Adaptive immune response to viral infections in the central nervous system
Identifieur interne : 000A50 ( Main/Exploration ); précédent : 000A49; suivant : 000A51Adaptive immune response to viral infections in the central nervous system
Auteurs : Jane E. Libbey ; Robert S. FujinamiSource :
- Handbook of clinical neurology [ 0072-9752 ] ; 2014.
Abstract
Historically, the central nervous system (CNS) has been considered to be an immunologically privileged site within the body (
Url:
DOI: 10.1016/B978-0-444-53488-0.00010-9
PubMed: 25015488
PubMed Central: 4370180
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000485
- to stream Pmc, to step Curation: 000485
- to stream Pmc, to step Checkpoint: 000428
- to stream Ncbi, to step Merge: 000399
- to stream Ncbi, to step Curation: 000399
- to stream Ncbi, to step Checkpoint: 000399
- to stream Main, to step Merge: 000A52
- to stream Main, to step Curation: 000A50
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Adaptive immune response to viral infections in the central nervous system</title>
<author><name sortKey="Libbey, Jane E" sort="Libbey, Jane E" uniqKey="Libbey J" first="Jane E." last="Libbey">Jane E. Libbey</name>
</author>
<author><name sortKey="Fujinami, Robert S" sort="Fujinami, Robert S" uniqKey="Fujinami R" first="Robert S." last="Fujinami">Robert S. Fujinami</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25015488</idno>
<idno type="pmc">4370180</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370180</idno>
<idno type="RBID">PMC:4370180</idno>
<idno type="doi">10.1016/B978-0-444-53488-0.00010-9</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">000485</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000485</idno>
<idno type="wicri:Area/Pmc/Curation">000485</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000485</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000428</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000428</idno>
<idno type="wicri:Area/Ncbi/Merge">000399</idno>
<idno type="wicri:Area/Ncbi/Curation">000399</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000399</idno>
<idno type="wicri:doubleKey">0072-9752:2014:Libbey J:adaptive:immune:response</idno>
<idno type="wicri:Area/Main/Merge">000A52</idno>
<idno type="wicri:Area/Main/Curation">000A50</idno>
<idno type="wicri:Area/Main/Exploration">000A50</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Adaptive immune response to viral infections in the central nervous system</title>
<author><name sortKey="Libbey, Jane E" sort="Libbey, Jane E" uniqKey="Libbey J" first="Jane E." last="Libbey">Jane E. Libbey</name>
</author>
<author><name sortKey="Fujinami, Robert S" sort="Fujinami, Robert S" uniqKey="Fujinami R" first="Robert S." last="Fujinami">Robert S. Fujinami</name>
</author>
</analytic>
<series><title level="j">Handbook of clinical neurology</title>
<idno type="ISSN">0072-9752</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Historically, the central nervous system (CNS) has been considered to be an immunologically privileged site within the body (<xref rid="R7" ref-type="bibr">Bailey et al., 2006</xref>
; <xref rid="R47" ref-type="bibr">Galea et al. 2007</xref>
; <xref rid="R40" ref-type="bibr">Engelhardt, 2008</xref>
; <xref rid="R152" ref-type="bibr">Prendergast and Anderton, 2009</xref>
). By definition, immunologically privileged sites, to include the brain, cornea, testis, and pregnant uterus, have a reduced/delayed ability to reject foreign tissue grafts compared to conventional sites within the body, such as skin (<xref rid="R178" ref-type="bibr">Streilein, 2003</xref>
; <xref rid="R7" ref-type="bibr">Bailey et al., 2006</xref>
; <xref rid="R24" ref-type="bibr">Carson et al., 2006</xref>
; <xref rid="R127" ref-type="bibr">Mrass and Weninger, 2006</xref>
; <xref rid="R85" ref-type="bibr">Kaplan and Niederkorn, 2007</xref>
). In addition and conversely, tissue grafts prepared from immunologically privileged sites have increased survival, compared to tissue grafts prepared from conventional sites, when implanted at conventional sites (<xref rid="R178" ref-type="bibr">Streilein, 2003</xref>
). The imune privilege of the CNS has been shown to be confined to the parenchyma, whereas the immune reactivity of the meninges and the ventricles, containing the choroid plexus, cerebrospinal fluid (CSF), and the circumventricular organs, is similar to conventionalsites (<xref rid="R24" ref-type="bibr">Carson et al., 2006</xref>
; <xref rid="R39" ref-type="bibr">Engelhardt, 2006</xref>
; <xref rid="R47" ref-type="bibr">Galea et al., 2007</xref>
). This confinement of the imm une privilege to the parenchyma has also been demonstrated for experimental influenza virus infection in which confinement of the infection to the brain parenchyma did not result in efficient immune system priming whereas infection of the CSF elicited a virus-specific immune response comparable to that of intranasal infection (<xref rid="R177" ref-type="bibr">Stevenson et al. 1997</xref>
). An important functional aspect of immune privilege is that damage due to the immune response and inflammation is limited within sensitive organs containing cell types that regenerate poorly, such as neurons within the brain (<xref rid="R127" ref-type="bibr">Mrass and Weninger, 2006</xref>
; <xref rid="R47" ref-type="bibr">Galea et al.. 2007</xref>
; <xref rid="R85" ref-type="bibr">Kaplan and Niederkorn, 2007</xref>
).</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Fujinami, Robert S" sort="Fujinami, Robert S" uniqKey="Fujinami R" first="Robert S." last="Fujinami">Robert S. Fujinami</name>
<name sortKey="Libbey, Jane E" sort="Libbey, Jane E" uniqKey="Libbey J" first="Jane E." last="Libbey">Jane E. Libbey</name>
</noCountry>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A50 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A50 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= CovidV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:4370180 |texte= Adaptive immune response to viral infections in the central nervous system }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25015488" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a CovidV1
This area was generated with Dilib version V0.6.33. |