Nasal cytokines in common cold and allergic rhinitis
Identifieur interne : 001275 ( Main/Exploration ); précédent : 001274; suivant : 001276Nasal cytokines in common cold and allergic rhinitis
Auteurs : M. Linden [Suède] ; L. Greiff [Suède] ; M. Andersson [Suède] ; C. Svensson [Suède] ; A. Kerlund [Suède] ; M. Bende [Suède] ; E. Andersson [Suède] ; C. G. A. Persson [Suède]Source :
- Clinical & Experimental Allergy [ 0954-7894 ] ; 1995-02.
Abstract
Coronavirus‐induced common cold and allergen‐induced rhinitis are characterized by nasal mucosal exudation of bulk blood plasma. The mucosal exudation process involves ‘flooding’ of the lamina propria with plasma‐derived binding proteins and it is possible that subepithelial inflammatory cytokines and mediators may be moved by the exudate to the mucosal surface. In this study, we have analysed cytokine levels in nasal lavage (NAL) fluids from non‐allergic subjects inoculated with coronavirus (n= 20) and from subjects with allergic (birch pollen) rhinitis subjected to additional allergen challenge (samples were obtained 35min post challenge) in the laboratory (n= 10). Ten of the 20 inoculated subjects developed common cold and 10 remained healthy. Interferon‐γ (IFN‐γ), interleukin‐1β (IL‐1β), granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), IL‐4, and IL‐6 were analysed in unprocessed NAL fluids using immunoassays. The subjects who developed common cold had increased NAL fluid levels of IFNγ (P < 0.05) that correlated well with the symptoms (P < 0.001). IFNγ did not increase in subjects with allergic rhinitis. IL‐1β levels were similar in NAL fluids obtained from all inoculated subjects. In the subjects with allergic rhinitis NAL fluid levels of both IL‐1β and GM‐CSF were increased (P < 0.05). GM‐CSF was not detected in common cold. IL‐4 and IL‐6 were not detectable in any of the NAL fluids. The present cytokines may not only emanate from superficial mucosal cells. By aiding plasma exudation subepithelial cytokines may potentially also be retrieved on the mucosal surface. Our study provides original in vivo data supporting the notion that a TH‐1 profile of cytokines, notably IFNγ, is present in viral infection and further supporting the view that GM‐CSF is an important cytokine in allergic airways disease.
Url:
DOI: 10.1111/j.1365-2222.1995.tb01022.x
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000615
- to stream Istex, to step Curation: 000595
- to stream Istex, to step Checkpoint: 000448
- to stream Main, to step Merge: 001291
- to stream Main, to step Curation: 001275
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nasal cytokines in common cold and allergic rhinitis</title><author><name sortKey="Linden, M" sort="Linden, M" uniqKey="Linden M" first="M." last="Linden">M. Linden</name></author><author><name sortKey="Greiff, L" sort="Greiff, L" uniqKey="Greiff L" first="L." last="Greiff">L. Greiff</name></author><author><name sortKey="Andersson, M" sort="Andersson, M" uniqKey="Andersson M" first="M." last="Andersson">M. Andersson</name></author><author><name sortKey="Svensson, C" sort="Svensson, C" uniqKey="Svensson C" first="C." last="Svensson">C. Svensson</name></author><author><name sortKey=" Kerlund, A" sort=" Kerlund, A" uniqKey=" Kerlund A" first="A." last=" Kerlund">A. Kerlund</name></author><author><name sortKey="Bende, M" sort="Bende, M" uniqKey="Bende M" first="M." last="Bende">M. Bende</name></author><author><name sortKey="Andersson, E" sort="Andersson, E" uniqKey="Andersson E" first="E." last="Andersson">E. Andersson</name></author><author><name sortKey="Persson, C G A" sort="Persson, C G A" uniqKey="Persson C" first="C. G. A." last="Persson">C. G. A. Persson</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:65A8B9A85ED2DABE8E50988AD3ADAF7A7DCBC98D</idno><date when="1995" year="1995">1995</date><idno type="doi">10.1111/j.1365-2222.1995.tb01022.x</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-6HC3JCGN-9/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000615</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000615</idno><idno type="wicri:Area/Istex/Curation">000595</idno><idno type="wicri:Area/Istex/Checkpoint">000448</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000448</idno><idno type="wicri:doubleKey">0954-7894:1995:Linden M:nasal:cytokines:in</idno><idno type="wicri:Area/Main/Merge">001291</idno><idno type="wicri:Area/Main/Curation">001275</idno><idno type="wicri:Area/Main/Exploration">001275</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Nasal cytokines in common cold and allergic rhinitis</title><author><name sortKey="Linden, M" sort="Linden, M" uniqKey="Linden M" first="M." last="Linden">M. Linden</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Preclinical Research and Development, Pharmacology 1, Astra Draco AB, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>epartment of Lung Medicine, University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Correspondence address: M. Linden, Astra Draco AB, Box 34, S‐221 00 Lund</wicri:regionArea><wicri:noRegion>S‐221 00 Lund</wicri:noRegion></affiliation></author><author><name sortKey="Greiff, L" sort="Greiff, L" uniqKey="Greiff L" first="L." last="Greiff">L. Greiff</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Otorhinolaryngology, University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Andersson, M" sort="Andersson, M" uniqKey="Andersson M" first="M." last="Andersson">M. Andersson</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Otorhinolaryngology, University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Svensson, C" sort="Svensson, C" uniqKey="Svensson C" first="C." last="Svensson">C. Svensson</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Otorhinolaryngology, University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey=" Kerlund, A" sort=" Kerlund, A" uniqKey=" Kerlund A" first="A." last=" Kerlund">A. Kerlund</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Otorhinolaryngology, University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Bende, M" sort="Bende, M" uniqKey="Bende M" first="M." last="Bende">M. Bende</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Otorhinolaryngology, Central Hospital, Skövde</wicri:regionArea><wicri:noRegion>Skövde</wicri:noRegion></affiliation></author><author><name sortKey="Andersson, E" sort="Andersson, E" uniqKey="Andersson E" first="E." last="Andersson">E. Andersson</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>epartment of Lung Medicine, University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Persson, C G A" sort="Persson, C G A" uniqKey="Persson C" first="C. G. A." last="Persson">C. G. A. Persson</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Preclinical Research and Development, Pharmacology 1, Astra Draco AB, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Pharmacology, University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical & Experimental Allergy</title><title level="j" type="alt">CLINICAL EXPERIMENTAL ALLERGY</title><idno type="ISSN">0954-7894</idno><idno type="eISSN">1365-2222</idno><imprint><biblScope unit="vol">25</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="166">166</biblScope><biblScope unit="page" to="172">172</biblScope><biblScope unit="page-count">7</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1995-02">1995-02</date></imprint><idno type="ISSN">0954-7894</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0954-7894</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Coronavirus‐induced common cold and allergen‐induced rhinitis are characterized by nasal mucosal exudation of bulk blood plasma. The mucosal exudation process involves ‘flooding’ of the lamina propria with plasma‐derived binding proteins and it is possible that subepithelial inflammatory cytokines and mediators may be moved by the exudate to the mucosal surface. In this study, we have analysed cytokine levels in nasal lavage (NAL) fluids from non‐allergic subjects inoculated with coronavirus (n= 20) and from subjects with allergic (birch pollen) rhinitis subjected to additional allergen challenge (samples were obtained 35min post challenge) in the laboratory (n= 10). Ten of the 20 inoculated subjects developed common cold and 10 remained healthy. Interferon‐γ (IFN‐γ), interleukin‐1β (IL‐1β), granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), IL‐4, and IL‐6 were analysed in unprocessed NAL fluids using immunoassays. The subjects who developed common cold had increased NAL fluid levels of IFNγ (P < 0.05) that correlated well with the symptoms (P < 0.001). IFNγ did not increase in subjects with allergic rhinitis. IL‐1β levels were similar in NAL fluids obtained from all inoculated subjects. In the subjects with allergic rhinitis NAL fluid levels of both IL‐1β and GM‐CSF were increased (P < 0.05). GM‐CSF was not detected in common cold. IL‐4 and IL‐6 were not detectable in any of the NAL fluids. The present cytokines may not only emanate from superficial mucosal cells. By aiding plasma exudation subepithelial cytokines may potentially also be retrieved on the mucosal surface. Our study provides original in vivo data supporting the notion that a TH‐1 profile of cytokines, notably IFNγ, is present in viral infection and further supporting the view that GM‐CSF is an important cytokine in allergic airways disease.</div></front></TEI><affiliations><list><country><li>Suède</li></country></list><tree><country name="Suède"><noRegion><name sortKey="Linden, M" sort="Linden, M" uniqKey="Linden M" first="M." last="Linden">M. Linden</name></noRegion><name sortKey=" Kerlund, A" sort=" Kerlund, A" uniqKey=" Kerlund A" first="A." last=" Kerlund">A. Kerlund</name><name sortKey="Andersson, E" sort="Andersson, E" uniqKey="Andersson E" first="E." last="Andersson">E. Andersson</name><name sortKey="Andersson, M" sort="Andersson, M" uniqKey="Andersson M" first="M." last="Andersson">M. Andersson</name><name sortKey="Bende, M" sort="Bende, M" uniqKey="Bende M" first="M." last="Bende">M. Bende</name><name sortKey="Greiff, L" sort="Greiff, L" uniqKey="Greiff L" first="L." last="Greiff">L. Greiff</name><name sortKey="Linden, M" sort="Linden, M" uniqKey="Linden M" first="M." last="Linden">M. Linden</name><name sortKey="Linden, M" sort="Linden, M" uniqKey="Linden M" first="M." last="Linden">M. Linden</name><name sortKey="Persson, C G A" sort="Persson, C G A" uniqKey="Persson C" first="C. G. A." last="Persson">C. G. A. Persson</name><name sortKey="Persson, C G A" sort="Persson, C G A" uniqKey="Persson C" first="C. G. A." last="Persson">C. G. A. Persson</name><name sortKey="Svensson, C" sort="Svensson, C" uniqKey="Svensson C" first="C." last="Svensson">C. Svensson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001275 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001275 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:65A8B9A85ED2DABE8E50988AD3ADAF7A7DCBC98D
|texte= Nasal cytokines in common cold and allergic rhinitis
}}
| This area was generated with Dilib version V0.6.33. |  |