CD13/aminopeptidase N in collagen vascular diseases
Identifieur interne : 001106 ( Main/Exploration ); précédent : 001105; suivant : 001107CD13/aminopeptidase N in collagen vascular diseases
Auteurs : Hirohumi Dan [Japon] ; Kenji Tani [Japon] ; Kayoko Hase [Japon] ; Teruki Shimizu [Japon] ; Hiroyuki Tamiya [Japon] ; Yanjmaa Biraa [Japon] ; Luping Huang [Japon] ; Hiroaki Yanagawa [Japon] ; Saburo Sone [Japon]Source :
- Rheumatology International [ 0172-8172 ] ; 2003-11-01.
English descriptors
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Abstract
Abstract: To determine the significance of CD13/aminopeptidase N in collagen vascular diseases (CVD), we examined its activity and expression in sera and disease sites of patients with CVD. Significantly higher aminopeptidase activity was detected in bronchoalveolar lavage fluid from patients with interstitial lung diseases due to rheumatoid arthritis (RA), polymyositis/dermatomyositis (PM/DM), systemic sclerosis (SSc), and Sjögren's syndrome than from control subjects. Increased aminopeptidase activity and increased expression of CD13/aminopeptidase N protein were found in alveolar macrophages from CVD patients with interstitial lung diseases. Significantly higher aminopeptidase activity was detected in pleural effusions from patients with systemic lupus erythematosus (SLE) than in transudate effusions. The mean aminopeptidase activity in synovial fluids from RA patients was significantly higher than from patients with osteoarthritis. The mean value of serum aminopeptidase activity was significantly higher in patients with SLE, RA, SSc, and PM/DM than in normal subjects. This study suggests that the activity of CD13/aminopeptidase N, locally produced in the disease site, is a useful marker for CVD and that CD13/aminopeptidase N may have an important role in the pathogenesis of CVD.
Url:
DOI: 10.1007/s00296-003-0292-5
Affiliations:
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determine the significance of CD13/aminopeptidase N in collagen vascular diseases (CVD), we examined its activity and expression in sera and disease sites of patients with CVD. Significantly higher aminopeptidase activity was detected in bronchoalveolar lavage fluid from patients with interstitial lung diseases due to rheumatoid arthritis (RA), polymyositis/dermatomyositis (PM/DM), systemic sclerosis (SSc), and Sjögren's syndrome than from control subjects. Increased aminopeptidase activity and increased expression of CD13/aminopeptidase N protein were found in alveolar macrophages from CVD patients with interstitial lung diseases. Significantly higher aminopeptidase activity was detected in pleural effusions from patients with systemic lupus erythematosus (SLE) than in transudate effusions. The mean aminopeptidase activity in synovial fluids from RA patients was significantly higher than from patients with osteoarthritis. The mean value of serum aminopeptidase activity was significantly higher in patients with SLE, RA, SSc, and PM/DM than in normal subjects. This study suggests that the activity of CD13/aminopeptidase N, locally produced in the disease site, is a useful marker for CVD and that CD13/aminopeptidase N may have an important role in the pathogenesis of CVD.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Dan, Hirohumi" sort="Dan, Hirohumi" uniqKey="Dan H" first="Hirohumi" last="Dan">Hirohumi Dan</name></noRegion><name sortKey="Biraa, Yanjmaa" sort="Biraa, Yanjmaa" uniqKey="Biraa Y" first="Yanjmaa" last="Biraa">Yanjmaa Biraa</name><name sortKey="Hase, Kayoko" sort="Hase, Kayoko" uniqKey="Hase K" first="Kayoko" last="Hase">Kayoko Hase</name><name sortKey="Huang, Luping" sort="Huang, Luping" uniqKey="Huang L" first="Luping" last="Huang">Luping Huang</name><name sortKey="Shimizu, Teruki" sort="Shimizu, Teruki" uniqKey="Shimizu T" first="Teruki" last="Shimizu">Teruki Shimizu</name><name sortKey="Sone, Saburo" sort="Sone, Saburo" uniqKey="Sone S" first="Saburo" last="Sone">Saburo Sone</name><name sortKey="Sone, Saburo" sort="Sone, Saburo" uniqKey="Sone S" first="Saburo" last="Sone">Saburo Sone</name><name sortKey="Tamiya, Hiroyuki" sort="Tamiya, Hiroyuki" uniqKey="Tamiya H" first="Hiroyuki" last="Tamiya">Hiroyuki Tamiya</name><name sortKey="Tani, Kenji" sort="Tani, Kenji" uniqKey="Tani K" first="Kenji" last="Tani">Kenji Tani</name><name sortKey="Yanagawa, Hiroaki" sort="Yanagawa, Hiroaki" uniqKey="Yanagawa H" first="Hiroaki" last="Yanagawa">Hiroaki Yanagawa</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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