Serum LDH in chronic cough: a potential marker of airway inflammation
Identifieur interne : 000C00 ( Main/Exploration ); précédent : 000B99; suivant : 000C01Serum LDH in chronic cough: a potential marker of airway inflammation
Auteurs : Shoaib Faruqi [Royaume-Uni] ; Rachel Wilmot [Royaume-Uni] ; Caroline Wright [Royaume-Uni] ; Alyn Hugh Morice [Royaume-Uni]Source :
- The Clinical Respiratory Journal [ 1752-6981 ] ; 2012-04.
Abstract
Introduction and Objectives: Lactate dehydrogenase (LDH) is found in almost all tissues of the body and five different isoenzymes are known (LDH‐1 to LDH‐5). LDH can be elevated in many pathological conditions. We have observed serum LDH to be increased in patients with chronic cough. We wanted to confirm this finding, study the reproducibility and determine the origin of the LDH. Methods: Patients prospectively seen at the Hull Cough Clinic had total and specific LDH isoenzyme levels in serum determined. A subgroup of patients also had a serum creatine phosphokinase (CK) measured. Patients completed cough symptom scores and the Hull Airway Reflux Questionnaire (HARQ). Spirometry was performed. Results: Eighty‐three patients were included. Forty‐two percent had LDH values above the reference range and 78% had LDH values in the fourth quartile of the reference range or above. This increase in LDH was predominantly because of a rise in isoenzymes 4 and 5. The increase in LDH was found to be reproducible at 8 weeks. Ten percent had CK values above the normal range. There was no correlation observed between LDH values and the cough scores, HARQ scores or lung function. Conclusion: Serum LDH levels are elevated in a substantial proportion of patients with chronic cough. This rise is likely to be due to airway inflammation known to be associated with chronic cough. Please cite this paper as: Faruqi S, Wilmot R, Wright C and Morice AH. Serum LDH in chronic cough: a potential marker of airway inflammation. Clin Respir J 2012; 6: 81–87.
Url:
DOI: 10.1111/j.1752-699X.2011.00250.x
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000508
- to stream Istex, to step Curation: 000488
- to stream Istex, to step Checkpoint: 000062
- to stream Main, to step Merge: 000C02
- to stream Main, to step Curation: 000C00
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Serum LDH in chronic cough: a potential marker of airway inflammation</title><author><name sortKey="Faruqi, Shoaib" sort="Faruqi, Shoaib" uniqKey="Faruqi S" first="Shoaib" last="Faruqi">Shoaib Faruqi</name></author><author><name sortKey="Wilmot, Rachel" sort="Wilmot, Rachel" uniqKey="Wilmot R" first="Rachel" last="Wilmot">Rachel Wilmot</name></author><author><name sortKey="Wright, Caroline" sort="Wright, Caroline" uniqKey="Wright C" first="Caroline" last="Wright">Caroline Wright</name></author><author><name sortKey="Morice, Alyn Hugh" sort="Morice, Alyn Hugh" uniqKey="Morice A" first="Alyn Hugh" last="Morice">Alyn Hugh Morice</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:EF159588EEE21BE787FAFA42E99077B9929FB5F0</idno><date when="2012" year="2012">2012</date><idno type="doi">10.1111/j.1752-699X.2011.00250.x</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-H6QVHLTC-R/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000508</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000508</idno><idno type="wicri:Area/Istex/Curation">000488</idno><idno type="wicri:Area/Istex/Checkpoint">000062</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000062</idno><idno type="wicri:doubleKey">1752-6981:2012:Faruqi S:serum:ldh:in</idno><idno type="wicri:Area/Main/Merge">000C02</idno><idno type="wicri:Area/Main/Curation">000C00</idno><idno type="wicri:Area/Main/Exploration">000C00</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Serum LDH in chronic cough: a potential marker of airway inflammation</title><author><name sortKey="Faruqi, Shoaib" sort="Faruqi, Shoaib" uniqKey="Faruqi S" first="Shoaib" last="Faruqi">Shoaib Faruqi</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cardiovascular and Respiratory Studies, Castle Hill Hospital, University of Hull, Hull York Medical School, Cottingham</wicri:regionArea><wicri:noRegion>Cottingham</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country></affiliation></author><author><name sortKey="Wilmot, Rachel" sort="Wilmot, Rachel" uniqKey="Wilmot R" first="Rachel" last="Wilmot">Rachel Wilmot</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Biochemistry, Hull Royal Infirmary, Hull</wicri:regionArea><wicri:noRegion>Hull</wicri:noRegion></affiliation></author><author><name sortKey="Wright, Caroline" sort="Wright, Caroline" uniqKey="Wright C" first="Caroline" last="Wright">Caroline Wright</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cardiovascular and Respiratory Studies, Castle Hill Hospital, University of Hull, Hull York Medical School, Cottingham</wicri:regionArea><wicri:noRegion>Cottingham</wicri:noRegion></affiliation></author><author><name sortKey="Morice, Alyn Hugh" sort="Morice, Alyn Hugh" uniqKey="Morice A" first="Alyn Hugh" last="Morice">Alyn Hugh Morice</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cardiovascular and Respiratory Studies, Castle Hill Hospital, University of Hull, Hull York Medical School, Cottingham</wicri:regionArea><wicri:noRegion>Cottingham</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Clinical Respiratory Journal</title><title level="j" type="alt">CLINICAL RESPIRATORY JOURNAL</title><idno type="ISSN">1752-6981</idno><idno type="eISSN">1752-699X</idno><imprint><biblScope unit="vol">6</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="81">81</biblScope><biblScope unit="page" to="87">87</biblScope><biblScope unit="page-count">7</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2012-04">2012-04</date></imprint><idno type="ISSN">1752-6981</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1752-6981</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Introduction and Objectives: Lactate dehydrogenase (LDH) is found in almost all tissues of the body and five different isoenzymes are known (LDH‐1 to LDH‐5). LDH can be elevated in many pathological conditions. We have observed serum LDH to be increased in patients with chronic cough. We wanted to confirm this finding, study the reproducibility and determine the origin of the LDH. Methods: Patients prospectively seen at the Hull Cough Clinic had total and specific LDH isoenzyme levels in serum determined. A subgroup of patients also had a serum creatine phosphokinase (CK) measured. Patients completed cough symptom scores and the Hull Airway Reflux Questionnaire (HARQ). Spirometry was performed. Results: Eighty‐three patients were included. Forty‐two percent had LDH values above the reference range and 78% had LDH values in the fourth quartile of the reference range or above. This increase in LDH was predominantly because of a rise in isoenzymes 4 and 5. The increase in LDH was found to be reproducible at 8 weeks. Ten percent had CK values above the normal range. There was no correlation observed between LDH values and the cough scores, HARQ scores or lung function. Conclusion: Serum LDH levels are elevated in a substantial proportion of patients with chronic cough. This rise is likely to be due to airway inflammation known to be associated with chronic cough. Please cite this paper as: Faruqi S, Wilmot R, Wright C and Morice AH. Serum LDH in chronic cough: a potential marker of airway inflammation. Clin Respir J 2012; 6: 81–87.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Faruqi, Shoaib" sort="Faruqi, Shoaib" uniqKey="Faruqi S" first="Shoaib" last="Faruqi">Shoaib Faruqi</name></noRegion><name sortKey="Faruqi, Shoaib" sort="Faruqi, Shoaib" uniqKey="Faruqi S" first="Shoaib" last="Faruqi">Shoaib Faruqi</name><name sortKey="Morice, Alyn Hugh" sort="Morice, Alyn Hugh" uniqKey="Morice A" first="Alyn Hugh" last="Morice">Alyn Hugh Morice</name><name sortKey="Wilmot, Rachel" sort="Wilmot, Rachel" uniqKey="Wilmot R" first="Rachel" last="Wilmot">Rachel Wilmot</name><name sortKey="Wright, Caroline" sort="Wright, Caroline" uniqKey="Wright C" first="Caroline" last="Wright">Caroline Wright</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C00 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000C00 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:EF159588EEE21BE787FAFA42E99077B9929FB5F0
|texte= Serum LDH in chronic cough: a potential marker of airway inflammation
}}
| This area was generated with Dilib version V0.6.33. |  |