Eating the enemy within: autophagy in infectious diseases
Identifieur interne : 000E40 ( Main/Exploration ); précédent : 000E39; suivant : 000E41Eating the enemy within: autophagy in infectious diseases
Auteurs : A. Orvedahl [États-Unis] ; B. Levine [États-Unis]Source :
- Cell death and differentiation [ 1350-9047 ] ; 2008.
Abstract
Autophagy is emerging as a central component of antimicrobial host defense against diverse viral, bacterial, and parasitic infections. In addition to pathogen degradation, autophagy has other functions during infection such as innate and adaptive immune activation. As an important host defense pathway, microbes have also evolved mechanisms to evade, subvert, or exploit autophagy. Additionally, some fungal pathogens harness autophagy within their own cells to promote pathogenesis. This review will highlight our current understanding of autophagy in infection, focusing on the most recent advances in the field, and will discuss the potential implications of these studies in the design of anti-infective therapeutics.
Url:
DOI: 10.1038/cdd.2008.130
PubMed: 18772897
PubMed Central: 2736877
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="P1">Autophagy is emerging as a central component of antimicrobial host defense against diverse viral, bacterial, and parasitic infections. In addition to pathogen degradation, autophagy has other functions during infection such as innate and adaptive immune activation. As an important host defense pathway, microbes have also evolved mechanisms to evade, subvert, or exploit autophagy. Additionally, some fungal pathogens harness autophagy within their own cells to promote pathogenesis. This review will highlight our current understanding of autophagy in infection, focusing on the most recent advances in the field, and will discuss the potential implications of these studies in the design of anti-infective therapeutics.</p>
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