Effects of acute and chronic dimethylamine exposure on the nasal mucociliary apparatus of F-344 rats
Identifieur interne : 001566 ( Main/Exploration ); précédent : 001565; suivant : 001567Effects of acute and chronic dimethylamine exposure on the nasal mucociliary apparatus of F-344 rats
Auteurs : E. A. Gross [États-Unis] ; D. L. Patterson [États-Unis] ; K. T. Morgan [États-Unis]Source :
- Toxicology and Applied Pharmacology [ 0041-008X ] ; 1987.
English descriptors
- Teeft :
- Acute exposure, Acute studies, Acute study, Acute treatment, Adjacent septum, Anterior extension, Appl, Chronic control animals, Chronic exposure, Chronic inflammation, Chronic study, Chronic study animals, Cigarette smoke, Ciliary, Ciliary activity, Ciliastasis, Control animals, Days exposure, Dimethylamine, Dorsal margin, Dorsal meatus, Drug metab, Epithelial, Epithelial erosions, Epithelial vacuolation, Epithelium, Ethmoid, Ethmoid turbinates, Exposure chambers, Fenestration, Flow patterns, Flow rates, Formaldehyde, Functional significance, Functional studies, Further studies, Good correlation, Histologic changes, Histopathology, Inhaled, Inhaled particles, Lateral, Lateral wall, Lesion, Male rats, Maxilloturbinate, Maxilloturbinates, Mcnulty, Metaplasia, Mucociliary, Mucociliary apparatus, Mucociliary function, Mucus, Mucus flow, Mucus flow patterns, Mucus flow rates, Nasal, Nasal cavity, Nasal mucociliary apparatus, Nasal mucosa, Nasal passages, Nasal structure, Nasal toxicity, Nasal turbinates, Naso, Older animals, Olfactory, Olfactory epithelia, Olfactory epithelium, Olfactory pigment, Olfactory region, Posterior extension, Posterior naso, Present study, Previous work, Rat, Relative humidity, Respiratory epithelium, Respiratory metaplasia, Respiratory mucosa, Respiratory tract, Rotational flow, Sensory cells, Severe vacuolation, Single exposure, Squamous, Squamous epithelium, Squamous metaplasia, Stainless steel cage racks, Surface area, Threshold limit values, Time points, Toxicity, Tracheobronchial tree, Turbinate, Vacuolation, Video recordings, Young animals, Young rats.
Abstract
Abstract: Dimethylamine (DMA) is a highly water soluble gas with many industrial applications. Male F-344 rats were exposed to 175 ppm DMA 6 hr per day for 1, 2, 4, or 9 days or 2 years. Gross changes in nasal structure were recorded, effects of DMA on the mucociliary apparatus were assessed using video analysis, and tissues were evaluated for histopathology. In vitro nasal mucociliary flow patterns, mucus flow rates, and ciliary activity were studied and recorded for video motion analysis. There were distinct and generally consistent differences in the shape of the naso-, maxillo-, and ethmoid turbinates between young and old animals. Acute and chronic DMA exposures resulted in erosion of the anterior margins of the naso- and maxillo-turbinates and fenestration of the adjacent septum. Ciliastasis and mucostasis were observed only on the anteromedial aspect of the maxilloturbinate. In the chronically exposed rats, mucociliary activity was present in areas adjacent to erosions of the turbinates and septum. Abnormal mucus flow patterns, including altered or reversed direction of flow and “whirlpool-like” formation, were observed in all treated rats, but were more severe following chronic exposure. There was a good correlation between the distribution of responses as assessed by histopathology and abnormal mucociliary function at all time points. In conclusion, the mucociliary apparatus continues to function in the nasal passages of rats having localized destruction of nasal epithelium, induced by DMA exposure, and this clearance system responds to alterations of nasal structure by modification of mucus flow patterns.
Url:
DOI: 10.1016/0041-008X(87)90129-3
Affiliations:
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A." last="Gross">E. A. Gross</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Experimental Pathology and Toxicology, Chemical Industry Institute of Toxicology, P.O. Box 12137, Research Triangle Park</wicri:cityArea></affiliation></author><author><name sortKey="Patterson, D L" sort="Patterson, D L" uniqKey="Patterson D" first="D. L." last="Patterson">D. L. Patterson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Experimental Pathology and Toxicology, Chemical Industry Institute of Toxicology, P.O. Box 12137, Research Triangle Park</wicri:cityArea></affiliation></author><author><name sortKey="Morgan, K T" sort="Morgan, K T" uniqKey="Morgan K" first="K. T." last="Morgan">K. T. Morgan</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Experimental Pathology and Toxicology, Chemical Industry Institute of Toxicology, P.O. Box 12137, Research Triangle Park</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Toxicology and Applied Pharmacology</title><title level="j" type="abbrev">YTAAP</title><idno type="ISSN">0041-008X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1987">1987</date><biblScope unit="volume">90</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="359">359</biblScope><biblScope unit="page" to="376">376</biblScope></imprint><idno type="ISSN">0041-008X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0041-008X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acute exposure</term><term>Acute studies</term><term>Acute study</term><term>Acute treatment</term><term>Adjacent septum</term><term>Anterior extension</term><term>Appl</term><term>Chronic control animals</term><term>Chronic exposure</term><term>Chronic inflammation</term><term>Chronic study</term><term>Chronic study animals</term><term>Cigarette smoke</term><term>Ciliary</term><term>Ciliary activity</term><term>Ciliastasis</term><term>Control animals</term><term>Days exposure</term><term>Dimethylamine</term><term>Dorsal margin</term><term>Dorsal meatus</term><term>Drug metab</term><term>Epithelial</term><term>Epithelial erosions</term><term>Epithelial vacuolation</term><term>Epithelium</term><term>Ethmoid</term><term>Ethmoid turbinates</term><term>Exposure chambers</term><term>Fenestration</term><term>Flow patterns</term><term>Flow rates</term><term>Formaldehyde</term><term>Functional significance</term><term>Functional studies</term><term>Further studies</term><term>Good correlation</term><term>Histologic changes</term><term>Histopathology</term><term>Inhaled</term><term>Inhaled particles</term><term>Lateral</term><term>Lateral wall</term><term>Lesion</term><term>Male rats</term><term>Maxilloturbinate</term><term>Maxilloturbinates</term><term>Mcnulty</term><term>Metaplasia</term><term>Mucociliary</term><term>Mucociliary apparatus</term><term>Mucociliary function</term><term>Mucus</term><term>Mucus flow</term><term>Mucus flow patterns</term><term>Mucus flow rates</term><term>Nasal</term><term>Nasal cavity</term><term>Nasal mucociliary apparatus</term><term>Nasal mucosa</term><term>Nasal passages</term><term>Nasal structure</term><term>Nasal toxicity</term><term>Nasal turbinates</term><term>Naso</term><term>Older animals</term><term>Olfactory</term><term>Olfactory epithelia</term><term>Olfactory epithelium</term><term>Olfactory pigment</term><term>Olfactory region</term><term>Posterior extension</term><term>Posterior naso</term><term>Present study</term><term>Previous work</term><term>Rat</term><term>Relative humidity</term><term>Respiratory epithelium</term><term>Respiratory metaplasia</term><term>Respiratory mucosa</term><term>Respiratory tract</term><term>Rotational flow</term><term>Sensory cells</term><term>Severe vacuolation</term><term>Single exposure</term><term>Squamous</term><term>Squamous epithelium</term><term>Squamous metaplasia</term><term>Stainless steel cage racks</term><term>Surface area</term><term>Threshold limit values</term><term>Time points</term><term>Toxicity</term><term>Tracheobronchial tree</term><term>Turbinate</term><term>Vacuolation</term><term>Video recordings</term><term>Young animals</term><term>Young rats</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Dimethylamine (DMA) is a highly water soluble gas with many industrial applications. Male F-344 rats were exposed to 175 ppm DMA 6 hr per day for 1, 2, 4, or 9 days or 2 years. Gross changes in nasal structure were recorded, effects of DMA on the mucociliary apparatus were assessed using video analysis, and tissues were evaluated for histopathology. In vitro nasal mucociliary flow patterns, mucus flow rates, and ciliary activity were studied and recorded for video motion analysis. There were distinct and generally consistent differences in the shape of the naso-, maxillo-, and ethmoid turbinates between young and old animals. Acute and chronic DMA exposures resulted in erosion of the anterior margins of the naso- and maxillo-turbinates and fenestration of the adjacent septum. Ciliastasis and mucostasis were observed only on the anteromedial aspect of the maxilloturbinate. In the chronically exposed rats, mucociliary activity was present in areas adjacent to erosions of the turbinates and septum. Abnormal mucus flow patterns, including altered or reversed direction of flow and “whirlpool-like” formation, were observed in all treated rats, but were more severe following chronic exposure. There was a good correlation between the distribution of responses as assessed by histopathology and abnormal mucociliary function at all time points. In conclusion, the mucociliary apparatus continues to function in the nasal passages of rats having localized destruction of nasal epithelium, induced by DMA exposure, and this clearance system responds to alterations of nasal structure by modification of mucus flow patterns.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li></region></list><tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Gross, E A" sort="Gross, E A" uniqKey="Gross E" first="E. A." last="Gross">E. A. Gross</name></region><name sortKey="Morgan, K T" sort="Morgan, K T" uniqKey="Morgan K" first="K. T." last="Morgan">K. T. Morgan</name><name sortKey="Patterson, D L" sort="Patterson, D L" uniqKey="Patterson D" first="D. L." last="Patterson">D. L. Patterson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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