The role of environmental ammonia in respiratory mycoplasmosis of rats.
Identifieur interne : 001768 ( Main/Exploration ); précédent : 001767; suivant : 001769The role of environmental ammonia in respiratory mycoplasmosis of rats.
Auteurs : J. R. Broderson ; J. R. Lindsey ; J. E. CrawfordSource :
- The American Journal of Pathology [ 0002-9440 ] ; 1976.
Abstract
Young adult, pathogen-free rats of Sherman and Fischer (F344) substrains were inoculated intranasally with 10(8) colony-forming units (GFU) of M. pulmonis and housed for 4 to 6 weeks in environments with ammonia maintained at specific concentrations from 25 to 250 ppm. All levels of NH3--whether produced naturally from soiled bedding or derived from a purified source--significantly increased the severity of the rhinitis, otitis media, tracheitis, and pneumonia (including bronchiectasis) characteristic of murine respiratory mycoplasmosis (MRM). The prevalence of pneumonia, but not that of other respiratory lesions of MRM, showed a strong tendency to increase directly with environmental NH3 concentration. In contrast, NH3 exposure of rats not infected with M. pulmonis caused anatomic lesions that were unlike those of MRM and were limited to the nasal passages. It was concluded that environmental NH3, at concentrations commonly encountered in present day cage environments for rats, plays an important role in pathogenesis of MRM.
Url:
PubMed: 970435
PubMed Central: 2032551
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000192
- to stream Pmc, to step Curation: 000192
- to stream Pmc, to step Checkpoint: 000801
- to stream Ncbi, to step Merge: 000E92
- to stream Ncbi, to step Curation: 000E92
- to stream Ncbi, to step Checkpoint: 000E92
- to stream Main, to step Merge: 001801
- to stream Main, to step Curation: 001768
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The role of environmental ammonia in respiratory mycoplasmosis of rats.</title><author><name sortKey="Broderson, J R" sort="Broderson, J R" uniqKey="Broderson J" first="J. R." last="Broderson">J. R. Broderson</name></author><author><name sortKey="Lindsey, J R" sort="Lindsey, J R" uniqKey="Lindsey J" first="J. R." last="Lindsey">J. R. Lindsey</name></author><author><name sortKey="Crawford, J E" sort="Crawford, J E" uniqKey="Crawford J" first="J. E." last="Crawford">J. E. Crawford</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">970435</idno><idno type="pmc">2032551</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2032551</idno><idno type="RBID">PMC:2032551</idno><date when="1976">1976</date><idno type="wicri:Area/Pmc/Corpus">000192</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000192</idno><idno type="wicri:Area/Pmc/Curation">000192</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000192</idno><idno type="wicri:Area/Pmc/Checkpoint">000801</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000801</idno><idno type="wicri:Area/Ncbi/Merge">000E92</idno><idno type="wicri:Area/Ncbi/Curation">000E92</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E92</idno><idno type="wicri:doubleKey">0002-9440:1976:Broderson J:the:role:of</idno><idno type="wicri:Area/Main/Merge">001801</idno><idno type="wicri:Area/Main/Curation">001768</idno><idno type="wicri:Area/Main/Exploration">001768</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The role of environmental ammonia in respiratory mycoplasmosis of rats.</title><author><name sortKey="Broderson, J R" sort="Broderson, J R" uniqKey="Broderson J" first="J. R." last="Broderson">J. R. Broderson</name></author><author><name sortKey="Lindsey, J R" sort="Lindsey, J R" uniqKey="Lindsey J" first="J. R." last="Lindsey">J. R. Lindsey</name></author><author><name sortKey="Crawford, J E" sort="Crawford, J E" uniqKey="Crawford J" first="J. E." last="Crawford">J. E. Crawford</name></author></analytic><series><title level="j">The American Journal of Pathology</title><idno type="ISSN">0002-9440</idno><idno type="eISSN">1525-2191</idno><imprint><date when="1976">1976</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Young adult, pathogen-free rats of Sherman and Fischer (F344) substrains were inoculated intranasally with 10(8) colony-forming units (GFU) of M. pulmonis and housed for 4 to 6 weeks in environments with ammonia maintained at specific concentrations from 25 to 250 ppm. All levels of NH3--whether produced naturally from soiled bedding or derived from a purified source--significantly increased the severity of the rhinitis, otitis media, tracheitis, and pneumonia (including bronchiectasis) characteristic of murine respiratory mycoplasmosis (MRM). The prevalence of pneumonia, but not that of other respiratory lesions of MRM, showed a strong tendency to increase directly with environmental NH3 concentration. In contrast, NH3 exposure of rats not infected with M. pulmonis caused anatomic lesions that were unlike those of MRM and were limited to the nasal passages. It was concluded that environmental NH3, at concentrations commonly encountered in present day cage environments for rats, plays an important role in pathogenesis of MRM.</p><sec sec-type="scanned-figures"><title>Images</title><fig id="F1"><label>Figure 1</label><graphic xlink:href="amjpathol00443-0140-a" xlink:role="129"></graphic></fig><fig id="F2"><label>Figure 2</label><graphic xlink:href="amjpathol00443-0141-a" xlink:role="130"></graphic></fig><fig id="F3"><label>Figure 3</label><graphic xlink:href="amjpathol00443-0141-b" xlink:role="130"></graphic></fig><fig id="F4"><label>Figure 4</label><graphic xlink:href="amjpathol00443-0141-c" xlink:role="130"></graphic></fig></sec></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Broderson, J R" sort="Broderson, J R" uniqKey="Broderson J" first="J. R." last="Broderson">J. R. Broderson</name><name sortKey="Crawford, J E" sort="Crawford, J E" uniqKey="Crawford J" first="J. E." last="Crawford">J. E. Crawford</name><name sortKey="Lindsey, J R" sort="Lindsey, J R" uniqKey="Lindsey J" first="J. R." last="Lindsey">J. R. Lindsey</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001768 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001768 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:2032551
|texte= The role of environmental ammonia in respiratory mycoplasmosis of rats.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:970435" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidV1
| This area was generated with Dilib version V0.6.33. |  |