The RT6 Rat Lymphocyte Alloantigen Circulates in Soluble Form
Identifieur interne : 001333 ( Main/Exploration ); précédent : 001332; suivant : 001334The RT6 Rat Lymphocyte Alloantigen Circulates in Soluble Form
Auteurs : Debra J. Waite [États-Unis] ; Eugene S. Handler [États-Unis] ; John P. Mordes [États-Unis] ; Aldo A. Rossini [États-Unis] ; Dale L. Greiner [États-Unis]Source :
- Cellular Immunology [ 0008-8749 ] ; 1993.
Abstract
Abstract: RT6 is a rat maturational lymphocyte alloantigen that appears to subserve important immunoregulatory functions. The lymphopenic diabetes-prone BioBreeding (BB)/Worcester rat is severely deficient in RT6+ T cells and develops spontaneous autoimmune diabetes mellitus. Transfusion of RT6+ T cells prevents the disease. Conversely, in vivo immune elimination of RT6+ T cells from the diabetes-resistant line of BB rats induces diabetes and thyroiditis. RT6 protein is expressed in two allotypic forms, each linked to the cell surface by a phosphatidylinositol (PI) anchor. The mechanism by which RT6+ T cells exert their regulatory function is not known, nor is the function of the RT6 protein defined. In this study, we investigated the possibility that, like other PI-linked proteins. RT6 also exists in a soluble from in the circulation. Using standard biochemical procedures we observed: (i) Soluble RT6 circulates in readily detectable amounts in all rat strains studied. (ii) The diabetes-prone BB rat circulates less RT6.1 than does any other strain, including the coisogenic diabetes-resistant line. (iii) Injections of monoclonal anti-RT6.1 antibody rapidly eliminate soluble RT6 from the circulation of diabetes resistant BB rats. The existence of a soluble form of a protein associated with immunoregulatory T cells suggests the possibility that soluble RT6 itself might possess immunomodulatory properties.
Url:
DOI: 10.1006/cimm.1993.1269
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000799
- to stream Istex, to step Curation: 000779
- to stream Istex, to step Checkpoint: 000498
- to stream Main, to step Merge: 001349
- to stream Main, to step Curation: 001333
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The RT6 Rat Lymphocyte Alloantigen Circulates in Soluble Form</title>
<author><name sortKey="Waite, Debra J" sort="Waite, Debra J" uniqKey="Waite D" first="Debra J." last="Waite">Debra J. Waite</name>
</author>
<author><name sortKey="Handler, Eugene S" sort="Handler, Eugene S" uniqKey="Handler E" first="Eugene S." last="Handler">Eugene S. Handler</name>
</author>
<author><name sortKey="Mordes, John P" sort="Mordes, John P" uniqKey="Mordes J" first="John P." last="Mordes">John P. Mordes</name>
</author>
<author><name sortKey="Rossini, Aldo A" sort="Rossini, Aldo A" uniqKey="Rossini A" first="Aldo A." last="Rossini">Aldo A. Rossini</name>
</author>
<author><name sortKey="Greiner, Dale L" sort="Greiner, Dale L" uniqKey="Greiner D" first="Dale L." last="Greiner">Dale L. Greiner</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:F95CB3C9269AC0C767DC9C6A7DD8111CA83CBBE5</idno>
<date when="1993" year="1993">1993</date>
<idno type="doi">10.1006/cimm.1993.1269</idno>
<idno type="url">https://api.istex.fr/ark:/67375/6H6-66MVNGVR-N/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000799</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000799</idno>
<idno type="wicri:Area/Istex/Curation">000779</idno>
<idno type="wicri:Area/Istex/Checkpoint">000498</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000498</idno>
<idno type="wicri:doubleKey">0008-8749:1993:Waite D:the:rt:rat</idno>
<idno type="wicri:Area/Main/Merge">001349</idno>
<idno type="wicri:Area/Main/Curation">001333</idno>
<idno type="wicri:Area/Main/Exploration">001333</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The RT6 Rat Lymphocyte Alloantigen Circulates in Soluble Form</title>
<author><name sortKey="Waite, Debra J" sort="Waite, Debra J" uniqKey="Waite D" first="Debra J." last="Waite">Debra J. Waite</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Massachusetts Medical School, Worcester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Handler, Eugene S" sort="Handler, Eugene S" uniqKey="Handler E" first="Eugene S." last="Handler">Eugene S. Handler</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Massachusetts Medical School, Worcester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mordes, John P" sort="Mordes, John P" uniqKey="Mordes J" first="John P." last="Mordes">John P. Mordes</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Massachusetts Medical School, Worcester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rossini, Aldo A" sort="Rossini, Aldo A" uniqKey="Rossini A" first="Aldo A." last="Rossini">Aldo A. Rossini</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Massachusetts Medical School, Worcester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Greiner, Dale L" sort="Greiner, Dale L" uniqKey="Greiner D" first="Dale L." last="Greiner">Dale L. Greiner</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Massachusetts Medical School, Worcester</wicri:cityArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Cellular Immunology</title>
<title level="j" type="abbrev">YCIMM</title>
<idno type="ISSN">0008-8749</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1993">1993</date>
<biblScope unit="volume">152</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="82">82</biblScope>
<biblScope unit="page" to="95">95</biblScope>
</imprint>
<idno type="ISSN">0008-8749</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0008-8749</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: RT6 is a rat maturational lymphocyte alloantigen that appears to subserve important immunoregulatory functions. The lymphopenic diabetes-prone BioBreeding (BB)/Worcester rat is severely deficient in RT6+ T cells and develops spontaneous autoimmune diabetes mellitus. Transfusion of RT6+ T cells prevents the disease. Conversely, in vivo immune elimination of RT6+ T cells from the diabetes-resistant line of BB rats induces diabetes and thyroiditis. RT6 protein is expressed in two allotypic forms, each linked to the cell surface by a phosphatidylinositol (PI) anchor. The mechanism by which RT6+ T cells exert their regulatory function is not known, nor is the function of the RT6 protein defined. In this study, we investigated the possibility that, like other PI-linked proteins. RT6 also exists in a soluble from in the circulation. Using standard biochemical procedures we observed: (i) Soluble RT6 circulates in readily detectable amounts in all rat strains studied. (ii) The diabetes-prone BB rat circulates less RT6.1 than does any other strain, including the coisogenic diabetes-resistant line. (iii) Injections of monoclonal anti-RT6.1 antibody rapidly eliminate soluble RT6 from the circulation of diabetes resistant BB rats. The existence of a soluble form of a protein associated with immunoregulatory T cells suggests the possibility that soluble RT6 itself might possess immunomodulatory properties.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Massachusetts</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Waite, Debra J" sort="Waite, Debra J" uniqKey="Waite D" first="Debra J." last="Waite">Debra J. Waite</name>
</region>
<name sortKey="Greiner, Dale L" sort="Greiner, Dale L" uniqKey="Greiner D" first="Dale L." last="Greiner">Dale L. Greiner</name>
<name sortKey="Handler, Eugene S" sort="Handler, Eugene S" uniqKey="Handler E" first="Eugene S." last="Handler">Eugene S. Handler</name>
<name sortKey="Mordes, John P" sort="Mordes, John P" uniqKey="Mordes J" first="John P." last="Mordes">John P. Mordes</name>
<name sortKey="Rossini, Aldo A" sort="Rossini, Aldo A" uniqKey="Rossini A" first="Aldo A." last="Rossini">Aldo A. Rossini</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001333 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001333 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= CovidV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:F95CB3C9269AC0C767DC9C6A7DD8111CA83CBBE5 |texte= The RT6 Rat Lymphocyte Alloantigen Circulates in Soluble Form }}
![]() | This area was generated with Dilib version V0.6.33. | ![]() |