The early immune response to infection of chickens with Infectious Bronchitis Virus (IBV) in susceptible and resistant birds
Identifieur interne : 000913 ( Main/Exploration ); précédent : 000912; suivant : 000914The early immune response to infection of chickens with Infectious Bronchitis Virus (IBV) in susceptible and resistant birds
Auteurs : Jacqueline Smith [Royaume-Uni] ; Jean-Remy Sadeyen ; David Cavanagh ; Pete Kaiser [Royaume-Uni] ; David W. Burt [Royaume-Uni]Source :
- BMC Veterinary Research [ 1746-6148 ] ; 2015.
Abstract
Infectious Bronchitis is a highly contagious respiratory disease which causes tracheal lesions and also affects the reproductive tract and is responsible for large economic losses to the poultry industry every year. This is due to both mortality (either directly provoked by IBV itself or due to subsequent bacterial infection) and lost egg production. The virus is difficult to control by vaccination, so new methods to curb the impact of the disease need to be sought. Here, we seek to identify genes conferring resistance to this coronavirus, which could help in selective breeding programs to rear chickens which do not succumb to the effects of this disease.
Whole genome gene expression microarrays were used to analyse the gene expression differences, which occur upon infection of birds with Infectious Bronchitis Virus (IBV). Tracheal tissue was examined from control and infected birds at 2, 3 and 4 days post-infection in birds known to be either susceptible or resistant to the virus. The host innate immune response was evaluated over these 3 days and differences between the susceptible and resistant lines examined.
Genes and biological pathways involved in the early host response to IBV infection were determined andgene expression differences between susceptible and resistant birds were identified. Potential candidate genes for resistance to IBV are highlighted.
The early host response to IBV is analysed and potential candidate genes for disease resistance are identified. These putative resistance genes can be used as targets for future genetic and functional studies to prove a causative link with resistance to IBV.
The online version of this article (doi:10.1186/s12917-015-0575-6) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s12917-015-0575-6
PubMed: 26452558
PubMed Central: 4600211
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Infectious Bronchitis is a highly contagious respiratory disease which causes tracheal lesions and also affects the reproductive tract and is responsible for large economic losses to the poultry industry every year. This is due to both mortality (either directly provoked by IBV itself or due to subsequent bacterial infection) and lost egg production. The virus is difficult to control by vaccination, so new methods to curb the impact of the disease need to be sought. Here, we seek to identify genes conferring resistance to this coronavirus, which could help in selective breeding programs to rear chickens which do not succumb to the effects of this disease.</p>
</sec>
<sec><title>Methods</title>
<p>Whole genome gene expression microarrays were used to analyse the gene expression differences, which occur upon infection of birds with Infectious Bronchitis Virus (IBV). Tracheal tissue was examined from control and infected birds at 2, 3 and 4 days post-infection in birds known to be either susceptible or resistant to the virus. The host innate immune response was evaluated over these 3 days and differences between the susceptible and resistant lines examined.</p>
</sec>
<sec><title>Results</title>
<p>Genes and biological pathways involved in the early host response to IBV infection were determined andgene expression differences between susceptible and resistant birds were identified. Potential candidate genes for resistance to IBV are highlighted.</p>
</sec>
<sec><title>Conclusions</title>
<p>The early host response to IBV is analysed and potential candidate genes for disease resistance are identified. These putative resistance genes can be used as targets for future genetic and functional studies to prove a causative link with resistance to IBV.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/s12917-015-0575-6) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Schalk, Af" uniqKey="Schalk A">AF Schalk</name>
</author>
<author><name sortKey="Hawn, Mc" uniqKey="Hawn M">MC Hawn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beach, Jr" uniqKey="Beach J">JR Beach</name>
</author>
<author><name sortKey="Schalm, Ow" uniqKey="Schalm O">OW Schalm</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beaudette, Fr" uniqKey="Beaudette F">FR Beaudette</name>
</author>
<author><name sortKey="Hudson, Cb" uniqKey="Hudson C">CB Hudson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cavanagh, D" uniqKey="Cavanagh D">D Cavanagh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L Enjuanes</name>
</author>
<author><name sortKey="Sola, I" uniqKey="Sola I">I Sola</name>
</author>
<author><name sortKey="Zu Iga, S" uniqKey="Zu Iga S">S Zúñiga</name>
</author>
<author><name sortKey="Almazan, F" uniqKey="Almazan F">F Almazán</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Casais, R" uniqKey="Casais R">R Casais</name>
</author>
<author><name sortKey="Dove, B" uniqKey="Dove B">B Dove</name>
</author>
<author><name sortKey="Cavanagh, D" uniqKey="Cavanagh D">D Cavanagh</name>
</author>
<author><name sortKey="Britton, P" uniqKey="Britton P">P Britton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Asif, M" uniqKey="Asif M">M Asif</name>
</author>
<author><name sortKey="Lowenthal, Jw" uniqKey="Lowenthal J">JW Lowenthal</name>
</author>
<author><name sortKey="Ford, Me" uniqKey="Ford M">ME Ford</name>
</author>
<author><name sortKey="Schat, Ka" uniqKey="Schat K">KA Schat</name>
</author>
<author><name sortKey="Kimpton, Wg" uniqKey="Kimpton W">WG Kimpton</name>
</author>
<author><name sortKey="Bean, Ag" uniqKey="Bean A">AG Bean</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jackwood, Mw" uniqKey="Jackwood M">MW Jackwood</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meulemans, G" uniqKey="Meulemans G">G Meulemans</name>
</author>
<author><name sortKey="Van Den Berg, Tp" uniqKey="Van Den Berg T">TP Van den Berg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ariaans, Mp" uniqKey="Ariaans M">MP Ariaans</name>
</author>
<author><name sortKey="Matthijs, Mg" uniqKey="Matthijs M">MG Matthijs</name>
</author>
<author><name sortKey="Van Haarlem, D" uniqKey="Van Haarlem D">D van Haarlem</name>
</author>
<author><name sortKey="Van De Haar, P" uniqKey="Van De Haar P">P van de Haar</name>
</author>
<author><name sortKey="Van Eck, Jh" uniqKey="Van Eck J">JH van Eck</name>
</author>
<author><name sortKey="Hensen, Ej" uniqKey="Hensen E">EJ Hensen</name>
</author>
<author><name sortKey="Vervelde, L" uniqKey="Vervelde L">L Vervelde</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matthijs, Mg" uniqKey="Matthijs M">MG Matthijs</name>
</author>
<author><name sortKey="Van Eck, Jh" uniqKey="Van Eck J">JH van Eck</name>
</author>
<author><name sortKey="Landman, Wj" uniqKey="Landman W">WJ Landman</name>
</author>
<author><name sortKey="Stegeman, Ja" uniqKey="Stegeman J">JA Stegeman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jackwood, Mw" uniqKey="Jackwood M">MW Jackwood</name>
</author>
<author><name sortKey="De Wit, S" uniqKey="De Wit S">S de Wit</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Worthington, Kj" uniqKey="Worthington K">KJ Worthington</name>
</author>
<author><name sortKey="Currie, Rjw" uniqKey="Currie R">RJW Currie</name>
</author>
<author><name sortKey="Jones, Rc" uniqKey="Jones R">RC Jones</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ignjatovic, J" uniqKey="Ignjatovic J">J Ignjatovic</name>
</author>
<author><name sortKey="Gould, G" uniqKey="Gould G">G Gould</name>
</author>
<author><name sortKey="Sapats, S" uniqKey="Sapats S">S Sapats</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mase, M" uniqKey="Mase M">M Mase</name>
</author>
<author><name sortKey="Kawanishi, N" uniqKey="Kawanishi N">N Kawanishi</name>
</author>
<author><name sortKey="Ootani, Y" uniqKey="Ootani Y">Y Ootani</name>
</author>
<author><name sortKey="Murayama, K" uniqKey="Murayama K">K Murayama</name>
</author>
<author><name sortKey="Karino, A" uniqKey="Karino A">A Karino</name>
</author>
<author><name sortKey="Inoue, T" uniqKey="Inoue T">T Inoue</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Banat, Gr" uniqKey="Banat G">GR Banat</name>
</author>
<author><name sortKey="Tkalcic, S" uniqKey="Tkalcic S">S Tkalcic</name>
</author>
<author><name sortKey="Dzielawa, Ja" uniqKey="Dzielawa J">JA Dzielawa</name>
</author>
<author><name sortKey="Jackwood, Mw" uniqKey="Jackwood M">MW Jackwood</name>
</author>
<author><name sortKey="Saggese, Md" uniqKey="Saggese M">MD Saggese</name>
</author>
<author><name sortKey="Yates, L" uniqKey="Yates L">L Yates</name>
</author>
<author><name sortKey="Kopulos, R" uniqKey="Kopulos R">R Kopulos</name>
</author>
<author><name sortKey="Briles, We" uniqKey="Briles W">WE Briles</name>
</author>
<author><name sortKey="Collisson, Ew" uniqKey="Collisson E">EW Collisson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dar, A" uniqKey="Dar A">A Dar</name>
</author>
<author><name sortKey="Munir, S" uniqKey="Munir S">S Munir</name>
</author>
<author><name sortKey="Vishwanathan, S" uniqKey="Vishwanathan S">S Vishwanathan</name>
</author>
<author><name sortKey="Manuja, A" uniqKey="Manuja A">A Manuja</name>
</author>
<author><name sortKey="Griebel, P" uniqKey="Griebel P">P Griebel</name>
</author>
<author><name sortKey="Tikoo, S" uniqKey="Tikoo S">S Tikoo</name>
</author>
<author><name sortKey="Townsend, H" uniqKey="Townsend H">H Townsend</name>
</author>
<author><name sortKey="Potter, A" uniqKey="Potter A">A Potter</name>
</author>
<author><name sortKey="Kapur, V" uniqKey="Kapur V">V Kapur</name>
</author>
<author><name sortKey="Babiuk, La" uniqKey="Babiuk L">LA Babiuk</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
<author><name sortKey="Rosa, Ajm" uniqKey="Rosa A">AJM Rosa</name>
</author>
<author><name sortKey="Oliverira, Hn" uniqKey="Oliverira H">HN Oliverira</name>
</author>
<author><name sortKey="Rosa, Gjm" uniqKey="Rosa G">GJM Rosa</name>
</author>
<author><name sortKey="Guo, X" uniqKey="Guo X">X Guo</name>
</author>
<author><name sortKey="Travnicek, M" uniqKey="Travnicek M">M Travnicek</name>
</author>
<author><name sortKey="Girshick, T" uniqKey="Girshick T">T Girshick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name>
</author>
<author><name sortKey="Gunther, S" uniqKey="Gunther S">S Günther</name>
</author>
<author><name sortKey="Preiser, W" uniqKey="Preiser W">W Preiser</name>
</author>
<author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S van der Werf</name>
</author>
<author><name sortKey="Brodt, Hr" uniqKey="Brodt H">HR Brodt</name>
</author>
<author><name sortKey="Becker, S" uniqKey="Becker S">S Becker</name>
</author>
<author><name sortKey="Rabenau, H" uniqKey="Rabenau H">H Rabenau</name>
</author>
<author><name sortKey="Panning, M" uniqKey="Panning M">M Panning</name>
</author>
<author><name sortKey="Kolesnikova, L" uniqKey="Kolesnikova L">L Kolesnikova</name>
</author>
<author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name>
</author>
<author><name sortKey="Berger, A" uniqKey="Berger A">A Berger</name>
</author>
<author><name sortKey="Burguiere, Am" uniqKey="Burguiere A">AM Burguière</name>
</author>
<author><name sortKey="Cinatl, J" uniqKey="Cinatl J">J Cinatl</name>
</author>
<author><name sortKey="Eickmann, M" uniqKey="Eickmann M">M Eickmann</name>
</author>
<author><name sortKey="Escriou, N" uniqKey="Escriou N">N Escriou</name>
</author>
<author><name sortKey="Grywna, K" uniqKey="Grywna K">K Grywna</name>
</author>
<author><name sortKey="Kramme, S" uniqKey="Kramme S">S Kramme</name>
</author>
<author><name sortKey="Manuguerra, Jc" uniqKey="Manuguerra J">JC Manuguerra</name>
</author>
<author><name sortKey="Muller, S" uniqKey="Muller S">S Müller</name>
</author>
<author><name sortKey="Rickerts, V" uniqKey="Rickerts V">V Rickerts</name>
</author>
<author><name sortKey="Sturmer, M" uniqKey="Sturmer M">M Stürmer</name>
</author>
<author><name sortKey="Vieth, S" uniqKey="Vieth S">S Vieth</name>
</author>
<author><name sortKey="Klenk, Hd" uniqKey="Klenk H">HD Klenk</name>
</author>
<author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name>
</author>
<author><name sortKey="Schmitz, H" uniqKey="Schmitz H">H Schmitz</name>
</author>
<author><name sortKey="Doerr, Hw" uniqKey="Doerr H">HW Doerr</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ksiazek, Tg" uniqKey="Ksiazek T">TG Ksiazek</name>
</author>
<author><name sortKey="Erdman, D" uniqKey="Erdman D">D Erdman</name>
</author>
<author><name sortKey="Goldsmith, Cs" uniqKey="Goldsmith C">CS Goldsmith</name>
</author>
<author><name sortKey="Zaki, Sr" uniqKey="Zaki S">SR Zaki</name>
</author>
<author><name sortKey="Peret, T" uniqKey="Peret T">T Peret</name>
</author>
<author><name sortKey="Emery, S" uniqKey="Emery S">S Emery</name>
</author>
<author><name sortKey="Tong, S" uniqKey="Tong S">S Tong</name>
</author>
<author><name sortKey="Urbani, C" uniqKey="Urbani C">C Urbani</name>
</author>
<author><name sortKey="Comer, Ja" uniqKey="Comer J">JA Comer</name>
</author>
<author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name>
</author>
<author><name sortKey="Rollin, Pe" uniqKey="Rollin P">PE Rollin</name>
</author>
<author><name sortKey="Dowell, Sf" uniqKey="Dowell S">SF Dowell</name>
</author>
<author><name sortKey="Ling, Ae" uniqKey="Ling A">AE Ling</name>
</author>
<author><name sortKey="Humphrey, Cd" uniqKey="Humphrey C">CD Humphrey</name>
</author>
<author><name sortKey="Shieh, Wj" uniqKey="Shieh W">WJ Shieh</name>
</author>
<author><name sortKey="Guarner, J" uniqKey="Guarner J">J Guarner</name>
</author>
<author><name sortKey="Paddock, Cd" uniqKey="Paddock C">CD Paddock</name>
</author>
<author><name sortKey="Rota, P" uniqKey="Rota P">P Rota</name>
</author>
<author><name sortKey="Fields, B" uniqKey="Fields B">B Fields</name>
</author>
<author><name sortKey="Derisi, J" uniqKey="Derisi J">J DeRisi</name>
</author>
<author><name sortKey="Yang, Jy" uniqKey="Yang J">JY Yang</name>
</author>
<author><name sortKey="Cox, N" uniqKey="Cox N">N Cox</name>
</author>
<author><name sortKey="Hughes, Jm" uniqKey="Hughes J">JM Hughes</name>
</author>
<author><name sortKey="Leduc, Jw" uniqKey="Leduc J">JW LeDuc</name>
</author>
<author><name sortKey="Bellini, Wj" uniqKey="Bellini W">WJ Bellini</name>
</author>
<author><name sortKey="Anderson, Lj" uniqKey="Anderson L">LJ Anderson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cook, J" uniqKey="Cook J">J Cook</name>
</author>
<author><name sortKey="Otsuki, K" uniqKey="Otsuki K">K Otsuki</name>
</author>
<author><name sortKey="Huggins, M" uniqKey="Huggins M">M Huggins</name>
</author>
<author><name sortKey="Bumstead, N" uniqKey="Bumstead N">N Bumstead</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Cole, Rk" uniqKey="Cole R">RK Cole</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Talloen, W" uniqKey="Talloen W">W Talloen</name>
</author>
<author><name sortKey="Clevert, Da" uniqKey="Clevert D">DA Clevert</name>
</author>
<author><name sortKey="Hochreiter, S" uniqKey="Hochreiter S">S Hochreiter</name>
</author>
<author><name sortKey="Amaratunga, D" uniqKey="Amaratunga D">D Amaratunga</name>
</author>
<author><name sortKey="Bijnens, L" uniqKey="Bijnens L">L Bijnens</name>
</author>
<author><name sortKey="Kass, S" uniqKey="Kass S">S Kass</name>
</author>
<author><name sortKey="Gohlmann, Hw" uniqKey="Gohlmann H">HW Göhlmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Khatri, P" uniqKey="Khatri P">P Khatri</name>
</author>
<author><name sortKey="Sellamuthu, S" uniqKey="Sellamuthu S">S Sellamuthu</name>
</author>
<author><name sortKey="Malhotra, P" uniqKey="Malhotra P">P Malhotra</name>
</author>
<author><name sortKey="Amin, K" uniqKey="Amin K">K Amin</name>
</author>
<author><name sortKey="Done, A" uniqKey="Done A">A Done</name>
</author>
<author><name sortKey="Draghici, S" uniqKey="Draghici S">S Draghici</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Kanehisa, M" uniqKey="Kanehisa M">M Kanehisa</name>
</author>
<author><name sortKey="Goto, S" uniqKey="Goto S">S Goto</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Eldaghayes, I" uniqKey="Eldaghayes I">I Eldaghayes</name>
</author>
<author><name sortKey="Rothwell, L" uniqKey="Rothwell L">L Rothwell</name>
</author>
<author><name sortKey="Williams, A" uniqKey="Williams A">A Williams</name>
</author>
<author><name sortKey="Withers, D" uniqKey="Withers D">D Withers</name>
</author>
<author><name sortKey="Balu, S" uniqKey="Balu S">S Balu</name>
</author>
<author><name sortKey="Davison, F" uniqKey="Davison F">F Davison</name>
</author>
<author><name sortKey="Kaiser, P" uniqKey="Kaiser P">P Kaiser</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Poh, Ty" uniqKey="Poh T">TY Poh</name>
</author>
<author><name sortKey="Pease, J" uniqKey="Pease J">J Pease</name>
</author>
<author><name sortKey="Young, Jr" uniqKey="Young J">JR Young</name>
</author>
<author><name sortKey="Bumstead, N" uniqKey="Bumstead N">N Bumstead</name>
</author>
<author><name sortKey="Kaiser, P" uniqKey="Kaiser P">P Kaiser</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rothwell, L" uniqKey="Rothwell L">L Rothwell</name>
</author>
<author><name sortKey="Hu, T" uniqKey="Hu T">T Hu</name>
</author>
<author><name sortKey="Wu, Z" uniqKey="Wu Z">Z Wu</name>
</author>
<author><name sortKey="Kaiser, P" uniqKey="Kaiser P">P Kaiser</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guo, X" uniqKey="Guo X">X Guo</name>
</author>
<author><name sortKey="Rosa, Ajm" uniqKey="Rosa A">AJM Rosa</name>
</author>
<author><name sortKey="Chen, D G" uniqKey="Chen D">D-G Chen</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Draghici, S" uniqKey="Draghici S">S Draghici</name>
</author>
<author><name sortKey="Khatri, P" uniqKey="Khatri P">P Khatri</name>
</author>
<author><name sortKey="Tarca, Al" uniqKey="Tarca A">AL Tarca</name>
</author>
<author><name sortKey="Amin, K" uniqKey="Amin K">K Amin</name>
</author>
<author><name sortKey="Done, A" uniqKey="Done A">A Done</name>
</author>
<author><name sortKey="Voichita, C" uniqKey="Voichita C">C Voichita</name>
</author>
<author><name sortKey="Georgescu, C" uniqKey="Georgescu C">C Georgescu</name>
</author>
<author><name sortKey="Romero, R" uniqKey="Romero R">R Romero</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kameka, Am" uniqKey="Kameka A">AM Kameka</name>
</author>
<author><name sortKey="Haddadi, S" uniqKey="Haddadi S">S Haddadi</name>
</author>
<author><name sortKey="Kim, Ds" uniqKey="Kim D">DS Kim</name>
</author>
<author><name sortKey="Cork, Sc" uniqKey="Cork S">SC Cork</name>
</author>
<author><name sortKey="Abdul Careem, Mf" uniqKey="Abdul Careem M">MF Abdul-Careem</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, N" uniqKey="Yang N">N Yang</name>
</author>
<author><name sortKey="Ma, P" uniqKey="Ma P">P Ma</name>
</author>
<author><name sortKey="Lang, J" uniqKey="Lang J">J Lang</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Deng, J" uniqKey="Deng J">J Deng</name>
</author>
<author><name sortKey="Ju, X" uniqKey="Ju X">X JU</name>
</author>
<author><name sortKey="Zhang, G" uniqKey="Zhang G">G Zhang</name>
</author>
<author><name sortKey="Jiang, C" uniqKey="Jiang C">C Jiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Favoreel, Hw" uniqKey="Favoreel H">HW Favoreel</name>
</author>
<author><name sortKey="Van De Walle, Gr" uniqKey="Van De Walle G">GR Van de Walle</name>
</author>
<author><name sortKey="Nauwynck, Hj" uniqKey="Nauwynck H">HJ Nauwynck</name>
</author>
<author><name sortKey="Pensaert, Mb" uniqKey="Pensaert M">MB Pensaert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ariaans, Mp" uniqKey="Ariaans M">MP Ariaans</name>
</author>
<author><name sortKey="Van De Haar, Pm" uniqKey="Van De Haar P">PM van de Haar</name>
</author>
<author><name sortKey="Hensen, Ej" uniqKey="Hensen E">EJ Hensen</name>
</author>
<author><name sortKey="Vervelde, L" uniqKey="Vervelde L">L Vervelde</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vervelde, L" uniqKey="Vervelde L">L Vervelde</name>
</author>
<author><name sortKey="Matthijs, Mg" uniqKey="Matthijs M">MG Matthijs</name>
</author>
<author><name sortKey="Van Haarlem, Da" uniqKey="Van Haarlem D">DA van Haarlem</name>
</author>
<author><name sortKey="De Wit, Jj" uniqKey="De Wit J">JJ de Wit</name>
</author>
<author><name sortKey="Jansen, Ca" uniqKey="Jansen C">CA Jansen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kint, J" uniqKey="Kint J">J Kint</name>
</author>
<author><name sortKey="Fernandez Gutierrez, M" uniqKey="Fernandez Gutierrez M">M Fernandez-Gutierrez</name>
</author>
<author><name sortKey="Maier, Hj" uniqKey="Maier H">HJ Maier</name>
</author>
<author><name sortKey="Britton, P" uniqKey="Britton P">P Britton</name>
</author>
<author><name sortKey="Langereis, Ma" uniqKey="Langereis M">MA Langereis</name>
</author>
<author><name sortKey="Koumans, J" uniqKey="Koumans J">J Koumans</name>
</author>
<author><name sortKey="Wiegertjes, Gf" uniqKey="Wiegertjes G">GF Wiegertjes</name>
</author>
<author><name sortKey="Forlenza, M" uniqKey="Forlenza M">M Forlenza</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sharan, R" uniqKey="Sharan R">R Sharan</name>
</author>
<author><name sortKey="Maron Katz, A" uniqKey="Maron Katz A">A Maron-Katz</name>
</author>
<author><name sortKey="Shamir, R" uniqKey="Shamir R">R Shamir</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Emmott, E" uniqKey="Emmott E">E Emmott</name>
</author>
<author><name sortKey="Munday, D" uniqKey="Munday D">D Munday</name>
</author>
<author><name sortKey="Bickerton, E" uniqKey="Bickerton E">E Bickerton</name>
</author>
<author><name sortKey="Britton, P" uniqKey="Britton P">P Britton</name>
</author>
<author><name sortKey="Rodgers, Ma" uniqKey="Rodgers M">MA Rodgers</name>
</author>
<author><name sortKey="Whitehouse, A" uniqKey="Whitehouse A">A Whitehouse</name>
</author>
<author><name sortKey="Zhou, Em" uniqKey="Zhou E">EM Zhou</name>
</author>
<author><name sortKey="Hiscox, Ja" uniqKey="Hiscox J">JA Hiscox</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Crinion, Ra" uniqKey="Crinion R">RA Crinion</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brionne, A" uniqKey="Brionne A">A Brionne</name>
</author>
<author><name sortKey="Nys, Y" uniqKey="Nys Y">Y Nys</name>
</author>
<author><name sortKey="Hennequet Antier, C" uniqKey="Hennequet Antier C">C Hennequet-Antier</name>
</author>
<author><name sortKey="Gautron, J" uniqKey="Gautron J">J Gautron</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cong, F" uniqKey="Cong F">F Cong</name>
</author>
<author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name>
</author>
<author><name sortKey="Han, Z" uniqKey="Han Z">Z Han</name>
</author>
<author><name sortKey="Shao, Y" uniqKey="Shao Y">Y Shao</name>
</author>
<author><name sortKey="Kong, X" uniqKey="Kong X">X Kong</name>
</author>
<author><name sortKey="Liu, S" uniqKey="Liu S">S Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, C" uniqKey="Liu C">C Liu</name>
</author>
<author><name sortKey="Xu, Hy" uniqKey="Xu H">HY Xu</name>
</author>
<author><name sortKey="Liu, Dx" uniqKey="Liu D">DX Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nii, T" uniqKey="Nii T">T Nii</name>
</author>
<author><name sortKey="Isobe, N" uniqKey="Isobe N">N Isobe</name>
</author>
<author><name sortKey="Yoshimura, Y" uniqKey="Yoshimura Y">Y Yoshimura</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Goodbourn, S" uniqKey="Goodbourn S">S Goodbourn</name>
</author>
<author><name sortKey="Didcock, L" uniqKey="Didcock L">L Didcock</name>
</author>
<author><name sortKey="Randall, Re" uniqKey="Randall R">RE Randall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Haller, O" uniqKey="Haller O">O Haller</name>
</author>
<author><name sortKey="Frese, M" uniqKey="Frese M">M Frese</name>
</author>
<author><name sortKey="Kochs, G" uniqKey="Kochs G">G Kochs</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Perreira, Jm" uniqKey="Perreira J">JM Perreira</name>
</author>
<author><name sortKey="Chin, Cr" uniqKey="Chin C">CR Chin</name>
</author>
<author><name sortKey="Feeley, Em" uniqKey="Feeley E">EM Feeley</name>
</author>
<author><name sortKey="Brass, Al" uniqKey="Brass A">AL Brass</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smith, J" uniqKey="Smith J">J Smith</name>
</author>
<author><name sortKey="Sadeyen, Jr" uniqKey="Sadeyen J">JR Sadeyen</name>
</author>
<author><name sortKey="Paton, Ir" uniqKey="Paton I">IR Paton</name>
</author>
<author><name sortKey="Hocking, Pm" uniqKey="Hocking P">PM Hocking</name>
</author>
<author><name sortKey="Salmon, N" uniqKey="Salmon N">N Salmon</name>
</author>
<author><name sortKey="Fife, M" uniqKey="Fife M">M Fife</name>
</author>
<author><name sortKey="Nair, V" uniqKey="Nair V">V Nair</name>
</author>
<author><name sortKey="Burt, Dw" uniqKey="Burt D">DW Burt</name>
</author>
<author><name sortKey="Kaiser, P" uniqKey="Kaiser P">P Kaiser</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
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</region>
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</settlement>
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</orgName>
</list>
<tree><noCountry><name sortKey="Cavanagh, David" sort="Cavanagh, David" uniqKey="Cavanagh D" first="David" last="Cavanagh">David Cavanagh</name>
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</noCountry>
<country name="Royaume-Uni"><region name="Écosse"><name sortKey="Smith, Jacqueline" sort="Smith, Jacqueline" uniqKey="Smith J" first="Jacqueline" last="Smith">Jacqueline Smith</name>
</region>
<name sortKey="Burt, David W" sort="Burt, David W" uniqKey="Burt D" first="David W." last="Burt">David W. Burt</name>
<name sortKey="Kaiser, Pete" sort="Kaiser, Pete" uniqKey="Kaiser P" first="Pete" last="Kaiser">Pete Kaiser</name>
</country>
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