from these livers. Untreated mice showed positive MHV titers, as detected by the enzyme-linked immunoabsorbent assay (ELISA) after 21 days in the room. This episode demonstrates that MHV have profound effects on macrophage parameters while causing few clinical signs or histopathologic alterations. Secondly, the complement fixation assay for MHV as included in routine viral screens appears relatively insensitive for detecting outbreaks of MHV.</p>
<sec sec-type="scanned-figures"><title>Images</title>
<fig id="F1"><label>Figure 2</label>
<graphic xlink:href="amjpathol00208-0119-a" xlink:role="113"></graphic>
</fig>
<fig id="F2"><label>Figure 4</label>
<graphic xlink:href="amjpathol00208-0121-a" xlink:role="115"></graphic>
</fig>
<fig id="F3"><label>Figure 5</label>
<graphic xlink:href="amjpathol00208-0122-a" xlink:role="116"></graphic>
</fig>
</sec>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Boorman, G A" sort="Boorman, G A" uniqKey="Boorman G" first="G. A." last="Boorman">G. A. Boorman</name>
<name sortKey="Campbell, M L" sort="Campbell, M L" uniqKey="Campbell M" first="M. L." last="Campbell">M. L. Campbell</name>
<name sortKey="Collins, M J" sort="Collins, M J" uniqKey="Collins M" first="M. J." last="Collins">M. J. Collins</name>
<name sortKey="Dean, J H" sort="Dean, J H" uniqKey="Dean J" first="J. H." last="Dean">J. H. Dean</name>
<name sortKey="Lauer, L A" sort="Lauer, L A" uniqKey="Lauer L" first="L. A." last="Lauer">L. A. Lauer</name>
<name sortKey="Luster, M I" sort="Luster, M I" uniqKey="Luster M" first="M. I." last="Luster">M. I. Luster</name>
<name sortKey="Talley, F A" sort="Talley, F A" uniqKey="Talley F" first="F. A." last="Talley">F. A. Talley</name>
<name sortKey="Wilson, R E" sort="Wilson, R E" uniqKey="Wilson R" first="R. E." last="Wilson">R. E. Wilson</name>
</noCountry>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001677 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001677 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= CovidV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:1915970 |texte= Peritoneal macrophage alterations caused by naturally occurring mouse hepatitis virus. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:6275707" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a CovidV1
This area was generated with Dilib version V0.6.33. |