Epimedium koreanum Nakai Water Extract Exhibits Antiviral Activity against Porcine Epidermic Diarrhea Virus In Vitro and In Vivo
Identifieur interne : 000B95 ( Main/Exploration ); précédent : 000B94; suivant : 000B96Epimedium koreanum Nakai Water Extract Exhibits Antiviral Activity against Porcine Epidermic Diarrhea Virus In Vitro and In Vivo
Auteurs : Won-Kyung Cho [Corée du Sud] ; Hyunil Kim [Corée du Sud] ; Yu Jeong Choi [Corée du Sud] ; Nam-Hui Yim [Corée du Sud] ; Hye Jin Yang [Corée du Sud] ; Jin Yeul Ma [Corée du Sud]Source :
- Evidence-based Complementary and Alternative Medicine : eCAM [ 1741-427X ] ; 2012.
Abstract
Porcine epidemic diarrhea virus (PEDV) causes diarrhea of pigs age-independently and death of young piglets, resulting in economic loss of porcine industry. We have screened 333 natural oriental herbal medicines to search for new antiviral candidates against PEDV. We found that two herbal extracts, KIOM 198 and KIOM 124, contain significant anti-PED viral effect. KIOM 198 and KIOM 124 were identified as
Url:
DOI: 10.1155/2012/985151
PubMed: 23259003
PubMed Central: 3521454
Affiliations:
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Medicine, Yuseong-gu, Daejeon 305-811</wicri:regionArea><wicri:noRegion>Daejeon 305-811</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Hyunil" sort="Kim, Hyunil" uniqKey="Kim H" first="Hyunil" last="Kim">Hyunil Kim</name><affiliation wicri:level="1"><nlm:aff id="I2">Optifarm Solution, 48 Songnam-ri, Seonggeo-eup, Seobuk-gu, Cheonan-si 331-834, Chungcheongnam-do, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Optifarm Solution, 48 Songnam-ri, Seonggeo-eup, Seobuk-gu, Cheonan-si 331-834, Chungcheongnam-do</wicri:regionArea><wicri:noRegion>Chungcheongnam-do</wicri:noRegion></affiliation></author><author><name sortKey="Choi, Yu Jeong" sort="Choi, Yu Jeong" uniqKey="Choi Y" first="Yu Jeong" last="Choi">Yu Jeong Choi</name><affiliation wicri:level="1"><nlm:aff id="I2">Optifarm Solution, 48 Songnam-ri, Seonggeo-eup, Seobuk-gu, Cheonan-si 331-834, Chungcheongnam-do, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Optifarm Solution, 48 Songnam-ri, Seonggeo-eup, Seobuk-gu, Cheonan-si 331-834, Chungcheongnam-do</wicri:regionArea><wicri:noRegion>Chungcheongnam-do</wicri:noRegion></affiliation></author><author><name sortKey="Yim, Nam Hui" sort="Yim, Nam Hui" uniqKey="Yim N" first="Nam-Hui" last="Yim">Nam-Hui Yim</name><affiliation wicri:level="1"><nlm:aff id="I1">Korean Medicine (KM)-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine, Yuseong-gu, Daejeon 305-811, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Korean Medicine (KM)-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine, Yuseong-gu, Daejeon 305-811</wicri:regionArea><wicri:noRegion>Daejeon 305-811</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Hye Jin" sort="Yang, Hye Jin" uniqKey="Yang H" first="Hye Jin" last="Yang">Hye Jin Yang</name><affiliation wicri:level="1"><nlm:aff id="I1">Korean Medicine (KM)-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine, Yuseong-gu, Daejeon 305-811, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Korean Medicine (KM)-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine, Yuseong-gu, Daejeon 305-811</wicri:regionArea><wicri:noRegion>Daejeon 305-811</wicri:noRegion></affiliation></author><author><name sortKey="Ma, Jin Yeul" sort="Ma, Jin Yeul" uniqKey="Ma J" first="Jin Yeul" last="Ma">Jin Yeul Ma</name><affiliation wicri:level="1"><nlm:aff id="I1">Korean Medicine (KM)-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine, Yuseong-gu, Daejeon 305-811, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Korean Medicine (KM)-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine, Yuseong-gu, Daejeon 305-811</wicri:regionArea><wicri:noRegion>Daejeon 305-811</wicri:noRegion></affiliation></author></analytic><series><title level="j">Evidence-based Complementary and Alternative Medicine : eCAM</title><idno type="ISSN">1741-427X</idno><idno type="eISSN">1741-4288</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Porcine epidemic diarrhea virus (PEDV) causes diarrhea of pigs age-independently and death of young piglets, resulting in economic loss of porcine industry. We have screened 333 natural oriental herbal medicines to search for new antiviral candidates against PEDV. We found that two herbal extracts, KIOM 198 and KIOM 124, contain significant anti-PED viral effect. KIOM 198 and KIOM 124 were identified as <italic>Epimedium koreanum</italic> Nakai and <italic>Lonicera japonica</italic> Thunberg, respectively. The further plaque and CPE inhibition assay <italic>in vitro</italic> showed that KIOM 198 has much stronger antiviral activity than KIOM 124. Additionally, KIOM 198 exhibited a similar extent of antiviral effect against other subtypes of Corona virus such as sm98 and TGE viruses. Cytotoxicity results showed that KIOM 198 is nontoxic on the cells and suggest that it can be delivered safely for therapy. Furthermore, when we orally administered KIOM 198 to piglets and then infected them with PEDV, the piglets did not show any disease symptoms like diarrhea and biopsy results showed clean intestine, whereas control pigs without KIOM 198 treatment exhibited PED-related severe symptoms. These results imply that KIOM 198 contains strong antiviral activity and has a potential to be developed as an antiviral phytomedicine to treat PEDV-related diseases in pigs.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Debouck, P" uniqKey="Debouck P">P Debouck</name></author><author><name sortKey="Pensaert, M" uniqKey="Pensaert M">M Pensaert</name></author><author><name sortKey="Coussement, W" uniqKey="Coussement W">W Coussement</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pensaert, Mb" uniqKey="Pensaert M">MB Pensaert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Debouck, P" uniqKey="Debouck P">P Debouck</name></author><author><name sortKey="Pensaert, M" uniqKey="Pensaert M">M Pensaert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ducatelle, R" uniqKey="Ducatelle R">R Ducatelle</name></author><author><name 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sortKey="Kim, Ij" uniqKey="Kim I">IJ Kim</name></author><author><name sortKey="Pyo, Hm" uniqKey="Pyo H">HM Pyo</name></author><author><name sortKey="Tark, Ds" uniqKey="Tark D">DS Tark</name></author><author><name sortKey="Song, Jy" uniqKey="Song J">JY Song</name></author><author><name sortKey="Hyun, Bh" uniqKey="Hyun B">BH Hyun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, Hj" uniqKey="Choi H">HJ Choi</name></author><author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name></author><author><name sortKey="Lee, Ch" uniqKey="Lee C">CH Lee</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li></country></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Cho, Won Kyung" sort="Cho, Won Kyung" uniqKey="Cho W" first="Won-Kyung" last="Cho">Won-Kyung Cho</name></noRegion><name sortKey="Choi, Yu Jeong" sort="Choi, Yu Jeong" uniqKey="Choi Y" first="Yu Jeong" last="Choi">Yu Jeong Choi</name><name sortKey="Kim, Hyunil" sort="Kim, Hyunil" uniqKey="Kim H" first="Hyunil" last="Kim">Hyunil Kim</name><name sortKey="Ma, Jin Yeul" sort="Ma, Jin Yeul" uniqKey="Ma J" first="Jin Yeul" last="Ma">Jin Yeul Ma</name><name sortKey="Yang, Hye Jin" sort="Yang, Hye Jin" uniqKey="Yang H" first="Hye Jin" last="Yang">Hye Jin Yang</name><name sortKey="Yim, Nam Hui" sort="Yim, Nam Hui" uniqKey="Yim N" first="Nam-Hui" last="Yim">Nam-Hui Yim</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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