An association between systemic cyclosporine administration and development of acute bullous keratopathy in cats
Identifieur interne : 000908 ( Main/Exploration ); précédent : 000907; suivant : 000909An association between systemic cyclosporine administration and development of acute bullous keratopathy in cats
Auteurs : Kenneth E. Pierce Jr. [États-Unis] ; David A. Wilkie [États-Unis] ; Anne J. Gemensky-Metzler [États-Unis] ; Paul G. Curran [États-Unis] ; Wendy M. Townsend [États-Unis] ; Simon M. Petersen-Jones [États-Unis] ; Joshua T. Bartoe [États-Unis]Source :
- Veterinary Ophthalmology [ 1463-5216 ] ; 2016-07.
Abstract
Objective: To determine whether any association exists between the onset of feline acute bullous keratopathy (ABK) and administration of systemic corticosteroid or immunosuppressive therapy. Animals studied: Medical records of cats diagnosed with ABK between the years of 2000 and 2008 were retrospectively reviewed. Breed, age at diagnosis, weight, systemic disease status, eye affected, ophthalmic examination findings, systemic and topical therapy instituted, dosage and duration of therapy, visual outcome and histopathological analyses were recorded in cases meeting the inclusion criteria. Results: A total of 12 cats of a surveyed population of 70 167 met the inclusion criteria with 17/24 eyes affected by ABK. Medical and/or surgical therapy was utilized for management of ABK with 13/17 eyes remaining sighted at the time of last follow‐up. In a subset of cases corneal cytology, aerobic bacterial culture, FHV‐1 PCR, virus isolation and/or histopathology were performed; no infectious organisms were identified. A rupture in Descemet's membrane of the cornea was identified histologically in two globes. A total of 10 of 12 cats had been previously diagnosed with ongoing systemic disease. A total of 10 of 12 cats were receiving systemic therapy, and a significant association (P < 0.001) was noted between systemic administration of corticosteroids and/or cyclosporine A and the development of ABK. A total of 8 of 10 cats were administered oral prednisolone at doses between 1–2 mg/kg every 12–24 h. A total of 5 of 8 cats receiving oral prednisolone were concurrently administered oral cyclosporine at doses of 1.5–7 mg/kg every 12–24 h. Systemic cyclosporine therapy was found to be a significant risk factor (P < 0.001) for ABK development, while systemic prednisolone was not significant (P = 0.10). Conclusions: Systemic cyclosporine administration appears to be a risk factor for development of ABK in the population of cats studied.
Url:
DOI: 10.1111/vop.12367
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000630
- to stream Istex, to step Curation: 000610
- to stream Istex, to step Checkpoint: 000013
- to stream Main, to step Merge: 000910
- to stream Main, to step Curation: 000908
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">An association between systemic cyclosporine administration and development of acute bullous keratopathy in cats</title><author><name sortKey="Pierce Jr, Kenneth E" sort="Pierce Jr, Kenneth E" uniqKey="Pierce Jr K" first="Kenneth E." last="Pierce Jr.">Kenneth E. Pierce Jr.</name></author><author><name sortKey="Wilkie, David A" sort="Wilkie, David A" uniqKey="Wilkie D" first="David A." last="Wilkie">David A. Wilkie</name></author><author><name sortKey="Gemensky Etzler, Anne J" sort="Gemensky Etzler, Anne J" uniqKey="Gemensky Etzler A" first="Anne J." last="Gemensky-Metzler">Anne J. Gemensky-Metzler</name></author><author><name sortKey="Curran, Paul G" sort="Curran, Paul G" uniqKey="Curran P" first="Paul G." last="Curran">Paul G. Curran</name></author><author><name sortKey="Townsend, Wendy M" sort="Townsend, Wendy M" uniqKey="Townsend W" first="Wendy M." last="Townsend">Wendy M. Townsend</name></author><author><name sortKey="Petersen Ones, Simon M" sort="Petersen Ones, Simon M" uniqKey="Petersen Ones S" first="Simon M." last="Petersen-Jones">Simon M. Petersen-Jones</name></author><author><name sortKey="Bartoe, Joshua T" sort="Bartoe, Joshua T" uniqKey="Bartoe J" first="Joshua T." last="Bartoe">Joshua T. Bartoe</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:AE4F5CA32D5EC76CCA5534EE0F67670D6DB7441E</idno><date when="2016" year="2016">2016</date><idno type="doi">10.1111/vop.12367</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-KVCZN4SG-X/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000630</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000630</idno><idno type="wicri:Area/Istex/Curation">000610</idno><idno type="wicri:Area/Istex/Checkpoint">000013</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000013</idno><idno type="wicri:doubleKey">1463-5216:2016:Pierce Jr K:an:association:between</idno><idno type="wicri:Area/Main/Merge">000910</idno><idno type="wicri:Area/Main/Curation">000908</idno><idno type="wicri:Area/Main/Exploration">000908</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">An association between systemic cyclosporine administration and development of acute bullous keratopathy in cats</title><author><name sortKey="Pierce Jr, Kenneth E" sort="Pierce Jr, Kenneth E" uniqKey="Pierce Jr K" first="Kenneth E." last="Pierce Jr.">Kenneth E. Pierce Jr.</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Small Animal Clinical Sciences, Michigan State University, MI, East Lansing</wicri:regionArea><orgName type="university">Université d'État du Michigan</orgName><placeName><settlement type="city">East Lansing</settlement><region type="state">Michigan</region></placeName></affiliation><affiliation></affiliation><affiliation></affiliation></author><author><name sortKey="Wilkie, David A" sort="Wilkie, David A" uniqKey="Wilkie D" first="David A." last="Wilkie">David A. Wilkie</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Veterinary Clinical Sciences, The Ohio State University, OH, Columbus</wicri:regionArea><wicri:noRegion>Columbus</wicri:noRegion></affiliation></author><author><name sortKey="Gemensky Etzler, Anne J" sort="Gemensky Etzler, Anne J" uniqKey="Gemensky Etzler A" first="Anne J." last="Gemensky-Metzler">Anne J. Gemensky-Metzler</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Veterinary Clinical Sciences, The Ohio State University, OH, Columbus</wicri:regionArea><wicri:noRegion>Columbus</wicri:noRegion></affiliation></author><author><name sortKey="Curran, Paul G" sort="Curran, Paul G" uniqKey="Curran P" first="Paul G." last="Curran">Paul G. Curran</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Statistical Training and Consulting, Michigan State University, MI, East Lansing</wicri:regionArea><orgName type="university">Université d'État du Michigan</orgName><placeName><settlement type="city">East Lansing</settlement><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Townsend, Wendy M" sort="Townsend, Wendy M" uniqKey="Townsend W" first="Wendy M." last="Townsend">Wendy M. Townsend</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Veterinary Clinical Sciences, Purdue University, IN, West Lafayette</wicri:regionArea><wicri:noRegion>West Lafayette</wicri:noRegion></affiliation></author><author><name sortKey="Petersen Ones, Simon M" sort="Petersen Ones, Simon M" uniqKey="Petersen Ones S" first="Simon M." last="Petersen-Jones">Simon M. Petersen-Jones</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Small Animal Clinical Sciences, Michigan State University, MI, East Lansing</wicri:regionArea><orgName type="university">Université d'État du Michigan</orgName><placeName><settlement type="city">East Lansing</settlement><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Bartoe, Joshua T" sort="Bartoe, Joshua T" uniqKey="Bartoe J" first="Joshua T." last="Bartoe">Joshua T. Bartoe</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Small Animal Clinical Sciences, Michigan State University, MI, East Lansing</wicri:regionArea><orgName type="university">Université d'État du Michigan</orgName><placeName><settlement type="city">East Lansing</settlement><region type="state">Michigan</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Veterinary Ophthalmology</title><title level="j" type="alt">VETERINARY OPHTHALMOLOGY</title><idno type="ISSN">1463-5216</idno><idno type="eISSN">1463-5224</idno><imprint><biblScope unit="vol">19</biblScope><biblScope unit="issue">S1</biblScope><biblScope unit="page" from="77">77</biblScope><biblScope unit="page" to="85">85</biblScope><biblScope unit="page-count">9</biblScope><date type="published" when="2016-07">2016-07</date></imprint><idno type="ISSN">1463-5216</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1463-5216</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Objective: To determine whether any association exists between the onset of feline acute bullous keratopathy (ABK) and administration of systemic corticosteroid or immunosuppressive therapy. Animals studied: Medical records of cats diagnosed with ABK between the years of 2000 and 2008 were retrospectively reviewed. Breed, age at diagnosis, weight, systemic disease status, eye affected, ophthalmic examination findings, systemic and topical therapy instituted, dosage and duration of therapy, visual outcome and histopathological analyses were recorded in cases meeting the inclusion criteria. Results: A total of 12 cats of a surveyed population of 70 167 met the inclusion criteria with 17/24 eyes affected by ABK. Medical and/or surgical therapy was utilized for management of ABK with 13/17 eyes remaining sighted at the time of last follow‐up. In a subset of cases corneal cytology, aerobic bacterial culture, FHV‐1 PCR, virus isolation and/or histopathology were performed; no infectious organisms were identified. A rupture in Descemet's membrane of the cornea was identified histologically in two globes. A total of 10 of 12 cats had been previously diagnosed with ongoing systemic disease. A total of 10 of 12 cats were receiving systemic therapy, and a significant association (P < 0.001) was noted between systemic administration of corticosteroids and/or cyclosporine A and the development of ABK. A total of 8 of 10 cats were administered oral prednisolone at doses between 1–2 mg/kg every 12–24 h. A total of 5 of 8 cats receiving oral prednisolone were concurrently administered oral cyclosporine at doses of 1.5–7 mg/kg every 12–24 h. Systemic cyclosporine therapy was found to be a significant risk factor (P < 0.001) for ABK development, while systemic prednisolone was not significant (P = 0.10). Conclusions: Systemic cyclosporine administration appears to be a risk factor for development of ABK in the population of cats studied.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Michigan</li></region><settlement><li>East Lansing</li></settlement><orgName><li>Université d'État du Michigan</li></orgName></list><tree><country name="États-Unis"><region name="Michigan"><name sortKey="Pierce Jr, Kenneth E" sort="Pierce Jr, Kenneth E" uniqKey="Pierce Jr K" first="Kenneth E." last="Pierce Jr.">Kenneth E. Pierce Jr.</name></region><name sortKey="Bartoe, Joshua T" sort="Bartoe, Joshua T" uniqKey="Bartoe J" first="Joshua T." last="Bartoe">Joshua T. Bartoe</name><name sortKey="Curran, Paul G" sort="Curran, Paul G" uniqKey="Curran P" first="Paul G." last="Curran">Paul G. Curran</name><name sortKey="Gemensky Etzler, Anne J" sort="Gemensky Etzler, Anne J" uniqKey="Gemensky Etzler A" first="Anne J." last="Gemensky-Metzler">Anne J. Gemensky-Metzler</name><name sortKey="Petersen Ones, Simon M" sort="Petersen Ones, Simon M" uniqKey="Petersen Ones S" first="Simon M." last="Petersen-Jones">Simon M. Petersen-Jones</name><name sortKey="Townsend, Wendy M" sort="Townsend, Wendy M" uniqKey="Townsend W" first="Wendy M." last="Townsend">Wendy M. Townsend</name><name sortKey="Wilkie, David A" sort="Wilkie, David A" uniqKey="Wilkie D" first="David A." last="Wilkie">David A. Wilkie</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000908 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000908 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:AE4F5CA32D5EC76CCA5534EE0F67670D6DB7441E
|texte= An association between systemic cyclosporine administration and development of acute bullous keratopathy in cats
}}
| This area was generated with Dilib version V0.6.33. |  |