Autoimmune disease triggered by infection with alphaproteobacteria
Identifieur interne : 000D82 ( Main/Exploration ); précédent : 000D81; suivant : 000D83Autoimmune disease triggered by infection with alphaproteobacteria
Auteurs : Javid P. Mohammed ; Jochen MattnerSource :
- Expert review of clinical immunology [ 1744-666X ] ; 2009.
Abstract
Despite having long been postulated, compelling evidence for the theory that microbial triggers drive autoimmunity has only recently been reported. A specific association between
Url:
DOI: 10.1586/ECI.09.23
PubMed: 20161124
PubMed Central: 2742979
Affiliations:
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Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Autoimmune disease triggered by infection with alphaproteobacteria</title><author><name sortKey="Mohammed, Javid P" sort="Mohammed, Javid P" uniqKey="Mohammed J" first="Javid P" last="Mohammed">Javid P. Mohammed</name></author><author><name sortKey="Mattner, Jochen" sort="Mattner, Jochen" uniqKey="Mattner J" first="Jochen" last="Mattner">Jochen Mattner</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20161124</idno><idno type="pmc">2742979</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742979</idno><idno type="RBID">PMC:2742979</idno><idno type="doi">10.1586/ECI.09.23</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000371</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000371</idno><idno type="wicri:Area/Pmc/Curation">000371</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000371</idno><idno type="wicri:Area/Pmc/Checkpoint">000633</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000633</idno><idno type="wicri:Area/Ncbi/Merge">000162</idno><idno type="wicri:Area/Ncbi/Curation">000162</idno><idno type="wicri:Area/Ncbi/Checkpoint">000162</idno><idno type="wicri:doubleKey">1744-666X:2009:Mohammed J:autoimmune:disease:triggered</idno><idno type="wicri:Area/Main/Merge">000D84</idno><idno type="wicri:Area/Main/Curation">000D82</idno><idno type="wicri:Area/Main/Exploration">000D82</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Autoimmune disease triggered by infection with alphaproteobacteria</title><author><name sortKey="Mohammed, Javid P" sort="Mohammed, Javid P" uniqKey="Mohammed J" first="Javid P" last="Mohammed">Javid P. Mohammed</name></author><author><name sortKey="Mattner, Jochen" sort="Mattner, Jochen" uniqKey="Mattner J" first="Jochen" last="Mattner">Jochen Mattner</name></author></analytic><series><title level="j">Expert review of clinical immunology</title><idno type="ISSN">1744-666X</idno><idno type="eISSN">1744-8409</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Despite having long been postulated, compelling evidence for the theory that microbial triggers drive autoimmunity has only recently been reported. A specific association between <italic>Novosphingobium aromaticivorans</italic>, an ubiquitous alphaproteobacterium, and primary biliary cirrhosis (PBC) has been uncovered in patients with PBC. Notably, the association between <italic>Novosphingobium</italic> infection and PBC has been confirmed in a mouse model in which infection leads to the development of liver lesions resembling PBC concomitant with the production of anti-PDC-E2 antibodies that cross-react with conserved PDC-E2 epitopes shared by <italic>Novosphingobium</italic>. The discovery of infectious triggers of autoimmunity is likely to change our current concepts about the etiology of various autoimmune syndromes and may suggest new and simpler ways to diagnose and treat these debilitating diseases.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Mattner, Jochen" sort="Mattner, Jochen" uniqKey="Mattner J" first="Jochen" last="Mattner">Jochen Mattner</name><name sortKey="Mohammed, Javid P" sort="Mohammed, Javid P" uniqKey="Mohammed J" first="Javid P" last="Mohammed">Javid P. Mohammed</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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