The “Nasal Pool”‐device for challenge and lavage of the nasal mucosa in children: Histamine‐induced plasma exudation responses
Identifieur interne : 001221 ( Main/Exploration ); précédent : 001220; suivant : 001222The “Nasal Pool”‐device for challenge and lavage of the nasal mucosa in children: Histamine‐induced plasma exudation responses
Auteurs : Lennart Greiff [Suède] ; Peter Meyer [Suède] ; Christer Svensson [Suède] ; Carl G. A. Persson [Suède] ; Morgan Andersson [Suède]Source :
- Pediatric Allergy and Immunology [ 0905-6157 ] ; 1997-08.
English descriptors
- Teeft :
- Airway, Airway mucosa, Allergy, Bulk plasma, Concomitant, Concomitant challenge, Defence, Exudation, First part, Greiff, Histamine, Histamine challenge, Isotonic saline, Lavage, Lavage fluids, Lumenal, Lumenal entry, Mucosa, Mucosal, Mucosal exudation, Nasal, Nasal airway, Nasal cavity, Nasal lavages, Nasal mucosa, Nasal pool, Present study, Second part, Subepithelial microcirculation.
Abstract
The accessibility of the nasal airway allows important examination of the airway mucosa in health and disease. However, the current methods for nasal challenge and lavage in children suffer from several shortcomings. In the present study, we have assessed the utility of a recently developed “nasal pool”‐device in 7–9 year old children, and explored the ability of the nasal mucosa of these school‐children to mount a plasma exudation res‐ponse (lumenal entry of bulk plasma). Isotonic saline was instilled and maintained (1 min) as a “pool” in the unilateral nasal cavity. Recovery of the “pool” (lavage fluids) was determined. Concomitant challenge and lavage was then performed by exposing the nasal mucosa to a “pool” of iso‐tonic saline and histamine (40‐400 μg/ml) for 2 min. “Pool” fluids were analysed for α2‐macroglobulin as an index of microvascular epithelial exudation of bulk plasma. The school‐children successfully managed to carry out nasal lavages as well as concomitant histamine challenges and lavages with the “nasal pool”‐device. The recovery of the nasal lavage fluids was almost quantitative (>85%) and thus well reproducible. Histamine produced significant exudation of bulk plasma (α2‐macroglobulin), We suggest that the “nasal pool”‐device is well suited for challenge and lavage of the nasal airway mucosa in children above 6 years of age. and conclude that lumenal entry of multipotent humoural protein‐systems may be an im‐portant first line respiratory defence mechanism in children.
Url:
DOI: 10.1111/j.1399-3038.1997.tb00167.x
Affiliations:
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A." last="Persson">Carl G. A. Persson</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Clinical Pharmacology University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Andersson, Morgan" sort="Andersson, Morgan" uniqKey="Andersson M" first="Morgan" last="Andersson">Morgan Andersson</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Departments of Otorhinolaryngology, Head and Neck Surgery University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Pediatric Allergy and Immunology</title><title level="j" type="alt">PEDIATRIC ALLERGY IMMUNOLOGY</title><idno type="ISSN">0905-6157</idno><idno type="eISSN">1399-3038</idno><imprint><biblScope unit="vol">8</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="137">137</biblScope><biblScope unit="page" to="142">142</biblScope><biblScope unit="page-count">6</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1997-08">1997-08</date></imprint><idno type="ISSN">0905-6157</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0905-6157</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Airway</term><term>Airway mucosa</term><term>Allergy</term><term>Bulk plasma</term><term>Concomitant</term><term>Concomitant challenge</term><term>Defence</term><term>Exudation</term><term>First part</term><term>Greiff</term><term>Histamine</term><term>Histamine challenge</term><term>Isotonic saline</term><term>Lavage</term><term>Lavage fluids</term><term>Lumenal</term><term>Lumenal entry</term><term>Mucosa</term><term>Mucosal</term><term>Mucosal exudation</term><term>Nasal</term><term>Nasal airway</term><term>Nasal cavity</term><term>Nasal lavages</term><term>Nasal mucosa</term><term>Nasal pool</term><term>Present study</term><term>Second part</term><term>Subepithelial microcirculation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The accessibility of the nasal airway allows important examination of the airway mucosa in health and disease. However, the current methods for nasal challenge and lavage in children suffer from several shortcomings. In the present study, we have assessed the utility of a recently developed “nasal pool”‐device in 7–9 year old children, and explored the ability of the nasal mucosa of these school‐children to mount a plasma exudation res‐ponse (lumenal entry of bulk plasma). Isotonic saline was instilled and maintained (1 min) as a “pool” in the unilateral nasal cavity. Recovery of the “pool” (lavage fluids) was determined. Concomitant challenge and lavage was then performed by exposing the nasal mucosa to a “pool” of iso‐tonic saline and histamine (40‐400 μg/ml) for 2 min. “Pool” fluids were analysed for α2‐macroglobulin as an index of microvascular epithelial exudation of bulk plasma. The school‐children successfully managed to carry out nasal lavages as well as concomitant histamine challenges and lavages with the “nasal pool”‐device. The recovery of the nasal lavage fluids was almost quantitative (>85%) and thus well reproducible. Histamine produced significant exudation of bulk plasma (α2‐macroglobulin), We suggest that the “nasal pool”‐device is well suited for challenge and lavage of the nasal airway mucosa in children above 6 years of age. and conclude that lumenal entry of multipotent humoural protein‐systems may be an im‐portant first line respiratory defence mechanism in children.</div></front></TEI><affiliations><list><country><li>Suède</li></country></list><tree><country name="Suède"><noRegion><name sortKey="Greiff, Lennart" sort="Greiff, Lennart" uniqKey="Greiff L" first="Lennart" last="Greiff">Lennart Greiff</name></noRegion><name sortKey="Andersson, Morgan" sort="Andersson, Morgan" uniqKey="Andersson M" first="Morgan" last="Andersson">Morgan Andersson</name><name sortKey="Greiff, Lennart" sort="Greiff, Lennart" uniqKey="Greiff L" first="Lennart" last="Greiff">Lennart Greiff</name><name sortKey="Meyer, Peter" sort="Meyer, Peter" uniqKey="Meyer P" first="Peter" last="Meyer">Peter Meyer</name><name sortKey="Persson, Carl G A" sort="Persson, Carl G A" uniqKey="Persson C" first="Carl G. A." last="Persson">Carl G. A. Persson</name><name sortKey="Svensson, Christer" sort="Svensson, Christer" uniqKey="Svensson C" first="Christer" last="Svensson">Christer Svensson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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