Design and Synthesis of Hydroxyferroquine Derivatives with Antimalarial and Antiviral Activities
Identifieur interne : 000F43 ( Main/Exploration ); précédent : 000F42; suivant : 000F44Design and Synthesis of Hydroxyferroquine Derivatives with Antimalarial and Antiviral Activities
Auteurs : Christophe Biot [Belgique, France] ; Wassim Daher [Belgique] ; Natascha Chavain [Belgique] ; Thierry Fandeur [Belgique] ; Jamal Khalife [Belgique] ; Daniel Dive [Belgique] ; Erik De Clercq [Belgique]Source :
- Journal of Medicinal Chemistry [ 0022-2623 ] ; 2006.
Abstract
Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert antiviral effects with some selectivity toward SARS−CoV infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.
Url:
DOI: 10.1021/jm0601856
Affiliations:
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UMR CNRS 8181, ENSCL, Bâtiment C7, USTL, B.P. 90108, 59652, Villeneuve d' Ascq Cedex,France, Inserm, U547, Institut Pasteur, 1 rue du Pr Calmette, B.P. 245, 59019 Lille Cedex, France, UMR Université-INRA d’ImmunologieParasitaire, Faculté des Sciences Pharmaceutiques, 31, avenue Monge, Parc Grandmont, 37200 Tours, France, andRega Institute for Medical Research, K.U.Leuven, B-3000 Leuven</wicri:regionArea><wicri:noRegion>B-3000 Leuven</wicri:noRegion></affiliation><affiliation></affiliation></author><author><name sortKey="Khalife, Jamal" sort="Khalife, Jamal" uniqKey="Khalife J" first="Jamal" last="Khalife">Jamal Khalife</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Unité de Catalyse et Chimie du Solide - UMR CNRS 8181, ENSCL, Bâtiment C7, USTL, B.P. 90108, 59652, Villeneuve d' Ascq Cedex,France, Inserm, U547, Institut Pasteur, 1 rue du Pr Calmette, B.P. 245, 59019 Lille Cedex, France, UMR Université-INRA d’ImmunologieParasitaire, Faculté des Sciences Pharmaceutiques, 31, avenue Monge, Parc Grandmont, 37200 Tours, France, andRega Institute for Medical Research, K.U.Leuven, B-3000 Leuven</wicri:regionArea><wicri:noRegion>B-3000 Leuven</wicri:noRegion></affiliation><affiliation></affiliation></author><author><name sortKey="Dive, Daniel" sort="Dive, Daniel" uniqKey="Dive D" first="Daniel" last="Dive">Daniel Dive</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Unité de Catalyse et Chimie du Solide - 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Med. Chem.</title><idno type="ISSN">0022-2623</idno><idno type="eISSN">1520-4804</idno><imprint><publisher>American Chemical Society</publisher><date type="e-published" when="2006-04-08">2006</date><date when="2006-05-04">2006</date><biblScope unit="vol">49</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="2845">2845</biblScope><biblScope unit="page" to="2849">2849</biblScope></imprint><idno type="ISSN">0022-2623</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-2623</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert antiviral effects with some selectivity toward SARS−CoV infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.</div></front></TEI><affiliations><list><country><li>Belgique</li><li>France</li></country></list><tree><country name="Belgique"><noRegion><name sortKey="Biot, Christophe" sort="Biot, Christophe" uniqKey="Biot C" first="Christophe" last="Biot">Christophe Biot</name></noRegion><name sortKey="Chavain, Natascha" sort="Chavain, Natascha" uniqKey="Chavain N" first="Natascha" last="Chavain">Natascha Chavain</name><name sortKey="Daher, Wassim" sort="Daher, Wassim" uniqKey="Daher W" first="Wassim" last="Daher">Wassim Daher</name><name sortKey="De Clercq, Erik" sort="De Clercq, Erik" uniqKey="De Clercq E" first="Erik" last="De Clercq">Erik De Clercq</name><name sortKey="Dive, Daniel" sort="Dive, Daniel" uniqKey="Dive D" first="Daniel" last="Dive">Daniel Dive</name><name sortKey="Fandeur, Thierry" sort="Fandeur, Thierry" uniqKey="Fandeur T" first="Thierry" last="Fandeur">Thierry Fandeur</name><name sortKey="Khalife, Jamal" sort="Khalife, Jamal" uniqKey="Khalife J" first="Jamal" last="Khalife">Jamal Khalife</name></country><country name="France"><noRegion><name sortKey="Biot, Christophe" sort="Biot, Christophe" uniqKey="Biot C" first="Christophe" last="Biot">Christophe Biot</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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