Rat Strains Differ in Susceptibility to Ureaplasma parvum-Induced Urinary Tract Infection and Struvite Stone Formation▿
Identifieur interne : 000F37 ( Main/Exploration ); précédent : 000F36; suivant : 000F38Rat Strains Differ in Susceptibility to Ureaplasma parvum-Induced Urinary Tract Infection and Struvite Stone Formation▿
Auteurs : Leticia Reyes [États-Unis] ; Mary Reinhard [États-Unis] ; L. J. O'Donell [États-Unis] ; Janet Stevens [États-Unis] ; Mary B. Brown [États-Unis]Source :
- Infection and Immunity [ 0019-9567 ] ; 2006.
Abstract
Individuals with struvite uroliths are susceptible to recurrent urinary tract infections (UTI), sepsis, and renal disease. Unfortunately, little is known about the host-specific factors that predispose to this disease. In order to develop a rodent model that can address this problem, we inoculated female Fischer 344 (F344), Lewis (LEW), Sprague-Dawley (SD), and Wistar (WIS) rats with a host-adapted strain of
Url:
DOI: 10.1128/IAI.00984-06
PubMed: 16982825
PubMed Central: 1698052
Affiliations:
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Box 110880, Gainesville, Florida 32610-0880</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>University of Florida, College of Veterinary Medicine, Department of Infectious Disease and Pathology, P.O. Box 110880, Gainesville</wicri:cityArea></affiliation></author><author><name sortKey="Reinhard, Mary" sort="Reinhard, Mary" uniqKey="Reinhard M" first="Mary" last="Reinhard">Mary Reinhard</name><affiliation wicri:level="2"><nlm:aff id="aff0">University of Florida, College of Veterinary Medicine, Department of Infectious Disease and Pathology, P.O. Box 110880, Gainesville, Florida 32610-0880</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>University of Florida, College of Veterinary Medicine, Department of Infectious Disease and Pathology, P.O. Box 110880, Gainesville</wicri:cityArea></affiliation></author><author><name sortKey="O Donell, L J" sort="O Donell, L J" uniqKey="O Donell L" first="L. J." last="O'Donell">L. J. O'Donell</name><affiliation wicri:level="2"><nlm:aff id="aff0">University of Florida, College of Veterinary Medicine, Department of Infectious Disease and Pathology, P.O. Box 110880, Gainesville, Florida 32610-0880</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>University of Florida, College of Veterinary Medicine, Department of Infectious Disease and Pathology, P.O. Box 110880, Gainesville</wicri:cityArea></affiliation></author><author><name sortKey="Stevens, Janet" sort="Stevens, Janet" uniqKey="Stevens J" first="Janet" last="Stevens">Janet Stevens</name><affiliation wicri:level="2"><nlm:aff id="aff0">University of Florida, College of Veterinary Medicine, Department of Infectious Disease and Pathology, P.O. Box 110880, Gainesville, Florida 32610-0880</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>University of Florida, College of Veterinary Medicine, Department of Infectious Disease and Pathology, P.O. Box 110880, Gainesville</wicri:cityArea></affiliation></author><author><name sortKey="Brown, Mary B" sort="Brown, Mary B" uniqKey="Brown M" first="Mary B." last="Brown">Mary B. Brown</name><affiliation wicri:level="2"><nlm:aff id="aff0">University of Florida, College of Veterinary Medicine, Department of Infectious Disease and Pathology, P.O. Box 110880, Gainesville, Florida 32610-0880</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>University of Florida, College of Veterinary Medicine, Department of Infectious Disease and Pathology, P.O. Box 110880, Gainesville</wicri:cityArea></affiliation></author></analytic><series><title level="j">Infection and Immunity</title><idno type="ISSN">0019-9567</idno><idno type="eISSN">1098-5522</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Individuals with struvite uroliths are susceptible to recurrent urinary tract infections (UTI), sepsis, and renal disease. Unfortunately, little is known about the host-specific factors that predispose to this disease. In order to develop a rodent model that can address this problem, we inoculated female Fischer 344 (F344), Lewis (LEW), Sprague-Dawley (SD), and Wistar (WIS) rats with a host-adapted strain of <italic>Ureaplasma parvum</italic>. Animals were necropsied at 2 weeks postinoculation; 100% of F344, 42% of SD, 10% of LEW, and 10% of WIS rats remained infected. Severe bladder lesions and struvite calculi were seen in 64% of F344 rats; in other rat strains, bladder lesions were mild or absent. F344 rats with struvite uroliths had the highest urinary levels of proinflammatory cytokines, such as GRO/KC, interleukin-1α (IL-1α), and IL-1β. F344 rats without struvite stones at necropsy had milder bladder lesions and significantly lower urinary levels of proinflammatory cytokines but a more prominent inflammatory response than did other rat strains. Based on our results, struvite stone formation is linked to a robust inflammatory response that does not resolve UTI but instead promotes damage to surrounding tissues.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Floride</li></region></list><tree><country name="États-Unis"><region name="Floride"><name sortKey="Reyes, Leticia" sort="Reyes, Leticia" uniqKey="Reyes L" first="Leticia" last="Reyes">Leticia Reyes</name></region><name sortKey="Brown, Mary B" sort="Brown, Mary B" uniqKey="Brown M" first="Mary B." last="Brown">Mary B. Brown</name><name sortKey="O Donell, L J" sort="O Donell, L J" uniqKey="O Donell L" first="L. J." last="O'Donell">L. J. O'Donell</name><name sortKey="Reinhard, Mary" sort="Reinhard, Mary" uniqKey="Reinhard M" first="Mary" last="Reinhard">Mary Reinhard</name><name sortKey="Stevens, Janet" sort="Stevens, Janet" uniqKey="Stevens J" first="Janet" last="Stevens">Janet Stevens</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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